MXPA04001240A - Analogos antitumorales. - Google Patents
Analogos antitumorales.Info
- Publication number
- MXPA04001240A MXPA04001240A MXPA04001240A MXPA04001240A MXPA04001240A MX PA04001240 A MXPA04001240 A MX PA04001240A MX PA04001240 A MXPA04001240 A MX PA04001240A MX PA04001240 A MXPA04001240 A MX PA04001240A MX PA04001240 A MXPA04001240 A MX PA04001240A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- unsubstituted
- independently selected
- alkynyl
- alkenyl
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical class C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Derivados de ecteinascidina 736 de la formula general (I): en la que cada uno de los grupos R1, R2, R3, R4 y R5 esta seleccionado independientemente del grupo que consiste de H, OH, OR, SH, SR', SOR', SO2R', C(=O)R', C(=O)OR', NO2, NH2, NHR', N(R')2, NHC(O)R', CN, halogeno, =O, alquilo sustituido o no sustituido de 1 a 25 atomos de carbono, alquinilo sustituido o no sustituido, de 2 a 18 atomos de carbono, alquinilo sustituido o no sustituido, de 2 a 18 atomos de carbono, arilo sustituido o no sustituido, heterociclico sustituido o no sustituido; donde X esta seleccionado independientemente de OR', CN, (=O) o H; donde cada uno de los grupos R' esta seleccionado independientemente del grupo que consiste de H, OH, NO2, NH2, SH, CN, halogeno, =O, C(=O)H, C(=O)CH3, CO2H, alquilo sustituido o no sustituido, de 1 a 25 atomos de carbono, alquenilo sustituido o no sustituido, de 2 a 18 atomos de carbono, alquinilo sustituido o no sustituido de 2 a 18 atomos de carbono, arilo sustituido o no sustituido; donde m es 0, 1 o 2; y donde n es 0, 1, 2, 3 o 4; y su uso como agente antitumoral.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119243.4A GB0119243D0 (en) | 2001-08-07 | 2001-08-07 | Antitumoral analogs of ET-743 |
| PCT/GB2002/003592 WO2003014127A1 (en) | 2001-08-07 | 2002-08-06 | Antitumoral analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04001240A true MXPA04001240A (es) | 2004-06-03 |
Family
ID=9919954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04001240A MXPA04001240A (es) | 2001-08-07 | 2002-08-06 | Analogos antitumorales. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7763615B2 (es) |
| EP (3) | EP1414828B9 (es) |
| JP (2) | JP4684552B2 (es) |
| KR (1) | KR20040032150A (es) |
| CN (1) | CN100334094C (es) |
| AT (1) | ATE374777T1 (es) |
| AU (1) | AU2002313540B2 (es) |
| CA (1) | CA2455768C (es) |
| CY (1) | CY1107830T1 (es) |
| DE (1) | DE60222775T2 (es) |
| DK (1) | DK1414828T3 (es) |
| ES (1) | ES2294151T3 (es) |
| GB (1) | GB0119243D0 (es) |
| HU (1) | HU229779B1 (es) |
| IL (2) | IL160051A0 (es) |
| MX (1) | MXPA04001240A (es) |
| NO (1) | NO337476B1 (es) |
| NZ (1) | NZ530837A (es) |
| PL (1) | PL218295B1 (es) |
| PT (1) | PT1414828E (es) |
| RU (1) | RU2283842C2 (es) |
| WO (1) | WO2003014127A1 (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| ES2523580T3 (es) | 2008-01-11 | 2014-11-27 | Albany Molecular Research, Inc. | Piridoindoles substituidos con (1-Azinona) |
| WO2011003012A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) * | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| US9073925B2 (en) * | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) * | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| JP6037337B2 (ja) * | 2010-05-25 | 2016-12-07 | ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａ Ｍｒｓ，Ｓ．Ａ． | エクチナサイジン化合物の製造のための合成方法 |
| JP6382516B2 (ja) * | 2010-11-12 | 2018-08-29 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍アルカロイドを用いる、組み合わせの治療法 |
| CN105611296B (zh) | 2010-11-26 | 2018-08-14 | 日本电气株式会社 | 视频解码设备、视频解码方法 |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| WO2012088124A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof |
| CN108271369A (zh) | 2015-10-23 | 2018-07-10 | 法尔玛赞公司 | 用于制备色胺及其衍生物的新工艺 |
| JOP20190254A1 (ar) * | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| TWI824043B (zh) * | 2018-10-25 | 2023-12-01 | 西班牙商瑪製藥股份有限公司 | 藥物抗體共軛物 |
| CA3148690A1 (en) | 2019-09-03 | 2021-03-11 | Ioannis METAXAS | Lurbinectedin in the treatment of malignant mesothelioma |
| CN112574234B (zh) * | 2019-09-27 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | 一种海鞘素衍生物的制备方法 |
| WO2021228414A1 (en) | 2020-05-14 | 2021-11-18 | Pharma Mar, S.A. | Methods of treating small cell lung cancer with lurbinectedin formulations |
| MA56827B2 (fr) | 2019-11-21 | 2023-09-27 | Pharma Mar Sa | Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine |
| CR20220289A (es) | 2019-11-21 | 2022-10-27 | Pharma Mar Sa | Métodos de tratamiento del cáncer de pulmón de células pequeñas con formulaciones de lurbinectedina |
| IL297028A (en) | 2020-04-21 | 2022-12-01 | Pharma Mar Sa | Drug-antibody conjugates |
| WO2021218896A1 (zh) * | 2020-04-26 | 2021-11-04 | 江苏恒瑞医药股份有限公司 | 海鞘素类衍生物及其制备方法与医药用途 |
| KR20230061434A (ko) * | 2020-09-04 | 2023-05-08 | 파르마 마르, 에스.에이. | 루비넥테딘 및 면역 체크포인트 억제제의 조합 |
| WO2022101255A1 (en) | 2020-11-10 | 2022-05-19 | Pharma Mar, S.A. | Lurbinectedin and irinotecan combinations |
| IN202141039393A (es) * | 2021-08-31 | 2023-03-03 | ||
| KR20240099455A (ko) | 2021-11-08 | 2024-06-28 | 파르마 마르, 에스.에이. | 루비넥테딘 및 아테졸리주맙 조합물 |
| CN115246846B (zh) * | 2021-11-19 | 2024-10-01 | 江苏慧聚药业股份有限公司 | 卢比替定新晶型及其制备 |
| CN115304619A (zh) * | 2022-04-08 | 2022-11-08 | 上海皓元医药股份有限公司 | 一种卢比替定的晶型及其制备方法 |
| CN114940682A (zh) * | 2022-05-18 | 2022-08-26 | 博瑞制药(苏州)有限公司 | 芦比替定的晶型及其制备方法和用途 |
| WO2024186263A1 (en) * | 2023-03-07 | 2024-09-12 | Axcynsis Therapeutics Pte. Ltd. | Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives |
| WO2024188978A1 (en) | 2023-03-10 | 2024-09-19 | Pharma Mar, S.A. | Lurbinectedin as mcl-1 inhibitor and combinations thereof for use in treating cancer |
| WO2025059336A1 (en) * | 2023-09-13 | 2025-03-20 | Navinta, Llc | An improved process for preparation of lurbinectedin |
| WO2025077996A1 (en) | 2023-10-09 | 2025-04-17 | Pharma Mar, S.A. | Synthetic process for the manufacture of ecteinascidin compounds |
| EP4563149A1 (en) | 2023-11-30 | 2025-06-04 | Pharma Mar, S.A. | Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers |
| TW202532075A (zh) * | 2024-02-08 | 2025-08-16 | 大陸商映恩生物製藥（蘇州）有限公司 | 海鞘素類化合物及其應用 |
| WO2026022359A2 (en) | 2024-07-26 | 2026-01-29 | Pharma Mar, S.A. | Synthetic process for the manufacture of ecteinascidin compounds |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| DE3774435D1 (de) | 1986-06-09 | 1991-12-12 | Univ Pennsylvania | Ekteinascidine 729, 743, 745, 759a, 759b and 770. |
| US5256663A (en) | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| IL138856A0 (en) | 1998-04-06 | 2001-10-31 | Univ Illinois | Semi-synthetic ecteinascidins |
| CA2331593C (en) | 1998-05-11 | 2008-08-05 | Pharma Mar, S.A. | Metabolites of ecteinascidin 743 |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| JP2003520801A (ja) * | 2000-01-19 | 2003-07-08 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成 |
| CA2406080C (en) * | 2000-04-12 | 2011-11-29 | Pharma Mar, S.A. | Antitumoral ecteinascidin derivatives |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
-
2001
- 2001-08-07 GB GBGB0119243.4A patent/GB0119243D0/en not_active Ceased
-
2002
- 2002-08-06 MX MXPA04001240A patent/MXPA04001240A/es active IP Right Grant
- 2002-08-06 EP EP02753134A patent/EP1414828B9/en not_active Expired - Lifetime
- 2002-08-06 KR KR10-2004-7001924A patent/KR20040032150A/ko not_active Ceased
- 2002-08-06 HU HU0401174A patent/HU229779B1/hu unknown
- 2002-08-06 RU RU2004106617/04A patent/RU2283842C2/ru active
- 2002-08-06 PL PL367940A patent/PL218295B1/pl unknown
- 2002-08-06 WO PCT/GB2002/003592 patent/WO2003014127A1/en not_active Ceased
- 2002-08-06 JP JP2003519076A patent/JP4684552B2/ja not_active Expired - Lifetime
- 2002-08-06 DK DK02753134T patent/DK1414828T3/da active
- 2002-08-06 CA CA2455768A patent/CA2455768C/en not_active Expired - Lifetime
- 2002-08-06 EP EP07001308A patent/EP1806349A1/en not_active Ceased
- 2002-08-06 ES ES02753134T patent/ES2294151T3/es not_active Expired - Lifetime
- 2002-08-06 NZ NZ530837A patent/NZ530837A/en not_active IP Right Cessation
- 2002-08-06 AT AT02753134T patent/ATE374777T1/de active
- 2002-08-06 IL IL16005102A patent/IL160051A0/xx unknown
- 2002-08-06 CN CNB028196511A patent/CN100334094C/zh not_active Expired - Lifetime
- 2002-08-06 US US10/485,536 patent/US7763615B2/en not_active Expired - Lifetime
- 2002-08-06 DE DE60222775T patent/DE60222775T2/de not_active Expired - Lifetime
- 2002-08-06 AU AU2002313540A patent/AU2002313540B2/en active Active
- 2002-08-06 EP EP10180740A patent/EP2270018A1/en not_active Withdrawn
- 2002-08-06 PT PT02753134T patent/PT1414828E/pt unknown
-
2004
- 2004-01-26 IL IL160051A patent/IL160051A/en active IP Right Grant
- 2004-03-05 NO NO20040961A patent/NO337476B1/no not_active IP Right Cessation
-
2007
- 2007-12-12 CY CY20071101576T patent/CY1107830T1/el unknown
-
2010
- 2010-09-17 JP JP2010209928A patent/JP2011026331A/ja active Pending
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |