MXPA99003918A - Methods and compositions for reducing body odor - Google Patents

Abstract

The present invention relates to an odor absorbing composition, which is safe for use on human skin, comprising from 0.1%to 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin;from 0.1%to 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants;an emulsifier;and an aqueous carrier. The odor absorbing compositions of the present invention may also contain an effective amount of hydrophobic antimicrobials. The present invention also relates to the use of cyclodextrin-containing compositions for the manufacture of an odor absorbing composition, which is safe for use on skin, for controlling environmental malodors on skin and for reducing body odor and/or vaginal odor.

Description

ETHODS AND COMPOSITIONS TO REDUCE BODY SMELL BACKGROUND OF THE INVENTION Body odor is most commonly caused by fatty acids in the skin and by bad odors from microbial sources. Human skin is naturally populated with numerous microorganisms that are nourished by various secreted substances in the skin (eccrine sweat and sebum), skin cell debris, skin breakage products and the same organisms. Said unpleasant body odors are mainly organic molecules having different structures and functional groups, such as amines, acids, alcohols, aldehydes, phenolic, polycyclic, indole, aromatic, polyaromatic ketones, etc. Or they can also be made of sulfur-containing functional groups, such as thiol, mercaptan, sulfur and / or disulfide groups. In addition, daily contact with substances that leave unpleasant and / or prolonged odors on the body and hair of an individual is almost inevitable. Foods such as fish, onions, garlic and other spices, cooking odors, smoke, tobacco and gasoline are just some of the common environmental sources of bad odors in everyday life. Numerous attempts have been made to control or absorb or cover odors. Attempts have been made to impede the microbes responsible for the smell of the wet / humid environment that is needed to proliferate and grow. Such efforts include the use of powders, antiperspirants and deodorants. However, powders for the body are often undesirable as they can be difficult to apply and can stick or fall on clothing and antiperspirants may not be desirable for use throughout the body. The deodorant compositions intended to combat / control the odor associated with skin secretions, which have been described in the chemical and cosmetic literature, include emulsion bars or suspensoid bars, aerosols, deodorants with movable balls, pads, pump sprays , and even bars of soap. Said known deodorizers are intended to control odor through a variety of means. For example, the patent of E.U.A. No. 5,525,331, to Betts, issued June 11, 1996, discloses compositions that inhibit the growth of microorganisms in bodily secretions. The deodorants can also include antibacterial compounds that help destroy / control the amount of bacteria present in the skin, thus minimizing the odor produced by the bacterial metabolism of skin secretions. Zeolites are known absorbers of the odor. However, said solid odor absorbers, in addition to the known activated charcoal odor absorbers, lose functionality when wet. Therefore, when moistened by body fluids, or when carried in an aqueous solution, said odor absorbers are not preferred since they lose their desired smell-absorbing properties. In addition, zeolites can cause a "rough" sensation if it is deposited heavily on the skin. In addition to the above, numerous attempts have been made to cover odors with other scents or perfumes. However, perfumes are often unsuitable to completely hide odors and can be irritating to the user when used only for odor control. Thus, there is still a need for safe and effective methods for controlling odor that are essentially free of irritating ingredients and that are capable of absorbing a broad spectrum of body odors that are not completely hidden by the aforementioned means. It has been found that such improved body odor control can be safely provided throughout the body by application of a composition, which is left on the skin, which incorporates odor absorption, non-complex cyclodextrins into an aqueous solution . Said compositions may also provide auxiliary benefits of the skin to the user. further, it has been found that the combination of cyclodextrin with low levels of antimicrobials provides optimal body odor absorption characteristics. It has also been discovered that a particular advantage of the present invention is the ability to provide convenient protection against odor, non-irritant in all areas of the body, including hidden areas of the skin such as the pelvic region, the outer vagina, the lines of the panties, the lines of the bras, the folds of the skin, which can be very sensitive.

These and other objects of the present invention will become apparent from the following detailed description. All percentages, relationships, and part of the present, in the specification, examples and claims are by weight unless stated otherwise. The term "g", as used herein refers to gram. The term "ml", as used herein refers to millimeter. The term "p", as used herein refers to weight.

BRIEF DESCRIPTION OF THE INVENTION The present invention relates to an odor absorbing composition, which is safe for use on human skin, comprising from 0.1% to 5% by weight of the composition, of solubilized cyclodextrin, soluble in water, which is not subjected to complexes; from 0.1% to 36% by weight of the composition, of the oil phase selected from the group consisting of emollients, humectants, skin protectants, and mixtures thereof; an emulsifier; and a watery vehicle. The odor absorbing compositions of the present invention may also contain an effective amount of hydrophobic antimicrobials. The present invention also relates to the use of 0.1% to 5% by weight of the composition, of solubilized cyclodextrin, soluble in water, which is not subjected to complexes; from 0.1% to 36% by weight of the composition, of an oil phase selected from the group consisting of emollients, humectants. skin protectors, and mixtures thereof; an emulsifier; and an aqueous vehicle for the manufacture of a composition, which is safe for use on the skin, for controlling bad environmental odors in the skin and for reducing body odor and / or vaginal odor.

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a perfume-free, odor-absorbent composition. The present invention also relates to the use of cyclodextrins for the manufacture of a perfume-free, odor-absorbing composition that controls the environmental malodors in the skin and reduces body odor and / or vaginal odor. The compositions can be applied directly as a sprinkler, poured from a bottle and applied by hand, or applied by a damp cloth. The term "body fluids", as used herein, includes eccrine sweat, apocrine sweat, bait, reasonable moisture accumulation of transpidermal water loss, vaginal discharge, urine, and mixtures thereof. The term "body odor" as used herein refers to odors that are generated as a result of the natural functioning of a human or a mammalian body. Such odors include, but are not limited to, odors produced by microorganisms from the skin of humans or humans. mammal (i.e., bacterial decomposition of skin secretions), urine, or vaginal discharge and mixtures thereof. The term "total body" refers to the entire outer surface of human or mammalian skin. The term "skin" refers to human or mammalian skin. The term "vaginal odor" refers specifically to those coforal odors that emanate from the pelvic region of the woman, particularly the vagina and the lines of the panties. The term "environmental malodors", as used herein, refers to any odor that may be in a human or mammal that is not the result of body odor and / or coforal fluids.

Such odors include but are not limited to the odors of foods such as fish, garlic, onions, peppers and spices; kitchen; smoke; tobacco; gasoline; and similar. The term "control" odors, as used herein refers to the absorption, reduction or elimination of environmental malodors as determined by the human sense of smell. A detailed description of essential and optional components of the present invention is given below.

CICLODEXTRIN As used herein, the term "cyclodextrin" includes any of the known cyclodextrins such as unsubstituted cyclodextrins containing from six to twelve glucose units, especially, alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, and / or their derivatives and / or mixtures thereof. The term "cyclodextrin which is not subject to complexes" as used herein refers to the fact that the cavities within the cyclodextrin in the solution of the present invention must remain essentially unfilled while in solution, to allow the cyclodextrin absorb several odor molecules when the solution is applied to a surface. The term "water-soluble cyclodextrin, which is not subject to complexes" as used herein refers to the cyclodextrin which is not subjected to complexes having a minimum solubility limit of 1% (1 gram in 100 grams of water). ). The non-derived beta-cyclodextrin may be present at a level up to its solubility limit of about 1.85% at room temperature. When beta-cyclodextrin is applied to a cleaning substrate, levels greater than its solubility limit can be used. Preferably, the cyclodextrins used in the present invention are highly soluble in water such as, alpha-cyclodextrin and / or derivatives thereof, gamma-cyclodextrin and / or depurated therefrom, beta-cyclodextrin derivatives, and / or mixtures thereof. the same. The cyclodextrin derivatives consist mainly of molecules where some of the OH groups are converted to OR groups. Cyclodextrins highly soluble in water are those that have solubility in water of at least about 10 g in 100 ml of water at room temperature, preferably at least about 20 g in 100 ml of water, most preferably at least about 25 g in 100 ml of water at room temperature. Most preferred are beta-cyclodextrin, hydroxypropyl alpha-cyclodextrin, hydroxylpropyl beta-cyclodextrin, methylated alpha-cyclodextrin or methylated beta-cyclodextrin. It is also preferred to use a mixture of cyclodextrins. Such mixtures absorb body odors more broadly by combining with a wider variety of odoriferous molecules that have a broader scale of molecular sizes. The cyclodextrin levels are from about 01% to about 5%, preferably from about 0.2% to about 4%, most preferably from about 0.3% to about 3%, most preferably from about 0.4% to about 2% by weight of the composition.

The concentrated compositions can also be used. When a concentrated product is used, ie, with the level of cyclodextrin used is from about 3% to about 5%, it is preferred to dilute the composition before applying to the skin to avoid the sticky feeling of the skin and / or an undesirable amount. of residue. Preferably the cyclodextrin is diluted with from about 50% to about 2,000%, most preferably from about 60% to about 1,000, most preferably from about 75% to about 500% by weight of the water composition.

Complex formation between cyclodextrin and odor molecules occurs rapidly in the presence of water when the solubilized cyclodextrin is first applied to the skin. Additionally, cyclodextrins that dry on skin surfaces will once again boost their absorption capabilities when rewetting with fluids. The above is convenient for the user because the cyclodextrins to be in the dry skin, will not fill their cavities with other scents that can make them less efficient otherwise. Most particularly, in the solubilization of the cyclodextrin by the coforal fluids, the isolated cavities are available to form the inclusion complexes with the cue and / or environmental odor molecules. In this way, finally, the capacity of ciclodextpna that is not subjected to complexes solubilized is essential for the development of effective and efficient odor control. A more complete description of the cyclodextrin and cyclodextrin derivatives useful in the present invention can be found in the patent of E.U.A. No. 5,534,165, Pilosof et al., Issued July 9, 1996, which is hereby incorporated herein by reference in its entirety.

