NL301128I2 - Risdiplam of een farmaceutisch aanvaardbaar zout daarvan - Google Patents

Risdiplam of een farmaceutisch aanvaardbaar zout daarvan

Info

Publication number: NL301128I2
Authority: NL; Netherlands
Prior art keywords: risdiplam; pharmaceutically acceptable; acceptable salt; salt; pharmaceutically
Prior art date: 2014-05-15

Application number

NL301128C

Other languages

English (en)

Other versions

NL301128I1 (nl

Original Assignee

Hoffmann La Roche

Ptc Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-15

Filing date

2021-09-15

Publication date

2021-10-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53175048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL301128(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2021-09-15 Application filed by Hoffmann La Roche, Ptc Therapeutics Inc filed Critical Hoffmann La Roche

2021-09-22 Publication of NL301128I1 publication Critical patent/NL301128I1/nl

2021-10-25 Publication of NL301128I2 publication Critical patent/NL301128I2/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NL301128C 2014-05-15 2021-09-15 Risdiplam of een farmaceutisch aanvaardbaar zout daarvan NL301128I2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461993839P	2014-05-15	2014-05-15
PCT/EP2015/060343 WO2015173181A1 (en)	2014-05-15	2015-05-11	Compounds for treating spinal muscular atrophy

Publications (2)

Publication Number	Publication Date
NL301128I1 NL301128I1 (nl)	2021-09-22
NL301128I2 true NL301128I2 (nl)	2021-10-25

Family

ID=53175048

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL301128C NL301128I2 (nl)	2014-05-15	2021-09-15	Risdiplam of een farmaceutisch aanvaardbaar zout daarvan

Country Status (36)

Country	Link
US (1)	US9969754B2 (nl)
EP (3)	EP3663296B1 (nl)
JP (1)	JP6236173B2 (nl)
KR (2)	KR102213740B1 (nl)
CN (1)	CN106459092B (nl)
AR (2)	AR100442A1 (nl)
AU (1)	AU2015261046C1 (nl)
BR (1)	BR112016026205B1 (nl)
CA (1)	CA2948561C (nl)
CL (1)	CL2016002836A1 (nl)
CR (1)	CR20160518A (nl)
DK (1)	DK3143025T3 (nl)
EA (2)	EA202090486A3 (nl)
ES (2)	ES2761423T3 (nl)
FR (1)	FR21C1039I2 (nl)
HR (2)	HRP20192159T1 (nl)
HU (2)	HUE046491T2 (nl)
IL (2)	IL248653B (nl)
LT (1)	LTC3143025I2 (nl)
MA (2)	MA51988A (nl)
MX (1)	MX371050B (nl)
MY (1)	MY174284A (nl)
NL (1)	NL301128I2 (nl)
NO (2)	NO2021035I1 (nl)
NZ (1)	NZ725008A (nl)
PE (1)	PE20170128A1 (nl)
PH (1)	PH12016502081B1 (nl)
PL (2)	PL3663296T3 (nl)
PT (1)	PT3143025T (nl)
RS (1)	RS59718B1 (nl)
SG (1)	SG11201609497TA (nl)
SI (2)	SI3143025T1 (nl)
TW (1)	TWI667239B (nl)
UA (1)	UA119670C2 (nl)
WO (1)	WO2015173181A1 (nl)
ZA (1)	ZA201607026B (nl)

