[go: up one dir, main page]

NL301111I2 - Entrectinib of een farmaceutisch aanvaardbaar zout daarvan - Google Patents

Entrectinib of een farmaceutisch aanvaardbaar zout daarvan

Info

Publication number
NL301111I2
NL301111I2 NL301111C NL301111C NL301111I2 NL 301111 I2 NL301111 I2 NL 301111I2 NL 301111 C NL301111 C NL 301111C NL 301111 C NL301111 C NL 301111C NL 301111 I2 NL301111 I2 NL 301111I2
Authority
NL
Netherlands
Prior art keywords
entrectinib
pharmaceutically acceptable
acceptable salt
salt
pharmaceutically
Prior art date
Application number
NL301111C
Other languages
English (en)
Other versions
NL301111I1 (nl
Original Assignee
Ignyta Inc
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ignyta Inc, Nerviano Medical Sciences Srl filed Critical Ignyta Inc
Publication of NL301111I1 publication Critical patent/NL301111I1/nl
Publication of NL301111I2 publication Critical patent/NL301111I2/nl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL301111C 2014-02-20 2021-06-22 Entrectinib of een farmaceutisch aanvaardbaar zout daarvan NL301111I2 (nl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461942287P 2014-02-20 2014-02-20
US201462052994P 2014-09-19 2014-09-19
US201462055450P 2014-09-25 2014-09-25
US201462069999P 2014-10-29 2014-10-29
PCT/EP2015/053544 WO2015124697A1 (en) 2014-02-20 2015-02-19 Compounds for treating patients with ros1 mutant cancer cells

Publications (2)

Publication Number Publication Date
NL301111I1 NL301111I1 (nl) 2021-06-23
NL301111I2 true NL301111I2 (nl) 2021-09-27

Family

ID=52544499

Family Applications (1)

Application Number Title Priority Date Filing Date
NL301111C NL301111I2 (nl) 2014-02-20 2021-06-22 Entrectinib of een farmaceutisch aanvaardbaar zout daarvan

Country Status (20)

Country Link
US (4) US10231965B2 (nl)
EP (2) EP3834827A1 (nl)
JP (1) JP6636933B2 (nl)
KR (2) KR102634514B1 (nl)
CN (1) CN106029073A (nl)
AU (1) AU2015220832B2 (nl)
BR (1) BR112016015818A2 (nl)
CA (1) CA2933623C (nl)
CL (1) CL2016001507A1 (nl)
EA (1) EA033457B1 (nl)
ES (1) ES2856231T3 (nl)
IL (1) IL246544B (nl)
MX (1) MX373042B (nl)
NL (1) NL301111I2 (nl)
PH (1) PH12016501394A1 (nl)
PL (1) PL3107541T3 (nl)
SG (1) SG11201605816TA (nl)
TW (1) TWI672141B (nl)
UA (1) UA118773C2 (nl)
WO (1) WO2015124697A1 (nl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8450322B2 (en) 2008-09-22 2013-05-28 Array Biopharma Inc. Substituted imidazo[1,2b]pyridazine compounds as Trk kinase inhibitors
KR102037619B1 (ko) 2008-10-22 2019-10-28 어레이 바이오파마 인크. ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５­ａ］ 피리미딘 화합물
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
ES2628418T3 (es) 2010-05-20 2017-08-02 Array Biopharma, Inc. Compuestos macrocíclicos como inhibidores de la TRK cinasa
ES2853485T3 (es) 2013-02-19 2021-09-16 Ono Pharmaceutical Co Derivado de urea como compuesto inhibidor de Trk
TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
CA2967951C (en) 2014-11-16 2023-11-07 Array Biopharma, Inc. Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
AU2015355220B2 (en) 2014-12-02 2020-02-27 Ignyta, Inc. Combinations for the treatment of neuroblastoma
US20170356918A1 (en) * 2014-12-03 2017-12-14 Ignyta, Inc. Multiplexed immunohistochemistry assays for diagnosis and treatment of cancer
BR112017025773A2 (en) 2015-06-01 2018-08-14 Loxo Oncology, Inc. cancer diagnosis and treatment methods
WO2017011776A1 (en) 2015-07-16 2017-01-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
CN108697708A (zh) 2015-10-26 2018-10-23 洛克索肿瘤学股份有限公司 Trk抑制剂抗性癌症中的点突变以及与此相关的方法
EP3389645A4 (en) * 2015-12-18 2019-12-18 Ignyta, Inc. COMBINATIONS FOR TREATING CANCER
SI3439662T1 (sl) 2016-04-04 2024-11-29 Loxo Oncology, Inc. Tekoče formulacije (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirolidin -1-il)-pirazološ1,5-aćpirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
HRP20241295T1 (hr) 2016-04-04 2024-12-06 Loxo Oncology, Inc. Postupci za liječenje pedijatrijskih karcinoma
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
DK3458456T3 (da) 2016-05-18 2020-12-14 Array Biopharma Inc Fremstilling af (s)-n-(5-((r)-2-(2,5-difluorphenyl)pyrrolidin-1-yl)pyrazol[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid
PL3464276T3 (pl) 2016-05-24 2022-04-04 Nerviano Medical Sciences S.R.L. Nowa postać krystaliczna n-[5-(3,5-difluoro-benzylo)-1h-indazol-3-ilo)-4-(4-metylopiperazyn-1-ylo)-2-tetrahydropiran-4-yloamino)-benzamidu
WO2018026663A1 (en) * 2016-08-01 2018-02-08 Ignyta, Inc. Combinations for the treatment of cancer
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
EP3571203B1 (en) 2017-01-18 2023-06-07 Array BioPharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
JP7203083B2 (ja) * 2017-07-19 2023-01-12 イグナイタ インコーポレイテッド エントレクチニブを含む薬学的組成物
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
JP7311498B2 (ja) * 2017-10-17 2023-07-19 イグナイタ インコーポレイテッド 薬学的組成物および剤形
WO2019084285A1 (en) 2017-10-26 2019-05-02 Qian Zhao FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR
WO2019143994A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
WO2019143977A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3095366A1 (en) 2018-03-29 2019-10-03 Loxo Oncology, Inc. Treatment of trk-associated cancers
WO2020028258A1 (en) 2018-07-31 2020-02-06 Loxo Oncology, Inc. Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
JP2022515197A (ja) 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体
WO2020131627A1 (en) 2018-12-19 2020-06-25 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
JPS6041489A (ja) 1983-08-12 1985-03-05 Kyowa Hakko Kogyo Co Ltd 新規生理活性物質ｋ―２５２
AU2882699A (en) 1998-02-27 1999-09-15 Watson Pharmaceuticals, Inc. Stabilizing composition for pharmaceutical dosage forms
JP2002275068A (ja) 2001-03-16 2002-09-25 Kyowa Hakko Kogyo Co Ltd アポトーシス誘導剤
WO2003027111A1 (en) 2001-09-27 2003-04-03 Smithkline Beecham Corporation Chemical compounds
AU2002353186A1 (en) 2001-12-19 2003-06-30 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors
FR2836915B1 (fr) 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
AU2003251875A1 (en) 2002-07-15 2004-02-02 Combinatorx, Incorporated Combination therapy for the treatment of neoplasms
BR0314098A (pt) 2002-09-05 2005-07-19 Aventis Pharma Sa Derivados da aminoindazóis a tìtulo de medicamentos e composições farmacêuticas que os contêm
MXPA05005554A (es) 2002-12-12 2005-07-26 Aventis Pharma Sa Derivados de aminoindazol y su utilizacion como inhibidores de quinasas.
TW200423938A (en) 2003-02-21 2004-11-16 Wyeth Corp 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury
RS53118B (sr) 2003-02-26 2014-06-30 Sugen Inc. Aminoheteroaril jedinjenja kao inhibitori protein kinaze
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
JP2007502329A (ja) 2003-05-23 2007-02-08 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド セルトラリン組成物
PL2392565T3 (pl) 2003-09-26 2014-08-29 Exelixis Inc Modulatory c-Met i sposoby stosowania
DK1675961T3 (da) 2003-10-24 2009-02-23 Oncalis Ag Fremgangsmåde til identifikation og/eller validering af receptortyrosinkinaseinhibitorer
FR2871158A1 (fr) 2004-06-04 2005-12-09 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
JPWO2006080450A1 (ja) 2005-01-27 2008-06-19 協和醗酵工業株式会社 Ｉｇｆ−１ｒ阻害剤
WO2006111035A1 (en) 2005-04-21 2006-10-26 Oncalis Ag Method for the identification of possibly harmful receptor tyrosine kinase (rtk) mutations and of inhibitors or medication directed against rtk mutantstitle
JP2008540622A (ja) 2005-05-16 2008-11-20 アストラゼネカ アクチボラグ 化合物
BRPI0614809A2 (pt) 2005-08-09 2011-04-12 Johannes Gutenberg Universitaet Mainz sensibilização de cánceres de pulmão resistentes a fármaco a inibidores de proteìna cinase
EP1966152A2 (en) 2005-12-20 2008-09-10 Takeda Pharmaceutical Company Limited Glucokinase activators
DE102006030479A1 (de) 2006-07-01 2008-03-20 Merck Patent Gmbh Indazolderivate
JP5185930B2 (ja) 2006-07-07 2013-04-17 ブリストル−マイヤーズ スクイブ カンパニー ピロロトリアジンキナーゼ阻害剤
US7790756B2 (en) 2006-10-11 2010-09-07 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
HRP20141260T1 (xx) 2006-12-08 2015-03-13 Irm Llc Spojevi i sastavi kao inhibitori kinaze proteina
BRPI0720059A2 (pt) 2006-12-11 2013-12-17 Irm Llc Compostos e composições como inibidores de cinase
SI2120932T1 (sl) * 2006-12-20 2014-09-30 Nerviano Medical Sciences S.R.L. Indazolni derivati kot kinazni inhibitorji za zdravljenje raka
EP2173338A1 (en) 2007-07-06 2010-04-14 OSI Pharmaceuticals, Inc. Combination anti-cancer therapy
SI2176231T1 (sl) 2007-07-20 2017-01-31 Nerviano Medical Sciences S.R.L. Substituirani indazolni derivati, aktivni kot kinazni inhibitorji
CA2697795C (en) 2007-08-29 2016-08-16 Methylgene Inc. Thieno[3,2,b]pyridinyl compounds as inhibitors of protein tyrosine kinase activity
KR102037619B1 (ko) 2008-10-22 2019-10-28 어레이 바이오파마 인크. ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５­ａ］ 피리미딘 화합물
CN102924479A (zh) 2011-08-09 2013-02-13 山东鲁北药业有限公司 一种星孢菌素类衍生物的半合成方法
WO2013119950A2 (en) 2012-02-08 2013-08-15 Insight Genetics, Inc. Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer
NZ627900A (en) 2012-03-06 2016-08-26 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases
EP3333166B1 (en) 2012-05-23 2019-11-06 Nerviano Medical Sciences S.R.L. Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
US20140107107A1 (en) 2012-09-28 2014-04-17 Oncoethix Sa Pharmaceutical formulation containing thienotriazolodiazepine compounds
WO2014093750A1 (en) 2012-12-14 2014-06-19 Glaxosmithkline Llc Method of administration and treatment
DE102013012850B4 (de) * 2013-08-02 2025-09-11 Sew-Eurodrive Gmbh & Co Kg Elektromotor mit Rotorwelle und Gehäuseteil
TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
HRP20191593T1 (hr) 2014-05-15 2019-11-29 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorfenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze
US20170114415A1 (en) * 2014-05-30 2017-04-27 The Regents Of The University Of Colorado, A Body Corporate Activating ntrk1 gene fusions predictive of kinase inhibitor therapy
KR20170016858A (ko) 2014-06-13 2017-02-14 온코에틱스 게엠베하 티에노트리아졸로디아제핀 화합물을 사용하는 비소세포성 폐암 및/또는 소세포성 폐암의 치료 방법
AU2015355220B2 (en) 2014-12-02 2020-02-27 Ignyta, Inc. Combinations for the treatment of neuroblastoma
US20170356918A1 (en) 2014-12-03 2017-12-14 Ignyta, Inc. Multiplexed immunohistochemistry assays for diagnosis and treatment of cancer
AU2016270321B2 (en) 2015-05-29 2020-09-10 Ignyta, Inc. Compositions and methods for treating patients with RTK mutant cells
BR112017025773A2 (en) 2015-06-01 2018-08-14 Loxo Oncology, Inc. cancer diagnosis and treatment methods
CN108697708A (zh) 2015-10-26 2018-10-23 洛克索肿瘤学股份有限公司 Trk抑制剂抗性癌症中的点突变以及与此相关的方法
EP3389645A4 (en) 2015-12-18 2019-12-18 Ignyta, Inc. COMBINATIONS FOR TREATING CANCER
JP7203083B2 (ja) 2017-07-19 2023-01-12 イグナイタ インコーポレイテッド エントレクチニブを含む薬学的組成物
JP7311498B2 (ja) 2017-10-17 2023-07-19 イグナイタ インコーポレイテッド 薬学的組成物および剤形

