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AU5348396A - Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors - Google Patents

Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors

Info

Publication number
AU5348396A
AU5348396A AU53483/96A AU5348396A AU5348396A AU 5348396 A AU5348396 A AU 5348396A AU 53483/96 A AU53483/96 A AU 53483/96A AU 5348396 A AU5348396 A AU 5348396A AU 5348396 A AU5348396 A AU 5348396A
Authority
AU
Australia
Prior art keywords
imidazo
pyridezine
pyridine
bone resorption
resorption inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU53483/96A
Inventor
Yoshio Kawai
Natsuko Kayakiri
Teruo Oku
Shigeki Satoh
Hitoshi Yamazaki
Kousei Yoshihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508826.6A external-priority patent/GB9508826D0/en
Priority claimed from GBGB9512972.2A external-priority patent/GB9512972D0/en
Priority claimed from GBGB9516647.6A external-priority patent/GB9516647D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of AU5348396A publication Critical patent/AU5348396A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU53483/96A 1995-05-01 1996-04-23 Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors Abandoned AU5348396A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9508826 1995-05-01
GBGB9508826.6A GB9508826D0 (en) 1995-05-01 1995-05-01 New Compound
GB9512972 1995-06-26
GBGB9512972.2A GB9512972D0 (en) 1995-06-26 1995-06-26 New compound
GB9516647 1995-08-14
GBGB9516647.6A GB9516647D0 (en) 1995-08-14 1995-08-14 New compound
PCT/JP1996/001103 WO1996034866A1 (en) 1995-05-01 1996-04-23 Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors

Publications (1)

Publication Number Publication Date
AU5348396A true AU5348396A (en) 1996-11-21

Family

ID=27267692

Family Applications (1)

Application Number Title Priority Date Filing Date
AU53483/96A Abandoned AU5348396A (en) 1995-05-01 1996-04-23 Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors

Country Status (3)

Country Link
JP (1) JPH11505524A (en)
AU (1) AU5348396A (en)
WO (1) WO1996034866A1 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU749214C (en) * 1997-11-21 2006-03-30 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
DE60112272T2 (en) * 2000-04-27 2006-05-24 Astellas Pharma Inc. Imidazopyridine DERIVATIVES
DE10117184A1 (en) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituted imidazole [1,2-a] pyridin-3-yl amide and amine compounds
PL366827A1 (en) 2001-06-21 2005-02-07 Smithkline Beecham Corporation Imidazo[1,2-a]pyridine derivatives for the prophylaxis and treatment of herpes viral infections
IL159811A0 (en) * 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
DE60211539T2 (en) 2001-10-05 2006-09-21 Smithkline Beecham Corp. IMIDAZOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HERPES VIRUS INFECTION
AU2002357740A1 (en) 2001-12-11 2003-06-23 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
WO2003076441A1 (en) 2002-03-07 2003-09-18 Smithkline Beecham Corporation Pyrazolopyrimidine and pyrazolotriazine derivatives and pharmaceutical compositions containing them
CN100537571C (en) 2002-04-19 2009-09-09 细胞基因组公司 Imidazo[1,2-a]pyrazin-8-ylamines, method of making and method of use thereof
JP2005529919A (en) 2002-05-10 2005-10-06 スミスクライン ビーチャム コーポレーション Therapeutic compounds
US7312341B2 (en) 2002-09-09 2007-12-25 Cgi Pharmaceuticals, Inc. 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
MXPA05003058A (en) * 2002-09-19 2005-05-27 Schering Corp Imidazopyridines as cyclin dependent kinase inhibitors.
DE10246890A1 (en) * 2002-10-08 2004-04-22 Grünenthal GmbH New C-(imidazo-(1,2-a)-pyridin-3-yl)-methylamines, are nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, septic shock, neurodegenerative diseases, inflammatory pain or cancer
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
WO2005019220A2 (en) 2003-08-11 2005-03-03 Cellular Genomics Inc. Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
JP5206405B2 (en) * 2005-03-21 2013-06-12 エムイーアイ・ファーマ・インコーポレイテッド Imidazo [1,2-a] pyridine derivatives: production and pharmaceutical use
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
TW200800213A (en) 2005-09-02 2008-01-01 Abbott Lab Novel imidazo based heterocycles
MX2008015747A (en) 2006-06-06 2008-12-19 Schering Corp Imidazopyrazines as protein kinase inhibitors.
PL2121687T3 (en) 2006-12-22 2016-03-31 Astex Therapeutics Ltd Tricyclic amine derivatives as protein tyrosine kinase inhibitors
JP5442448B2 (en) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド Bicyclic heterocyclic compounds as FGFR inhibitors
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
EP2252617A1 (en) 2008-02-13 2010-11-24 CGI Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a]pyrazine derivatives, method of making, and method of use thereof
EP2291187B1 (en) 2008-04-24 2018-08-15 Newlink Genetics Corporation Ido inhibitors
KR20110019385A (en) * 2008-05-29 2011-02-25 서트리스 파마슈티컬즈, 인코포레이티드 Imidazopyridine and related analogs as sirtuin modulators
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
ES2590804T3 (en) 2008-12-08 2016-11-23 Gilead Connecticut, Inc. Imidazopyrazine Syk inhibitors
WO2010068258A1 (en) 2008-12-08 2010-06-17 Cgi Pharmaceuticals, Inc. Imidazopyrazine syk inhibitors
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
WO2011051342A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (en) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv IMIDAZO DERIVATIVES (1,2-A) PIRAZINA AND ITS USE AS PDE10 INHIBITORS
KR101717809B1 (en) 2010-03-11 2017-03-17 질레드 코네티컷 인코포레이티드 Imidazopyridines syk inhibitors
US9173887B2 (en) 2010-12-22 2015-11-03 Abbvie Inc. Hepatitis C inhibitors and uses thereof
CA2838645C (en) 2011-06-27 2020-03-10 Janssen Pharmaceutica Nv 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
DE102012200349A1 (en) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituted fused pyrimidines and triazines and their use
US9669035B2 (en) 2012-06-26 2017-06-06 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders
WO2014009305A1 (en) 2012-07-09 2014-01-16 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
US8778964B2 (en) 2012-11-05 2014-07-15 Bayer Pharma Aktiengesellschaft Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
US8796305B2 (en) 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US9126998B2 (en) 2012-11-05 2015-09-08 Bayer Pharma AG Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US9624214B2 (en) 2012-11-05 2017-04-18 Bayer Pharma Aktiengesellschaft Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
DK2925757T3 (en) 2012-11-19 2018-01-15 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9243001B2 (en) * 2013-03-15 2016-01-26 Epizyme, Inc. Substituted benzene compounds
US20160031907A1 (en) * 2013-03-15 2016-02-04 Epizyme, Inc. Substituted Benzene Compounds
CN105339368B (en) 2013-06-04 2017-08-15 拜耳制药股份公司 Imidazo [1,2 a] pyridine of 3 aryl substitution and application thereof
CN105745215A (en) 2013-07-10 2016-07-06 拜耳制药股份公司 Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof
US9918939B2 (en) 2013-07-30 2018-03-20 Gilead Connecticut, Inc. Formulation of Syk inhibitors
EP3027618B1 (en) 2013-07-30 2020-07-08 Gilead Connecticut, Inc. Polymorph of syk inhibitors
AU2014360537B2 (en) 2013-12-04 2017-09-07 Gilead Sciences, Inc. Methods for treating cancers
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI735853B (en) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 Syk inhibitors
WO2015124544A1 (en) 2014-02-19 2015-08-27 Bayer Pharma Aktiengesellschaft 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines
WO2015140199A1 (en) 2014-03-21 2015-09-24 Bayer Pharma Aktiengesellschaft Cyano-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US20170057958A1 (en) 2014-05-02 2017-03-02 Bayer Pharma Aktiengesellschaft Enantiomers of the n-(2-amino-5-fluoro-2-methylpentyl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide, as well as of the di- and trifluoro derivatives for the treatment of cardiovascular diseases
JP6310144B2 (en) 2014-07-14 2018-04-18 ギリアード サイエンシーズ, インコーポレイテッド Combinations for treating cancer
US10174021B2 (en) 2014-12-02 2019-01-08 Bayer Pharma Aktiengesellschaft Substituted pyrazolo[1,5-A]pyridines and their use
EP3227287B1 (en) 2014-12-02 2019-08-07 Bayer Pharma Aktiengesellschaft Heteroaryl-substituted imidazo[1,2-a]pyridines and their use
WO2016124564A1 (en) 2015-02-05 2016-08-11 Bayer Pharma Aktiengesellschaft N-substituted 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyrazin-3-carboxamide derivatives as stimulators of soluble guanylate cylase (sgc) for the treatment of cardiovascular diseases
WO2016124565A1 (en) 2015-02-05 2016-08-11 Bayer Pharma Aktiengesellschaft Substituted pyrazolo[1,5-a]-pyridine-3-carboxamides and use thereof
WO2016161572A1 (en) * 2015-04-08 2016-10-13 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
WO2018184976A1 (en) 2017-04-05 2018-10-11 Bayer Pharma Aktiengesellschaft Substituted imidazo[1,2-a]pyridinecarboxamides and use of same
CN115028640A (en) 2017-08-25 2022-09-09 吉利德科学公司 Polymorphic forms of a SYK inhibitor
CN113950479A (en) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 Solid forms of condensed pyrazines as SYK inhibitors
US11718622B2 (en) 2020-03-16 2023-08-08 Exelixis Inc. Heterocyclic adenosine receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8704248D0 (en) * 1987-10-30 1987-10-30 Haessle Ab MEDICAL USE
JPH0331280A (en) * 1989-06-28 1991-02-12 Fujisawa Pharmaceut Co Ltd New imidazopyridine compound
AU686115B2 (en) * 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
ATE188377T1 (en) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd QUINOLINES OR QUINAZOLINE DERIVATIVES AND THE USE THEREOF IN THE PRODUCTION OF A MEDICATION FOR THE TREATMENT OF OSTEOPOROSIS
RU2121997C1 (en) * 1993-09-10 1998-11-20 Эйсай Ко., ЛТД 7-amino-1h-indole derivatives

Also Published As

Publication number Publication date
WO1996034866A1 (en) 1996-11-07
JPH11505524A (en) 1999-05-21

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