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MXPA03011113A - Nitrilos novedosos utiles como inhibidores reversibles de proteasas de cisteina. - Google Patents

Nitrilos novedosos utiles como inhibidores reversibles de proteasas de cisteina.

Info

Publication number
MXPA03011113A
MXPA03011113A MXPA03011113A MXPA03011113A MXPA03011113A MX PA03011113 A MXPA03011113 A MX PA03011113A MX PA03011113 A MXPA03011113 A MX PA03011113A MX PA03011113 A MXPA03011113 A MX PA03011113A MX PA03011113 A MXPA03011113 A MX PA03011113A
Authority
MX
Mexico
Prior art keywords
compounds
cysteine proteases
reversible inhibitors
useful
novel
Prior art date
Application number
MXPA03011113A
Other languages
English (en)
Inventor
R Hickey Eugene
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03011113A publication Critical patent/MXPA03011113A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
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Abstract

Se describen compuestos de nitrilo novedosos de la formula (I) definidos en la presente, que son utiles como inhibidores reversibles de las proteasas de cisteina tales como catepsina K, S, F, L y B. Estos compuestos son utiles para el tratamiento de enfermedades y sintomas patologicos exacerbados mediante estas proteasas, tales como aunque no se limitan a osteoporosis, artritis reumatoide, esclerosis multiple, asma, y otras enfermedades autoinmunes, enfermedad de Alzheimer, y ateroesclerosis. Tambien se describen los procedimientos para la obtencion de tales compuestos novedosos.
MXPA03011113A 2001-06-08 2002-06-05 Nitrilos novedosos utiles como inhibidores reversibles de proteasas de cisteina. MXPA03011113A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29686301P 2001-06-08 2001-06-08
PCT/US2002/017590 WO2002100849A2 (en) 2001-06-08 2002-06-05 Novel nitriles useful as reversible inhibitors of cysteine proteases

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MXPA03011113A true MXPA03011113A (es) 2004-03-19

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MXPA03011113A MXPA03011113A (es) 2001-06-08 2002-06-05 Nitrilos novedosos utiles como inhibidores reversibles de proteasas de cisteina.

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US (1) US6982263B2 (es)
EP (1) EP1399431B1 (es)
JP (1) JP4309251B2 (es)
AT (1) ATE423108T1 (es)
CA (1) CA2449192C (es)
DE (1) DE60231207D1 (es)
ES (1) ES2319396T3 (es)
MX (1) MXPA03011113A (es)
WO (1) WO2002100849A2 (es)

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ATE423108T1 (de) 2009-03-15
CA2449192A1 (en) 2002-12-19
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US6982263B2 (en) 2006-01-03
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US20030119827A1 (en) 2003-06-26

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