[go: up one dir, main page]

MXPA02000992A - Microarreglos y su fabricacion. - Google Patents

Microarreglos y su fabricacion.

Info

Publication number
MXPA02000992A
MXPA02000992A MXPA02000992A MXPA02000992A MXPA02000992A MX PA02000992 A MXPA02000992 A MX PA02000992A MX PA02000992 A MXPA02000992 A MX PA02000992A MX PA02000992 A MXPA02000992 A MX PA02000992A MX PA02000992 A MXPA02000992 A MX PA02000992A
Authority
MX
Mexico
Prior art keywords
microarrays
manufacture
Prior art date
Application number
MXPA02000992A
Other languages
English (en)
Inventor
Anderson N Leigh
Original Assignee
Large Scale Proteomics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Large Scale Proteomics Corp filed Critical Large Scale Proteomics Corp
Publication of MXPA02000992A publication Critical patent/MXPA02000992A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50857—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using arrays or bundles of open capillaries for holding samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/00515—Essentially linear supports in the shape of strings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/0052—Essentially linear supports in the shape of elongated tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00513—Essentially linear supports
    • B01J2219/00524—Essentially linear supports in the shape of fiber bundles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00664—Three-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00673—Slice arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00731—Saccharides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MXPA02000992A 1999-07-30 2000-07-28 Microarreglos y su fabricacion. MXPA02000992A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14665399P 1999-07-30 1999-07-30
US09/482,460 US6713309B1 (en) 1999-07-30 2000-01-13 Microarrays and their manufacture
PCT/US2000/020695 WO2001009607A1 (en) 1999-07-30 2000-07-28 Microarrays and their manufacture

Publications (1)

Publication Number Publication Date
MXPA02000992A true MXPA02000992A (es) 2003-07-21

Family

ID=26844141

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02000992A MXPA02000992A (es) 1999-07-30 2000-07-28 Microarreglos y su fabricacion.

Country Status (9)

