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MXPA06001592A - Derivados de (4-hidroxifenil)-1h-indol-3-carbaldehido oxima como agentes estrogenicos. - Google Patents

Derivados de (4-hidroxifenil)-1h-indol-3-carbaldehido oxima como agentes estrogenicos.

Info

Publication number
MXPA06001592A
MXPA06001592A MXPA06001592A MXPA06001592A MXPA06001592A MX PA06001592 A MXPA06001592 A MX PA06001592A MX PA06001592 A MXPA06001592 A MX PA06001592A MX PA06001592 A MXPA06001592 A MX PA06001592A MX PA06001592 A MXPA06001592 A MX PA06001592A
Authority
MX
Mexico
Prior art keywords
indole
hydroxyphenyl
oxime derivative
carbaldehyde oxime
estrogenic agents
Prior art date
Application number
MXPA06001592A
Other languages
English (en)
Inventor
Stephen Marc Bowen
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA06001592A publication Critical patent/MXPA06001592A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

Esta invencion proporciona moduladores del receptor de estrogeno de la formula I, que tienen la estructura: (ver formula) en donde R1, R2, R3 y R4 son como se definen en la especificacion, o una sal farmaceuticamente aceptable del mismo.
MXPA06001592A 2003-08-12 2004-08-10 Derivados de (4-hidroxifenil)-1h-indol-3-carbaldehido oxima como agentes estrogenicos. MXPA06001592A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49436503P 2003-08-12 2003-08-12
US10/914,747 US7250440B2 (en) 2003-08-12 2004-08-09 (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
PCT/US2004/025764 WO2005018636A1 (en) 2003-08-12 2004-08-10 (4-hydroxyphenyl)-1h-indole-3-carbaldehyde oxime derivative as estrogenic agents

Publications (1)

Publication Number Publication Date
MXPA06001592A true MXPA06001592A (es) 2006-05-19

Family

ID=34221360

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06001592A MXPA06001592A (es) 2003-08-12 2004-08-10 Derivados de (4-hidroxifenil)-1h-indol-3-carbaldehido oxima como agentes estrogenicos.

Country Status (13)

Country Link
US (2) US7250440B2 (es)
EP (1) EP1653947B1 (es)
JP (1) JP2007502277A (es)
AT (1) ATE383856T1 (es)
AU (1) AU2004266603A1 (es)
BR (1) BRPI0413523A (es)
CA (1) CA2535341A1 (es)
DE (1) DE602004011358T2 (es)
DK (1) DK1653947T3 (es)
ES (1) ES2298823T3 (es)
MX (1) MXPA06001592A (es)
PL (1) PL1653947T3 (es)
WO (1) WO2005018636A1 (es)

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ATE383856T1 (de) 2008-02-15
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