OLEOUS PHASE The present invention also includes an oil phase. The oil phase is selected from the following ingredients: skin protectants, emollients, and / or humectants. The saturated or hydrogenated oils are the preferred. Said ingredients promote the skin feel characteristics and / or skin care benefits of the present invention. Additionally, the oil phase provides a medium in which hydrophobic antibacterials, if present, can be dissolved. The protective ingredients of the skin can prevent or reduce irritation, skin irritation and / or skin friction that may occur between skin-to-skin contact sites. Skin protectors useful in the present invention include, but are not limited to: vitamin A, cod liver oils, cocoa butter, shark liver oil, dimethicone, petrolatum, white petrolatum, mineral oil, jojoba oil and lanolin. The most preferred are dimethicone petrolatum, white petrolatum, mineral oil, jojoba oil and lanolin. Dimethicones are most preferred. Moisturizers that can aid in the addition of moisture to the skin can be included in the oily vehicle of the present invention. Preferred humectants useful in the present invention include, but are not limited to, vegetable oils and mineral oil. Most preferred are hydrogenated or saturated vegetable or mineral oils. Other humectants useful in the present invention may be selected from the oily humectants in Cosmetic Bench Ref. 1994, pages 46-48, incorporated herein by reference. Emollients to soften the skin are also useful in the present invention. Emollients useful herein include tocopherol or tocopherol acetate, triglycerides, vegetable oils or mineral oil. Others Emollients useful in the present invention can be selected from the fatty emollients in Cosmetic Bench Ref. 1994, pages 27-31, hereby incorporated by reference. The oil phase or vehicle of the present invention is present at an "effective level" which is a level that provides the desired skin benefits of the particular ingredients. Typically, the oil phase is present at a level of from about 0.1% to about 26%, preferably from about 0.2% to about 6% by weight of the composition.

EMULSIFIER An emulsifier should be used in the present invention. Emulsifiers are known in the art of forming oil-in-water emulsions. Preferably, a pair of emulsifiers are used for improved stability. A preferred emulsifier is a non-foam or low foam emulsifier. Suitable emulsifiers are nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants, detersive surfactants and mixtures thereof. When an emulsifier containing one or more aliphatic alkyl groups is used, it is preferred that they contain relatively short alkyl chains of about 5 to about 14 carbon atoms.

Preferred nonionic surfactants are ethoxylated alkylphenols, such as Igepal® surfactants from Rhóne-Poulenc; ethoxylated sorbitan fatty acid esters; polyethylene glycol-polypropylene glycol block copolymers, such as Pluronic®, and Pluronic R® surfactants from BASF; surfactants Tetronic® and Tetronic R® from BASF, ethoxylated branched aliphatic diols such as surfactants Surfinol® from Air Products; ethoxylated aliphatic alcohols and carboxylic acids; polyethylene glycol diesters of fatty acids; and mixtures thereof. Preferred anionic surfactants are dialkylsulfosuccinate, alkylarylsulfonate, fatty alcohol sulfate, paraffin sulfonate, alkyl sarcosinate, alkyl isethionate salts having suitable cations, ie, sodium, potassium, alkanolammonium, etc., and mixtures thereof. The amphoteric surfactants are the betaines. Also preferred are emulsifiers having the hydrophilic groups located between the hydrophobic chains, such as the surfactant Pluronic R®, surfinol surfactants, polyethylene glycol fatty acid diesters, sorbitol ethoxylated fatty acid esters, dialkylsulfosuccinate, halides, di ( C8-C12 alkyl) di (C-C-Cyanonium alkyl), and mixtures thereof; or emulsifiers having the hydrophobic chains located between the hydrophilic groups, such as the pluronic surfactants; and mixtures thereof. Mixtures of said emulsifiers are also preferred.

The emulsifier is used in the present compositions at a level of from about 0.05% to about 1%, most preferably from about 0.1% to about 1.00% by weight of the composition. If a hydrophobic antimicrobial agent is included, more emulsifiers should be included, typically from about 0.75% to about 1% by weight of the composition. The emulsion concentrates can also use. Emulsion concentrates are preformed emulsions comprising an emulsifier and an oil phase and an aqueous phase. An example of an emulsion concentrate useful in the present invention is Dow Corning® 365, 35% dimethicone emulsion.

HYDROPHOBIC ANTIBATERIAL AGENTS Optionally, the present invention may include hydrophobic antibacterial compounds to help destroy and / or control the amount of bacteria present in the skin, which aids in the control of body odor. The hydrophobic antibacterials useful in the present invention include triclosan, triclocarbon, eucalyptol, menthol, methylsalicylate, thymol, and mixtures thereof. Preferred are triclosan and triclocarbon. When included in the composition of the present invention, the hirophobic antibacterials may be at a level of approximately 0. 1% to about 1.5% and preferably from about 0.1% to about 0.3% by weight of the composition.

AQUEOUS VEHICLE The cyclodextrins useful in the present invention must be solubilized and dispersed in an aqueous vehicle. The diluted aqueous solution provides maximum separation of the cyclodextrin molecules in the skin and maximizes the possibility of an odor molecule interacting with a cyclodextrin molecule. A watery vehicle is also beneficial as it provides clean, convenient means to apply the cyclodextrin to the desired skin sites. Additionally, an aqueous vehicle can impart a degree of cleaning power and by itself wash away the cell debris from the skin and the secretions of the skin deposited by the bacteria, as well as the bacteria themselves. The term "aqueous vehicle", as used herein, refers to water and / or any water-soluble material suitable for use as a solvent. Any water, such as distilled, deionized, or tap water can be used. Water not only serves as a liquid vehicle for the cyclodextrins, but also facilitates the complexation reaction between the cyclodextrin molecules and any odor molecule that is found at the site of the skin when applied to the composition.

The aqueous vehicle of the present invention will typically comprise from about 80% to about 98% of the composition of the present invention. Preferably, the composition of the present invention comprises the aqueous vehicle from about 85% to about 95% by weight of the composition.

ANTIMICROBIAL CONSERVATIVE The compositions may optionally, but preferably, contain solubilized, mild, water-soluble antimicrobial preservatives that are effective to inhibit and / or regulate microbial growth in the composition. Contamination of the compositions of the present invention by microorganisms and subsequent microbial growth can result in unpleasant or malodorous compositions. Similarly, microorganisms are typically found in cyclodextrin supplies and their growth in aqueous solutions is possible. The inclusion of the antimicrobial preservatives helps in increasing the storage stability of the composition of the present invention. In the present invention, the water-soluble antimicrobial preservative is included in an effective amount. The phrase "effective amount" of water-soluble antimicrobial preservative as used herein refers to a level sufficient to prevent filtration, or prevent the growth of microorganisms unexpectedly added to the composition, over a specific period.

Antimicrobial preservatives useful in the present invention include biosidic and bloatic compounds (substances that kill microorganisms and / or regulate the growth of microorganisms). Suitable antimicrobial preservatives have a solubility of 0.3% or greater. In addition, suitable preservatives are those that can be brought into contact with the skin without a high potential irritation. Preferred antimicrobial preservatives are those that are soluble in water and effective at lower levels because water-insoluble organic preservatives can form inclusion complexes with the cyclodextrin molecules and compete with the malodour molecules for the cyclodextrin cavities, thus making cyclodextrins inefficient as odor control assets. Suitable preservatives for use in the present compositions are described in full in The Theorv and Practice of Industrial Pharmacv, by Lachman, Lieberman, Kanig, 3ra. Edition, pages 466-467 and 520-522 (1986), and patent of E.U.A. No. 5,534,165, to Pilosof et al., Issued July 9, 1996, which are hereby incorporated by reference. It is preferred to use a broad spectrum preservative such as that which is effective in bacteria (in positive gram and negative gram) and fungi. A limited spectrum conservative such as that which is effective only in a single group of microorganisms, for example fungi, can be used in conjunction with a broad spectrum conservator or other conservators of Limited spectrum with complementary and / or supplementary activity. A mixture of broad spectrum conservatives can also be used. Preferred water-soluble preservatives include the following: sodium hydroxymethylglycinate (i.e., Suttocide® A. from Sutton Labs, Chatham, NJ); sodium benzoate; cyclic organic nitrogen compounds including imidazolidenedione compounds (such as dimethyloldimethylhydantoin ie Lonly Glydant® Plus, diazolidinyl urea and imidazolidinyl urea) and bicyclic oxazolidine polymethoxy; phenyl and phenoxy compounds including benzylalcohol, 2-phenoxyethanol and hexamidine isethionate; quaternary ammonium compounds including polyhexamethylene biguanide; low molecular weight aldehydes including formaldehyde and glutaraldehyde; halogenated compounds including florhexidine, chlorobutanol, and dibromopropamidine; and mixtures thereof. To reserve most of the cyclodextrins for odor control, the minimum amount of effective preservative should be used. Preferred levels of preservative are from about 0.0001% to about 2%, most preferably from about 0.0002% to about 1%, most preferably from about 0.01% to about 0.5% by weight of the composition. PH The aqueous compositions of the present invention should have a pH of from about 3 to about 10, preferably from about 3.5 to about 8, most preferably from about 3.5 to about 6. Some conventional pH regulating agents are known in the prior art, which can be used to adjust the pH to the desired level if necessary. For example, combinations of salts and acids, such as the following examples: sodium lactate, sodium citrate, potassium phosphate, lactic acid, citric acid, phosphoric acid are useful. A part of the effectiveness of said ingredients can be lost when combined with the cyclodextrin, so that care is taken in the formulation to adjust said combination. Other optional pH regulators appear in The Theory and Practice of Industrial Pharmacy, Lachman, Lieberman and Kanig, third edition, which is hereby incorporated by reference.

LOW MOLECULAR WEIGHT PQLIQLES The present composition may also optionally comprise low molecular weight polyols. The phrase "low molecular weight polyols", as used herein, refers to linear organic compounds with more than one alcohol functional group per molecule where the molecular weight is less than 95. Low molecular weight polyols with relatively high boiling points, when compared with water, such as propylene glycol and glycerol are preferred ingredients for improving the development of odor control of the composition of the present invention. Without being limited by theory, it is believed that the incorporation of a small amount of low molecular weight glycols in the composition of the present invention promotes the formation of cyclodextrin inclusion complexes as the skin dries. It is believed that the ability of polyols to remain in the skin for a longer period than in water, as the skin dries. It allows to form complex compounds with the clclodextrin and some molecules of bad odor. It is believed that the addition of glycols fills the empty space in the cyclodextrin cavity which is not able to be filled by some malodor molecules of relatively lower sizes. Preferably, the glycol used is propylene glycol. The cyclodextrins prepared by the processes resulting in a level of said chicken are highly desirable, since they can be used without the removal of the polyols. Optimally, the low molecular weight chicken will be added at an effective level to aid in the formation of the complex without significantly reducing the available cyclodextrin capacity to absorb the odor molecules having higher sizes. Typically, low molecular weight polyols are added to the composition of the present invention at a level of from about 0.01% to about 1% by weight of the composition, preferably from about 0.02% to about 0.5%, most preferably about 0.03% to about 0.3% by weight of the composition.