Country Link
US (3) US6713309B1 (es)
EP (1) EP1204867A4 (es)
JP (16) JP2003527569A (es)
KR (1) KR20020042632A (es)
AU (1) AU6750200A (es)
CA (1) CA2376489A1 (es)
IL (1) IL147683A0 (es)
MX (1) MXPA02000992A (es)
WO (1) WO2001009607A1 (es)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794127B1 (en) * 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
DE69930726T2 (de) * 1998-01-12 2007-01-25 Massachusetts Institute Of Technology, Cambridge Verfahren und vorrichtung zur mikrotestdurchführung
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US7132247B1 (en) * 1998-09-17 2006-11-07 Regents Of The University Of Minnesota Composite devices incorporating biological material and methods
ATE431848T1 (de) * 1999-03-05 2009-06-15 Mitsubishi Rayon Co Microarray mit einer biologischen substanz
CN1348396A (zh) * 1999-03-19 2002-05-08 金克克国际有限公司 用于高效筛选的多通孔测试板
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US6713309B1 (en) * 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US6406840B1 (en) * 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
CA2400644C (en) 2000-02-18 2009-07-14 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US20010031495A1 (en) * 2000-03-13 2001-10-18 Hideji Tajima Integrated support, integrated minute vessels and permeable membrane and method of making and using same
DE10023505A1 (de) * 2000-05-13 2001-11-22 Fraunhofer Ges Forschung Reaktormodul mit Kapillarmembranen
CA2413273C (en) * 2000-06-20 2008-12-09 Mitsubishi Rayon Co., Ltd. Organism-related substance microarray and method of producing the same
CA2635452A1 (en) 2000-06-21 2001-12-27 Bioarray Solutions, Ltd. Looped probe design to control hybridization stringency
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
GB0024276D0 (en) * 2000-10-04 2000-11-15 Univ Cranfield Substrate specific materials
US20020051995A1 (en) * 2000-10-30 2002-05-02 Rajan Kumar Stacked arrays
ATE299593T1 (de) * 2000-11-07 2005-07-15 Advanced Gene Technology Corp Verfahren zum screenen von pflanzenextrakten nach wirkstoffen
DE10110511C1 (de) * 2001-02-28 2002-10-10 Attomol Gmbh Molekulare Diagno Verfahren zur Herstellung eines Arrays zur Detektion von Komponenten aus einer biologischen Probe
US20020129889A1 (en) * 2001-03-15 2002-09-19 Anderson Norman G. Method and apparatus for making fibers for sectioned arrays
JP3937742B2 (ja) * 2001-03-28 2007-06-27 キヤノン株式会社 プローブ担体及びその製造方法
DE10117135A1 (de) * 2001-04-05 2002-10-17 Biotechnolog Forschung Gmbh Verfahren zur Herstellung einer Vielzahl identischer Kopien einer planaren Testanordnung von Sondenmolekülen
DE10117275B4 (de) * 2001-04-06 2005-02-24 Hte Ag The High Throughput Experimentation Company Vorrichtung zur Archivierung und Analyse von Materialien
US6872320B2 (en) * 2001-04-19 2005-03-29 Xerox Corporation Method for printing etch masks using phase-change materials
WO2002085926A2 (de) * 2001-04-19 2002-10-31 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Verfahren zur herstellung stabiler, regenerierbarer antikörper-arrays
US6742884B2 (en) 2001-04-19 2004-06-01 Xerox Corporation Apparatus for printing etch masks using phase-change materials
CN100404692C (zh) 2001-05-11 2008-07-23 松下电器产业株式会社 生物分子基底,使用它的检验和诊断方法及装置
DE10122836A1 (de) * 2001-05-11 2002-11-28 November Ag Molekulare Medizin Faser, Faden und Verfahren zur Markierung und Identifizierung
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
JP2003014746A (ja) * 2001-06-27 2003-01-15 Fuji Photo Film Co Ltd 生物学的素材が固定された構造体及びその製造方法
EP1281966A3 (en) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Method and apparatus for conducting a receptor-ligand reaction
EP1420250A4 (en) * 2001-07-31 2006-03-22 Olympus Corp GENE INSPECTION DEVICE AND THESE TARGET NUCLEIC ACID EXTRACTION PROCEDURES
CN1217009C (zh) * 2001-09-01 2005-08-31 三星电子株式会社 利用具有环氧基的星状聚乙二醇衍生物制备水凝胶生物芯片的方法
KR100614951B1 (ko) * 2001-09-28 2006-08-25 가부시끼가이샤 히다치 세이사꾸쇼 발광검출장치, 발광검출용 마이크로어레이플레이트
GB0124338D0 (en) 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
US7085404B2 (en) * 2001-10-11 2006-08-01 Industry-University Cooperation Foundation, Hangyang University Image analysis system and method of biochip
IL161391A0 (en) 2001-10-15 2004-09-27 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US6797393B2 (en) 2001-11-30 2004-09-28 Eastman Kodak Company Method for making biochip substrate
EP1462454A4 (en) * 2001-12-11 2007-05-23 Mitsubishi Rayon Co ARRANGEMENT FOR CRYSTALLIZING PROTEIN, DEVICE FOR CRYSTALLIZING PROTEIN AND METHOD FOR ANALYZING PROTEIN CRYSTALLIZATION USING IT
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US7371582B2 (en) * 2002-01-23 2008-05-13 Boditechmed Inc. Lateral flow quantitative assay method and strip and laser-induced fluorescence detection device therefor
EP1333281A3 (en) * 2002-01-31 2004-01-14 Fuji Photo Film Co., Ltd. Method and reactor for conducting receptor-ligand association reactions
JP3933058B2 (ja) * 2002-02-25 2007-06-20 日立化成工業株式会社 マイクロ流体システム用支持ユニット及びその製造方法
WO2003078621A1 (en) * 2002-03-13 2003-09-25 Genomics Usa Inc. Method for manufacturing microarrays based on the immobilization of porous substrates on thermally modifiable surfaces
US20040052412A1 (en) * 2002-05-10 2004-03-18 Large Scale Biology Corporation Satellite image enhancement and feature identification using information theory radial-basis bio-marker filter
JP2003337117A (ja) * 2002-05-17 2003-11-28 Hitachi High-Technologies Corp キャピラリアレイ及びキャピラリアレイの生産方法
