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AU2001293189A1 - Compositions and methods for regulating apoptosis - Google Patents

Compositions and methods for regulating apoptosis

Info

Publication number
AU2001293189A1
AU2001293189A1 AU2001293189A AU9318901A AU2001293189A1 AU 2001293189 A1 AU2001293189 A1 AU 2001293189A1 AU 2001293189 A AU2001293189 A AU 2001293189A AU 9318901 A AU9318901 A AU 9318901A AU 2001293189 A1 AU2001293189 A1 AU 2001293189A1
Authority
AU
Australia
Prior art keywords
compositions
methods
regulating apoptosis
apoptosis
regulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001293189A
Inventor
Yigong Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Publication of AU2001293189A1 publication Critical patent/AU2001293189A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001293189A 2000-09-29 2001-09-28 Compositions and methods for regulating apoptosis Abandoned AU2001293189A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60/236,574 2000-09-29
US25683000P 2000-12-20 2000-12-20
US60/256,830 2000-12-20
PCT/US2001/030567 WO2002026775A2 (en) 2000-09-29 2001-09-28 Compositions and methods for regulating apoptosis

Publications (1)

Publication Number Publication Date
AU2001293189A1 true AU2001293189A1 (en) 2002-04-08

Family

ID=34806773

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001293189A Abandoned AU2001293189A1 (en) 2000-09-29 2001-09-28 Compositions and methods for regulating apoptosis

Country Status (2)

Country Link
AU (1) AU2001293189A1 (en)
WO (1) WO2002026775A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002030959A2 (en) * 2000-10-13 2002-04-18 Abbott Laboratories Peptides derived from smac (diablo) and methods of use therefor
US20050176649A1 (en) * 2001-05-31 2005-08-11 Mclendon George Iap binding peptides and assays for identifying compounds that bind iap
CN1507491A (en) * 2002-02-19 2004-06-23 株式会社Bf研究所 Substances that interact with CGI-94 to promote apoptosis and inhibit apoptosis and screening methods thereof
WO2003086470A2 (en) * 2002-04-17 2003-10-23 Deutsches Krebsforschungszentrum Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1354952A1 (en) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1354953A1 (en) * 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1378515A1 (en) * 2002-07-01 2004-01-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Peptides for inducing apoptosis in tumor cells
ES2318167T3 (en) 2002-07-15 2009-05-01 The Trustees Of Princeton University IAP UNION COMPOUNDS.
DE60322120D1 (en) * 2003-02-07 2008-08-21 Genentech Inc COMPOSITIONS AND METHODS FOR REINFORCED APOPTOSIS
AU2005218555B2 (en) 2004-03-01 2008-01-03 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
JP5122275B2 (en) 2004-03-23 2013-01-16 ジェネンテック， インコーポレイテッド Azabicyclo-octane inhibitors of IAP
NZ588799A (en) 2004-07-02 2012-06-29 Genentech Inc Inhibitors of iap
WO2006020060A2 (en) 2004-07-15 2006-02-23 Tetralogic Pharmaceuticals Corporation Iap binding compounds
DE602005022936D1 (en) 2004-12-20 2010-09-23 Genentech Inc PYRROLIDINES AS INHIBITORS OF IAP
WO2006091972A2 (en) 2005-02-25 2006-08-31 Tetralogic Pharmaceuticals Dimeric iap inhibitors
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
AU2006308453B9 (en) 2005-10-25 2011-12-01 Pharmascience Inc. IAP BIR domain binding compounds
EP1973899A4 (en) 2005-12-19 2010-10-20 Genentech Inc IPA INHIBITORS
TWI543988B (en) 2006-03-16 2016-08-01 科學製藥股份有限公司 Iap bir domain binding compounds
WO2008014252A2 (en) 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Iap inhibitors
AR063943A1 (en) 2006-07-24 2009-03-04 Tetralogic Pharmaceuticals Cor IAP ANTAGONIST DIPEPTIDES, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND THE USE OF THEM FOR THE TREATMENT OF CANCER.
CA2671607A1 (en) 2006-12-19 2008-07-03 Genentech, Inc. Imidazopyridine inhibitors of iap
AR066348A1 (en) 2007-04-30 2009-08-12 Genentech Inc IAP INHIBITORS
EP2116602A1 (en) 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
CN102171209A (en) 2008-08-02 2011-08-31 健泰科生物技术公司 Inhibitors of IAP
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
EP2534170B1 (en) 2010-02-12 2017-04-19 Pharmascience Inc. Iap bir domain binding compounds
AU2021399292A1 (en) * 2020-12-17 2023-07-13 Council Of Scientific & Industrial Research Smac mimetics for treatment of cancer, process for preparation and pharmaceutical composition thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608026B1 (en) * 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
WO2002016418A2 (en) * 2000-08-24 2002-02-28 Thomas Jefferson University An iap binding peptide or polypeptide and methods of using the same
WO2002030959A2 (en) * 2000-10-13 2002-04-18 Abbott Laboratories Peptides derived from smac (diablo) and methods of use therefor

Also Published As

Publication number Publication date
WO2002026775A3 (en) 2003-01-23
WO2002026775A2 (en) 2002-04-04

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