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MXPA04003795A - Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos. - Google Patents

Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos.

Info

Publication number
MXPA04003795A
MXPA04003795A MXPA04003795A MXPA04003795A MXPA04003795A MX PA04003795 A MXPA04003795 A MX PA04003795A MX PA04003795 A MXPA04003795 A MX PA04003795A MX PA04003795 A MXPA04003795 A MX PA04003795A MX PA04003795 A MXPA04003795 A MX PA04003795A
Authority
MX
Mexico
Prior art keywords
optionally substituted
pyrimidine compound
compound
medicinal composition
hydrocarbon ring
Prior art date
Application number
MXPA04003795A
Other languages
English (en)
Inventor
Nakagawa Makoto
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of MXPA04003795A publication Critical patent/MXPA04003795A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona un compuesto de pirimidina novedoso que tiene una excelente accion antagonica sobre el receptor (receptor A1, A2A, A2B) de adenosina. Mas especificamente, proporciona un compuesto representado por la siguiente formula, una sal del mismo o sus solvatos.(ver formula I)En la formula, R1 y R2 son iguales o diferentes entre si y cada uno representa un atomo de hidrogeno, un grupo alquilo que tiene de uno a seis atomos de carbono que puede estar sustituido, un grupo alquenilo que tiene de dos a seis atomos de carbono que puede estar sustituido, un grupo cicloalquilo que tiene de tres a ocho atomos de carbono que puede estar sustituido, un grupo cicloalquenilo que tiene de tres a ocho atomos de carbono que puede esta sustituido, un grupo heterociclico no aromatico de 5 a 14 miembros que puede estas sustituido, un grupo ciclico hidrocarbonato aromatico que tiene de seis a catorce atomos de carbono que puede estar sustituido, un grupo heterociclico no aromatico de 5 a 14 miembros que puede estar sustituido, un grupo acilo que tiene de uno a seis atomos de carbono que puede estas sustituido o un grupo alquilsulfonilo que tiene de uno a seis atomos de carbono que puede estar sustituido; R3 representa un atomo de hidrogeno, un atomo de halogeno, un grupo ciano, un grupo alquilo que tiene de uno a seis atomos de carbono que puede esta sustituido, un grupo alquenilo que tiene de dos a seis atomos de carbono que puede estar sustituido, un grupo alquinilo que tiene de dos a seis atomos de carbono que puede estar sustituido, un grupo ciclico hidrocarbonato aromatico que tiene de seis a catorce atomos de carbono que puede esta sustituido, un grupo heterociclico aromatico de 5 a 14 miembros que puede estar sustituido, un grupo ciclico hidrocarbonato aromatico que tiene de seis a catorce atomos de carbono que puede estar sustituido, un grupo heterociclico aromatico de 5 a 14 miembros que puede estar sustituido o un grupo acilo que tiene de uno a seis atomos de carbono que puede estar sustituido o un grupo alquilsulfonilo que tiene de uno a seis atomos de carbono que puede estar sustituido, R3 representa un atomo de hidrogeno, un atomo de halogeno, un grupo ciano, un grupo alquilo que tiene de uno a seis atomos de carbono que puede estar sustituido, un grupo alquenilo que tiene de dos a seis atomos de carbono que puede estar sustituido, un grupo alquinilo que tiene de dos a seis atomos de carbono que puede estar sustituido, un grupo ciclico hidrocarbonato aromatico que tiene de seis a catorce atomos de carbono que puede estar sustituido, un grupo heterociclico aromatico de 5 14 miembros que puede estar sustituido, un atomo de nitrogeno que puede estar sustituido, un atomo de oxigeno que puede estar sustituido o un atomo de azufre que puede estar sustituido; R4 representa un grupo ciclico hidrocarbonato aromatico que tiene de seis a catorce atomos de carbono que puede estar sustituido, un grupo heterociclico aromatico de 5 a 14 miembros que puede estar sustituido o un grupo heterociclico no aromatico de 5 a 14 miembros que tiene al menos uno o mas enlaces insaturados que puede estar sustituido; R5 representa un grupo ciclico hidrocarbonato aromatico que tiene de seis a catorce atomos de carbono que puede estar sustituido o un grupo heterociclico aromatico de 5 a 14 miembros que puede estar sustituido.
MXPA04003795A 2001-10-22 2002-10-22 Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos. MXPA04003795A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001324018 2001-10-22
PCT/JP2002/010952 WO2003035639A1 (en) 2001-10-22 2002-10-22 Pyrimidine compound and medicinal composition thereof

Publications (1)

Publication Number Publication Date
MXPA04003795A true MXPA04003795A (es) 2004-07-30

Family

ID=19140824

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003795A MXPA04003795A (es) 2001-10-22 2002-10-22 Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos.

Country Status (24)

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US (2) US7396836B2 (es)
EP (2) EP2246344A1 (es)
JP (1) JP4462930B2 (es)
KR (1) KR100884025B1 (es)
CN (1) CN100519549C (es)
AT (1) ATE507217T1 (es)
AU (1) AU2002335536B2 (es)
BR (1) BR0213455A (es)
CA (1) CA2463284C (es)
CY (1) CY1112341T1 (es)
DE (1) DE60239884D1 (es)
DK (1) DK1439175T3 (es)
ES (1) ES2364328T3 (es)
HU (1) HUP0401950A3 (es)
IL (2) IL161493A0 (es)
MX (1) MXPA04003795A (es)
NO (1) NO327581B1 (es)
NZ (1) NZ532373A (es)
PL (1) PL215572B1 (es)
PT (1) PT1439175E (es)
RU (1) RU2288227C2 (es)
TW (1) TWI330183B (es)
WO (1) WO2003035639A1 (es)
ZA (1) ZA200402898B (es)

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