US7011971B2 (en) * 2002-06-03 2006-03-14 Eastman Kodak Company Method of making random array of microspheres using enzyme digestion
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
WO2004023142A1 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US7364896B2 (en) * 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
CA2521999A1 (en) * 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
GB0304515D0 (en) * 2003-02-27 2003-04-02 Dakocytomation Denmark As Standard
DE10316689A1 (de) * 2003-04-10 2004-10-28 Dimitrij Dr. Plachov Dreidimensionaler Chip
US20070101549A1 (en) * 2003-05-19 2007-05-10 Mitsubishi Rayon Co., Ltd. Yarn arrangement device and method for yarn arrangement using the device, yarn arrangement tool, method of manufacturing yarn arranged body, and method of manufacturing living body-related substance immobilizing micro array
US7556660B2 (en) 2003-06-11 2009-07-07 James Kevin Shurtleff Apparatus and system for promoting a substantially complete reaction of an anhydrous hydride reactant
GB0315991D0 (en) * 2003-07-08 2003-08-13 Dakocytomation Denmark As Standard
WO2005014805A1 (en) * 2003-08-08 2005-02-17 Regents Of The University Of Minnesota A structured material for the production of hydrogen
US7280727B1 (en) * 2003-09-05 2007-10-09 Schott Corporation Micro-well and methods of fabricating and selectively blackening the same
US20090052850A1 (en) * 2003-09-05 2009-02-26 Loic Barbedette Micro-well plates and methods of fabricating and selectively blackening the same
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ES2375962T3 (es) 2003-09-22 2012-03-07 Bioarray Solutions Ltd Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
JP2007521017A (ja) 2003-10-28 2007-08-02 バイオアレイ ソリューションズ リミテッド 固定化捕捉プローブを用いる遺伝子発現分析法の最適化
EP1694859B1 (en) 2003-10-29 2015-01-07 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
JPWO2005064334A1 (ja) * 2003-12-30 2007-12-20 ユニバーサル・バイオ・リサーチ株式会社 粒子三次元配列体を利用した反応容器及び反応装置
JPWO2005084792A1 (ja) * 2004-02-18 2007-08-02 日立化成工業株式会社 マイクロ流体システム用支持ユニット
WO2005080570A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Rayon Co., Ltd. 乳癌の術後予後予測に関与する遺伝子
EP1735097B1 (en) 2004-03-12 2016-11-30 Life Technologies Corporation Nanoliter array loading
RU2252411C1 (ru) * 2004-04-09 2005-05-20 Общество с ограниченной ответственностью "Институт рентгеновской оптики" Флюоресцентный сенсор на основе многоканальных структур
EP1758981A4 (en) 2004-05-28 2013-01-16 Wafergen Inc DEVICES AND METHOD FOR MULTIPLEX ANALYZES
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
US20070045777A1 (en) * 2004-07-08 2007-03-01 Jennifer Gillies Micronized semiconductor nanocrystal complexes and methods of making and using same
US7697808B2 (en) * 2004-07-27 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US12070731B2 (en) 2004-08-04 2024-08-27 Life Technologies Corporation Methods and systems for aligning dispensing arrays with microfluidic sample arrays
US20060105453A1 (en) * 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US7595157B2 (en) * 2004-08-19 2009-09-29 Biocept, Inc. Microarrays utilizing hydrogels
CN100348324C (zh) * 2004-11-10 2007-11-14 厦门大学 阵列微量多通道移液器
JP4006002B2 (ja) * 2004-11-26 2007-11-14 キヤノン株式会社 Ｄｎａ担持繊維及びｄｎａ担持繊維シート並びにこれらの製造方法
JP4687653B2 (ja) 2004-11-30 2011-05-25 日立化成工業株式会社 分析前処理用部品
US20090291264A1 (en) * 2004-12-09 2009-11-26 Hitachi Chemical Co., Ltd. Microfluid-System-Supporting Unit And Production Method Thereof
US20060194215A1 (en) * 2005-02-28 2006-08-31 Kronick Mel N Methods, reagents and kits for reusing arrays
US7189522B2 (en) * 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007012982A2 (en) * 2005-07-28 2007-02-01 Biosystems International Sas Normalization of complex analyte mixtures
EP1913392A4 (en) * 2005-08-02 2010-03-10 Univ Utah Res Found BIOSENSORS WITH METALLIC NANOCONITIES
US20080020260A1 (en) * 2005-11-12 2008-01-24 Brydon Chris A Apparatus, system, and method for manifolded integration of a humidification chamber for input gas for a proton exchange membrane fuel cell
US20070148677A1 (en) * 2005-12-02 2007-06-28 Chagovetz Alexander M Methods and systems for acquiring real-time quantitative melt data
US20070134814A1 (en) * 2005-12-09 2007-06-14 Kajander E O Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease
US20090221433A1 (en) * 2006-01-03 2009-09-03 Barnes David W Small molecule printing
US7657070B2 (en) * 2006-01-20 2010-02-02 Sakura Finetek U.S.A., Inc. Automated system of processing biological specimens and method
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US20110111225A1 (en) * 2006-05-10 2011-05-12 Armark Authentication Technologies, Llc Extruded Filament Having High Definition Cross-Sectional Indicia/Coding, Microscopic Tagging System Formed Therefrom and Method of Use Thereof for Anti-Counterfeiting of Product Authentication
US7651542B2 (en) 2006-07-27 2010-01-26 Thulite, Inc System for generating hydrogen from a chemical hydride
US7648786B2 (en) 2006-07-27 2010-01-19 Trulite, Inc System for generating electricity from a chemical hydride
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
JP2010516281A (ja) * 2007-01-22 2010-05-20 ウェハージェン，インコーポレイテッド 高スループット化学反応用装置
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
US8357214B2 (en) 2007-04-26 2013-01-22 Trulite, Inc. Apparatus, system, and method for generating a gas from solid reactant pouches
KR20100061453A (ko) 2007-07-25 2010-06-07 트루라이트 인크. 하이브리드 전력의 생성 및 사용을 관리하는 장치, 시스템 및 방법
US20090029227A1 (en) * 2007-07-25 2009-01-29 John Patton Apparatus, system, and method for securing a cartridge
US20110195852A1 (en) * 2007-08-30 2011-08-11 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
US8340913B2 (en) * 2008-03-03 2012-12-25 Schlumberger Technology Corporation Phase behavior analysis using a microfluidic platform
US8735846B1 (en) 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
US7812318B1 (en) 2008-03-14 2010-10-12 Advanced Technology Applications, Llc Electromagnetic biosensor
CN103203210A (zh) * 2008-03-27 2013-07-17 哈佛学院院长等 基于纸的细胞阵列
CN102016594B (zh) * 2008-03-27 2014-04-23 哈佛学院院长等 用作低成本多重分析诊断平台的棉线
CN102016596B (zh) * 2008-03-27 2014-09-17 哈佛学院院长等 纸基微流体系统
WO2009121037A2 (en) 2008-03-27 2009-10-01 President And Fellows Of Harvard College Three-dimensional microfluidic devices
EP2274445A2 (en) 2008-04-11 2011-01-19 University of Utah Research Foundation Methods and compositions related to quantitative array based methylation analysis
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
US8715590B2 (en) * 2008-08-15 2014-05-06 Prognosys LLC Multiplexed lateral flow assay arrays
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
DK2389116T3 (en) 2009-01-22 2018-02-12 Biopath Automation Llc BIOPSY SUPPORT TO ORIENT TESTS FOR SECTION IN A MICROTOM
WO2010102279A1 (en) 2009-03-06 2010-09-10 President And Fellows Of Harvard College Microfluidic, electromechanical devices
WO2011015359A1 (en) * 2009-08-05 2011-02-10 Eth Zurich Bioanalytical device
JP2012231678A (ja) * 2009-09-11 2012-11-29 Espinex:Kk 微生物検出方法
CN102821861B (zh) 2010-02-03 2015-03-25 哈佛大学校长及研究员协会 用于多重测定的装置和方法
DE102010001714A1 (de) * 2010-02-09 2011-08-11 Robert Bosch GmbH, 70469 Vorrichtung und Verfahren zur optischen Parallelanalyse einer Probenanordnung und entsprechendes Herstellungsverfahren
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
CA2791655C (en) 2010-03-01 2014-11-04 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
WO2011145908A2 (ko) * 2010-05-20 2011-11-24 고려대학교 산학협력단 효소가 집적된 미세튜브를 이용한 정량분석법
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
JP5609700B2 (ja) 2011-02-17 2014-10-22 ソニー株式会社 電気泳動素子および表示装置
JP5660468B2 (ja) * 2011-03-15 2015-01-28 三菱レイヨン株式会社 生体関連物質検出用ゲルマイクロアレイの製造方法
JP2012198417A (ja) * 2011-03-22 2012-10-18 Sony Corp 電気泳動素子、表示装置および電子機器
JP5673269B2 (ja) * 2011-03-22 2015-02-18 ソニー株式会社 電気泳動素子、表示装置および電子機器
JP5741122B2 (ja) * 2011-03-28 2015-07-01 ソニー株式会社 電気泳動素子、表示装置および電子機器
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
US20120275753A1 (en) * 2011-04-28 2012-11-01 Reinhardt Sherrh C Fiber assembly with tray feature
US9599623B2 (en) * 2011-06-09 2017-03-21 Immucor Gti Diagnostics, Inc. Diagnostic devices, methods and systems for detecting platelet factor 4 (PF4)/heparin antibodies
JP2013045074A (ja) * 2011-08-26 2013-03-04 Sony Corp 電気泳動素子およびその製造方法、表示装置、表示基板ならびに電子機器
WO2013037046A1 (en) * 2011-09-16 2013-03-21 The Governors Of The University Of Alberta Method and system for amplification of nucleic acids in microfluidic volume hydrogels
JP5870605B2 (ja) * 2011-10-13 2016-03-01 ソニー株式会社 表示装置およびその駆動方法、ならびに電子機器
JP5942394B2 (ja) * 2011-11-22 2016-06-29 ソニー株式会社 電気泳動素子および表示装置
CN103135309B (zh) * 2011-11-22 2017-11-17 索尼公司 电泳装置、电泳装置的制造方法、以及显示器
WO2013080941A1 (ja) * 2011-12-01 2013-06-06 三菱レイヨン株式会社 核酸増幅用基材及び核酸増幅方法
JP5953128B2 (ja) * 2012-06-01 2016-07-20 秀明 久本 アッセイ用キャピラリアレイの製造方法
JP5884659B2 (ja) * 2012-06-29 2016-03-15 ソニー株式会社 電気泳動素子および表示装置
TWI622845B (zh) * 2012-09-05 2018-05-01 Sony Corp Electrophoresis element, display device and electronic device
JP2014106333A (ja) * 2012-11-27 2014-06-09 Sony Corp 電気泳動素子、表示装置および電子機器
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
WO2014130542A1 (en) * 2013-02-19 2014-08-28 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge with non-reflective beads
JP6230091B2 (ja) * 2013-03-13 2017-11-15 国立研究開発法人産業技術総合研究所 マイクロアレイ、その製造方法、及びその用途
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
MY198463A (en) 2014-04-02 2023-08-30 Chembio Diagnostic Systems Inc Immunoassay Utilizing Trapping Conjugate
US20150375149A1 (en) 2014-06-27 2015-12-31 Eastman Chemical Company Acetate tow and filters with shape and size used for coding
US9442074B2 (en) 2014-06-27 2016-09-13 Eastman Chemical Company Fibers with surface markings used for coding
US9863920B2 (en) 2014-06-27 2018-01-09 Eastman Chemical Company Fibers with chemical markers and physical features used for coding
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
EP3259602B9 (en) 2015-02-20 2021-05-19 Takara Bio USA, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
JP6713601B2 (ja) * 2015-03-24 2020-07-01 国立大学法人東海国立大学機構 分析デバイス
JP6631771B2 (ja) * 2015-05-11 2020-01-15 国立研究開発法人情報通信研究機構 微生物分析装置及び微生物分析方法
JP7075394B2 (ja) 2016-07-21 2022-05-25 タカラ バイオ ユーエスエー， インコーポレイテッド マルチウェルデバイスを用いたマルチｚ撮像及び分注
US20200392439A1 (en) * 2017-12-23 2020-12-17 The University Of Tokyo Array and use thereof
EP4647508A3 (en) 2018-04-02 2026-01-21 Enumera Molecular, Inc. Methods, systems, and compositions for counting nucleic acid molecules
GB2582906B (en) * 2019-04-01 2022-09-07 Ip2Ipo Innovations Ltd Electrochemical sensor cable
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
CN114181804A (zh) * 2022-02-15 2022-03-15 深圳市研元生物科技有限公司 一种基因芯片及其制备和使用方法

Family Cites Families (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238757A (en) 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
JPS6310560Y2 (es) 1979-04-23 1988-03-29
JPS6310562Y2 (es) 1980-07-14 1988-03-29
US4459360A (en) 1981-10-05 1984-07-10 Mast Medical Industries, Ltd. Multiple-component binding assay system and method of making and using it
SE8200442L (sv) 1982-01-27 1983-07-28 Forsvarets Forsknings Forfarande vid detektion av organiska molekyler, sasom biomolekyler
JPS58152708U (ja) 1982-04-06 1983-10-13 株式会社井上ジャパックス研究所 照明装置
JPS5936502U (ja) 1982-08-31 1984-03-07 株式会社小糸製作所 自動車用前照灯
JPS59186903U (ja) 1983-05-30 1984-12-12 松下電工株式会社 昇降式照明器具
JPS59194206U (ja) 1983-06-10 1984-12-24 松下電工株式会社 両サイド型照明器具用の吊具
US4623355A (en) 1984-03-16 1986-11-18 Sawruk Stephen D Prosthetic axon
US4708931A (en) 1984-06-01 1987-11-24 Regents Of University Of California Laminated rod having alternating detection and spacer layers for binding assays
JPS60210805A (ja) 1984-06-25 1985-10-23 Taamo:Kk 係合具
CH669265A5 (de) 1985-12-18 1989-02-28 Celldynamics Ag Multiindikator-teststreifen fuer immunologische analysen, ihre herstellung und verwendung.
US4859538A (en) 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
JPS63172454U (es) 1987-04-30 1988-11-09
WO1988008875A1 (en) 1987-05-05 1988-11-17 The Washington Technology Center Cycling biochip sensor
US4896363A (en) 1987-05-28 1990-01-23 Thumbscan, Inc. Apparatus and method for matching image characteristics such as fingerprint minutiae
US5540828A (en) 1987-06-08 1996-07-30 Yacynych; Alexander Method for making electrochemical sensors and biosensors having a polymer modified surface
US4914022A (en) 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
US4981653A (en) 1988-10-06 1991-01-01 Miles Inc. Self-indicating strip
US5503975A (en) 1989-03-01 1996-04-02 City Of Hope Mechanism based inhibitors of DNA methyltransferase
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
WO1991007087A1 (en) 1989-11-13 1991-05-30 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
DE4024545A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
WO1992010588A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
CA2097708A1 (en) 1990-12-06 1992-06-07 Stephen P. A. Fodor Very large scale immobilized polymer synthesis
US5264565A (en) 1991-01-22 1993-11-23 Affymax Technologies, N.V. Nucleic acid encoding the D2 /Ml chimeric receptor
GB2262163B (en) 1991-03-09 1995-12-20 Flor Henry Michel Whole cell sheet photometer
US5273656A (en) 1991-09-04 1993-12-28 Large Scale Biology Corporation System for solid phase reactions
US5186824A (en) 1991-09-04 1993-02-16 Large Scale Biology Corporation System for solid phase reactions
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
EP0916396B1 (en) 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Combinatorial strategies for polymer synthesis
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5258627A (en) 1991-12-04 1993-11-02 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Semiconductor structure using protein as its active element
US5302707A (en) 1992-03-26 1994-04-12 Affymax Technologies N.V. 5-fluorouridine nucleoside phosphate compounds
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5728802A (en) 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5648458A (en) 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5792664A (en) 1992-05-29 1998-08-11 The Rockefeller University Methods for producing and analyzing biopolymer ladders
US5814603A (en) 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
WO1993025197A1 (en) 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5622944A (en) 1992-06-12 1997-04-22 Affymax Technologies N.V. Testosterone prodrugs for improved drug delivery
US5585275A (en) 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5420328A (en) 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
AU5449094A (en) 1992-11-02 1994-05-24 Affymax Technologies N.V. Novel photoreactive protecting groups
JPH08510720A (ja) 1993-01-27 1996-11-12 アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ 経皮的薬物送り出しのための組成物及び方法
AU6171194A (en) 1993-02-05 1994-08-29 Affymax Technologies N.V. Receptor-binding antiproliferative peptides
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5484639A (en) * 1993-04-15 1996-01-16 Shaw Industires, Inc. Carpet and carpet backing with directional guide
EP0700301B1 (en) 1993-05-05 1999-09-01 Affymax Technologies N.V. Peptides and compounds that bind to elam-1
AU7212494A (en) 1993-06-25 1995-01-17 Affymax Technologies N.V. Hybridization and sequencing of nucleic acids
US20020048749A1 (en) 1998-04-15 2002-04-25 Robert J. Lipshutz Methods for polymorphism identifcation and profiling
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5874239A (en) 1993-07-30 1999-02-23 Affymax Technologies N.V. Biotinylation of proteins
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
DE69435196D1 (de) 1993-10-28 2009-04-23 Houston Advanced Res Ct Mikrofabriziertes poröses Durchflussgerät zur diskreten Bestimmung von Bindungsreaktionen
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