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WO2015024876A2 (en)	2013-08-19	2015-02-26	F. Hoffmann-La Roche Ag	Screening method
US10882868B2 (en) *	2014-05-15	2021-01-05	Hoffmann-La Roche Inc.	Compounds for treating spinal muscular atrophy
EP3298017B1 (en)	2015-05-20	2019-08-14	H. Hoffnabb-La Roche Ag	Compounds for treating spinal muscular atrophy
EP3310169B1 (en)	2015-05-30	2023-05-17	PTC Therapeutics, Inc.	Methods for modulating rna splicing
EP4360707A3 (en) *	2015-11-12	2024-08-07	F. Hoffmann-La Roche AG	Compositions for treating spinal muscular atrophy
AU2016351919B2 (en) *	2015-11-12	2020-11-12	F. Hoffmann-La Roche Ag	Compounds for treating amyotrophic lateral sclerosis
PL3386511T3 (pl)	2015-12-10	2021-11-08	Ptc Therapeutics, Inc.	Sposoby leczenia choroby huntingtona
CN108137579B (zh)	2015-12-10	2022-01-07	豪夫迈·罗氏有限公司	桥连哌啶衍生物
EP3544435A4 (en) *	2016-11-28	2020-11-04	PTC Therapeutics, Inc.	RNA SPLICE MODULATION PROCESSES
KR20200033249A (ko)	2017-06-05	2020-03-27	피티씨 테라퓨틱스, 인크.	헌팅턴병 치료 화합물
US11608501B2 (en)	2017-06-14	2023-03-21	Ptc Therapeutics, Inc.	Methods for modifying RNA splicing
US11395822B2 (en)	2017-06-28	2022-07-26	Ptc Therapeutics, Inc.	Methods for treating Huntington's disease
CN111182898B (zh)	2017-06-28	2024-04-16	Ptc医疗公司	用于治疗亨廷顿氏病的方法
CN111132981B (zh) *	2017-09-22	2023-10-31	豪夫迈·罗氏有限公司	制备吡啶并[1,2-a]嘧啶-4-酮衍生物的方法
CA3078137A1 (en) *	2017-10-03	2019-04-11	F. Hoffmann-La Roche Ag	New treatment of sma
EA202092001A1 (ru)	2018-03-27	2021-01-29	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Соединения для лечения болезни гентингтона
SG11202012674PA (en)	2018-06-27	2021-01-28	Ptc Therapeutics Inc	Heterocyclic and heteroaryl compounds for treating huntington's disease
AU2019294482B2 (en)	2018-06-27	2022-09-01	Ptc Therapeutics, Inc.	Heteroaryl compounds for treating Huntington's disease
EP3814360B8 (en)	2018-06-27	2024-11-06	PTC Therapeutics, Inc.	Heteroaryl compounds for treating huntington's disease
EA202190116A1 (ru)	2018-06-27	2021-08-30	Реборна Биосайенсиз, Инк.	Агент для профилактики или лечения спинальной мышечной атрофии
EP3867256A1 (en)	2018-10-19	2021-08-25	F. Hoffmann-La Roche AG	New forms of pyrido[1,2-a]pyrimidin-4-one derivatives, its formulation and its process of making
WO2020249577A1 (en)	2019-06-12	2020-12-17	F. Hoffmann-La Roche Ag	New treatment of sma
WO2021021775A1 (en)	2019-07-31	2021-02-04	Teva Pharmaceuticals International Gmbh	Solid state forms of risdiplam and process for preparation thereof
WO2021207550A1 (en) *	2020-04-08	2021-10-14	Remix Therapeutics Inc.	Compounds and methods for modulating splicing
WO2022048675A1 (zh) *	2020-09-07	2022-03-10	苏州科睿思制药有限公司	Risdiplam晶型及其制备方法和用途
WO2022162107A1 (en)	2021-02-01	2022-08-04	Sandoz Ag	Crystalline form of risdiplam
EP4308577B1 (en) *	2021-03-17	2024-12-25	F. Hoffmann-La Roche AG	New thiadiazolopyrimidone derivatives
IL305203A (en) *	2021-03-17	2023-10-01	Hoffmann La Roche	New histories of thiazolopyrimidines
EP4308572B1 (en) *	2021-03-17	2025-04-23	F. Hoffmann-La Roche AG	New thienopyrimidinone derivatives
KR20230145461A (ko)	2021-03-18	2023-10-17	에프. 호프만-라 로슈 아게	리스디플람의 제조 방법
EP4426306A1 (en)	2021-10-06	2024-09-11	F. Hoffmann-La Roche AG	Novel combined administration
WO2023202501A1 (zh) *	2022-04-18	2023-10-26	深圳市塔吉瑞生物医药有限公司	取代的吡啶并嘧啶酮类化合物及包含该化合物的组合物及其用途
WO2023240236A1 (en)	2022-06-10	2023-12-14	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of spinal muscular atrophy related disorders
WO2024069646A1 (en) *	2022-09-26	2024-04-04	Natco Pharma Limited	Improved process for the preparation of risdiplam and its intermediates
EP4601651A1 (en)	2022-10-14	2025-08-20	Genentech, Inc.	Methods for treating spinal muscular atrophy
CN120530115A (zh) *	2023-01-21	2025-08-22	哈曼菲诺化学有限公司	利司扑兰的制备方法、新型中间体及其制备方法
WO2024218207A1 (en)	2023-04-20	2024-10-24	F. Hoffmann-La Roche Ag	Thieno[3,2-b]pyridine derivatives
WO2024251925A1 (en)	2023-06-09	2024-12-12	F. Hoffmann-La Roche Ag	Inducible gene expression system
CN117050096A (zh) *	2023-07-17	2023-11-14	杭州诺澳生物医药科技有限公司	一种利司扑兰的制备方法
WO2025088083A1 (en)	2023-10-27	2025-05-01	F. Hoffmann-La Roche Ag	New composition for treating spinal muscular atrophy