OTHER COMPONENTS The composition of the present invention may optionally contain adjunct odor control materials, such as zinc salts, water soluble cationic polymers, water soluble anionic polymers, water soluble carbonate salts, water soluble bicarbonate salts, zeolites. , and activated carbon; quilatation agents; dyes, and / or antltranspirantes. Optionally, but highly preferred, the present invention may include zinc salts to add odor absorption and / or antimicrobial benefit to the cilcodextrin solution. Zinc compounds have been used more frequently for their ability to reduce malodor, that is, in mouthwash products, as described in the U.S. Patents. numbers 4,325,939, issued on April 20, 1982 and 4,469,674, issued September 4, 1983 to N.B. Shah, and others who will be shaping in the present as a reference in its entirety. Zinc salts highly ionized and soluble in water, such as zinc chloride, provide the best source of zinc ions. The zinc salt, zinc phenosulfonate, is preferred for use in the skin composition of the present invention; although others may also be found within the scope of the present invention. However, care must be taken in the selection of zinc salts, as well as in their levels, since some salts may be irritating to the skin and therefore are not preferred for use in the present invention.

Said zinc salts help to absorb the low molecular weight amine and sulfur-containing compounds. Low molecular weight amines and / or low molecular weight sulfur containing materials such as sulfur and mercaptans; They are components of various types of bad odors such as food odors (garlic, onion), breath odor, odors from urine, and particularly smell of the body / perspiration. When the zinc salts are added to the composition of the present invention they are typically present at a level of from about 0.1% to about 10%, preferably from about 0.2% to about 8%, most preferably from about 0.3% to about 5% by weight of the composition.

Some water-soluble polymers such as the water-soluble cationic polymer and the water-soluble anionic polymers can be used in the composition of the present invention to provide additional odor control benefits. Water-soluble cationic polymers such as those containing amino functionalities, amide functionalities, and mixtures thereof, are useful in the present invention for controlling certain acid type odors. Water-soluble anionic polymers such as polyacrylic acids and their water-soluble salts are useful in the present invention to control certain amine-type odors. Preferred polyacrylic acids and their alkali metal salts have an average molecular weight of less than about 20,000, most preferably less than 5,000. Polymers containing acid groups sulphonic, phosphoric acid groups, phosphonic acid groups, and their water soluble salts, and mixtures thereof, and mixtures with carboxylic acid and carboxylate groups, are also suitable. Water-soluble polymers containing cationic and anionic functionalities are also suitable. Example of said polymers are given in the patent of E.U.A. 4,909,986, issued March 20, 1990, to N. Kobayashi and A. Kawazoe, incorporated herein by reference in its entirety. Another example of water-soluble polymers containing cationic and anionic functionalities is a copolymer of dimethyldiallylammonium chloride and acrylic acid, commercially available under the tradename Merquat 280® from Calgon. Although the aforementioned water-soluble polymers are useful in the present invention, when used with such materials, care must be taken to ensure that no residual acrylic acid is present due to the safety associated with the presence of acrylic acid. The water-soluble alkali metal carbonate and / or bicarbonate salts, such as sodium bicarbonate, potassium bicarbonate, potassium carbonate, sodium carbonate, and mixtures thereof can be added to the composition of the present invention for help control certain acid-type odors Preferred salts are sodium carbonate monohydrate, potassium carbonate, sodium bicarbonate, potassium bicarbonate and mixture thereof. When said salts are added to the Composition of the present invention are typically present at a level of from about 0.1% to about 5%, preferably from about 0.2% to about 3%, most preferably from about 0.3% to about 2% by weight of the composition. When said salts are added to the composition of the present invention, it is preferred that the incompatible metal salts are not present in the invention. Preferably, when said salts are used, the composition must essentially be free of zinc and other incompatible metal ions, ie Ca, Fe, etc., which form water-insoluble salts. Amine acid-halting agents such as ethylenediaminetetraacetic acid (EDTA) can optionally be added to the composition of the present invention to boost the activity of the water-soluble antimicrobial preservative. When an equilatation agent is added to the composition of the present invention, it is typically present at a level of from about 0.01% to about 0.3%, preferably from about 0.05% to about 0.2% by weight of the composition. Zeolites can also be used in the present invention. A preferred class of zeolites is characterized as "intermediate" silicate / aluminate zeolites, particularly for use in the obstruction of amine-type odors. "High" zeolites are preferred for controlling odors containing sulfur, ie, thiols, mercaptans. The zeolites are explained in more detail in the patent of E.U.A. No. 5,429,628, to Trihn et al., issued on July 4, 1995, which is hereby incorporated herein by reference in its entirety. The carbon material suitable for use in the present invention is the material well known in commercial practice as an absorbent for organic molecules and / or for the purpose of air purification. Often, said carbon material is called "activated" carbon or "activated" charcoal. Said carbon is available from commercial sources under said commercial names; Calgon-Type CPG®; Type PCB®; Type SCI®; Type CAL®; and Type OL®. The dyes and dyes can optionally be added to the odor absorption compositions for visual appearance and development impression. When corollans are used, care must be taken in the selection of the selected dyes that will not stain the skin. Preferred colorants for use in the present compositions are highly water soluble dyes, ie blue 3 acid, blue 104 acid, green 1 acid, green 25 acid, yellow 3 acid, sodium salt of acid yellow 73, green number 5, 6 and 8 of D and C, yellow number 7, 8, 10 and 11 of D and C, violet number 2 of D and C, blue number 1 and 2 of FD and C green number 3 of FD and C, yellow number 5 and 6 of FD and C, and mixtures thereof. Optionally, the present skin composition may also comprise known antiperspirants and / or other known deodorant compositions previously described explicitly. Examples of Suitable antiperspirants for the aqueous solutions include tetrachlorohydrex aluminum-zirconium glycine, aluminum-zirconium tenhydrochloride, aluminum sesquichlorhydrate, or aluminum chlorohydrate and mixtures thereof.

