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MXPA99009107A - Procedimiento para la preparacion de acido pantotenico por medio del refuerzo de las secuencias nucleotidas que codifican a la reductasa de cetopantoato. - Google Patents

Procedimiento para la preparacion de acido pantotenico por medio del refuerzo de las secuencias nucleotidas que codifican a la reductasa de cetopantoato.

Info

Publication number
MXPA99009107A
MXPA99009107A MXPA99009107A MX9909107A MXPA99009107A MX PA99009107 A MXPA99009107 A MX PA99009107A MX PA99009107 A MXPA99009107 A MX PA99009107A MX 9909107 A MX9909107 A MX 9909107A MX PA99009107 A MXPA99009107 A MX PA99009107A
Authority
MX
Mexico
Prior art keywords
pantothenic acid
preparation
nucleotide sequences
amplification
code
Prior art date
Application number
MXPA99009107A
Other languages
English (en)
Inventor
Frank Elischewski
Nicole Dusch
Joern Kalinowski
Alfred Puehler
Juergen Dohmen
Mike Farwick
Georg Thierbach
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7883894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA99009107(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Degussa filed Critical Degussa
Publication of MXPA99009107A publication Critical patent/MXPA99009107A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invención se refiere a un procedimiento para la preparación y mejora de microorganismos productores de ácido D-pantoténico al reforzar las secuencias nucleótidas que codifican a la reductasa de cetopantoato, en especial del gen panE, individualmente o combinadas entre si, y en caso dado adicionalmente el gen ilvC, los microorganismos que contienen esas secuencias nucleótidas y un procedimiento para la preparación de ácido D-pantoténico consistente de la fermentación de esos microorganismos, el enriquecimiento del ácido pantoténico en el medio o en las células de los microorganismos y el aislado del ácido D-pantoténico.
MXPA99009107A 1998-10-09 1999-10-05 Procedimiento para la preparacion de acido pantotenico por medio del refuerzo de las secuencias nucleotidas que codifican a la reductasa de cetopantoato. MXPA99009107A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19846499A DE19846499A1 (de) 1998-10-09 1998-10-09 Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen

Publications (1)

Publication Number Publication Date
MXPA99009107A true MXPA99009107A (es) 2012-02-21

Family

ID=7883894

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA99009107A MXPA99009107A (es) 1998-10-09 1999-10-05 Procedimiento para la preparacion de acido pantotenico por medio del refuerzo de las secuencias nucleotidas que codifican a la reductasa de cetopantoato.

Country Status (17)

Country Link
US (1) US6171845B1 (es)
EP (1) EP1001027B2 (es)
JP (1) JP2000116387A (es)
KR (1) KR20000028952A (es)
CN (1) CN1254758A (es)
AT (1) ATE266098T1 (es)
AU (1) AU5357099A (es)
BR (1) BR9904449A (es)
CA (1) CA2284117A1 (es)
DE (2) DE19846499A1 (es)
ES (1) ES2221280T3 (es)
HU (1) HUP9903458A3 (es)
IL (1) IL132292A0 (es)
MX (1) MXPA99009107A (es)
PL (1) PL335926A1 (es)
SK (1) SK137799A3 (es)
ZA (1) ZA996367B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19855314A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE19855313A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
US8232081B2 (en) 1999-09-21 2012-07-31 Basf Se Methods and microorganisms for production of panto-compounds
DE10101501A1 (de) * 2001-01-12 2002-08-01 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen Herstellung von Pantothensäure
MXPA03006342A (es) * 2001-01-19 2004-12-03 Basf Antiengesellschaft Procesos para una produccion incrementada de pantotenato.
EP1390519B1 (en) * 2001-01-19 2006-12-06 BASF Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
DE10106459A1 (de) * 2001-02-13 2002-08-14 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106461A1 (de) * 2001-02-13 2002-08-14 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106460A1 (de) 2001-02-13 2002-08-14 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
SK10422003A3 (sk) 2001-02-21 2004-02-03 Basf Aktiengesellschaft Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív
EP1385975B1 (de) 2001-02-21 2007-01-03 Basf Aktiengesellschaft Verfahren zur herstellung von d-pantothensäure und/oder salze als zusatz zu tierfuttermitteln
DE10108225A1 (de) 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
US6623944B2 (en) 2001-03-14 2003-09-23 Degussa Ag Process for preparation of D-pantothenic acid and/or salts thereof
JP2002330763A (ja) 2001-05-02 2002-11-19 Ajinomoto Co Inc 発酵法による目的物質の製造法
US20030073219A1 (en) * 2001-05-21 2003-04-17 Blundell Tom L. Crystal structure
DE10128780A1 (de) * 2001-06-13 2002-12-19 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10147960A1 (de) * 2001-09-28 2003-04-10 Degussa Verfahren zur fermentativen Herstellung von D-Panthothensäure und/oder deren Salzen
US20060099692A1 (en) * 2002-07-03 2006-05-11 Yocum R R Microorganisms and processes for enhanced production of pantothenate
MXPA04012812A (es) 2002-07-03 2005-02-24 Basf Ag Microorganismos y proceso para la produccion aumentada de pantotenato.
DE10344200A1 (de) * 2003-09-22 2005-05-04 Basf Ag Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
WO2007131750A1 (en) 2006-05-16 2007-11-22 Dsm Ip Assets B.V. Process for the production of panthenol
US8765426B2 (en) * 2011-04-07 2014-07-01 E I Du Pont De Nemours And Company Pantothenic acid biosynthesis in zymomonas
CN109868254B (zh) * 2019-03-14 2021-02-19 浙江工业大学 一种高产泛酸的基因工程菌、构建方法及应用
CN113278569B (zh) * 2021-05-11 2022-04-19 浙江工业大学 无质粒、无诱导剂使用的产d-泛酸基因工程菌及构建方法
CN116024278B (zh) * 2022-12-16 2024-05-07 黑龙江新和成生物科技有限公司 一种发酵法制备d-泛酸的方法
KR102879056B1 (ko) * 2023-01-27 2025-10-30 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
CN116590209A (zh) * 2023-06-13 2023-08-15 浙江工业大学 一种产d-泛酸的基因工程菌、构建方法及应用
WO2025244515A1 (ko) * 2024-05-24 2025-11-27 씨제이제일제당 (주) 옥타노일트랜스퍼라아제의 활성이 강화된 미생물 및 이의 용도

Also Published As

Publication number Publication date
KR20000028952A (ko) 2000-05-25
HUP9903458A2 (hu) 2000-12-28
EP1001027A2 (de) 2000-05-17
DE19846499A1 (de) 2000-04-20
DE59909391D1 (de) 2004-06-09
BR9904449A (pt) 2000-11-14
JP2000116387A (ja) 2000-04-25
SK137799A3 (en) 2000-09-12
ES2221280T3 (es) 2004-12-16
AU5357099A (en) 2000-04-13
HUP9903458A3 (en) 2001-04-28
US6171845B1 (en) 2001-01-09
CN1254758A (zh) 2000-05-31
PL335926A1 (en) 2000-04-10
HU9903458D0 (en) 1999-12-28
IL132292A0 (en) 2001-03-19
EP1001027B2 (de) 2009-06-24
ATE266098T1 (de) 2004-05-15
CA2284117A1 (en) 2000-04-09
EP1001027A3 (de) 2001-08-16
ZA996367B (en) 2000-04-13
EP1001027B1 (de) 2004-05-06

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