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CA2862084C (en) *	2012-01-26	2021-05-11	Ptc Therapeutics, Inc.	1h-isochromen-1-one derivatives and compositions thereof for treating spinal muscular atrophy
UA116981C2 (uk) *	2012-02-10	2018-06-11	ПіТіСі ТЕРАП'ЮТІКС, ІНК.	Сполуки для лікування спінальної м'язової атрофії
AU2013289938A1 (en)	2012-07-13	2015-01-29	Indiana University Research & Technology Corporation	Compounds for treatment of spinal muscular atrophy
EP4360707A3 (en)	2015-11-12	2024-08-07	F. Hoffmann-La Roche AG	Compositions for treating spinal muscular atrophy

2015
- 2015-05-11 PL PL19200058.6T patent/PL3663296T3/pl unknown
- 2015-05-11 CR CR20160518A patent/CR20160518A/es unknown
- 2015-05-11 EA EA202090486A patent/EA202090486A3/ru unknown
- 2015-05-11 JP JP2016567816A patent/JP6236173B2/ja active Active
- 2015-05-11 EP EP19200058.6A patent/EP3663296B1/en active Active
- 2015-05-11 MA MA051988A patent/MA51988A/fr unknown
- 2015-05-11 PL PL15721701T patent/PL3143025T3/pl unknown
- 2015-05-11 CN CN201580027306.9A patent/CN106459092B/zh active Active
- 2015-05-11 HR HRP20192159TT patent/HRP20192159T1/hr unknown
- 2015-05-11 SI SI201531021T patent/SI3143025T1/sl unknown
- 2015-05-11 CA CA2948561A patent/CA2948561C/en active Active
- 2015-05-11 PT PT157217019T patent/PT3143025T/pt unknown
- 2015-05-11 BR BR112016026205-0A patent/BR112016026205B1/pt active IP Right Grant
- 2015-05-11 RS RS20191541A patent/RS59718B1/sr unknown
- 2015-05-11 DK DK15721701T patent/DK3143025T3/da active
- 2015-05-11 HR HRP20230637TT patent/HRP20230637T1/hr unknown
- 2015-05-11 KR KR1020167034983A patent/KR102213740B1/ko active Active
- 2015-05-11 PH PH1/2016/502081A patent/PH12016502081B1/en unknown
- 2015-05-11 SG SG11201609497TA patent/SG11201609497TA/en unknown
- 2015-05-11 MY MYPI2016001903A patent/MY174284A/en unknown
- 2015-05-11 EP EP23169721.0A patent/EP4241772A3/en not_active Withdrawn
- 2015-05-11 NZ NZ72500815A patent/NZ725008A/en unknown
- 2015-05-11 MA MA39995A patent/MA39995B1/fr unknown
- 2015-05-11 SI SI201531952T patent/SI3663296T1/sl unknown
- 2015-05-11 ES ES15721701T patent/ES2761423T3/es active Active
- 2015-05-11 EP EP15721701.9A patent/EP3143025B1/en active Active
- 2015-05-11 HU HUE15721701A patent/HUE046491T2/hu unknown
- 2015-05-11 ES ES19200058T patent/ES2949660T3/es active Active
- 2015-05-11 EA EA201692280A patent/EA035068B1/ru active Protection Beyond IP Right Term
- 2015-05-11 KR KR1020217002966A patent/KR102256013B1/ko active Active
- 2015-05-11 MX MX2016014547A patent/MX371050B/es active IP Right Grant
- 2015-05-11 AU AU2015261046A patent/AU2015261046C1/en active Active
- 2015-05-11 PE PE2016002128A patent/PE20170128A1/es unknown
- 2015-05-11 WO PCT/EP2015/060343 patent/WO2015173181A1/en not_active Ceased
- 2015-05-11 UA UAA201612716A patent/UA119670C2/uk unknown
- 2015-05-14 TW TW104115433A patent/TWI667239B/zh active
- 2015-05-14 AR ARP150101500A patent/AR100442A1/es not_active Application Discontinuation
2016
- 2016-10-12 ZA ZA2016/07026A patent/ZA201607026B/en unknown
- 2016-10-31 IL IL24865316A patent/IL248653B/en active IP Right Grant
- 2016-11-08 CL CL2016002836A patent/CL2016002836A1/es unknown
- 2016-11-14 US US15/351,267 patent/US9969754B2/en active Active
2019
- 2019-10-17 IL IL270027A patent/IL270027B/en active IP Right Grant
2021
- 2021-09-09 FR FR21C1039C patent/FR21C1039I2/fr active Active
- 2021-09-10 NO NO2021035C patent/NO2021035I1/no unknown
- 2021-09-14 LT LTPA2021010C patent/LTC3143025I2/lt unknown
- 2021-09-14 HU HUS2100037C patent/HUS2100037I1/hu unknown
- 2021-09-15 NL NL301128C patent/NL301128I2/nl unknown
2023
- 2023-12-01 AR ARP230103289A patent/AR131260A2/es unknown
2025
- 2025-08-14 NO NO2025038C patent/NO2025038I1/no unknown

Also Published As

Publication number	Publication date
PL3663296T3 (pl)	2023-08-07
BR112016026205A8 (pt)	2021-07-20
BR112016026205A2 (pt)	2017-08-15
UA119670C2 (uk)	2019-07-25
CL2016002836A1 (es)	2017-04-21
AU2015261046C1 (en)	2019-07-25
MY174284A (en)	2020-04-01
IL248653A0 (en)	2017-01-31
IL270027B (en)	2020-08-31
ES2949660T3 (es)	2023-10-02
EP4241772A3 (en)	2023-11-15
FR21C1039I2 (fr)	2022-09-02
US9969754B2 (en)	2018-05-15
HRP20192159T1 (hr)	2020-02-21
SI3143025T1 (sl)	2020-01-31
AU2015261046B2 (en)	2019-04-18
MX2016014547A (es)	2017-02-23
CN106459092B (zh)	2019-10-15
CA2948561C (en)	2019-10-22
PH12016502081B1 (en)	2022-11-23
MX371050B (es)	2020-01-14
ZA201607026B (en)	2022-05-25
EA035068B1 (ru)	2020-04-23
EP3143025B1 (en)	2019-10-09
EP3663296A1 (en)	2020-06-10
KR102213740B1 (ko)	2021-02-09
HUS2100037I1 (hu)	2021-10-28
ES2761423T3 (es)	2020-05-19
KR102256013B1 (ko)	2021-05-26
HRP20230637T1 (hr)	2023-09-29
MA39995B1 (fr)	2019-11-29
KR20210014219A (ko)	2021-02-08
CR20160518A (es)	2017-02-21
CA2948561A1 (en)	2015-11-19
BR112016026205B1 (pt)	2021-12-07
AU2015261046A1 (en)	2016-10-27
EA202090486A2 (ru)	2020-06-30
LTC3143025I2 (nl)	2023-11-10
PL3143025T3 (pl)	2020-03-31
AR131260A2 (es)	2025-03-05
EA201692280A1 (ru)	2018-07-31
JP2017515863A (ja)	2017-06-15
TWI667239B (zh)	2019-08-01
NO2021035I1 (no)	2021-09-10
SG11201609497TA (en)	2016-12-29
JP6236173B2 (ja)	2017-11-22
KR20170003687A (ko)	2017-01-09
PE20170128A1 (es)	2017-03-16
FR21C1039I1 (nl)	2021-10-15
PH12016502081A1 (en)	2017-01-09
EA202090486A3 (ru)	2020-08-31
US20170197990A1 (en)	2017-07-13
HUE046491T2 (hu)	2020-03-30
AR100442A1 (es)	2016-10-05
DK3143025T3 (da)	2019-12-09
WO2015173181A1 (en)	2015-11-19
RS59718B1 (sr)	2020-01-31
NO2025038I1 (no)	2025-08-14
PT3143025T (pt)	2019-12-03
IL248653B (en)	2019-11-28
MA51988A (fr)	2021-01-20
LTPA2021010I1 (nl)	2021-10-11
SI3663296T1 (sl)	2023-08-31
TW201609738A (zh)	2016-03-16
EP3143025A1 (en)	2017-03-22
NL301128I1 (nl)	2021-09-22
EP4241772A2 (en)	2023-09-13
CN106459092A (zh)	2017-02-22
NZ725008A (en)	2019-11-29
EP3663296B1 (en)	2023-05-17

