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MXPA03010762A - Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap. - Google Patents

Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap.

Info

Publication number
MXPA03010762A
MXPA03010762A MXPA03010762A MXPA03010762A MXPA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A
Authority
MX
Mexico
Prior art keywords
iap
assays
binding peptides
bind
identifying compounds
Prior art date
Application number
MXPA03010762A
Other languages
English (en)
Inventor
Shi Yigong
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Publication of MXPA03010762A publication Critical patent/MXPA03010762A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Se revelan ensayos para identificar pepticos y peptidomimeticos para promover la apoptosis en celulas, a traves de una trayectoria que incluye Inhibidor de Proteinas de Apoptosis (IAPs), ejemplificado por XIAP, y la proteina mitocondrial Smac/DIABOLO (en lo sucesivo Smac) y sus homologos. Tambien se revelan peptidomimeticos y peptidos enlazantes de IAP identificados a traves del uso del ensayo.
MXPA03010762A 2001-05-31 2002-05-31 Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap. MXPA03010762A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29468201P 2001-05-31 2001-05-31
US34563002P 2002-01-03 2002-01-03
PCT/US2002/017342 WO2002096930A2 (en) 2001-05-31 2002-05-31 Iap binding peptides and assays for identifying compounds that bind iap

Publications (1)

Publication Number Publication Date
MXPA03010762A true MXPA03010762A (es) 2005-03-07

Family

ID=26968661

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010762A MXPA03010762A (es) 2001-05-31 2002-05-31 Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap.

Country Status (6)

Country Link
US (1) US20050176649A1 (es)
EP (1) EP1421204A4 (es)
JP (1) JP2004531731A (es)
CA (1) CA2449168A1 (es)
MX (1) MXPA03010762A (es)
WO (1) WO2002096930A2 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030157522A1 (en) * 2001-11-09 2003-08-21 Alain Boudreault Methods and reagents for peptide-BIR interaction screens
AU2003216203A1 (en) * 2003-02-07 2004-09-06 Genentech, Inc. Compositions and methods for enhancing apoptosis
US20080199439A1 (en) * 2003-02-12 2008-08-21 Mclendon George L IAP-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods
CN1933847A (zh) * 2004-01-16 2007-03-21 密歇根大学董事会 Smac肽模拟物及其应用
JP4674231B2 (ja) * 2004-03-01 2011-04-20 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム ２量体小分子アポトーシス増強剤
EP1740173A4 (en) 2004-03-23 2009-05-27 Genentech Inc AZABICYCLOOCTAN IAP INHIBITORS
RS53734B1 (sr) 2004-07-02 2015-06-30 Genentech Inc. Inhibitori iap
JP5230865B2 (ja) * 2004-07-15 2013-07-10 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ結合性化合物
KR20120127754A (ko) 2004-12-20 2012-11-23 제넨테크, 인크. Ｉａｐ의 피롤리딘 억제제
CN101128425B (zh) * 2005-02-25 2012-12-26 泰特拉洛吉克药业公司 Iap二聚体抑制剂
US7517906B2 (en) * 2005-02-25 2009-04-14 Tetralogic Pharmaceuticals Corporation Dimeric IAP inhibitors
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
US8318717B2 (en) 2005-05-25 2012-11-27 2Curex Compounds modifying apoptosis
EP1888619B1 (en) * 2005-05-25 2013-04-17 2cureX ApS Compounds modifying apoptosis
CA2625183C (en) 2005-10-04 2019-09-03 Inimex Pharmaceuticals Inc. Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity
BRPI0617751A2 (pt) 2005-10-25 2011-08-02 Aegera Therapeutics Inc compostos de ligação do domìnio iap bir
US8247557B2 (en) 2005-12-19 2012-08-21 Genentech, Inc. IAP inhibitors
TWI504597B (zh) 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
BRPI0715195A2 (pt) 2006-07-24 2013-06-11 Tetralogic Pharm Corp composto, mÉtodos para induzir e para estimular a apoptose em uma cÉlula, para intensificar a apoptose de cÉlulas patogÊnicas in vivo em um indivÍduo, e para tratar uma doenÇa, e, composiÇço farmacÊutica
CL2007002166A1 (es) 2006-07-24 2008-01-25 Tetralogic Pharm Corp Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer.
BRPI0719481A2 (pt) 2006-12-19 2014-02-11 Genentech Inc " composto, método de indução de apoptose em uma célula, de sensibilização de uma célula, para inibir a ligação de uma proteína iap a uma proteína caspase, para tratar uma doença ou condição associada com a superexpressão de uma proteína iap e para tratar câncer"
RU2491276C2 (ru) 2007-04-30 2013-08-27 Дженентек, Инк. Ингибиторы iap
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
ES2706063T3 (es) 2010-02-11 2019-03-27 Univ Northwestern Agonistas del receptor de NMDA y usos del mismo
KR101692275B1 (ko) * 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
US20150158731A1 (en) * 2012-06-25 2015-06-11 Silicor Materials, Inc. Lining for surfaces of a refractory crucible for purification of silicon melt and method of purification of the silicon melt using that crucible
KR102302971B1 (ko) * 2020-04-24 2021-09-15 성신여자대학교 연구 산학협력단 활성 기반 htra 검출용 테트라 펩타이드 프로브

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698448A (en) * 1988-12-02 1997-12-16 Soldin; Steven J. Immunosuppressive drug binding proteins and use
US6187557B1 (en) * 1995-08-08 2001-02-13 Tularik Inc. c-IAP1 and c-IAP2: inhibitors of apoptosis
US5786173A (en) * 1996-03-19 1998-07-28 Idun Pharmaceuticals, Inc. MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use
CA2222453C (en) * 1996-04-26 2009-06-30 Universite D'ottawa/ University Of Ottawa Therapeutic and drug screening methods for the treatment and prevention of neuronal disease
US5977311A (en) * 1997-09-23 1999-11-02 Curagen Corporation 53BP2 complexes
US6110691A (en) * 2000-01-06 2000-08-29 Board Of Regents, The University Of Texas System Activators of caspases
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
EP1315811A2 (en) * 2000-08-24 2003-06-04 Thomas Jefferson University An iap binding peptide or polypeptide and methods of using the same
AU2001293189A1 (en) * 2000-09-29 2002-04-08 Trustees Of Princeton University Compositions and methods for regulating apoptosis
US6992063B2 (en) * 2000-09-29 2006-01-31 The Trustees Of Princeton University Compositions and method for regulating apoptosis
US20020160975A1 (en) * 2001-02-08 2002-10-31 Thomas Jefferson University Conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO for mediating apoptosis

Also Published As

Publication number Publication date
WO2002096930A3 (en) 2004-03-18
US20050176649A1 (en) 2005-08-11
EP1421204A4 (en) 2004-12-15
JP2004531731A (ja) 2004-10-14
EP1421204A2 (en) 2004-05-26
CA2449168A1 (en) 2002-12-05
WO2002096930A2 (en) 2002-12-05

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