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MXPA04003865A - Compuestos de amonio cuaternario y sus usos como agentes antimuscarinicos. - Google Patents

Compuestos de amonio cuaternario y sus usos como agentes antimuscarinicos.

Info

Publication number
MXPA04003865A
MXPA04003865A MXPA04003865A MXPA04003865A MXPA04003865A MX PA04003865 A MXPA04003865 A MX PA04003865A MX PA04003865 A MXPA04003865 A MX PA04003865A MX PA04003865 A MXPA04003865 A MX PA04003865A MX PA04003865 A MXPA04003865 A MX PA04003865A
Authority
MX
Mexico
Prior art keywords
compounds
alkyl
independently represent
ammonium compounds
quarternary ammonium
Prior art date
Application number
MXPA04003865A
Other languages
English (en)
Inventor
Richards Ivan
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MXPA04003865A publication Critical patent/MXPA04003865A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Compuestos novedosos de amonio cuaternario de la formula (I) y cualquier estereoisomeros de los mismos, en donde, R1, R2 Y R3 independientemente representan alquilo C1-C2, opcionalmente sustituidos con fenilo o hidroxilo, o ambos y en donde cualquiera de los dos R1, R2 y R3 pueden formar un anillo junto con el nitrogeno del amonio cuaternario; R4 representa-H, -CH3, o -CO-R1-1,en donde R4-1 representa -(alquilo C1-C4), o NR4-2R4-3, en donde R4-2 y R4-3 independientemente representan -H o -(alquilo C1-C4); R5 R6 y R7 independientemente representan -H, -OCH3, -OH, -CONH2 -SO2NH2, -F, -CI, -Br, -I, -CF3 o -(alquiloC1-C4), opcionalmente sustituido con uno o dos -OH, -(alcoxi C1-C4), -COOH, o -CO-O-(alquiloC1-C3); y X representan un anion de un acido farmaceuticamente aceptable, los compuestos para uso como medicamentos, uso de los compuestos para la fabricacion de medicamentos especificos y composiciones farmaceuticas que comprenden los compuestos. La presente invencion tambien se refiere a un metodo de tratamiento que implica la administracion de los compuestos.
MXPA04003865A 2001-10-26 2002-10-25 Compuestos de amonio cuaternario y sus usos como agentes antimuscarinicos. MXPA04003865A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34893001P 2001-10-26 2001-10-26
US36197902P 2002-03-06 2002-03-06
US39152102P 2002-06-25 2002-06-25
PCT/US2002/034529 WO2003035599A1 (en) 2001-10-26 2002-10-25 Quarternary ammonium compounds and their use as antimuscarinic agents

Publications (1)

Publication Number Publication Date
MXPA04003865A true MXPA04003865A (es) 2004-07-08

Family

ID=27407868

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003865A MXPA04003865A (es) 2001-10-26 2002-10-25 Compuestos de amonio cuaternario y sus usos como agentes antimuscarinicos.

Country Status (16)

Country Link
US (2) US6890920B2 (es)
EP (1) EP1461306B1 (es)
JP (1) JP3981357B2 (es)
AT (1) ATE418534T1 (es)
BR (1) BR0206207A (es)
CA (1) CA2464223C (es)
CY (1) CY1109898T1 (es)
DE (1) DE60230546D1 (es)
DK (1) DK1461306T3 (es)
ES (1) ES2315425T3 (es)
MX (1) MXPA04003865A (es)
MY (1) MY130316A (es)
NO (1) NO20032938L (es)
PT (1) PT1461306E (es)
SG (1) SG168451A1 (es)
WO (1) WO2003035599A1 (es)

