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MXPA04005347A - Derivados de pirimidina como moduladores del receptor (igf-i) del factor-1 de crecimiento similares a la insulina. - Google Patents

Derivados de pirimidina como moduladores del receptor (igf-i) del factor-1 de crecimiento similares a la insulina.

Info

Publication number
MXPA04005347A
MXPA04005347A MXPA04005347A MXPA04005347A MXPA04005347A MX PA04005347 A MXPA04005347 A MX PA04005347A MX PA04005347 A MXPA04005347 A MX PA04005347A MX PA04005347 A MXPA04005347 A MX PA04005347A MX PA04005347 A MXPA04005347 A MX PA04005347A
Authority
MX
Mexico
Prior art keywords
insuline
igf
modulators
receptor
growth factor
Prior art date
Application number
MXPA04005347A
Other languages
English (en)
Inventor
Thomas Andrew
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MXPA04005347A publication Critical patent/MXPA04005347A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion proporciona compuestos de la formula (I), en donde R1, R2, R3 y R4 tienen los significados mencionados en la presente descripcion, a los procesos para su preparacion; a las composiciones farmaceuticas que contienen a los mismos; a un proceso para la preparacion de las composiciones farmaceuticas y su uso en terapia.
MXPA04005347A 2001-12-07 2002-12-03 Derivados de pirimidina como moduladores del receptor (igf-i) del factor-1 de crecimiento similares a la insulina. MXPA04005347A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104140A SE0104140D0 (sv) 2001-12-07 2001-12-07 Novel Compounds
PCT/SE2002/002221 WO2003048133A1 (en) 2001-12-07 2002-12-03 Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i)

Publications (1)

Publication Number Publication Date
MXPA04005347A true MXPA04005347A (es) 2004-09-27

Family

ID=20286257

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005347A MXPA04005347A (es) 2001-12-07 2002-12-03 Derivados de pirimidina como moduladores del receptor (igf-i) del factor-1 de crecimiento similares a la insulina.

Country Status (32)

Country Link
US (3) US7521453B2 (es)
EP (1) EP1456182B1 (es)
JP (1) JP4347051B2 (es)
KR (1) KR100930558B1 (es)
CN (1) CN1289486C (es)
AR (1) AR037736A1 (es)
AT (1) ATE425150T1 (es)
AU (1) AU2002365864B2 (es)
BR (1) BR0214605A (es)
CA (1) CA2467838C (es)
CO (1) CO5590919A2 (es)
CY (1) CY1109101T1 (es)
DE (1) DE60231542D1 (es)
DK (1) DK1456182T3 (es)
EG (1) EG24930A (es)
ES (1) ES2323125T3 (es)
HU (1) HUP0401855A3 (es)
IL (2) IL162376A0 (es)
IS (1) IS7294A (es)
MX (1) MXPA04005347A (es)
MY (1) MY135705A (es)
NO (1) NO327502B1 (es)
NZ (1) NZ533130A (es)
PL (1) PL369528A1 (es)
PT (1) PT1456182E (es)
RU (1) RU2317291C2 (es)
SE (1) SE0104140D0 (es)
SI (1) SI1456182T1 (es)
TW (1) TWI324152B (es)
UA (1) UA78259C2 (es)
WO (1) WO2003048133A1 (es)
ZA (1) ZA200404223B (es)

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WO2003048133A1 (en) 2003-06-12
CN1289486C (zh) 2006-12-13
RU2004121029A (ru) 2006-01-10
ZA200404223B (en) 2005-08-29
JP2005515998A (ja) 2005-06-02
TW200409634A (en) 2004-06-16
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IL162376A0 (en) 2005-11-20
AU2002365864B2 (en) 2007-08-30
EP1456182B1 (en) 2009-03-11
KR20050044698A (ko) 2005-05-12
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DK1456182T3 (da) 2009-06-29
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