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NI201000195A - Derivados de quinuclidina como antagonistas de receptores muscarinicos m3. - Google Patents

Derivados de quinuclidina como antagonistas de receptores muscarinicos m3.

Info

Publication number
NI201000195A
NI201000195A NI201000195A NI201000195A NI201000195A NI 201000195 A NI201000195 A NI 201000195A NI 201000195 A NI201000195 A NI 201000195A NI 201000195 A NI201000195 A NI 201000195A NI 201000195 A NI201000195 A NI 201000195A
Authority
NI
Nicaragua
Prior art keywords
quinuclidine
antagonists
derivatives
muscarinic receptors
pharmaceutical compositions
Prior art date
Application number
NI201000195A
Other languages
English (en)
Inventor
Lee Ford Rhonan
Nigel Mather Andrew
Mete Antonio
Anne Skidmore Elizabeth
James Bull Richard
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NI201000195A publication Critical patent/NI201000195A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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Abstract

La invención proporciona los compuestos nombrados de fórmula (I) en la que R4 es una quinuclidina N-sustituida (I), composiciones farmacéuticas que los contienen y un proceso para preparar las composiciones farmacéuticas muscarínicos M3, tales como la enfermedad pulmonar obstructiva crónica.
NI201000195A 2008-05-13 2010-11-12 Derivados de quinuclidina como antagonistas de receptores muscarinicos m3. NI201000195A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2008/001647 WO2009138707A1 (en) 2008-05-13 2008-05-13 Quinuclidine derivatives as muscarinic m3 receptor antagonists

Publications (1)

Publication Number Publication Date
NI201000195A true NI201000195A (es) 2012-08-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NI201000195A NI201000195A (es) 2008-05-13 2010-11-12 Derivados de quinuclidina como antagonistas de receptores muscarinicos m3.

Country Status (17)

Country Link
US (2) US8329729B2 (es)
EP (1) EP2300464A1 (es)
JP (1) JP4837800B2 (es)
CN (1) CN102089304A (es)
AU (1) AU2008356409B2 (es)
BR (1) BRPI0822693A2 (es)
CA (1) CA2723981A1 (es)
CL (1) CL2009001137A1 (es)
EA (1) EA017627B1 (es)
EC (1) ECSP10010606A (es)
HN (1) HN2010002403A (es)
IL (1) IL209126A0 (es)
MX (1) MX2010012189A (es)
NI (1) NI201000195A (es)
NZ (1) NZ589091A (es)
WO (1) WO2009138707A1 (es)
ZA (1) ZA201007988B (es)

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TW200825084A (en) * 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
KR20110010725A (ko) * 2008-05-13 2011-02-07 아스트라제네카 아베 무스카린성 수용체 길항제 및 β２­아드레날린수용체 효능제를 포함하는 제약 생성물
BRPI0822693A2 (pt) 2008-05-13 2015-07-07 Astrazeneca Ab Derivados de quinuclidina como antagonistas do receptor muscarínico m3
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
CN103265478B (zh) * 2013-05-20 2015-09-30 中国人民解放军第二军医大学 巯基烟酸类化合物及其制备方法
CN114716380B (zh) * 2022-04-01 2024-06-21 新乡医学院 一种相转移催化的4-取代吡唑酮类化合物不对称氟化方法
WO2025171311A1 (en) * 2024-02-09 2025-08-14 University Of Florida Research Foundation, Incorporated Aryl and pyridyl amide pesticides and compositions thereof

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US20110172237A1 (en) 2011-07-14
AU2008356409B2 (en) 2012-01-19
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NZ589091A (en) 2011-07-29
EA201001645A1 (ru) 2011-06-30
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IL209126A0 (en) 2011-01-31
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BRPI0822693A2 (pt) 2015-07-07

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