MXPA03000498A - Procedimiento para la preparacion de derivados de acido 2-(6-sustituido-1,3-dioxan-4-il)acetico. - Google Patents
Procedimiento para la preparacion de derivados de acido 2-(6-sustituido-1,3-dioxan-4-il)acetico.Info
- Publication number
- MXPA03000498A MXPA03000498A MXPA03000498A MXPA03000498A MXPA03000498A MX PA03000498 A MXPA03000498 A MX PA03000498A MX PA03000498 A MXPA03000498 A MX PA03000498A MX PA03000498 A MXPA03000498 A MX PA03000498A MX PA03000498 A MXPA03000498 A MX PA03000498A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- formula
- dioxane
- preparation
- acetic acid
- Prior art date
Links
- -1 2-(6-substituted-1,3-dioxane-4-yl)acetic acid Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- XYICPZVNNCLGCU-UHFFFAOYSA-N 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid Chemical compound OCC1CC(CC(O)=O)OCO1 XYICPZVNNCLGCU-UHFFFAOYSA-N 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 238000006359 acetalization reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1015744A NL1015744C2 (nl) | 2000-07-19 | 2000-07-19 | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| PCT/NL2001/000535 WO2002006266A1 (en) | 2000-07-19 | 2001-07-12 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03000498A true MXPA03000498A (es) | 2003-06-24 |
Family
ID=19771761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03000498A MXPA03000498A (es) | 2000-07-19 | 2001-07-12 | Procedimiento para la preparacion de derivados de acido 2-(6-sustituido-1,3-dioxan-4-il)acetico. |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US6870059B2 (es) |
| EP (2) | EP1700854B1 (es) |
| JP (2) | JP5006499B2 (es) |
| KR (3) | KR20070121063A (es) |
| CN (3) | CN100378091C (es) |
| AT (1) | ATE340790T1 (es) |
| AU (2) | AU7583001A (es) |
| BR (1) | BR0112535A (es) |
| CA (1) | CA2415963C (es) |
| CY (1) | CY1105881T1 (es) |
| CZ (1) | CZ302718B6 (es) |
| DE (1) | DE60123444T2 (es) |
| DK (1) | DK1317440T3 (es) |
| EE (1) | EE200300024A (es) |
| ES (2) | ES2387313T3 (es) |
| HU (1) | HUP0303166A3 (es) |
| IL (3) | IL153980A0 (es) |
| IS (2) | IS2386B (es) |
| MX (1) | MXPA03000498A (es) |
| NL (1) | NL1015744C2 (es) |
| NO (1) | NO328935B1 (es) |
| NZ (1) | NZ523703A (es) |
| PL (1) | PL207115B1 (es) |
| PT (1) | PT1317440E (es) |
| RU (1) | RU2266903C2 (es) |
| SK (2) | SK287756B6 (es) |
| UA (1) | UA77944C2 (es) |
| WO (1) | WO2002006266A1 (es) |
| ZA (1) | ZA200300478B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| SI1417180T1 (sl) | 2001-07-13 | 2007-04-30 | Astrazeneca Uk Ltd | Priprava aminopirimidinskih spojin |
| EP1323717A1 (en) * | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| EP1375493A1 (en) * | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| JP2006512086A (ja) * | 2002-09-20 | 2006-04-13 | ダイヴァーサ コーポレイション | スタチンおよびスタチン中間体の合成のための酵素化学的方法 |
| US9740817B1 (en) | 2002-10-18 | 2017-08-22 | Dennis Sunga Fernandez | Apparatus for biological sensing and alerting of pharmaco-genomic mutation |
| PT1578731E (pt) | 2002-12-16 | 2010-01-12 | Astrazeneca Uk Ltd | Processo para a preparação de compostos pirimidina |
| ATE386734T1 (de) * | 2003-05-02 | 2008-03-15 | Dsm Ip Assets Bv | Verfahren zur herstellung von (4-hydroxy-6-oxo- tetrahydropyran-2-yl) acetonitril und dessen derivaten |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| US8346482B2 (en) * | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0321827D0 (en) * | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| DE10352659B4 (de) * | 2003-11-11 | 2007-09-13 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| US7264743B2 (en) * | 2006-01-23 | 2007-09-04 | Lam Research Corporation | Fin structure formation |
| TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
| ES2398802T3 (es) * | 2009-04-15 | 2013-03-21 | Pharmathen S.A. | Procedimiento mejorado para la preparación de fluvastatina y sales de la misma |
| GB2482525A (en) * | 2010-08-05 | 2012-02-08 | Phoenix Chemicals Ltd | A process for the production of acyloxymethyldioxanylacetic derivatives |
| SI2614057T1 (sl) | 2010-09-09 | 2016-03-31 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Soli estrov 7-amino-3,5-dihidroksi heptanojske kisline |
| US20130178636A1 (en) | 2010-09-16 | 2013-07-11 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Esters of hexanoic acids as intermediates for the preparation of atorvastatin |
| CN103328470A (zh) | 2011-01-18 | 2013-09-25 | 中化帝斯曼制药有限公司荷兰公司 | 制备二醇砜的方法 |
| EP2665721B1 (en) | 2011-01-18 | 2015-07-08 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Methyltetrazole sulfides and sulfones |
| WO2012098049A1 (en) | 2011-01-18 | 2012-07-26 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the preparation of statins in the presence of base |
| CN103987705B (zh) * | 2011-12-09 | 2015-09-30 | 中化帝斯曼制药有限公司荷兰公司 | 制备他汀含硫前体的方法 |
