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MXPA99009874A - Nuevos derivados de amidina. - Google Patents

Nuevos derivados de amidina.

Info

Publication number
MXPA99009874A
MXPA99009874A MXPA99009874A MX9909874A MXPA99009874A MX PA99009874 A MXPA99009874 A MX PA99009874A MX PA99009874 A MXPA99009874 A MX PA99009874A MX 9909874 A MX9909874 A MX 9909874A MX PA99009874 A MXPA99009874 A MX PA99009874A
Authority
MX
Mexico
Prior art keywords
compounds
thienyl
racemates
therapy
alkyl
Prior art date
Application number
MXPA99009874A
Other languages
English (en)
Inventor
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of MXPA99009874A publication Critical patent/MXPA99009874A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona nuevos compuestos de la formula (I) en donde R1 representa un anillo de 2-tienilo o de 3-tienilo y R2 representa un alquilo con 1 a 4 atomos de carbono y los isomeros y racematos opticos de los mismos y las sales de los mismos aceptables farmaceuticamente; junto con procesos para su preparacion, composiciones que los contienen y su uso en terapia. Los compuestos son inhibidores selectivos de la isoforma neuronal de la oxido nitrico sintasa.
MXPA99009874A 1997-05-05 1998-04-28 Nuevos derivados de amidina. MXPA99009874A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701682A SE9701682D0 (sv) 1997-05-05 1997-05-05 Compounds
PCT/SE1998/000792 WO1998050380A1 (en) 1997-05-05 1998-04-28 Compounds

Publications (1)

Publication Number Publication Date
MXPA99009874A true MXPA99009874A (es) 2004-09-30

Family

ID=20406836

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA99009874A MXPA99009874A (es) 1997-05-05 1998-04-28 Nuevos derivados de amidina.

Country Status (28)

Country Link
US (1) US6166030A (es)
EP (1) EP0983266B1 (es)
JP (1) JP2001523263A (es)
KR (1) KR20010012227A (es)
CN (1) CN1255130A (es)
AR (1) AR012602A1 (es)
AT (1) ATE210661T1 (es)
AU (1) AU734394B2 (es)
BR (1) BR9808725A (es)
CA (1) CA2287999A1 (es)
DE (1) DE69802923T2 (es)
DK (1) DK0983266T3 (es)
EE (1) EE9900475A (es)
ES (1) ES2168757T3 (es)
HU (1) HUP0003766A3 (es)
ID (1) ID23156A (es)
IL (1) IL132677A0 (es)
IS (1) IS5237A (es)
MX (1) MXPA99009874A (es)
NO (1) NO995404L (es)
NZ (1) NZ500676A (es)
PL (1) PL336854A1 (es)
PT (1) PT983266E (es)
SE (1) SE9701682D0 (es)
SK (1) SK140699A3 (es)
TR (1) TR199902719T2 (es)
WO (1) WO1998050380A1 (es)
ZA (1) ZA983740B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566081B1 (en) 1999-10-06 2003-05-20 The Brigham And Women's Hospital, Inc. Methods of identifying a compound which modulates the non-transcriptional non-map-kinase induced effects of steroid hormones
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US20050154229A1 (en) * 2002-03-22 2005-07-14 Aeri Kim Maleic acid salt of(2s)-n-{5-[amino(imino)methy]-2-thienyl}methyl-1-{(2r)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl}-2-pyrrolidine carboxamide and a process for
EP1883451B9 (en) 2005-04-13 2011-02-09 Neuraxon Inc. Substituted indole compounds having nos inhibitory activity
TWI417099B (zh) * 2007-03-23 2013-12-01 Neuraxon Inc 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物
CA2705835A1 (en) 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
IL110643A (en) * 1993-08-12 1998-07-15 Astra Ab Amidine derivatives their preparation and pharmaceutical compositions containing them
ATE177078T1 (de) * 1993-10-21 1999-03-15 Searle & Co Amidino-derivate als no-synthetase inhibitoren
CA2188680A1 (en) * 1994-05-07 1996-01-25 James Edwin Macdonald Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
EE9700207A (et) * 1995-08-10 1998-02-16 Astra Aktiebolag Teraapias kasutatavad bitsüklilised amidiini derivaadid

Also Published As

Publication number Publication date
BR9808725A (pt) 2000-07-11
SE9701682D0 (sv) 1997-05-05
EP0983266B1 (en) 2001-12-12
IS5237A (is) 1999-11-01
HUP0003766A3 (en) 2001-09-28
EP0983266A1 (en) 2000-03-08
CN1255130A (zh) 2000-05-31
DK0983266T3 (da) 2002-03-11
SK140699A3 (en) 2000-06-12
PT983266E (pt) 2002-05-31
NO995404L (no) 2000-01-05
DE69802923D1 (de) 2002-01-24
AU7460098A (en) 1998-11-27
ATE210661T1 (de) 2001-12-15
NZ500676A (en) 2001-05-25
NO995404D0 (no) 1999-11-04
AU734394B2 (en) 2001-06-14
AR012602A1 (es) 2000-11-08
ID23156A (id) 2000-03-23
PL336854A1 (en) 2000-07-17
EE9900475A (et) 2000-06-15
US6166030A (en) 2000-12-26
HUP0003766A2 (en) 2001-03-28
JP2001523263A (ja) 2001-11-20
DE69802923T2 (de) 2002-07-04
WO1998050380A1 (en) 1998-11-12
KR20010012227A (ko) 2001-02-15
ES2168757T3 (es) 2002-06-16
TR199902719T2 (xx) 2000-02-21
CA2287999A1 (en) 1998-11-12
IL132677A0 (en) 2001-03-19
ZA983740B (en) 1999-02-19

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