NI200700043A - Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. - Google Patents
Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan.Info
- Publication number
- NI200700043A NI200700043A NI200700043A NI200700043A NI200700043A NI 200700043 A NI200700043 A NI 200700043A NI 200700043 A NI200700043 A NI 200700043A NI 200700043 A NI200700043 A NI 200700043A NI 200700043 A NI200700043 A NI 200700043A
- Authority
- NI
- Nicaragua
- Prior art keywords
- hepatitis
- virus
- inhibitors
- rna
- treatments
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 108060004795 Methyltransferase Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención proporciona compuestos de fórmula (4) y sus sales farmacéuticamente aceptables y solvatos, que son útiles como inhibidores de la enzima polimerasa del virus de la Hepatitis C (HCV) y también son útiles para el tratamiento de infecciones por HCV en mamíferos infectados por HCV. La presente invención también proporciona composiciones farmacéuticas que comprenden compuestos de fórmula (4), sus sales farmacéuticamente aceptables y solvatos. Además la presente invención proporciona compuestos intermedios y métodos útiles en la preparación de compuestos de fórmula (4).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60261804P | 2004-08-18 | 2004-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI200700043A true NI200700043A (es) | 2008-01-02 |
Family
ID=35429645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI200700043A NI200700043A (es) | 2004-08-18 | 2007-02-15 | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. |
Country Status (42)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005273619B2 (en) * | 2004-08-18 | 2009-05-28 | Pfizer Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| US7807838B2 (en) * | 2005-08-24 | 2010-10-05 | Pfizer Inc. | Methods for the preparation of HCV polymerase inhibitors |
| ES2381410T3 (es) | 2007-05-04 | 2012-05-28 | Vertex Pharmceuticals Incorporated | Terapia de combinación paa el tratamiento de infecciones por VHC |
| EP2008996A1 (en) * | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Process for the production of pyrazoles |
| EP2280989B1 (en) | 2008-06-06 | 2016-02-10 | Scynexis, Inc. | Cyclosporin analogs and their use in the treatment of hcv infections |
| MX2011001663A (es) | 2008-08-11 | 2011-03-24 | Glaxosmithkline Llc | Derivados novedosos de adenina. |
| EP2324025A1 (en) | 2008-08-11 | 2011-05-25 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| UY32940A (es) | 2009-10-27 | 2011-05-31 | Bayer Cropscience Ag | Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas |
| US8822496B2 (en) | 2009-10-30 | 2014-09-02 | Boehringer Ingelheim International Gmbh | Dosage regimens for HCV combination therapy |
| EP2325173A1 (de) | 2009-11-19 | 2011-05-25 | Bayer CropScience AG | Verfahren zum Herstellen von 5-Fluor-1-alkyl-3-fluoralkyl-1H-pyrazol-4-carbonsäurechloriden |
| PH12012501216A1 (en) * | 2009-12-18 | 2012-11-05 | Boehringer Ingelheim Int | Hcv combination therapy |
| PL2534149T3 (pl) | 2010-02-10 | 2015-03-31 | Glaxosmithkline Llc | Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu |
| JP2013519644A (ja) | 2010-02-10 | 2013-05-30 | グラクソスミスクライン エルエルシー | プリン誘導体およびそれらの薬学的使用 |
| EP2571854B1 (en) | 2010-05-20 | 2014-11-05 | Bayer Intellectual Property GmbH | Method for manufacturing 1-alkyl-3-difluormethyl-5-hydroxypyrazoles |
| US8987307B2 (en) | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
| FR2972452B1 (fr) * | 2011-03-09 | 2013-03-15 | Rhodia Operations | Procede de preparation du difluoroacetonitrile et de ses derives |
| KR102006518B1 (ko) | 2012-05-14 | 2019-08-01 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 1-알킬-3-플루오로알킬-1h-피라졸-4-카르복실산 클로라이드의 제조 방법 |
| WO2014081878A2 (en) | 2012-11-21 | 2014-05-30 | Stategics, Inc. | Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival |
| BR112015015833B1 (pt) | 2013-01-17 | 2020-05-19 | Bayer Cropscience Ag | processo de preparação de 5-fluoro-1 -metil-3-difluorometil-1 h-pirazol-4-carbaldeído |
| DK2953942T3 (en) | 2013-02-06 | 2018-01-22 | Bayer Cropscience Ag | HALOGEN-SUBSTITUTED PYRAZOLD DERIVATIVES AS PESTICIDES. |
| RU2016131792A (ru) | 2014-01-03 | 2018-02-06 | Байер Энимэл Хельс ГмбХ | Новые пиразолил-гетероариламиды в качестве средств для борьбы с вредителями |
| MX361770B (es) | 2014-01-24 | 2018-12-17 | Bayer Cropscience Ag | Método para la preparación de 1-alquil-3-difluorometil-5-fluor-1h- pirazol-4-carbaldehídos y 1-alquil-3-difluorometil-5-fluor-1h-pira zol-4-carboxilatos. |
| CN106029668B (zh) | 2014-02-20 | 2018-02-23 | 葛兰素史克知识产权第二有限公司 | 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂 |
| MA40281B1 (fr) | 2014-06-03 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Composés de pyrazole et leur utilisation en tant qu' agents de blocage des canaux calciques de type t |
| BR112017009648A2 (pt) | 2014-11-13 | 2017-12-19 | Glaxosmithkline Biologicals Sa | composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto. |
| WO2017093180A1 (de) | 2015-12-01 | 2017-06-08 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| RU2020113165A (ru) | 2015-12-03 | 2020-06-09 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
| WO2017175156A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| IL295649B2 (en) | 2016-04-07 | 2025-12-01 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| BR112019003158B1 (pt) | 2016-08-15 | 2022-10-25 | Bayer Cropscience Aktiengesellschaft | Derivados de heterociclo bicíclico condensado, seu uso, formulação agroquímica, e método para controlar pragas animais |
| EP3301094A1 (en) * | 2016-09-30 | 2018-04-04 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| PT3554490T (pt) | 2016-12-16 | 2022-03-17 | Idorsia Pharmaceuticals Ltd | Combinação farmacêutica compreendendo um bloqueador de canais de cálcio de tipo t |
| MX376203B (es) | 2017-02-06 | 2025-03-07 | Idorsia Pharmaceuticals Ltd | Un proceso novedoso para la sintesis de 1-aril-1-trifluoro-metil-ciclopropanos. |
| BR112020006659B1 (pt) | 2017-10-04 | 2022-01-25 | Bayer Aktiengesellschaft | Derivados de compostos heterocíclicos, formulação agroquímica, método para controlar uma ou mais pragas animais, e produto |
| EP3692033A1 (en) | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (sting) useful in treating hiv |
| JP7291130B2 (ja) | 2017-10-05 | 2023-06-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | インターフェロン遺伝子の刺激物質（ｓｔｉｎｇ）の調節物質 |
| BR112020016991A2 (pt) | 2018-03-12 | 2020-12-15 | Bayer Aktiengesellschaft | Derivados heterocíclicos bicíclicos condensados como agentes de controle de pragas |
| AU2019254499A1 (en) | 2018-04-20 | 2020-12-03 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| US12435060B2 (en) | 2019-01-25 | 2025-10-07 | Beijing Scitech-Mq Pharmaceuticals Limited | Acylamino bridged heterocyclic compound, and composition and application thereof |
| JP2022533194A (ja) | 2019-05-16 | 2022-07-21 | スティングセラ インコーポレイテッド | ベンゾ［ｂ］［１，８］ナフチリジン酢酸誘導体および使用方法 |
| EP3969438A1 (en) | 2019-05-16 | 2022-03-23 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| JP7662644B2 (ja) | 2019-12-18 | 2025-04-15 | シーティーエックスティー・ピーティーワイ・リミテッド | 化合物 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CN112194620B (zh) * | 2020-12-04 | 2021-02-26 | 苏州开元民生科技股份有限公司 | 一种2-乙基-4-氰基吡啶的制备方法 |
| CN113563167B (zh) * | 2021-07-16 | 2023-09-08 | 南通华祥医药科技有限公司 | 一种2-甲基-1-四氢萘酮的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3786063A (en) * | 1971-05-24 | 1974-01-15 | Universal Oil Prod Co | Thiazolethiosulfonates |
| DE2155360C3 (de) * | 1971-11-08 | 1980-04-03 | Cassella Ag, 6000 Frankfurt | Verfahren zur Herstellung von Acylbernsteinsäuredialkylestern |
| CA1144937A (en) * | 1977-12-22 | 1983-04-19 | Dke J.E. Helgstrand | Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections |
| US4326058A (en) * | 1979-02-05 | 1982-04-20 | Sumitomo Chemical Company, Limited | Organo-phosphoric esters and their production and use |
| US4489077A (en) * | 1983-03-23 | 1984-12-18 | Warner-Lambert Company | 3-Isoxa-zolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides |
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| WO1995003056A1 (en) * | 1993-07-19 | 1995-02-02 | Tokyo Tanabe Company Limited | Hepatitis c virus proliferation inhibitor |
| US6005103A (en) * | 1993-11-19 | 1999-12-21 | Warner-Lambert Company | Pyrone derivatives as protease inhibitors and antiviral agents |
| RU2140917C1 (ru) | 1993-11-19 | 1999-11-10 | Парк, Дэвис энд Компани | Производные 5,6-дигидропирона и фармацевтическая композиция на их основе |
| MD1560G2 (ro) | 1993-11-19 | 2001-07-31 | Parke, Davis & Company | Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri |
| US5504104A (en) * | 1993-11-19 | 1996-04-02 | Warner-Lambert Company | Tricyclic pyrone derivatives as protease inhibitors and antiviral agents |
| US5789440A (en) * | 1993-11-19 | 1998-08-04 | Warner-Lambert Company | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
| US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| CA2339275A1 (en) * | 1998-09-11 | 2000-03-23 | Warner-Lambert Company | 5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease inhibitors |
| US6512006B1 (en) * | 1999-12-09 | 2003-01-28 | Warner-Lambert Company | HIV protease inhibitors |
| EP1256628A3 (en) | 2001-05-10 | 2003-03-19 | Agouron Pharmaceuticals, Inc. | Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof |
| DOP2003000641A (es) * | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) * | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| AU2005273619B2 (en) * | 2004-08-18 | 2009-05-28 | Pfizer Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
-
2005
- 2005-08-05 AU AU2005273619A patent/AU2005273619B2/en not_active Ceased
- 2005-08-05 NZ NZ552874A patent/NZ552874A/en not_active IP Right Cessation
- 2005-08-05 WO PCT/IB2005/002697 patent/WO2006018725A1/en not_active Ceased
- 2005-08-05 AP AP2007003918A patent/AP2313A/xx active
- 2005-08-05 HR HR20110458T patent/HRP20110458T1/hr unknown
- 2005-08-05 BR BRPI0514425-6A patent/BRPI0514425A/pt not_active IP Right Cessation
- 2005-08-05 RS RS20110257A patent/RS51794B/sr unknown
- 2005-08-05 GE GEAP200510998A patent/GEP20115305B/en unknown
- 2005-08-05 UA UAA200700852A patent/UA88909C2/ru unknown
- 2005-08-05 ES ES05775853T patent/ES2361845T3/es not_active Expired - Lifetime
- 2005-08-05 CA CA2577525A patent/CA2577525C/en not_active Expired - Fee Related
- 2005-08-05 EP EP05775853A patent/EP1781662B1/en not_active Expired - Lifetime
- 2005-08-05 JP JP2007526609A patent/JP4372195B2/ja not_active Expired - Fee Related
- 2005-08-05 CN CN2005800280919A patent/CN101006092B/zh not_active Expired - Fee Related
- 2005-08-05 GE GEAP20059868A patent/GEP20094751B/en unknown
- 2005-08-05 EA EA200700338A patent/EA012605B1/ru not_active IP Right Cessation
- 2005-08-05 DK DK05775853.4T patent/DK1781662T3/da active
- 2005-08-05 SI SI200531314T patent/SI1781662T1/sl unknown
- 2005-08-05 PL PL05775853T patent/PL1781662T3/pl unknown
- 2005-08-05 DE DE602005027580T patent/DE602005027580D1/de not_active Expired - Lifetime
- 2005-08-05 CN CN2009101381353A patent/CN101538268B/zh not_active Expired - Fee Related
- 2005-08-05 KR KR1020077006118A patent/KR100851178B1/ko not_active Expired - Fee Related
- 2005-08-05 PT PT05775853T patent/PT1781662E/pt unknown
- 2005-08-05 MX MX2007001527A patent/MX2007001527A/es active IP Right Grant
- 2005-08-05 AT AT05775853T patent/ATE506364T1/de active
- 2005-08-12 MY MYPI20053809A patent/MY146123A/en unknown
- 2005-08-15 US US11/204,269 patent/US7151105B2/en not_active Expired - Fee Related
- 2005-08-15 UY UY29068A patent/UY29068A1/es not_active Application Discontinuation
- 2005-08-15 PE PE2005000945A patent/PE20060677A1/es not_active Application Discontinuation
- 2005-08-16 GT GT200500221A patent/GT200500221A/es unknown
- 2005-08-16 AR ARP050103438A patent/AR050699A1/es active IP Right Grant
- 2005-08-17 TW TW094128016A patent/TWI376379B/zh not_active IP Right Cessation
- 2005-08-17 NL NL1029755A patent/NL1029755C2/nl not_active IP Right Cessation
- 2005-08-18 HN HN2005000449A patent/HN2005000449A/es unknown
- 2005-08-18 SV SV2005002202A patent/SV2007002202A/es not_active Application Discontinuation
-
2006
- 2006-09-06 US US11/470,540 patent/US7622605B2/en not_active Expired - Fee Related
-
2007
- 2007-01-24 IL IL180933A patent/IL180933A/en not_active IP Right Cessation
- 2007-01-26 ZA ZA200700779A patent/ZA200700779B/xx unknown
- 2007-02-15 NI NI200700043A patent/NI200700043A/es unknown
- 2007-02-16 EC EC2007007264A patent/ECSP077264A/es unknown
- 2007-02-16 TN TNP2007000066A patent/TNSN07066A1/fr unknown
- 2007-02-16 MA MA29684A patent/MA28803B1/fr unknown
- 2007-02-16 CR CR8935A patent/CR8935A/es unknown
- 2007-03-08 NO NO20071274A patent/NO20071274L/no not_active Application Discontinuation
-
2008
- 2008-07-20 IL IL192919A patent/IL192919A0/en unknown
-
2009
- 2009-07-15 US US12/503,286 patent/US8268835B2/en not_active Expired - Fee Related
-
2011
- 2011-03-21 CR CR20110153A patent/CR20110153A/es unknown
- 2011-05-17 CY CY20111100486T patent/CY1111480T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NI200700043A (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. | |
| UY28192A1 (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan. | |
| CO2022018715A2 (es) | Análogos de nucleósido de 1’-ciano y usos de los mismos | |
| NI201300107A (es) | Derivados de nucleósidos 2' - sustituidos y métodos de uso de los mismos para el tratamiento de enfermedades virales. | |
| BRPI0517463A (pt) | inibidores da protease do vìrus da hepatite c, composições e tratamentos usando os mesmos | |
| EA201290993A1 (ru) | Нуклеозидфосфорамидаты | |
| ECSP12011684A (es) | Inhibidores de los virus flaviviridae. | |
| BRPI0415883A (pt) | compostos e composições de nucleosìdeo para o tratamento de infecções virais | |
| ECSP12012147A (es) | Compuestos de sililo tricíclicos fusionados y métodos de uso de los mismos para el tratamiento de enfermedades virales | |
| EA200901241A1 (ru) | Соединения для лечения гепатита с | |
| CU23787B7 (es) | Compuestos macrocíclicos como inhibidores de la replicación viral | |
| EA201170915A1 (ru) | Фосфорамидатные производные гуанозиновых нуклеозидов для лечения вирусных инфекций | |
| CO6382185A2 (es) | Compuestos nucleosidos antivirales | |
| UY28084A1 (es) | Derivados antivirales de nucleosidos | |
| ECSP12012104A (es) | Inhibidores de virus flaviviridae | |
| PA8573401A1 (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan | |
| CY1118729T1 (el) | Παραγωγα 9-μεθυλ υποκατεστημενου εξαδεκαϋδροκυκλοπροπα(ε)πυρρολο(1,2-α)(1,4)διαζακυκλοπενταδεκινυλ καρβαμικου ως μη δομικοι 3 (ns3) αναστολεις πρωτεασης για την αγωγη λοιμωξεων απο ιο ηπατιτιδας c | |
| UY31685A (es) | Compuestos antivirales, composiciones y metodos para usarlos | |
| BR112013000245A2 (pt) | compostos antivirais heterocíclicos | |
| CU23533A3 (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan | |
| DOP2005000165A (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamientos que los usan | |
| DOP2004000828A (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatitis c y composiciones y tratamiento que los usan | |
| ECSP034699A (es) | Compuestos nucleosidos como inhibidores de polimerasa de arn viral dependiente de arn |