CA2175587A1 (en) 1993-11-02 1995-05-11 Jeffrey H. Sugarman Synthesizing and screening molecular diversity
AU1602995A (en) 1994-01-11 1995-08-01 Affymax Technologies N.V. Methods for the solid phase synthesis of glycoconjugates
US5786331A (en) 1994-02-02 1998-07-28 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5880096A (en) 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5608035A (en) 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5861476A (en) 1994-02-02 1999-01-19 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
EP0750680B1 (en) 1994-03-15 1999-01-13 Scientific Generics Ltd Electrochemical denaturation of double-stranded nucleic acid
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
EP0695941B1 (en) 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5990112A (en) 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
EP0776330B1 (en) 1994-06-23 2003-08-20 Affymax Technologies N.V. Photolabile compounds and methods for their use
WO1996000391A1 (en) 1994-06-23 1996-01-04 Affymax Technologies N.V. Methods for the synthesis of diketopiperazines
US5817751A (en) 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
US6060288A (en) 1994-08-03 2000-05-09 Mosaic Technologies Method for performing amplification of nucleic acid on supports
US5506420A (en) 1994-09-14 1996-04-09 The Regents Of The University Of California Semiconductor bio-electronic devices incorporating biochemical stabilization layers
US5710000A (en) 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
JP3342590B2 (ja) 1994-10-20 2002-11-11 株式会社サンギ 半導体集積回路
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5840698A (en) 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
WO1996016333A1 (en) 1994-11-23 1996-05-30 Affymax Technologies, N.V. METHODS FOR SYNTHESIZING DIVERSE COLLECTIONS OF β-LACTAM COMPOUNDS
SE9404166D0 (sv) 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5655560A (en) 1994-12-16 1997-08-12 Affymax Technologies N.V. Clog-free valving system
WO1996023813A1 (en) 1995-02-01 1996-08-08 Affymax Technologies N.V. Peptides and compounds that bind to sh2 domains
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
AU5321796A (en) 1995-03-23 1996-10-08 Affymax Technologies N.V. Novel piperazine derivatives as type il-1 receptor antagonists
WO2000000808A2 (en) 1998-06-09 2000-01-06 California Institute Of Technology Colloidal particles used in sensing arrays
US5961923A (en) 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US6025129A (en) 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US5925562A (en) 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
WO1996033736A1 (en) 1995-04-27 1996-10-31 Affymax Technologies N.V. Malaria peptides and vaccines
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5668110A (en) 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
ES2210374T3 (es) 1995-06-07 2004-07-01 Ortho Pharmaceutical Corporation Compuestos y peptidos que se unen al receptor de eritropoyetina.
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5759779A (en) 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6147205A (en) 1995-12-15 2000-11-14 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
AU2189397A (en) 1996-02-08 1997-08-28 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
AU2411197A (en) 1996-04-30 1997-11-19 Affymax Technologies N.V. Methods for the synthesis of fmoc protected amines
JP2000512744A (ja) 1996-05-16 2000-09-26 アフィメトリックス，インコーポレイテッド 標識材料を検出するシステムおよび方法
JPH1099085A (ja) 1996-05-16 1998-04-21 Affymetrix Inc ヒトミトコンドリアｄｎａの多形性
US6057100A (en) * 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
US5932579A (en) 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
WO1997049845A1 (en) 1996-06-26 1997-12-31 Sumitomo Metal Industries, Ltd. Crystal-growing method and solid element and device for crystal growth used in the method
CA2259395C (en) 1996-07-15 2002-03-05 Sumitomo Metal Industries, Ltd. Equipment for crystal growth and crystal-growing method using the same
US6329140B1 (en) 1996-09-19 2001-12-11 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
WO1998012559A1 (en) 1996-09-20 1998-03-26 Demers James P Spatially addressable combinatorial chemical arrays in cd-rom format
US5856104A (en) 1996-10-28 1999-01-05 Affymetrix, Inc. Polymorphisms in the glucose-6 phosphate dehydrogenase locus
WO1998020967A1 (en) 1996-11-14 1998-05-22 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
US6114116A (en) 1996-12-02 2000-09-05 Lemieux; Bertrand Brassica polymorphisms
EP1007969A4 (en) 1996-12-17 2006-12-13 Affymetrix Inc DESIGN OF LITHOGRAPHIC MASKS AND SYNTHESIS OF VARIOUS PROBES ON A SUBSTRATE
US5998875A (en) 1996-12-19 1999-12-07 Telefonaktiebolaget Lm Ericsson Flip-chip type connection with elastic contacts
US6180389B1 (en) 1997-01-03 2001-01-30 The Research And Development Institute, Inc. Virion-constrained nanoparticles comprising a plant virion coat protein shell and encapsulated guest molecules
JP2002512511A (ja) 1997-03-07 2002-04-23 アフィメトリックス，インコーポレイテッド 遺伝子組成物および方法
DE69830395T2 (de) 1997-03-20 2006-01-26 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Iterative resequenzierung
GB9706654D0 (en) 1997-04-02 1997-05-21 Scient Generics Ltd Disassociation of interacting molecules
US6221586B1 (en) 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
WO1998046551A1 (en) 1997-04-16 1998-10-22 Arqule, Inc. Synthesis and use of biased arrays
WO1998053841A1 (en) 1997-05-27 1998-12-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Scaffold-organized metal, alloy, semiconductor and/or magnetic clusters and electronic devices made using such clusters
JP3693352B2 (ja) 1997-06-13 2005-09-07 アフィメトリックス インコーポレイテッド プローブアレイを使用して、遺伝子多型性を検出し、対立遺伝子発現をモニターする方法
US6333179B1 (en) 1997-06-20 2001-12-25 Affymetrix, Inc. Methods and compositions for multiplex amplification of nucleic acids
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5993627A (en) 1997-06-24 1999-11-30 Large Scale Biology Corporation Automated system for two-dimensional electrophoresis
WO1998058529A2 (en) 1997-06-24 1998-12-30 Affymetrix, Inc. Genetic compositions and methods
WO1999002682A1 (en) 1997-07-09 1999-01-21 Affymetrix, Inc. p53 MUTANTS FOUND IN TUMORS
IL121312A (en) 1997-07-14 2001-09-13 Technion Res & Dev Foundation Microelectronic components, their manufacture and electronic networks containing them
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6188783B1 (en) 1997-07-25 2001-02-13 Affymetrix, Inc. Method and system for providing a probe array chip design database
WO1999006833A1 (en) 1997-07-29 1999-02-11 Huston James S Methods for obtaining probes of peptide function
US6177282B1 (en) 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6223127B1 (en) 1997-08-15 2001-04-24 Affymetrix, Inc. Polymorphism detection utilizing clustering analysis
DE69833698T2 (de) * 1997-09-11 2006-11-16 Bioventures, Inc., Murfreesboro Verfahren zur Herstellung von Arrays hoher Dichte
KR20010024251A (ko) 1997-09-23 2001-03-26 사이퍼젠 바이오시스템스, 인코오포레이티드 비행 시간형 질량 분석계용 2차 이온 발생기 검출기
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
EP1032674B1 (en) 1997-11-21 2007-01-24 Serono Genetics Institute S.A. (chlamydia pneumoniae) genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
EP1032676A2 (en) 1997-11-28 2000-09-06 Genset $i(CHLAMYDIA TRACHOMATIS) GENOMIC SEQUENCE AND POLYPEPTIDES, FRAGMENTS THEREOF AND USES THEREOF, IN PARTICULAR FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INFECTION
EP0926260A3 (en) 1997-12-12 2001-04-11 Matsushita Electric Industrial Co., Ltd. Using antibody - antigen interaction for formation of a patterened metal film
US5945522A (en) 1997-12-22 1999-08-31 Genset Prostate cancer gene
US6093302A (en) 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis
US20020025552A1 (en) 1998-01-06 2002-02-28 Institut Pasteur Screening interactor molecules with whole genome oligonucleotide or polynucleotide arrays
WO1999037659A1 (en) 1998-01-23 1999-07-29 The Regents Of The University Of California Identification and expression of a novel kinesin motor protein
WO1999039004A1 (en) 1998-02-02 1999-08-05 Affymetrix, Inc. Iterative resequencing
US6150147A (en) 1998-02-06 2000-11-21 Affymetrix, Inc. Biological array fabrication methods with reduction of static charge
EP1056882A4 (en) * 1998-02-21 2002-04-17 Technology Foundation Wisys One dimensional chemical compound arrays and methods for assaying them
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
AU2892199A (en) 1998-03-03 1999-09-20 Affymetrix, Inc. Cell cycle regulated genes
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
ATE284957T1 (de) 1998-04-07 2005-01-15 Wisconsin Alumni Res Found Enterotoxindefizierende bacillus
GB9808264D0 (en) 1998-04-17 1998-06-17 Imperial College Biochemical devices and their methods of manufacture
AU3659199A (en) 1998-04-20 1999-11-08 Affymetrix, Inc. Methods for reducing non-specific binding to a nucleic acid probe array
US6130046A (en) 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
US6525185B1 (en) 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
DE19823454A1 (de) 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren zur photolithographischen Herstellung von DNA, PNA und Protein Chips
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US6699659B2 (en) 1998-06-01 2004-03-02 Affymetrix, Inc. Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions
EP1084273A1 (en) 1998-06-06 2001-03-21 Genostic Pharma Limited Probes used for genetic profiling
AU4573599A (en) 1998-06-17 2000-01-05 Board Of Trustees Of The University Of Illinois, The Force-regulated molecular recognition switches
ATE313548T1 (de) 1998-06-22 2006-01-15 Affymetrix Inc Reagenz und verfahren zu fester phase synthese
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6129896A (en) * 1998-12-17 2000-10-10 Drawn Optical Components, Inc. Biosensor chip and manufacturing method
ATE431848T1 (de) 1999-03-05 2009-06-15 Mitsubishi Rayon Co Microarray mit einer biologischen substanz
US6103518A (en) 1999-03-05 2000-08-15 Beecher Instruments Instrument for constructing tissue arrays
WO2000065098A2 (en) 1999-04-27 2000-11-02 University Of Chicago Nucleotide extension on a microarray of gel-immobilized primers
US6713309B1 (en) * 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture

Also Published As

Publication number Publication date
JP2003028868A (ja) 2003-01-29
US6846635B1 (en) 2005-01-25
JP2003014759A (ja) 2003-01-15
JP2003527569A (ja) 2003-09-16
US20010041339A1 (en) 2001-11-15
US6887701B2 (en) 2005-05-03
JP2003028879A (ja) 2003-01-29
IL147683A0 (en) 2002-08-14
JP2003014750A (ja) 2003-01-15
JP2003014757A (ja) 2003-01-15
JP2003014758A (ja) 2003-01-15
KR20020042632A (ko) 2002-06-05
WO2001009607A1 (en) 2001-02-08
WO2001009607A8 (en) 2002-02-07
CA2376489A1 (en) 2001-02-08
AU6750200A (en) 2001-02-19
JP2003014752A (ja) 2003-01-15
JP2003028869A (ja) 2003-01-29
JP2003014753A (ja) 2003-01-15
US6713309B1 (en) 2004-03-30
EP1204867A1 (en) 2002-05-15
JP2003004738A (ja) 2003-01-08
JP2003014751A (ja) 2003-01-15
JP2003028870A (ja) 2003-01-29
JP2003014754A (ja) 2003-01-15
JP2003014756A (ja) 2003-01-15
JP2003014755A (ja) 2003-01-15
EP1204867A4 (en) 2006-05-10

Similar Documents

Publication Publication Date Title
MXPA02000992A (es) Microarreglos y su fabricacion.
MXPA01013362A (es) Anticuerpos de humano, anti-alfavbeta3 recombinantes, °cidos nucleicos que codifican a los mismos y metodos de uso.
ZA200201806B (en) Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof.
ZA200200477B (en) 2-pyrazolin-5-ones.
EG24361A (en) 4-pyrimiding1-n-acy1.l.phenlalanines
ZA200103880B (en) Catalyst.
IL142917A0 (en) Substituted 2-phenylbenzimidazoles, the production thereof and their use
MXPA02006460A (es) Trifluorometilpirrolcarboxamidas y trifluorometilpirroltioamidas como fungicidas.
ZA200202537B (en) Pour-on-formulations.
ZA200203762B (en) 4-pyridinyl-IN-acyl-L-phenylalanines.
ZA991845B (en) Catalyst and use thereof.
ZA200203707B (en) Pharmaceutical combinations.
GB9927590D0 (en) Microarray slides
GB0007933D0 (en) Assays,methods and means
MXPA02000261A (es) Aminoindanos novedosos.
ZA200110454B (en) Pharmaceutical complex.
ZA200108246B (en) Making and using microclonal uncloned cDNA libraries.
ZA200002546B (en) Sorbate-preserved compositions, method for the manufacture thereof and their use.
GB0029720D0 (en) I.S machine7544232001
ZA992018B (en) Banners.
ZA200204581B (en) Nitro-sulfobenzamides.
GB9928605D0 (en) Rein
GB0006533D0 (en) Assays,methods and means
PL354184A1 (en) The prv-1 gene and use thereof
GB0007510D0 (en) D.o.t.t.s