MX2010004308A - Moduladores enlazados a amida gamma secretasa. - Google Patents
Moduladores enlazados a amida gamma secretasa.Info
- Publication number
- MX2010004308A MX2010004308A MX2010004308A MX2010004308A MX2010004308A MX 2010004308 A MX2010004308 A MX 2010004308A MX 2010004308 A MX2010004308 A MX 2010004308A MX 2010004308 A MX2010004308 A MX 2010004308A MX 2010004308 A MX2010004308 A MX 2010004308A
- Authority
- MX
- Mexico
- Prior art keywords
- secretase
- amide linked
- modulators
- linked modulators
- compounds
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a los compuestos de la Fórmula 1 como se muestran a continuación, en donde las definiciones de A, R1 R2, R3, R4, R5, R6, R7, y R8 se proporcionan en la especificación. Los compuestos de la Fórmula I son útiles para el tratamiento de enfermedades asociadas con la actividad de la ?-secretasa, que incluye la enfermedad de Alzheimer. (Ver fórmula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98117007P | 2007-10-19 | 2007-10-19 | |
| PCT/US2008/079782 WO2009052079A1 (en) | 2007-10-19 | 2008-10-14 | Amide linked modulators of y-secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010004308A true MX2010004308A (es) | 2010-05-03 |
Family
ID=40091367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010004308A MX2010004308A (es) | 2007-10-19 | 2008-10-14 | Moduladores enlazados a amida gamma secretasa. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7951843B2 (es) |
| EP (1) | EP2212280B1 (es) |
| JP (1) | JP5543353B2 (es) |
| KR (1) | KR20100090265A (es) |
| CN (1) | CN101888990B (es) |
| AU (1) | AU2008312653B2 (es) |
| BR (1) | BRPI0817425A2 (es) |
| CA (1) | CA2702835A1 (es) |
| CO (1) | CO6280529A2 (es) |
| CR (1) | CR11436A (es) |
| EA (1) | EA017907B1 (es) |
| ES (1) | ES2447842T3 (es) |
| IL (1) | IL205044A (es) |
| MX (1) | MX2010004308A (es) |
| NI (1) | NI201000063A (es) |
| NZ (1) | NZ584721A (es) |
| WO (1) | WO2009052079A1 (es) |
| ZA (1) | ZA201003518B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2212277B1 (en) * | 2007-10-19 | 2016-08-31 | Janssen Pharmaceutica, N.V. | Amine linked modulators of y-secretase |
| NZ584716A (en) * | 2007-10-19 | 2011-12-22 | Janssen Pharmaceutica Nv | PIPERIDINYL AND PIPERAZINYL MODULATORS OF gamma-SECRETASE |
| CA2702959C (en) * | 2007-10-19 | 2016-07-26 | Janssen Pharmaceutica Nv | Carbon linked modulators of .gamma.-secretase |
| WO2011009064A1 (en) * | 2009-07-17 | 2011-01-20 | The J. David Gladstone Institutes | Methods of controlling cell proliferation |
| US8871460B2 (en) * | 2009-11-09 | 2014-10-28 | Neurogenetic Pharmaceuticals, Inc. | Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| AU5702201A (en) | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| CN104788328B (zh) * | 2004-06-24 | 2017-09-12 | 沃泰克斯药物股份有限公司 | Atp‑结合弹夹转运蛋白的调控剂 |
| GB0416508D0 (en) * | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| EP1650183A1 (en) * | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| CA2654784A1 (en) * | 2006-06-09 | 2007-12-13 | Icos Corporation | Substituted phenylacetic acids as dp-2 antagonists |
-
2008
- 2008-10-14 BR BRPI0817425-3A patent/BRPI0817425A2/pt not_active IP Right Cessation
- 2008-10-14 CA CA2702835A patent/CA2702835A1/en not_active Abandoned
- 2008-10-14 AU AU2008312653A patent/AU2008312653B2/en not_active Ceased
- 2008-10-14 NZ NZ584721A patent/NZ584721A/en not_active IP Right Cessation
- 2008-10-14 ES ES08838993.7T patent/ES2447842T3/es active Active
- 2008-10-14 CN CN200880119162.XA patent/CN101888990B/zh not_active Expired - Fee Related
- 2008-10-14 EP EP08838993.7A patent/EP2212280B1/en active Active
- 2008-10-14 JP JP2010530057A patent/JP5543353B2/ja not_active Expired - Fee Related
- 2008-10-14 EA EA201070494A patent/EA017907B1/ru not_active IP Right Cessation
- 2008-10-14 WO PCT/US2008/079782 patent/WO2009052079A1/en not_active Ceased
- 2008-10-14 KR KR1020107010765A patent/KR20100090265A/ko not_active Abandoned
- 2008-10-14 MX MX2010004308A patent/MX2010004308A/es active IP Right Grant
- 2008-10-14 US US12/250,622 patent/US7951843B2/en not_active Expired - Fee Related
-
2010
- 2010-04-13 IL IL205044A patent/IL205044A/en not_active IP Right Cessation
- 2010-04-16 NI NI201000063A patent/NI201000063A/es unknown
- 2010-04-26 CO CO10048723A patent/CO6280529A2/es not_active Application Discontinuation
- 2010-05-17 CR CR11436A patent/CR11436A/es not_active Application Discontinuation
- 2010-05-18 ZA ZA2010/03518A patent/ZA201003518B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA017907B1 (ru) | 2013-04-30 |
| KR20100090265A (ko) | 2010-08-13 |
| ES2447842T3 (es) | 2014-03-13 |
| EP2212280A1 (en) | 2010-08-04 |
| ZA201003518B (en) | 2012-07-25 |
| NZ584721A (en) | 2011-11-25 |
| AU2008312653B2 (en) | 2013-03-07 |
| NI201000063A (es) | 2010-09-13 |
| WO2009052079A1 (en) | 2009-04-23 |
| JP5543353B2 (ja) | 2014-07-09 |
| CO6280529A2 (es) | 2011-05-20 |
| IL205044A0 (en) | 2010-11-30 |
| JP2011500699A (ja) | 2011-01-06 |
| US7951843B2 (en) | 2011-05-31 |
| AU2008312653A1 (en) | 2009-04-23 |
| CN101888990A (zh) | 2010-11-17 |
| EP2212280B1 (en) | 2013-12-04 |
| EA201070494A1 (ru) | 2010-12-30 |
| CR11436A (es) | 2011-01-14 |
| IL205044A (en) | 2015-02-26 |
| BRPI0817425A2 (pt) | 2015-06-16 |
| CN101888990B (zh) | 2014-01-29 |
| CA2702835A1 (en) | 2009-04-23 |
| US20090105345A1 (en) | 2009-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |