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MXPA04000372A - Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa. - Google Patents

Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa.

Info

Publication number
MXPA04000372A
MXPA04000372A MXPA04000372A MXPA04000372A MXPA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A
Authority
MX
Mexico
Prior art keywords
compounds
formula
relates
heteroaryl
fused bicyclic
Prior art date
Application number
MXPA04000372A
Other languages
English (en)
Inventor
Liu Nian
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of MXPA04000372A publication Critical patent/MXPA04000372A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta invencion se refiere a compuestos de heteroarilo biciclico fusionados substituidos con heteroarilo, tales como imidazopiridinas, imidazopirazinas, impidazopiridizinas, imidazopirimidinas e imidazotiazoles substituidos con heteroarilo, que se pueden describir por la formula I o la formula II. La invencion se refiere particularmente a tales compuestos que enlazan con alta selectividad y alta afinidad al sitio de benzodiazepina de los receptores GABAA. Esta invencion tambien se refiere a composiciones farmaceuticas que comprenden tales compuestos y al uso de tales compuestos en el tratamiento de ciertas enfermedades del sistema nervioso central (SNC). Se describen los procesos para la preparacion de compuestos de Formula I y Formula II. Esta invencion tambien se refiere al uso de bencimidazoles, piridilimidazoles y compuestos de heteroarilo biciclicos relacionados de Formula I o Formula II en combinacion con uno o mas de otros agentes del SNC, para potenciar los efectos de los otros agentes del SNC. Adicionalmente, esta invencion se refiere al uso de tales compuestos como sondas para la localizacion de los receptores GABAA en secciones de tejidos.
MXPA04000372A 2001-07-13 2002-07-12 Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa. MXPA04000372A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30553301P 2001-07-13 2001-07-13
PCT/US2002/022130 WO2003006471A1 (en) 2001-07-13 2002-07-12 Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands

Publications (1)

Publication Number Publication Date
MXPA04000372A true MXPA04000372A (es) 2004-07-23

Family

ID=23181185

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000372A MXPA04000372A (es) 2001-07-13 2002-07-12 Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa.

Country Status (16)

Country Link
US (2) US6936617B2 (es)
EP (1) EP1406906A1 (es)
JP (1) JP2005505518A (es)
KR (1) KR20040015356A (es)
CN (2) CN101220027A (es)
AR (1) AR036168A1 (es)
BR (1) BR0211124A (es)
CA (1) CA2453554A1 (es)
GT (1) GT200200148A (es)
IL (1) IL159811A0 (es)
MX (1) MXPA04000372A (es)
NZ (1) NZ530992A (es)
PA (1) PA8550401A1 (es)
PE (1) PE20030292A1 (es)
UY (1) UY27380A1 (es)
WO (1) WO2003006471A1 (es)

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EP1880998A1 (en) * 2003-07-25 2008-01-23 Neurogen Corporation Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
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US7534798B2 (en) 2004-02-11 2009-05-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1713784A1 (en) * 2004-02-12 2006-10-25 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
US20080004269A1 (en) * 2004-11-04 2008-01-03 Yuelian Xu Pyrazolylmethy Heteroaryl Derivatives
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US7750000B2 (en) * 2005-09-02 2010-07-06 Bayer Schering Pharma Ag Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
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US10206921B2 (en) 2009-06-03 2019-02-19 The Regents Of The University Of California Methods and compositions for treating a subject for central nervous system (CNS) injury
EP2298296A1 (en) * 2009-08-25 2011-03-23 CNRS Centre National De La Recherche Scientifique Composition and method for treating cognitive impairments in down syndrome subjects
BR112012010041A2 (pt) 2009-10-30 2016-05-24 Janssen Pharmaceutica Nv derivados de imidazo [1,2-b] piridazina e seu uso como inibidores de pde10
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
US20130150351A1 (en) * 2010-06-03 2013-06-13 Stanley T. Carmichael Methods and compositions for treating a subject for central nervous system (cns) injury
KR101034040B1 (ko) * 2010-08-16 2011-05-16 정동영 백업트랙터
WO2013000924A1 (en) 2011-06-27 2013-01-03 Janssen Pharmaceutica Nv 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
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Also Published As

Publication number Publication date
WO2003006471A1 (en) 2003-01-23
PE20030292A1 (es) 2003-04-03
US20060014746A1 (en) 2006-01-19
CN1553916A (zh) 2004-12-08
UY27380A1 (es) 2003-02-28
PA8550401A1 (es) 2004-02-07
AR036168A1 (es) 2004-08-18
IL159811A0 (en) 2004-06-20
NZ530992A (en) 2005-06-24
US6936617B2 (en) 2005-08-30
JP2005505518A (ja) 2005-02-24
CN101220027A (zh) 2008-07-16
GT200200148A (es) 2003-05-15
EP1406906A1 (en) 2004-04-14
US20030207885A1 (en) 2003-11-06
KR20040015356A (ko) 2004-02-18
BR0211124A (pt) 2004-06-29
CA2453554A1 (en) 2003-01-23
CN100369912C (zh) 2008-02-20

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