[go: up one dir, main page]

NL7215682A - 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins - Google Patents

6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins

Info

Publication number
NL7215682A
NL7215682A NL7215682A NL7215682A NL7215682A NL 7215682 A NL7215682 A NL 7215682A NL 7215682 A NL7215682 A NL 7215682A NL 7215682 A NL7215682 A NL 7215682A NL 7215682 A NL7215682 A NL 7215682A
Authority
NL
Netherlands
Prior art keywords
penicillins
amino
penicillanic acid
enzymatic splitting
acid prepn
Prior art date
Application number
NL7215682A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2157972A external-priority patent/DE2157972C3/en
Priority claimed from DE2157970A external-priority patent/DE2157970C3/en
Application filed filed Critical
Publication of NL7215682A publication Critical patent/NL7215682A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

6-APA is prepd. by stirring penicillin soln. of pH 6-8, pref. 7-7.8, at 20-50 degrees C, pref. 38 degrees C, with suspension of penicillin acylase which is covalently bound to a copolymer of acrylamide, N,N1-methylene bisacrylamide and maleic acid anhydride, for 3-20 hrs. The mixt. neutralised and the 6-APA isolated in known manner.
NL7215682A 1971-11-23 1972-11-20 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins NL7215682A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2157972A DE2157972C3 (en) 1971-11-23 1971-11-23 Carrier-bound penicillin acylase
DE2157970A DE2157970C3 (en) 1971-11-23 1971-11-23 Process for the production of 6-aminopenicillanic acid by cleavage of penicillin G by means of carrier-bound penicillin acylase

Publications (1)

Publication Number Publication Date
NL7215682A true NL7215682A (en) 1973-05-25

Family

ID=25762064

Family Applications (2)

Application Number Title Priority Date Filing Date
NL7215683A NL7215683A (en) 1971-11-23 1972-11-20
NL7215682A NL7215682A (en) 1971-11-23 1972-11-20 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NL7215683A NL7215683A (en) 1971-11-23 1972-11-20

Country Status (1)

Country Link
NL (2) NL7215683A (en)

Also Published As

Publication number Publication date
NL7215683A (en) 1973-05-25

Similar Documents

Publication Publication Date Title
DE69119216D1 (en) Enzymatic process for the production of 7-aminocephalosporic acid and derivatives
NL7215682A (en) 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins
GB1369462A (en) Enzymic resolution of racemic n-acyl-dl-amino acids
ES420695A1 (en) 6-Aminopenicillanic acid preparation
EP0268343A3 (en) Enzymatic process for 3-substituted cephalosporins
IE38150L (en) Desacetoxycephalosporins and intermediates
ES433375A1 (en) Enzyme complexes and their use
FR2078427A5 (en) Enzyme-attachment to silicon-contg - materials using activating agents
IE36851L (en) Production of 6-aminopenicillanic acid
FR2188608A5 (en) Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
ES385907A1 (en) Process for the production of 6-aminopenicillanic acid
FR2301498A1 (en) Racemisation of amino acids - esp. lysine, by refluxing in an aqueous solvent
BE807564A (en) 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn
FR2313394A1 (en) Enzymes immobilised on polymers contg. aldehyde and acid gps. - with pH - deppedent solubility
NL7416548A (en) PROCESS FOR THE ENZYMATIC PREPARATION OF SEMI-SYNTHETIC PENICILLINS AND CEPHALOSPORIN USING AN INSOLUBLE ACYLASE.
IE35525B1 (en) Enzymes
GB1264147A (en)
ES486162A3 (en) Procedure of production of 6-aminopenicilanico acid (Machine-translation by Google Translate, not legally binding)
GB939708A (en) Production of ª -hydroxybenzylpenicillin
FR2299343A1 (en) Immobilisation of enzymes - by reacting their amino gps. with halogenoamide gps. contained in a carrier
ES439790A3 (en) Producción enzymatic de cephalotine. (Machine-translation by Google Translate, not legally binding)
GB1387459A (en) Penicillin acylase
ES305735A1 (en) Process for making penicillin amidase
FI863678L (en) FOERFARANDE FOER SUBMERS ODLING AV PSEUDOMONAS AERUGINOSA-BAKTERIESTAMMAR.
GB1324910A (en) Maleimide derivative and its use

Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed