MXPA04009283A - Nuevos derivados de alcoxipiridina. - Google Patents
Nuevos derivados de alcoxipiridina.Info
- Publication number
- MXPA04009283A MXPA04009283A MXPA04009283A MXPA04009283A MXPA04009283A MX PA04009283 A MXPA04009283 A MX PA04009283A MX PA04009283 A MXPA04009283 A MX PA04009283A MX PA04009283 A MXPA04009283 A MX PA04009283A MX PA04009283 A MXPA04009283 A MX PA04009283A
- Authority
- MX
- Mexico
- Prior art keywords
- alkoxypyridine
- derivatives
- novel
- purin
- imidazo
- Prior art date
Links
- -1 3H-imidazo (4,5-b) pyridin-2-yl Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Los compuestos de formula (I) en donde R1 es alcoxi de 1 a 4 atomos de carbono, A es alquileno de 1 a 4 atomos de carbono, B representa 3H-imidazo(4,5-b)piridin-2-ilo, 3H-imidazo(4,5-b)piridin-2-ilo sustituido por R2 y/o R8, 9H-purin-8-ilo o 9H-purin-8-ilo sustituido por R4 y/o R5 son inhibidores de iNOS efectivos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02007049 | 2002-03-27 | ||
| PCT/EP2003/003076 WO2003080607A1 (en) | 2002-03-27 | 2003-03-25 | Novel alkoxypyridine-derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04009283A true MXPA04009283A (es) | 2005-01-25 |
Family
ID=28051741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04009283A MXPA04009283A (es) | 2002-03-27 | 2003-03-25 | Nuevos derivados de alcoxipiridina. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7138399B2 (es) |
| EP (1) | EP1490366B1 (es) |
| JP (1) | JP4448695B2 (es) |
| KR (1) | KR20050002910A (es) |
| CN (1) | CN1307176C (es) |
| AT (1) | ATE384722T1 (es) |
| AU (1) | AU2003226706A1 (es) |
| BR (1) | BR0308785A (es) |
| CA (1) | CA2480385A1 (es) |
| DE (1) | DE60318826T2 (es) |
| ES (1) | ES2300599T3 (es) |
| IL (1) | IL163625A0 (es) |
| MX (1) | MXPA04009283A (es) |
| NO (1) | NO20044633L (es) |
| NZ (1) | NZ535959A (es) |
| PL (1) | PL372409A1 (es) |
| WO (1) | WO2003080607A1 (es) |
| ZA (1) | ZA200407766B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7279488B2 (en) | 2003-10-01 | 2007-10-09 | Nycomed Gmbh | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| US7317021B2 (en) * | 2003-10-01 | 2008-01-08 | Altana Pharma Ag | Aminopyridine-derivatives as inductible no-synthase inhibitors |
| RS20060205A (sr) | 2003-10-01 | 2008-08-07 | Altana Pharma Ag., | Derivati imidazo (4,5-b)piridina kao inhibitori inducibilne no-sintaze |
| KR20060092222A (ko) * | 2003-10-01 | 2006-08-22 | 알타나 파마 아게 | 유도성 ｎｏ-합성효소 억제제로서의 이미다조피리딘-유도체 |
| DE602004014630D1 (de) | 2003-10-01 | 2008-08-07 | Nycomed Gmbh | Imidazopyridinderivate als inhibitoren der induzierbaren no-synthase |
| WO2005063732A1 (en) * | 2003-12-23 | 2005-07-14 | Microbia, Inc. | Compounds and methods for the treatment of asthma |
| EP1753512B1 (en) | 2004-05-28 | 2008-07-09 | Nycomed GmbH | Tetrahydropyridothiophenes |
| AU2005251485A1 (en) | 2004-06-11 | 2005-12-22 | 4Sc Ag | Tetrahydropyridothiophenes for treating hyperproliferative disorders |
| EP1851229A1 (en) | 2005-02-09 | 2007-11-07 | Nycomed GmbH | Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer |
| JP2008530053A (ja) | 2005-02-11 | 2008-08-07 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌の治療のための抗増殖性剤としてのテトラヒドロピリドチオフェン |
| CA2602284A1 (en) | 2005-03-31 | 2006-10-05 | Nycomed Gmbh | Imidazopyridine derivatives useful as inos inhibitors |
| JP2008542242A (ja) | 2005-05-25 | 2008-11-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のテトラヒドロピリドチオフェン |
| JP2008542243A (ja) | 2005-05-25 | 2008-11-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のテトラヒドロピリドチオフェン |
| AR057525A1 (es) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| WO2008031788A1 (en) * | 2006-09-12 | 2008-03-20 | Nycomed Gmbh | Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase |
| US20080139608A1 (en) * | 2006-12-06 | 2008-06-12 | Universiteit Leiden | 2,6,8, Trisubstituted 1-deazapurines and their different uses |
| BR112013021236B1 (pt) * | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
| EP3495366A1 (en) * | 2011-07-15 | 2019-06-12 | Shionogi & Co., Ltd | Azabenzimidazole derivative having ampk-activating activity |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
| SE512835C2 (sv) * | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
-
2003
- 2003-03-25 CN CNB038069172A patent/CN1307176C/zh not_active Expired - Fee Related
- 2003-03-25 AU AU2003226706A patent/AU2003226706A1/en not_active Abandoned
- 2003-03-25 PL PL03372409A patent/PL372409A1/xx not_active Application Discontinuation
- 2003-03-25 WO PCT/EP2003/003076 patent/WO2003080607A1/en not_active Ceased
- 2003-03-25 CA CA002480385A patent/CA2480385A1/en not_active Abandoned
- 2003-03-25 IL IL16362503A patent/IL163625A0/xx unknown
- 2003-03-25 DE DE60318826T patent/DE60318826T2/de not_active Expired - Lifetime
- 2003-03-25 NZ NZ535959A patent/NZ535959A/en not_active IP Right Cessation
- 2003-03-25 US US10/509,396 patent/US7138399B2/en not_active Expired - Fee Related
- 2003-03-25 MX MXPA04009283A patent/MXPA04009283A/es active IP Right Grant
- 2003-03-25 JP JP2003578361A patent/JP4448695B2/ja not_active Expired - Fee Related
- 2003-03-25 ES ES03744851T patent/ES2300599T3/es not_active Expired - Lifetime
- 2003-03-25 EP EP03744851A patent/EP1490366B1/en not_active Expired - Lifetime
- 2003-03-25 BR BR0308785-9A patent/BR0308785A/pt not_active IP Right Cessation
- 2003-03-25 KR KR10-2004-7015438A patent/KR20050002910A/ko not_active Ceased
- 2003-03-25 AT AT03744851T patent/ATE384722T1/de not_active IP Right Cessation
-
2004
- 2004-09-27 ZA ZA200407766A patent/ZA200407766B/en unknown
- 2004-10-27 NO NO20044633A patent/NO20044633L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1078850A1 (en) | 2006-03-24 |
| US7138399B2 (en) | 2006-11-21 |
| PL372409A1 (en) | 2005-07-25 |
| BR0308785A (pt) | 2005-01-11 |
| CN1642955A (zh) | 2005-07-20 |
| CN1307176C (zh) | 2007-03-28 |
| NZ535959A (en) | 2006-05-26 |
| JP4448695B2 (ja) | 2010-04-14 |
| EP1490366A1 (en) | 2004-12-29 |
| ZA200407766B (en) | 2006-06-28 |
| DE60318826D1 (de) | 2008-03-13 |
| ATE384722T1 (de) | 2008-02-15 |
| AU2003226706A1 (en) | 2003-10-08 |
| IL163625A0 (en) | 2005-12-18 |
| EP1490366B1 (en) | 2008-01-23 |
| US20050171125A1 (en) | 2005-08-04 |
| ES2300599T3 (es) | 2008-06-16 |
| JP2005525388A (ja) | 2005-08-25 |
| WO2003080607A1 (en) | 2003-10-02 |
| DE60318826T2 (de) | 2009-01-22 |
| KR20050002910A (ko) | 2005-01-10 |
| NO20044633L (no) | 2004-12-23 |
| CA2480385A1 (en) | 2003-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |