MXPA04006039A - Metodo para el tratamiento de afecciones vasculares y neuronales perifericas. - Google Patents
Metodo para el tratamiento de afecciones vasculares y neuronales perifericas.Info
- Publication number
- MXPA04006039A MXPA04006039A MXPA04006039A MXPA04006039A MXPA04006039A MX PA04006039 A MXPA04006039 A MX PA04006039A MX PA04006039 A MXPA04006039 A MX PA04006039A MX PA04006039 A MXPA04006039 A MX PA04006039A MX PA04006039 A MXPA04006039 A MX PA04006039A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- methods
- compositions
- peripheral neural
- conditions
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
Abstract
Se describen las composiciones y metodos para el tratamiento de afecciones vasculares y neuronales perifericas; el metodo comprende la administracion de un compuesto flavonoide con propiedades antioxidantes, formulado opcionalmente en un transportador farmaceuticamente aceptable; este compuesto o combinacion de compuestos proporciona alivio significativo efectivo de los sintomas de las afecciones vasculares o neuronales perifericas; adicionalmente, las composiciones, cuando son utilizadas de acuerdo con los metodos de la presente invencion, no exhiben los efectos secundarios severos de muchas de las composiciones de la tecnica anterior para el tratamiento de esas afecciones.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/049297 WO2002049575A2 (en) | 2000-12-21 | 2001-12-19 | Method and composition for the treatment of diabetic neuropathy |
| PCT/US2002/035654 WO2003053336A2 (en) | 2001-12-19 | 2002-11-06 | Methods for the treatment of peripheral neural and vascular ailments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04006039A true MXPA04006039A (es) | 2004-09-27 |
Family
ID=21743140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04006039A MXPA04006039A (es) | 2001-12-19 | 2002-11-06 | Metodo para el tratamiento de afecciones vasculares y neuronales perifericas. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1455778A4 (es) |
| JP (1) | JP2005518381A (es) |
| CA (1) | CA2470603A1 (es) |
| IL (1) | IL162505A0 (es) |
| MX (1) | MXPA04006039A (es) |
| NZ (1) | NZ533439A (es) |
| WO (1) | WO2003053336A2 (es) |
| ZA (1) | ZA200404614B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2543404A1 (en) * | 2003-10-24 | 2005-05-06 | Meiji Seika Kaisha, Ltd. | Novel inhibitor of the formation of advanced glycation end product and aldose reductase inhibitor |
| EP1681297A4 (en) * | 2003-10-30 | 2009-06-17 | Meiji Seika Kaisha | INHIBITOR OF TYROSINASE ACTIVITY AND MEANS TO IMPROVE THE BLOOD OF THE FACE |
| WO2005046584A2 (en) | 2003-11-05 | 2005-05-26 | Osteoscreen, Inc. | Stimulation of hair growth by ginkgo biloba flavanoids |
| JP2006083105A (ja) * | 2004-09-16 | 2006-03-30 | Ito En Ltd | 血液流動性改善剤および飲食物 |
| CA2613803A1 (en) * | 2005-06-28 | 2007-01-04 | Kgk Synergize Inc. | Compositions to improve the bioavailability of polymethoxyflavones and tocotrienols for treatment of cardiovascular disease |
| DE102005048777A1 (de) * | 2005-10-10 | 2007-04-12 | Beiersdorf Ag | Kosmetische Formulierungen zur Verbesserung der Mikrozirkulation der Haut |
| DE102005048778A1 (de) * | 2005-10-10 | 2007-04-12 | Beiersdorf Ag | Kosmetische Formulierungen zur Verbesserung des Aussehens der Haut |
| JP5132889B2 (ja) * | 2006-02-27 | 2013-01-30 | 株式会社ポッカコーポレーション | 神経成長因子増強剤 |
| SG170828A1 (en) * | 2006-04-05 | 2011-05-30 | Vertex Pharmaceuticals Inc Us | Deazapurines useful as inhibitors of janus kinases |
| FR2904557B1 (fr) * | 2006-08-01 | 2010-04-30 | Pf Medicament | Nouvel extrait d'eucalyptus, son procede de preparation et ses utilisations therapeutiques |
| GB0618168D0 (en) * | 2006-09-15 | 2006-10-25 | Babraham Inst | Compounds |
| US20090060878A1 (en) * | 2007-09-04 | 2009-03-05 | The Procter & Gamble Company | Oral Compositions, Products And Methods Of Use |
| KR20110033304A (ko) * | 2008-07-23 | 2011-03-30 | 메사추세츠 인스티튜트 오브 테크놀로지 | Dna 손상에 대해 보호하고 신경세포 생존을 증가시키는 히스톤 디아세틸라제 1 (hdac1)의 활성화 |
| JP5415216B2 (ja) * | 2009-10-02 | 2014-02-12 | 日本メナード化粧品株式会社 | 皮膚外用剤 |
| CN102266320B (zh) * | 2010-07-20 | 2015-06-17 | 浙江养生堂天然药物研究所有限公司 | 橙皮素的新用途 |
| KR101021835B1 (ko) | 2010-09-06 | 2011-03-17 | 충남대학교산학협력단 | 크리소스플레놀 시를 함유하는 심장 질환의 예방 및 치료용 조성물 |
| CN102151281B (zh) * | 2011-01-24 | 2014-03-26 | 中国药科大学 | 防治糖尿病的黄酮类化合物及其药物用途 |
| SI2734510T1 (sl) | 2011-07-22 | 2019-05-31 | Massachusetts Institute Of Technology | Aktivatorji histon deacetilaz (HDACS) razreda I in njihove uporabe |
| NZ596015A (en) * | 2011-10-26 | 2014-04-30 | Anzamed Internat Ltd | Method and composition for the treatment of pain and/or inflammation |
| CN102526248B (zh) * | 2012-03-22 | 2013-07-17 | 赵海潞 | 一种治疗糖尿病伤口溃烂并可持续降血糖的中药组合物 |
| US9901564B2 (en) * | 2012-03-23 | 2018-02-27 | Cardero Therapeutics, Inc. | Compounds and compositions for the treatment of muscular disorders |
| US20180193306A1 (en) | 2012-03-23 | 2018-07-12 | Cardero Therapeutics, Inc. | Compounds and compositions for the treatment of muscular disorders and bone disorders |
| ITRM20120335A1 (it) * | 2012-07-13 | 2014-01-14 | Aboca Spa Societa Agricola | Nuove composizioni per il trattamento del dolore neuropatico. |
| WO2014095289A2 (en) * | 2012-12-20 | 2014-06-26 | Unilever Plc | Method of treating hair ageing |
| BR112015023031A2 (pt) | 2013-03-15 | 2017-07-18 | Abbott Lab | métodos de conservação e melhoria da função múscular |
| CN104547872A (zh) * | 2015-01-30 | 2015-04-29 | 山东省立医院 | 一种治疗癫痫的中药组合物 |
| CN107126437A (zh) * | 2016-02-29 | 2017-09-05 | 上海中医药大学 | 一种槐角苷的药物用途 |
| KR101828379B1 (ko) | 2016-03-30 | 2018-02-12 | 우석대학교 산학협력단 | 해당화 꽃 추출물 또는 분획물을 유효성분으로 함유하는 기억력 개선, 인지능력 개선, 치매 예방, 지연, 개선 또는 치료용 조성물 |
| KR101715294B1 (ko) * | 2016-06-09 | 2017-03-10 | 연세대학교 산학협력단 | 디오스민 또는 이의 염을 유효성분으로 함유하는 피부보습 개선, 피부각질 제거, 피부탄력 증진, 홍반 억제, 피부주름 개선 또는 피부광노화 개선 효과를 갖는 조성물 |