COMPOSITION MANUFACTURING PROCEDURE The compositions can be prepared by oil-in-water emulsion techniques such as are commonly known in the art. Examples of such techniques are described in Remington's Pharmaceutical Science, Dieciochava Edition, pp. 304-306, 1990, hereby incorporated by reference. The compositions of the present invention may also be prepared by a process comprising the steps of: preparing a mixture by mixing an emulsifier and an oil phase until it is homogeneous and adding an aqueous phase with the mixture until the mixture is homogeneous. The preparation of a solution by adding cyclodextrin with an aqueous phase mixing until the cyclodextrin is dissolved. The preparation of a second mixture by mixing the solution with the mixture until the second mixture is homogeneous. When desired, the second mixture can be further diluted by the addition of an aqueous phase with the mixture until it is homogeneous. Where the hydrophobic antimicrobials also comprise the compositions, the process of preparing the mixture in the first step further comprises adding a premix with the mixture to an emulsifier and the oil phase until homogeneous, wherein the premix is prepared by mixing a hydrophobic antimicrobial with an emulsifier until the premix is homogeneous. The term "homogeneous", as used herein, refers to the uniformly distributed solution. The homogeneity is indicated by a composition that is substantially smooth, chromium free and uniform in appearance. A stable emulsion remains homogeneous for a given time which is determined by the required shelf life of the composition. As an alternative for the preparation of the mixture to mix an emulsifier, an oil phase and an aqueous phase; An emulsion concentrate comprises an emulsifier, an oil phase, and a minimum amount of aqueous carrier can be used. The emulsion concentrates useful in the present invention will be from about 3 times to about 20 times concentrate. The concentrated emulsion can then be diluted by the aqueous addition vehicle followed by the addition of the residual ingredients as described above. A suitable method of forming an emulsion concentrate is described in the U.S.A. No. 5,043,155, to Puchalski et al., Issued August 27, 1991. An example of an emulsion concentrate useful in the present invention is Dow Corning® 365, 35% dimethicone emulsion.

Other process variations for preparing the compositions that are useful include preparing the mixture in one step by adding and mixing each of the ingredients. Alternatively, less than all of the ingredients can be pre-blended for subsequent combination with other ingredients or with other pre-blended ingredients to form the composition. Suitable equipment for forming the mixtures and emulsion can be selected from those known in the art or which become known in the art. For example, suitable apparatuses include double propeller blade mixers. A turbine mixer and an in-line homogenizer using tandem rotors-stators, such as those described in the U.S.A. 5,043,155 reference to the above, can also be used.

The resulting emulsion containing the ingredients in their total amounts has a preferred viscosity at room temperature (ie, 20 ° -25 ° C) on the scale of about 10 to about 200 centipoise, most preferably about 15 to about 150 centipoise; most preferably from about 20 to about 100 centipoises. Although the compositions of the present invention are applied directly to the skin, several applicators are useful for delivering the compositions to the entire body for maximum odor control. For example, the compositions preferably are deposited in a paper product such Like a cloth that later comes into contact with the skin to transfer the composition to the skin. Any cloth structure and / or cloth structure preparation method commonly known in the art can be used in the present invention. The cloth comprises flexible distribution means. The term "flexible dispensing means", as used herein, includes papers, fabrics, non-wovens, films, foams, sponges, rolls, pads, cloths, pieces of cotton, and the like. Preferred rub substrates comprise a pore material, such as nonwoven substrates, foams, or sponges, which are capable of maintaining the composition within the pores of the substrates. Examples of particularly useful and inexpensive nonwovens in the present invention are described in the U.S.A. No. 4,191, 609, Trokhan, issued March 4, 180. Another description of useful rubs and methods of preparing such rubs is found in world patent 95/17175, to Mitra et al., Publication date June 29. of 1995. Both references are incoforan in the present as reference in their totalities. Techniques for combining the rub substrates with the composition of the present invention are well known in the art. Examples of common methods of combining the composition to the rubbing substrate may involve coating, immersing, soaking, or sprinkling the rubbing substrate with the composition of the present invention. The composition of the present invention is added to the rubbing substrate at a sufficient level to provide the desired odor control and / or other desired skin benefits of the present invention. A convenient method of combining the composition of the present invention with a selected substrate is to place the substrate within an open package that will ultimately house the finished product until use. The composition is poured into a substrate and allowed to be completely distributed. It is preferred that the homogeneous composition be poured into each rub individually instead of a cloth assembly. The packaging is then closed and the cloths are ready for use. The composition of the present invention can also be supplied as a liquid by a spray distributor or bottle. A manually activated spray dispenser is preferred to avoid the use of aerosols that can irritate sensitive areas of the body. Spray dispensers useful in the present invention are described more fully in the U.S.A. No. 5,534,165, which is incorporated herein by reference in its entirety.

