MXPA02012707A - Preparacion terapeutica para neurosis de ansiedad o depresion y derivados de piperazina. - Google Patents
Preparacion terapeutica para neurosis de ansiedad o depresion y derivados de piperazina.Info
- Publication number
- MXPA02012707A MXPA02012707A MXPA02012707A MXPA02012707A MXPA02012707A MX PA02012707 A MXPA02012707 A MX PA02012707A MX PA02012707 A MXPA02012707 A MX PA02012707A MX PA02012707 A MXPA02012707 A MX PA02012707A MX PA02012707 A MXPA02012707 A MX PA02012707A
- Authority
- MX
- Mexico
- Prior art keywords
- depression
- hydrogen
- piperazine derivative
- anxiety neurosis
- formula
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 title abstract 2
- 208000020401 Depressive disease Diseases 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 230000000246 remedial effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 abstract 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona una preparacion terapeutica para la neurosis de ansiedad o depresion que comprende un antagonista del receptor MC4 como ingrediente efectivo; y un derivado de piperazina representado por la Formula [1]: (Ver formula) [en donde Ar1 es un grupo fenilo, un grupo fenilo sustituido, un grupo naftilo o un grupo naftilo sustituido; Ar2 es un grupo naftilo, un grupo naftilo sustituido, un grupo quinolilo, un grupo representado por la formula: (ver formula) (en donde R4 es un atomo de hidrogeno o un atomo de halogeno y X-Y es CH-NH, CH-O, CH-S o N-O) o un grupo representado por la formula: (en donde R5 es un atomo de hidrogeno, un grupo de hidroxilo o un grupo alcoxi C1-10); R1 es un atomo de hidrogeno, un grupo alquilo C1-10, un grupo cicloalquilo C3-8, un grupo alquenilo C3-10, un grupo fenilo, un grupo 1-cianoetilo, un grupo pirimidin-2-il o un grupo amidil; R2 y R3 son el mismo o diferentes y son cada uno un atomo de hidrogeno o un grupo alquilo C1-10; A-B es N-CH2, CH-CH2, C(OH) -CH2 o C=CH; T1 es un enlace unico, -N(R6)- (en donde R6 es un atomo de hidrogeno o un grupo alquilo C1-10) -O-, -CH=CH- o -C(=O)-, n es un entero de 1 a 10, y cuando T1 es un enlace unico, -CH=CH- o - C(=O)-, n es un entero de 2 a 10 cuando T1 es -N(R6) - o -O- o una sal farmaceuticamente aceptable de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000192856 | 2000-06-27 | ||
| PCT/JP2001/005524 WO2002000259A1 (en) | 2000-06-27 | 2001-06-27 | Remedial agent for anxiety neurosis or depression and piperazine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02012707A true MXPA02012707A (es) | 2003-04-25 |
Family
ID=18691931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02012707A MXPA02012707A (es) | 2000-06-27 | 2001-06-27 | Preparacion terapeutica para neurosis de ansiedad o depresion y derivados de piperazina. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6949552B2 (es) |
| EP (1) | EP1295608A4 (es) |
| JP (1) | JP5002881B2 (es) |
| KR (1) | KR20030013470A (es) |
| CN (1) | CN1438897A (es) |
| AU (2) | AU2001266342B2 (es) |
| BG (1) | BG107371A (es) |
| BR (1) | BR0111976A (es) |
| CA (1) | CA2413506A1 (es) |
| CZ (1) | CZ20024165A3 (es) |
| EA (2) | EA200500087A1 (es) |
| EE (1) | EE200200717A (es) |
| HR (1) | HRP20030056A2 (es) |
| HU (1) | HUP0301719A2 (es) |
| IL (1) | IL153706A0 (es) |
| MX (1) | MXPA02012707A (es) |
| NO (1) | NO20026122L (es) |
| NZ (1) | NZ523800A (es) |
| PL (1) | PL360286A1 (es) |
| SK (1) | SK18322002A3 (es) |
| WO (1) | WO2002000259A1 (es) |
| ZA (1) | ZA200210386B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200500087A1 (ru) | 2000-06-27 | 2005-06-30 | Тайсо Фармасьютикал Ко., Лтд. | Производные пиперазина |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| JP2005504043A (ja) | 2001-08-10 | 2005-02-10 | パラチン テクノロジーズ インク． | 生物学的に活性な金属ペプチド類のペプチド模倣体類 |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| EP1468990A4 (en) * | 2001-12-21 | 2006-01-04 | Taisho Pharmaceutical Co Ltd | PIPERAZINE DERIVATIVE |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7968548B2 (en) * | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7491723B2 (en) * | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
| US7419980B2 (en) * | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| KR20070118103A (ko) * | 2005-04-04 | 2007-12-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 우울증 또는 불안신경증의 예방 또는 치료제 |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| US20080108574A1 (en) * | 2006-09-27 | 2008-05-08 | Braincells, Inc. | Melanocortin receptor mediated modulation of neurogenesis |
| EP2072050A1 (en) * | 2007-12-21 | 2009-06-24 | Santhera Pharmaceuticals (Schweiz) AG | Compounds with anti-emetic effect |
| AR078340A1 (es) * | 2009-09-07 | 2011-11-02 | Vifor Int Ag | Antagonistas de la etanodiamina-hepcidina |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US9018395B2 (en) | 2011-01-27 | 2015-04-28 | Université de Montréal | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1317053A (fr) * | 1961-03-17 | 1963-02-01 | Soc Ind Fab Antibiotiques Sifa | Nouveaux dérivés de la pipérazine, et procédé de préparation |
| CA918659A (en) * | 1969-07-31 | 1973-01-09 | Yoshitomi Pharmaceutical Industries | 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines |
| FR2601364B1 (fr) * | 1986-07-09 | 1988-10-21 | Adir | Nouveaux derives de la piperazine dione-2,6, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB9021453D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
| JPH0641071A (ja) * | 1991-09-06 | 1994-02-15 | Taisho Pharmaceut Co Ltd | インドール酢酸エステル誘導体 |
| GB9200293D0 (en) * | 1992-01-08 | 1992-02-26 | Wyeth John & Brother Ltd | Piperazine derivatives |
| SE9700620D0 (sv) * | 1997-02-21 | 1997-02-21 | Wapharm Ab | Cykliska peptider med selektivitet för MSH-receptor subtyper |
| EP1085869A4 (en) * | 1998-06-11 | 2001-10-04 | Merck & Co Inc | Spiropiperidine derivatives as melanocortin receptor agonists |
| EA200500087A1 (ru) | 2000-06-27 | 2005-06-30 | Тайсо Фармасьютикал Ко., Лтд. | Производные пиперазина |
-
2001
- 2001-06-27 EA EA200500087A patent/EA200500087A1/ru unknown
- 2001-06-27 NZ NZ523800A patent/NZ523800A/en unknown
- 2001-06-27 MX MXPA02012707A patent/MXPA02012707A/es unknown
- 2001-06-27 EP EP01943844A patent/EP1295608A4/en not_active Withdrawn
- 2001-06-27 JP JP2002505040A patent/JP5002881B2/ja not_active Expired - Fee Related
- 2001-06-27 BR BR0111976-1A patent/BR0111976A/pt not_active IP Right Cessation
- 2001-06-27 HR HR20030056A patent/HRP20030056A2/hr not_active Application Discontinuation
- 2001-06-27 AU AU2001266342A patent/AU2001266342B2/en not_active Ceased
- 2001-06-27 WO PCT/JP2001/005524 patent/WO2002000259A1/ja not_active Ceased
- 2001-06-27 PL PL36028601A patent/PL360286A1/xx not_active Application Discontinuation
- 2001-06-27 CN CN01811767A patent/CN1438897A/zh active Pending
- 2001-06-27 AU AU6634201A patent/AU6634201A/xx not_active Withdrawn
- 2001-06-27 CA CA002413506A patent/CA2413506A1/en not_active Abandoned
- 2001-06-27 EA EA200300071A patent/EA005737B1/ru not_active IP Right Cessation
- 2001-06-27 US US10/311,429 patent/US6949552B2/en not_active Expired - Fee Related
- 2001-06-27 KR KR1020027017682A patent/KR20030013470A/ko not_active Withdrawn
- 2001-06-27 EE EEP200200717A patent/EE200200717A/xx unknown
- 2001-06-27 IL IL15370601A patent/IL153706A0/xx unknown
- 2001-06-27 HU HU0301719A patent/HUP0301719A2/hu unknown
- 2001-06-27 SK SK1832-2002A patent/SK18322002A3/sk unknown
- 2001-06-27 CZ CZ20024165A patent/CZ20024165A3/cs unknown
-
2002
- 2002-12-11 BG BG107371A patent/BG107371A/bg unknown
- 2002-12-19 NO NO20026122A patent/NO20026122L/no not_active Application Discontinuation
- 2002-12-20 ZA ZA200210386A patent/ZA200210386B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL360286A1 (en) | 2004-09-06 |
| ZA200210386B (en) | 2004-02-10 |
| HUP0301719A2 (hu) | 2003-09-29 |
| IL153706A0 (en) | 2003-07-06 |
| EA005737B1 (ru) | 2005-06-30 |
| WO2002000259A1 (en) | 2002-01-03 |
| JP5002881B2 (ja) | 2012-08-15 |
| NZ523800A (en) | 2005-02-25 |
| EA200300071A1 (ru) | 2003-06-26 |
| NO20026122L (no) | 2003-02-25 |
| US6949552B2 (en) | 2005-09-27 |
| CA2413506A1 (en) | 2002-12-20 |
| SK18322002A3 (sk) | 2003-09-11 |
| AU2001266342B2 (en) | 2005-01-27 |
| NO20026122D0 (no) | 2002-12-19 |
| BG107371A (bg) | 2003-08-29 |
| AU6634201A (en) | 2002-01-08 |
| EP1295608A1 (en) | 2003-03-26 |
| EP1295608A4 (en) | 2004-03-31 |
| KR20030013470A (ko) | 2003-02-14 |
| CN1438897A (zh) | 2003-08-27 |
| US20030186992A1 (en) | 2003-10-02 |
| HRP20030056A2 (en) | 2005-02-28 |
| BR0111976A (pt) | 2003-12-09 |
| CZ20024165A3 (cs) | 2004-03-17 |
| EE200200717A (et) | 2004-08-16 |
| EA200500087A1 (ru) | 2005-06-30 |
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