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NI201000064A - MODULADORES DE PIPERIDINIL Y PIPERAZINIL DE LA y-SECRETASA. - Google Patents

MODULADORES DE PIPERIDINIL Y PIPERAZINIL DE LA y-SECRETASA.

Info

Publication number
NI201000064A
NI201000064A NI201000064A NI201000064A NI201000064A NI 201000064 A NI201000064 A NI 201000064A NI 201000064 A NI201000064 A NI 201000064A NI 201000064 A NI201000064 A NI 201000064A NI 201000064 A NI201000064 A NI 201000064A
Authority
NI
Nicaragua
Prior art keywords
secretase
piperidinil
piperazinil
modulators
compounds
Prior art date
Application number
NI201000064A
Other languages
English (en)
Inventor
Yung Ho Chih
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NI201000064A publication Critical patent/NI201000064A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona a compuestos de la Fórmula I como se muestran abajo, en donde las definiciones de Het, R0, R1, R2, R3, R4, R5, R6, R7, R8 y R9 se proporcionan en la especificación. Los compuestos de la Fórmula I son útiles para el tratamiento de enfermedades asociadas con la actividad de la y-secretasa, incluyendo la enfermedad de Alzheimer.
NI201000064A 2007-10-19 2010-04-16 MODULADORES DE PIPERIDINIL Y PIPERAZINIL DE LA y-SECRETASA. NI201000064A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98118907P 2007-10-19 2007-10-19

Publications (1)

Publication Number Publication Date
NI201000064A true NI201000064A (es) 2010-09-13

Family

ID=40090456

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201000064A NI201000064A (es) 2007-10-19 2010-04-16 MODULADORES DE PIPERIDINIL Y PIPERAZINIL DE LA y-SECRETASA.

Country Status (19)

Country Link
US (1) US8252935B2 (es)
EP (1) EP2212287B1 (es)
JP (1) JP5439381B2 (es)
KR (1) KR101569391B1 (es)
CN (1) CN101903347B (es)
AT (1) ATE543799T1 (es)
AU (1) AU2008312612B2 (es)
BR (1) BRPI0817433A2 (es)
CA (1) CA2702837A1 (es)
CO (1) CO6270359A2 (es)
CR (1) CR11447A (es)
EA (1) EA017119B1 (es)
ES (1) ES2378594T3 (es)
IL (1) IL205045A (es)
MX (1) MX2010004309A (es)
NI (1) NI201000064A (es)
NZ (1) NZ584716A (es)
WO (1) WO2009052126A1 (es)
ZA (1) ZA201003519B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010004309A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
EP2215043B1 (en) * 2007-10-19 2013-03-06 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
JP5543354B2 (ja) * 2007-10-19 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ γ−セクレターゼのアミン結合調節物質
WO2011009064A1 (en) * 2009-07-17 2011-01-20 The J. David Gladstone Institutes Methods of controlling cell proliferation
CN102482228A (zh) 2009-07-17 2012-05-30 盐野义制药株式会社 含有内酰胺或苯磺酰胺化合物的药物
CN102781898B (zh) * 2009-11-05 2014-12-24 菲布他丁有限合伙公司 使用q2拟肽的gpbp抑制
SI3846903T1 (sl) 2018-09-03 2024-02-29 F. Hoffmann - La Roche Ag Biciklični heteroarilni derivati
DK3894411T3 (da) 2018-12-13 2024-08-19 Hoffmann La Roche 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-aminderivater og beslægtede forbindelser som gamma-sekretase-modulatorer til behandling af Alzheimers sygdom

Family Cites Families (27)

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US2212287A (en) * 1938-09-13 1940-08-20 William S Stateler Milk bottle holder
BE790287A (fr) * 1971-10-28 1973-04-19 Delalande Sa Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
BE826017R (fr) 1974-03-19 1975-08-26 Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
US4252951A (en) 1979-10-09 1981-02-24 Eli Lilly And Company Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid
US5391817A (en) 1993-12-21 1995-02-21 Bristol-Myers Squibb Biaryl phospholipase A2 inhibitors
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US5416187A (en) * 1994-04-04 1995-05-16 Eastman Chemical Company Process for the preparation of phenol-functional polyester resins
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
JP2007531742A (ja) * 2004-04-05 2007-11-08 シェーリング　コーポレイション 新規のγセクレターゼインヒビター
WO2005110963A1 (en) 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
EP1789404B1 (en) * 2004-06-30 2010-03-24 Schering Corporation Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors
WO2006004555A1 (en) 2004-06-30 2006-01-12 Paysetter Pte Ltd System and method for facilitating transfer of physical money and/or credit
DE102004033876B4 (de) 2004-07-13 2009-01-15 Christoph Kaesbohrer Dreidimensionales Struktursystem
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
EP1650183A1 (en) 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
WO2006088705A1 (en) * 2005-02-14 2006-08-24 Wyeth Terphenyl guanidines as [beta symbol] -secretase inhibitors
PL1847524T3 (pl) 2006-04-21 2010-03-31 Cellzome Ltd Pochodne terfenylu do leczenia choroby Alzheimera
PT1849762E (pt) 2006-04-21 2009-09-16 Cellzome Ltd Ácidos bifenilcarboxílicos substituídos e seus derivados
BRPI0712332A2 (pt) * 2006-06-09 2012-12-18 Icos Corp composto e derivados farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, método de antagonização de um receptor dp-2, e, uso de um composto
ES2395083T3 (es) 2007-10-17 2013-02-08 Janssen Pharmaceutica, N.V. Ácidos bifenilcarboxílicos y sus derivados
CA2702911A1 (en) 2007-10-19 2009-04-23 Chih Yung Ho Gsm intermediates
MX2010004309A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
WO2009052079A1 (en) 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Amide linked modulators of y-secretase
EP2215043B1 (en) 2007-10-19 2013-03-06 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
JP5543354B2 (ja) 2007-10-19 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ γ−セクレターゼのアミン結合調節物質
US7968725B2 (en) 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase

Also Published As

Publication number Publication date
ES2378594T3 (es) 2012-04-16
ZA201003519B (en) 2012-07-25
US20090105275A1 (en) 2009-04-23
IL205045A0 (en) 2010-11-30
BRPI0817433A2 (pt) 2015-06-16
EA201070495A1 (ru) 2010-10-29
JP2011500700A (ja) 2011-01-06
MX2010004309A (es) 2010-05-03
KR101569391B1 (ko) 2015-11-16
JP5439381B2 (ja) 2014-03-12
EP2212287B1 (en) 2012-02-01
CN101903347A (zh) 2010-12-01
NZ584716A (en) 2011-12-22
EP2212287A1 (en) 2010-08-04
AU2008312612B2 (en) 2013-11-28
AU2008312612A8 (en) 2010-05-27
KR20100083829A (ko) 2010-07-22
ATE543799T1 (de) 2012-02-15
CN101903347B (zh) 2013-03-27
CO6270359A2 (es) 2011-04-20
AU2008312612A2 (en) 2010-07-22
CA2702837A1 (en) 2009-04-23
WO2009052126A1 (en) 2009-04-23
IL205045A (en) 2015-08-31
US8252935B2 (en) 2012-08-28
ES2378594T8 (es) 2013-02-27
EA017119B1 (ru) 2012-09-28
AU2008312612A1 (en) 2009-04-23
CR11447A (es) 2011-01-14

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