METHODS OF USE The present invention also comprises the use of compositions containing cyclodextrin for the manufacture of the odor absorption composition for controlling environmental malodours in the skin to reduce body odor and / or vaginal odor. The compositions that contain cyclodextrin may also optionally comprise one or more of the following: hydrophobic antibiothobi; antimicrobial preservatives soluble in water; low molecular weight polyols; zinc salts; water soluble polymers; soluble carbonate and / or bicarbonate salts; chelating agents; zeiolites; activated carbon; and mixtures thereof. The compositions are applied to the skin and can be applied to a pelvic region, external vagina, and / or underwear line. However, the compositions of the present invention should not be inserted into the vagina, nor applied to the vulva. An "effective amount" of the compositions of the present invention, as used herein, refers to an amount sufficient to absorb the coforal odor to the point that is not discernible by the human sense of smell. The compositions of the present invention are typically applied directly to the skin or hair. The compositions can be supplied by placing the composition in the delivery means and by applying an effective amount by spraying or rubbing the composition on the desired skin surface.; typically the whole story. Preferably, the supply means is a cloth comprising a flexible supply means. The distribution of the composition of the present invention can also be achieved using a hand. Alternatively, the user may combine the composition of the present invention with a flexible dispensing medium of his choice. For Doing the above, the user simply selects a flexible distribution means such as a laundry; pouring a solution of the composition of the present invention from a bottle or other suitable container into the selected flexible dispensing medium, and applying the composition to the desired area of the body. In this way, the user can use as much as he wishes the composition of the present invention, depending on its intended use and degree of odor control needed. The following non-limiting examples illustrate the formulations and methods of the use of the present invention.

EXAMPLES I. II AND III Ingredients Example I Example I Example Dow Corning R 365.35% from 11.42 5.71 2.86 Dimethicone Emulsion Propiienglicol 1 - 1 Citric acid 0.03 0.03 0.03 Disodium phosphate 0.02 0.02 0.02 SuttocideR 0.50 - 0.25 Glydant PlusR - 0.3 - Tetrasodium EDTA 0.1 __ Hydroxypropyl beta-cyclodexin 1 1.5 0.5 Zinc phenolsulfate 1.01 - 1.01 Sodium Benzoate - - 0.1 Hydrogenated castor oil - 0.75 polyoxyl Triclosan - 0.25 - Distilled Abua EL RESTO EL RESTO EL REST Prepare Example 1 as follows: Prepare a premix by mixing an amount of water equal to approximately 11.42% by weight of the total formula with the Dow dimethicone emulsion mixture. Prepare an aqueous solution by mixing an amount of water equal to approximately 5.71% of the weight of the total formula with propylene glycol, citric acid, disodium phosphate, and zinc phenolsulfonate until dissolved. Prepare a second aqueous solution by mixing an amount of water equal to about 5.71% of the weight of the total formula with hydroxypropyl beta-cyclodextrin until dissolved. Prepare a mixture by combining the aqueous solution with the premix with mixing until it is homogeneous. Prepare a second mixture by combining the remaining water of the total formula with the mixture and mixing until it is homogeneous. Prepare a third mixture by combining the second solution with the mixture until it is homogeneous.

Combine Suttocide® with the third mixture with the mixture until homogeneity is achieved and Suttocide® A is dissolved. Prepare Example II as follows: prepare a premix by mixing triclosan with polyoxyl 40 hydrogenated castor oil with low heat, so that a hot plate is placed on the bottom, until the triclosan is dissolved, and then combine with Dow ComigR 365, 35% dimethicone emulsion with the mixture until it is homogeneous. Prepare a mixture by adding a quantity of water equal to approximately 5.71% of the weight of the total formula of the premix with the mixture until it is homogeneous. Prepare a solution Prepare an aqueous solution by adding propylene glycol, citric acid, disodium phosphate, tetrasodium EDTA and zinc phenolsulfonate to an amount of water equal to about 5.71% of the weight of the total formula with the mixture until it dissolves. Prepare a second aqueous solution by adding hydrodiplexyldextrin of hydroxypropyl to an amount of water equal to about 5.71% by weight of the total formula with a mixture until the beta-cyclodextrin of hydroxypropyl is dissolved. Prepare a second mixture by mixing the aqueous solution with the mixture until it is homogeneous, and then adding the residual water of the weight of the total formula with the mixture until it is homogeneous. Prepare a third mixture by adding the second aqueous solution to the second mixture with the mixture until it is homogeneous. Add Glydant PlusR to the third mixture with the mixture until the Glydant Plus® dissolves and the mixture is homogeneous.

Prepare Example III as follows: prepare a mixture by mixing an amount of water equal to approximately 2.86% of the weight of the total formula with Dow Corning® 365, 35% dimethicone emulsion until homogeneous. Prepare an aqueous solution by adding propylene glycol, citric acid, sodium benzoate and disodium phosphate to an amount of water equal to about 5.71% of the weight of the total formula with the mixture until it dissolves. Prepare a second aqueous solution by adding hydroxypropyl beta-cyclodextrin to an amount of water at approximately 5.71% by weight of the total formula with the mixture until the hydroxypropyl beta-cyclodextrin dissolves. Prepare a mixture by adding the aqueous solution to the premix, and then add in the residual water of the total formula with the mixture until it is homogeneous. Prepare a second mixture by adding the second aqueous solution to the mixture with the mixture until it is homogeneous. Add Suttocide® to the second mixture with the mixture until it is homogeneous. Preparation for application to the skin: The solutions of the present invention, such as those formed of the examples can be loaded onto a cloth or poured into a spray device or poured directly into the skin or flexible dispensing means of the user by selecting to the convenient application to the skin. To prepare the cloths: Place the dry cloth or cloth substance inside an open package that will finally contain the finished product. Pour the composition of the fabric to distribute it. Close the package store until the consumer uses it. Prepare aspersion: Pour the composition into the selected spray pack. Close the packaging for storage until the consumer uses it.