| WO2018078412A1 (en) * | 2016-10-31 | 2018-05-03 | Posi Visionary Solutions Llp | Topical microemulsion of diosmetin and uses thereof |
| CN108164489B (zh) * | 2018-03-20 | 2019-11-26 | 武汉轻工大学 | 一种高良姜素的制备方法 |
| BR102018005599A2 (pt) * | 2018-03-21 | 2019-10-08 | Pedro Barboza Da Rocha | Composição cicatrizante, hidratante, umectante e emoliente para administração tópica em lesões de pele intertrigo, lesões de pele por incontinência urinária e fecal e outras lesões afins. |
| WO2020051644A1 (en) * | 2018-09-13 | 2020-03-19 | Norbio No. 2 Pty Ltd | Treatment of peripheral nervous tissue inflammation |
| CN112014480B (zh) * | 2019-05-28 | 2023-03-28 | 黄河科技学院 | 一种uplc-ms/ms检测降脂宁颗粒中有效成分含量的方法 |
| JP7642212B2 (ja) * | 2020-02-18 | 2025-03-10 | 国立大学法人 筑波大学 | 神経機能調節用組成物 |
| WO2022157381A1 (en) * | 2021-01-25 | 2022-07-28 | Universiteit Hasselt | Phloretin for use in the treatment of neurodegenerative and demyelinating diseases |
| CN115317497A (zh) * | 2022-01-13 | 2022-11-11 | 宁夏医科大学 | 甘草苷在制备胸主动脉血管舒张药物中的用途 |
| CN114392256B (zh) * | 2022-02-22 | 2023-05-09 | 中山大学附属第八医院(深圳福田) | 矢车菊素在防治血管钙化中的应用 |
| JP2025539362A (ja) * | 2022-11-23 | 2025-12-05 | ブライトシード・インコーポレイテッド | 睡眠を調節するための組成物及び方法ならびにその使用 |
Family Cites Families (7)
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|---|---|---|---|---|
| JPH03232851A (ja) * | 1989-12-26 | 1991-10-16 | Nippon Flour Mills Co Ltd | アルドース還元酵素阻害剤 |
| JPH09235284A (ja) * | 1995-02-23 | 1997-09-09 | Nissan Chem Ind Ltd | インドール系チアゾリジン類 |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| IT1302307B1 (it) * | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| JP4497566B2 (ja) * | 1998-09-02 | 2010-07-07 | 株式会社 日本薬用食品研究所 | アルドース還元酵素阻害剤並びに新規サポニン及び新規サポゲノール |
| TWI233353B (en) * | 2000-04-11 | 2005-06-01 | Takara Bio Inc | Therapeutic or preventive agents containing polyphenols |
| MXPA03005672A (es) * | 2000-12-21 | 2004-12-03 | The Quigley Corp | Metodo y composicion para el tratamiento de la neuropatia diabetica. |
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2002
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- 2002-11-06 WO PCT/US2002/035654 patent/WO2003053336A2/en not_active Ceased
- 2002-11-06 EP EP02789474A patent/EP1455778A4/en not_active Withdrawn
- 2002-11-06 CA CA002470603A patent/CA2470603A1/en not_active Abandoned
- 2002-11-06 JP JP2003554096A patent/JP2005518381A/ja active Pending
- 2002-11-06 IL IL16250502A patent/IL162505A0/xx not_active IP Right Cessation
- 2002-11-06 NZ NZ533439A patent/NZ533439A/en not_active IP Right Cessation
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|---|---|
| WO2003053336A3 (en) | 2003-11-27 |
| IL162505A0 (en) | 2005-11-20 |
| JP2005518381A (ja) | 2005-06-23 |
| EP1455778A4 (en) | 2007-09-12 |
| ZA200404614B (en) | 2005-08-29 |
| AU2002352501A1 (en) | 2003-07-09 |
| EP1455778A2 (en) | 2004-09-15 |
| WO2003053336A2 (en) | 2003-07-03 |
| NZ533439A (en) | 2006-06-30 |
| CA2470603A1 (en) | 2003-07-03 |
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