Publication	Publication Date	Title
NL301128I2 (nl)	2021-10-25	Risdiplam of een farmaceutisch aanvaardbaar zout daarvan
NL301344I2 (nl)	2025-11-10	lnavolisib of een farmaceutisch aanvaardbaar zout daarvan
NL301111I2 (nl)	2021-09-27	Entrectinib of een farmaceutisch aanvaardbaar zout daarvan
NL301286I2 (nl)	2024-09-18	Danicopan, of een farmaceutisch aanvaardbaar zout ervan
NL301208I2 (nl)	2025-03-20	capmatinib of een farmaceutisch aanvaardbaar zout daarvan
NL301292I2 (nl)	2024-10-30	Iptacopan of een farmaceutisch aanvaardbaar zout daarvan
NL301253I2 (nl)	2024-01-10	mavacamten of een farmaceutisch aanvaardbaar zout daarvan
NL301329I2 (nl)	2025-09-09	Lazertinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout
FIC20265004I1 (fi)	2026-01-13	Sebetralstaatti tai sen farmaseuttisesti hyväksyttävä suola tai solvaatti
NO2022046I1 (no)	2022-11-07	Berotralstat and pharmaceutically acceptable salts thereof
NO2024007I1 (no)	2024-02-21	Elacestrant or a salt thereof
NO2022009I1 (no)	2022-04-05	Lumasiran, optionally in the form of a salt
NL301342I2 (nl)	2025-11-10	Elafibranor, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout
NO2024009I1 (no)	2024-03-06	Gefapixant, or a pharmaceutically acceptable salt thereof
IL256018A (en)	2018-01-31	Audible indicator
NL301061I2 (nl)	2020-10-08	givosiran of een farmaceutisch aanvaardbaar zout daarvan
DK3125836T3 (da)	2020-11-09	Vejrtrækningshjæpeapparat
NL301338I2 (nl)	2025-09-11	seladelpar of een farmaceutisch aanvaardbaar zout daarvan, in het bijzonder seladelpar-L-lysinedihydraat
HUE059703T2 (hu)	2022-12-28	Gombaölõ készítmények
LT3188717T (lt)	2020-03-25	Vaisto forma, apimanti daleles
HUE042087T2 (hu)	2019-06-28	Inhalátor
DK3199161T3 (da)	2022-01-03	Farmaceutisk præparat
NL301306I2 (nl)	2024-12-30	Delgocitinib of een farmaceutisch aanvaardbaar zout daarvan
LT3212237T (lt)	2022-02-25	Metotreksato vaistinė forma
EP3437644A4 (en)	2019-11-27	MEDICINE