| CN103974946B (zh) * | 2011-12-09 | 2017-09-29 | 中化帝斯曼制药有限公司荷兰公司 | 制备他汀前体的方法 |
| JP6065862B2 (ja) * | 2013-04-10 | 2017-01-25 | 信越化学工業株式会社 | パターン形成方法、レジスト組成物、高分子化合物及び単量体 |
| WO2014203045A1 (en) | 2013-06-20 | 2014-12-24 | Lupin Limited | A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate |
| CN105624127B (zh) * | 2014-10-28 | 2019-07-26 | 上海弈柯莱生物医药科技有限公司 | 一种葡萄糖脱氢酶及其在合成他汀类药物中间体中的应用 |
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| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| SI1417180T1 (sl) | 2001-07-13 | 2007-04-30 | Astrazeneca Uk Ltd | Priprava aminopirimidinskih spojin |
| EP1323717A1 (en) | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| CZ2004863A3 (cs) | 2002-02-25 | 2004-12-15 | Biocon Limited | Nové boranátové estery |
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| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| PT1578731E (pt) | 2002-12-16 | 2010-01-12 | Astrazeneca Uk Ltd | Processo para a preparação de compostos pirimidina |
| WO2004103977A2 (en) | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
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| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0321827D0 (en) | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
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| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| TW200831469A (en) | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
-
2000
- 2000-07-19 NL NL1015744A patent/NL1015744C2/nl not_active IP Right Cessation
-
2001
- 2001-07-12 BR BR0112535-4A patent/BR0112535A/pt not_active IP Right Cessation
- 2001-07-12 CN CNB2005100657442A patent/CN100378091C/zh not_active Expired - Lifetime
- 2001-07-12 PL PL359332A patent/PL207115B1/pl not_active IP Right Cessation
- 2001-07-12 WO PCT/NL2001/000535 patent/WO2002006266A1/en not_active Ceased
- 2001-07-12 EP EP06010837A patent/EP1700854B1/en not_active Expired - Lifetime
- 2001-07-12 HU HU0303166A patent/HUP0303166A3/hu unknown
- 2001-07-12 ES ES06010837T patent/ES2387313T3/es not_active Expired - Lifetime
- 2001-07-12 EE EEP200300024A patent/EE200300024A/xx unknown
- 2001-07-12 CZ CZ20030163A patent/CZ302718B6/cs not_active IP Right Cessation
- 2001-07-12 AU AU7583001A patent/AU7583001A/xx active Pending
- 2001-07-12 CN CN01812999A patent/CN1443183A/zh not_active Withdrawn
- 2001-07-12 CN CN2007101118797A patent/CN101081842B/zh not_active Expired - Lifetime
- 2001-07-12 SK SK123-2010A patent/SK287756B6/sk not_active IP Right Cessation
- 2001-07-12 NZ NZ523703A patent/NZ523703A/en not_active IP Right Cessation
- 2001-07-12 DK DK01953373T patent/DK1317440T3/da active
- 2001-07-12 RU RU2003104825/04A patent/RU2266903C2/ru not_active IP Right Cessation
- 2001-07-12 KR KR1020077027471A patent/KR20070121063A/ko not_active Ceased
- 2001-07-12 SK SK35-2003A patent/SK287755B6/sk not_active IP Right Cessation
- 2001-07-12 MX MXPA03000498A patent/MXPA03000498A/es active IP Right Grant
- 2001-07-12 AU AU2001275830A patent/AU2001275830B2/en not_active Ceased
- 2001-07-12 AT AT01953373T patent/ATE340790T1/de active
- 2001-07-12 ES ES01953373T patent/ES2272506T3/es not_active Expired - Lifetime
- 2001-07-12 KR KR1020027017684A patent/KR100865016B1/ko not_active Expired - Fee Related
- 2001-07-12 CA CA002415963A patent/CA2415963C/en not_active Expired - Fee Related
- 2001-07-12 EP EP01953373A patent/EP1317440B1/en not_active Expired - Lifetime
- 2001-07-12 IL IL15398001A patent/IL153980A0/xx active IP Right Grant
- 2001-07-12 KR KR1020087019878A patent/KR20080078925A/ko not_active Ceased
- 2001-07-12 PT PT01953373T patent/PT1317440E/pt unknown
- 2001-07-12 JP JP2002512170A patent/JP5006499B2/ja not_active Expired - Lifetime
- 2001-07-12 DE DE60123444T patent/DE60123444T2/de not_active Expired - Lifetime
- 2001-07-12 US US10/333,351 patent/US6870059B2/en not_active Expired - Lifetime
- 2001-12-07 UA UA2003010456A patent/UA77944C2/uk unknown
-
2003
- 2003-01-03 NO NO20030025A patent/NO328935B1/no not_active IP Right Cessation
- 2003-01-15 IS IS6680A patent/IS2386B/is unknown
- 2003-01-16 IL IL153980A patent/IL153980A/en not_active IP Right Cessation
- 2003-01-17 ZA ZA200300478A patent/ZA200300478B/en unknown
-
2005
- 2005-02-07 US US11/053,090 patent/US7642363B2/en not_active Expired - Lifetime
-
2006
- 2006-08-31 IL IL177824A patent/IL177824A0/en not_active IP Right Cessation
- 2006-12-21 CY CY20061101848T patent/CY1105881T1/el unknown
-
2007
- 2007-11-15 IS IS8690A patent/IS8690A/is unknown
-
2009
- 2009-11-24 US US12/625,156 patent/US7989643B2/en not_active Expired - Fee Related
-
2011
- 2011-06-22 US US13/166,607 patent/US20110251406A1/en not_active Abandoned
- 2011-12-06 JP JP2011267056A patent/JP2012111757A/ja active Pending
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