EXAMPLE IV A woman with urinary incontinence stress finds that the moisture associated with this condition causes vaginal odor, which she wants to remove from her skin and control. After urinating, the woman cleans her outer vagina with a cloth containing the compositions of Example I. The cyclodextrin and zinc salts in the complex of the composition with odors such as the polycyclic compounds and amines (respectively) found in the urine. This woman shows less odor after using the cloths.

EXAMPLE V A woman with large breasts notes that when she exercises, she tends to experience sweating and irritation of the skin under the breast. Before and after exercise, apply the composition of Example II, using a portable spray bottle per actuator. Spray the composition under your Chest and composition provides odor protection against odor compounds that perspire with sweat and / or decomposition of sweat. The woman observes less odor and feels more comfortable after using the spray.

EXAMPLE VI A man has several allergies to cosmetic deodorants and antiperspirants and edits using such products. The above results in uncontrolled and embarrassing body odor. Your doctor suggests applying a mild odor absorption composition of example III after bathing. The man applies the composition to his whole body by dew every morning after bathing, and does not suffer an allergic reaction. The man feels more comfortable without prolonged, uncontrollable, embarrassing body odor. The man keeps a bag of cloths at work, which also contains the composition of example III, for convenient and discreet reapplication as necessary, particularly on hot and humid days.

EXAMPLE VII A man is cooking fish and a sauce that requires garlic, onions and several peppers. They tell him that his hands and hair have the smell of those food odors and he wants to remove those odors from his body. He man rubs his hands and his hair with cloths that contains the composition in the example 1. The man observes less smells after using the cloths.

EXAMPLE VIII A woman discovers that after she smokes a cigarette during a break at work, her hands and face smell of smoke and tobacco. Apply the composition of Example II using a portable bottle of spray gun. Sprays the composition on your face and hands and the composition removes the odors of residual smoke and tobacco that you find so unpleasant. The woman observes less odor and feels more comfortable when returning to her desk after using the dew.

EXAMPLE IX A man, when he goes to an important meeting, stops to put gasoline in the car. While the gas tank is filling up: splash your hands on gasoline. The man rubs his hands on a paper towel but the smell of gasoline remains in his hands. This man takes a small bottle from his suitcase, which contains the composition of Example III. Open the bottle and pour the composition into your hands. Then he smells his hands and notes that the smell of gasoline is no longer present.

Claims (14)

NOVELTY OF THE INVENTION CLAIMS

1. - An aqueous odor absorption composition containing: a) from about 0.1% to about 5% by weight of the composition, of cyclodextrin, solubilized, soluble in water, without combining; b) an aqueous vehicle; c) from about 0.1% to about 36% by weight of the composition of an oil phase selected from the group consisting of emollients, humectants and skin protectants; and d) an emulsifier.

2. The composition according to claim 1, further comprising one or more water-soluble antimicrobial preservatives.

3. The composition according to claim 2, further characterized in that the water-soluble antimicrobial preservative is sodium hydroxymethylglycinate.

4. The composition according to claim 1, 2 or 3 further comprises low molecular weight polyols.

5. The composition according to claim 1, 2 or 3, further characterized in that the cyclodextrin is selected from the group consisting of beta-cyclodextrins, beta-cyclodextrin derivatives, alpha- cyclodextrins, alpha-cyclodextrin derivatives, gamma-cyclodextrins derived from gamma-cyclodextrins and mixtures thereof.

6. The composition according to any of claims 1-3, further comprising one or more odor control adjuncts selected from the group consisting of zinc salts, zeolites, activated carbon, water-soluble carbonates, water-soluble bicarbonate. and mixtures thereof.

7. The composition according to any of claims 1-3 further characterized in that hydrophobic antimicrobial is selected from the group consisting of triclosan, trichlorocarbon, eucalyptol, menthol, methylsalicylate and thymol; and is present at a level of approximately 1% to about 1.5% by weight of the composition.

8. A preformed cloth composition, further characterized in that the composition of any of claims 1-3 is deposited on a cloth comprising a flexible supply means.

9. The composition according to claim 8, further characterized in that it comprises the hydrophobic antimicrobial selected from the group consisting of triclosan, trichlorocarbon, eucalyptol, menthol, methylsalicylate, and thymol; and is present at a level of from about 0.1% to about 1.5% by weight of the composition.

10. The compositions according to any of claims 1-3, supplied as liquid by a spray bottle.

11. - The use of the composition according to any of claims 1-3 for the manufacture of a topical deodorant to be applied on human skin to control the bad environmental odors in the skin and to reduce body and / or vaginal odor .

12. The use of the composition according to any of claims 1-3 for the manufacture of a topical deodorant to be applied to human skin in a pelvic region, an external vagina and / or a line of the panty.

13. A process for preparing an aqueous odor absorption composition comprising the steps of: a) preparing a mixture by mixing an emulsifier, an oil phase, and an aqueous phase until the mixture is homogeneous; b) preparing a second mixture by adding cyclodextrin to the mixture from mixing step until the cyclodextrin is dissolved and the second mixture is homogeneous.

14. A process according to claim 13, further comprising preparing a premix by mixing a hydrophobic antimicrobial and a second aqueous phase until the premix is homogeneous; and adding the premix to the mixture in step 13 and mixing until the mixture is homogeneous.