NL192109B - Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten. - Google Patents
Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten.Info
- Publication number
- NL192109B NL192109B NL8100922A NL8100922A NL192109B NL 192109 B NL192109 B NL 192109B NL 8100922 A NL8100922 A NL 8100922A NL 8100922 A NL8100922 A NL 8100922A NL 192109 B NL192109 B NL 192109B
- Authority
- NL
- Netherlands
- Prior art keywords
- preparation
- salts
- bypiridinone
- crystalline
- derivatives
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 3
- 230000003177 cardiotonic effect Effects 0.000 title 1
- 150000007975 iminium salts Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/124,808 US4264609A (en) | 1980-02-26 | 1980-02-26 | N-[3-Dimethylamino-2-(4-pyridinyl)-2-propenylidene]-N-methylmethaniminium chloride hydrochloride, its use in preparing 5-(cyano or carbamyl)-[3,4'-bipyridin]-6(1H)-one and its use as a cardiotonic |
| US12480880 | 1980-02-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8100922A NL8100922A (nl) | 1981-09-16 |
| NL192109B true NL192109B (nl) | 1996-10-01 |
| NL192109C NL192109C (nl) | 1997-02-04 |
Family
ID=22416880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8100922A NL192109C (nl) | 1980-02-26 | 1981-02-25 | Kristallijne iminiumzouten, werkwijze ter bereiding daarvan, cardiotonische preparaten die deze zouten bevatten, alsmede hun toepassing ter bereiding van bypiridinonderivaten. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4264609A (nl) |
| JP (1) | JPS56128758A (nl) |
| KR (2) | KR840002067B1 (nl) |
| AR (1) | AR230630A1 (nl) |
| AT (2) | AT380237B (nl) |
| AU (1) | AU541644B2 (nl) |
| BE (1) | BE887663A (nl) |
| CA (1) | CA1128523A (nl) |
| CH (1) | CH647509A5 (nl) |
| DE (1) | DE3107306A1 (nl) |
| DK (1) | DK171253B1 (nl) |
| ES (1) | ES499776A1 (nl) |
| FI (1) | FI76787C (nl) |
| FR (1) | FR2476646A1 (nl) |
| GB (1) | GB2070600B (nl) |
| HK (1) | HK71789A (nl) |
| IE (1) | IE51696B1 (nl) |
| IL (1) | IL62161A (nl) |
| IT (1) | IT1210992B (nl) |
| LU (1) | LU83169A1 (nl) |
| MX (1) | MX6908E (nl) |
| NL (1) | NL192109C (nl) |
| NO (1) | NO156689C (nl) |
| NZ (1) | NZ196282A (nl) |
| PH (2) | PH19904A (nl) |
| PT (1) | PT72573B (nl) |
| SE (2) | SE437514B (nl) |
| ZA (1) | ZA811124B (nl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE77817T1 (de) | 1985-04-30 | 1992-07-15 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
| US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
-
1980
- 1980-02-26 US US06/124,808 patent/US4264609A/en not_active Expired - Lifetime
-
1981
- 1981-02-17 NZ NZ196282A patent/NZ196282A/xx unknown
- 1981-02-18 IL IL62161A patent/IL62161A/xx not_active IP Right Cessation
- 1981-02-20 ZA ZA00811124A patent/ZA811124B/xx unknown
- 1981-02-20 AU AU67487/81A patent/AU541644B2/en not_active Expired
- 1981-02-20 GB GB8105369A patent/GB2070600B/en not_active Expired
- 1981-02-24 CH CH1222/81A patent/CH647509A5/fr not_active IP Right Cessation
- 1981-02-24 SE SE8101205A patent/SE437514B/sv not_active IP Right Cessation
- 1981-02-24 FR FR8103609A patent/FR2476646A1/fr active Granted
- 1981-02-24 IT IT8119952A patent/IT1210992B/it active
- 1981-02-24 PH PH25258A patent/PH19904A/en unknown
- 1981-02-25 NL NL8100922A patent/NL192109C/nl not_active IP Right Cessation
- 1981-02-25 IE IE397/81A patent/IE51696B1/en not_active IP Right Cessation
- 1981-02-25 DK DK083981A patent/DK171253B1/da not_active IP Right Cessation
- 1981-02-25 FI FI810582A patent/FI76787C/fi not_active IP Right Cessation
- 1981-02-25 KR KR1019810000616A patent/KR840002067B1/ko not_active Expired
- 1981-02-25 BE BE1/10150A patent/BE887663A/fr not_active IP Right Cessation
- 1981-02-25 NO NO810639A patent/NO156689C/no unknown
- 1981-02-25 ES ES499776A patent/ES499776A1/es not_active Expired
- 1981-02-25 PT PT72573A patent/PT72573B/pt unknown
- 1981-02-25 CA CA371,690A patent/CA1128523A/en not_active Expired
- 1981-02-25 MX MX819321U patent/MX6908E/es unknown
- 1981-02-25 AT AT0088581A patent/AT380237B/de not_active IP Right Cessation
- 1981-02-26 DE DE19813107306 patent/DE3107306A1/de active Granted
- 1981-02-26 JP JP2759981A patent/JPS56128758A/ja active Granted
- 1981-02-26 LU LU83169A patent/LU83169A1/fr unknown
- 1981-02-26 AR AR284447A patent/AR230630A1/es active
-
1982
- 1982-03-01 PH PH26927A patent/PH17145A/en unknown
-
1983
- 1983-08-26 AT AT0305683A patent/AT380236B/de not_active IP Right Cessation
-
1984
- 1984-05-21 SE SE8402727A patent/SE452764B/sv not_active IP Right Cessation
- 1984-08-22 KR KR1019840005058A patent/KR840002066B1/ko not_active Expired
-
1989
- 1989-09-07 HK HK717/89A patent/HK71789A/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| SNR | Assignments of patents or rights arising from examined patent applications |
Owner name: SANOFI PHARMACEUTICALS, INC. |
|
| TNT | Modifications of names of proprietors of patents or applicants of examined patent applications |
Owner name: STERLING WINTHROP INC. |
|
| TNT | Modifications of names of proprietors of patents or applicants of examined patent applications |
Owner name: SANOFI-SYNTHELABO INC. |
|
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Free format text: 20010225 |