Also Published As

Publication number Publication date
EA201691151A1 (ru) 2017-01-30
CA2933623C (en) 2022-05-17
NZ722405A (en) 2021-03-26
CL2016001507A1 (es) 2017-02-10
IL246544B (en) 2019-12-31
US20170007599A1 (en) 2017-01-12
ES2856231T3 (es) 2021-09-27
NL301111I1 (nl) 2021-06-23
SG11201605816TA (en) 2016-08-30
KR102634514B1 (ko) 2024-02-07
KR20220165787A (ko) 2022-12-15
MX373042B (es) 2020-06-19
EP3107541B1 (en) 2020-12-23
IL246544A0 (en) 2016-08-31
MX2016010519A (es) 2016-11-16
CA2933623A1 (en) 2015-08-27
US10231965B2 (en) 2019-03-19
BR112016015818A2 (pt) 2017-08-08
TWI672141B (zh) 2019-09-21
US10561651B2 (en) 2020-02-18
PH12016501394A1 (en) 2017-02-20
EP3107541A1 (en) 2016-12-28
JP2017506255A (ja) 2017-03-02
EA033457B1 (ru) 2019-10-31
CN106029073A (zh) 2016-10-12
KR20160117611A (ko) 2016-10-10
US10682348B2 (en) 2020-06-16
US20150283132A1 (en) 2015-10-08
JP6636933B2 (ja) 2020-01-29
AU2015220832A1 (en) 2016-09-08
PL3107541T3 (pl) 2021-09-20
UA118773C2 (uk) 2019-03-11
AU2015220832B2 (en) 2020-02-27
EP3834827A1 (en) 2021-06-16
US20180333412A1 (en) 2018-11-22
WO2015124697A1 (en) 2015-08-27
AU2015220832A2 (en) 2016-09-08
TW201613593A (en) 2016-04-16
US20190282564A1 (en) 2019-09-19

Similar Documents

Publication Publication Date Title
NL301128I2 (nl) Risdiplam of een farmaceutisch aanvaardbaar zout daarvan
NL301344I2 (nl) lnavolisib of een farmaceutisch aanvaardbaar zout daarvan
NL301111I2 (nl) Entrectinib of een farmaceutisch aanvaardbaar zout daarvan
NL301286I2 (nl) Danicopan, of een farmaceutisch aanvaardbaar zout ervan
NL301208I2 (nl) capmatinib of een farmaceutisch aanvaardbaar zout daarvan
NL301292I2 (nl) Iptacopan of een farmaceutisch aanvaardbaar zout daarvan
NL301253I2 (nl) mavacamten of een farmaceutisch aanvaardbaar zout daarvan
NL301329I2 (nl) Lazertinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout
FIC20265004I1 (fi) Sebetralstaatti tai sen farmaseuttisesti hyväksyttävä suola tai solvaatti
NO2022046I1 (no) Berotralstat and pharmaceutically acceptable salts thereof
NO2024007I1 (no) Elacestrant or a salt thereof
NO2022009I1 (no) Lumasiran, optionally in the form of a salt
NL301342I2 (nl) Elafibranor, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout
NO2024009I1 (no) Gefapixant, or a pharmaceutically acceptable salt thereof
IL256018A (en) Audible indicator
NL301061I2 (nl) givosiran of een farmaceutisch aanvaardbaar zout daarvan
DK3125836T3 (da) Vejrtrækningshjæpeapparat
NL301338I2 (nl) seladelpar of een farmaceutisch aanvaardbaar zout daarvan, in het bijzonder seladelpar-L-lysinedihydraat
HUE059703T2 (hu) Gombaölõ készítmények
LT3188717T (lt) Vaisto forma, apimanti daleles
HUE042087T2 (hu) Inhalátor
DK3199161T3 (da) Farmaceutisk præparat
NL301306I2 (nl) Delgocitinib of een farmaceutisch aanvaardbaar zout daarvan
LT3212237T (lt) Metotreksato vaistinė forma
EP3437644A4 (en) MEDICINE