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ES2315425T3 (es) * 2001-10-26 2009-04-01 PHARMACIA & UPJOHN COMPANY LLC Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
ES2322896T3 (es) * 2002-04-29 2009-07-01 Supernus Pharmaceuticals, Inc. Formulaciones farmaceuticas con biodisponibilidad mejorada.
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
WO2004091597A2 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Method of treating irritable bowel syndrome (ibs)
MXPA05011059A (es) * 2003-04-15 2005-12-12 Pharmacia & Upjohn Co Llc Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.
EP1620083A2 (en) * 2003-04-18 2006-02-01 Pharmacia & Upjohn Company LLC Combination therapies
CA2523226A1 (en) * 2003-04-25 2004-11-11 Pharmacia & Upjohn Company Llc Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity
AU2004289222B2 (en) 2003-11-04 2010-01-21 Supernus Pharmaceuticals Inc. Compositions of quaternary ammonium containing bioavailability enhancers
EP2210605B1 (en) * 2003-11-04 2017-03-01 TCD Royalty Sub, LLC Once daily dosage forms of trospium
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
EP1701932B1 (en) * 2003-12-24 2012-07-18 Cipla Ltd. Tolterodine, compositions and uses thereof, and preparation of the same
US20070179131A1 (en) * 2004-03-11 2007-08-02 Jian Jin Novel M3 Muscarinic Acetylcholine Receptor Antagonists
JP5207518B2 (ja) * 2004-12-24 2013-06-12 レツク・フアーマシユーテイカルズ・デー・デー ３−（２−ヒドロキシ−５−メチルフェニル）−ｎ，ｎ−ジイソプロピル−３−フェニルプロピルアミンの製造プロセス
CA2653105A1 (en) * 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Novel medicament combinations for the treatment of respiratory diseases
EP1908502A1 (en) * 2006-10-02 2008-04-09 Koninklijke Philips Electronics N.V. Interactive modular tile system
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
EP2114972A2 (en) * 2006-12-13 2009-11-11 Gilead Sciences, Inc. Monophosphates as mutual prodrugs of muscarinic receptor antagonists and beta-agonists for the treatment of copd and chronic bronchitis
KR101495708B1 (ko) * 2007-02-23 2015-02-25 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 무스카린 수용체 안타고니스트로 유용한 4차 암모늄 디페닐메틸 화합물
EP2146957B1 (en) 2007-04-24 2013-06-12 Theravance, Inc. Quaternary ammonium compounds useful as muscarinic receptor antagonists
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US20110171274A1 (en) * 2008-07-21 2011-07-14 Actavis Group Ptc Ehf Fesoterodine Substantially Free of Dehydroxy Impurity
JP5801997B2 (ja) 2009-07-07 2015-10-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物
CN110845357B (zh) * 2019-11-22 2022-09-30 华东理工大学 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用
CN116033893A (zh) 2020-06-26 2023-04-28 迈兰制药英国有限公司 包含5-[3-(3-羟基苯氧基)氮杂环丁烷-1-基]-5-甲基-2,2-二苯基己酰胺的制剂

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CA2523226A1 (en) * 2003-04-25 2004-11-11 Pharmacia & Upjohn Company Llc Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity

Also Published As

Publication number Publication date
EP1461306A1 (en) 2004-09-29
US6890920B2 (en) 2005-05-10
WO2003035599A1 (en) 2003-05-01
EP1461306B1 (en) 2008-12-24
CY1109898T1 (el) 2014-09-10
SG168451A1 (en) 2011-02-28
NO20032938L (no) 2003-08-25
ATE418534T1 (de) 2009-01-15
US7439397B2 (en) 2008-10-21
JP3981357B2 (ja) 2007-09-26
DE60230546D1 (de) 2009-02-05
JP2005524605A (ja) 2005-08-18
US20050148672A1 (en) 2005-07-07
CA2464223A1 (en) 2003-05-01
CA2464223C (en) 2009-05-26
MY130316A (en) 2007-06-29
DK1461306T3 (da) 2009-03-09
ES2315425T3 (es) 2009-04-01
BR0206207A (pt) 2003-12-23
PT1461306E (pt) 2009-04-01
US20030158176A1 (en) 2003-08-21
NO20032938D0 (no) 2003-06-26

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