[go: up one dir, main page]

MX9806249A - Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Info

Publication number
MX9806249A
MX9806249A MX9806249A MX9806249A MX9806249A MX 9806249 A MX9806249 A MX 9806249A MX 9806249 A MX9806249 A MX 9806249A MX 9806249 A MX9806249 A MX 9806249A MX 9806249 A MX9806249 A MX 9806249A
Authority
MX
Mexico
Prior art keywords
branched
dihydrobenzofuran
straight
cyclic alkyl
hydrogen
Prior art date
Application number
MX9806249A
Other languages
English (en)
Inventor
James Madison Ridgeway Iii
John Michael Janusz
Original Assignee
Procter 6 Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter 6 Gamble Company filed Critical Procter 6 Gamble Company
Publication of MX9806249A publication Critical patent/MX9806249A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describe un compuesto que tiene la estructura (Ver Formula) en donde, n es de 1 a aproximadamente 3, X se selecciona del grupo que consiste de 0, S, SO, SO2; y es independientemente hidrogeno o alquilo o aralquilo de cadena recta, ramificada o cíclica que tiene de 1 aproximadamente 4 átomos de carbono; o las Y's son enlazadas entre sí para formar un anillo de alcanilo que tiene de 3 a 7 átomos; Z es hidrogeno o un alquilo de cadena recta, ramificada o cíclica que tiene de 3 a aproximadamente 10 átomos distintos al hidrogeno; R1 es hidrogeno o alquilo de cadena recta, ramificada o cíclica, arilo o C(=N)=NHR4; y R2, R3 y R4 son independientemente hidrogeno, alquilo de cadena recta, ramificada o cíclica que tiene de 1 a 10 átomos de carbono, o arilo; R2 y R3 se pueden enlazar entre sí para formar un anillo que tiene 5 o 6 átomos; también se describen composiciones farmacéuticas que comprenden dichos compuestos, así como métodos de tratamiento de inflamacion o dolor utilizando dichos compuestos.
MX9806249A 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. MX9806249A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/595,122 US5684031A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MX9806249A true MX9806249A (es) 1998-11-30

Family

ID=24381828

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806249A MX9806249A (es) 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Country Status (15)

Country Link
US (1) US5684031A (es)
EP (1) EP0904270B1 (es)
JP (1) JP3095423B2 (es)
KR (1) KR100322400B1 (es)
CN (1) CN1109680C (es)
AT (1) ATE250594T1 (es)
AU (1) AU730263B2 (es)
BR (1) BR9707321A (es)
CA (1) CA2244402C (es)
DE (1) DE69725133T2 (es)
DK (1) DK0904270T3 (es)
ES (1) ES2208872T3 (es)
MX (1) MX9806249A (es)
NO (1) NO983527L (es)
WO (1) WO1997028145A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866579A (en) * 1997-04-11 1999-02-02 Synaptic Pharmaceutical Corporation Imidazole and imidazoline derivatives and uses thereof
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551456A (en) * 1968-04-18 1970-12-29 Universal Oil Prod Co Acetyl derivatives of substituted chromans and coumarans
JPS6031829B2 (ja) * 1975-06-26 1985-07-24 ウェルファイド株式会社 アミノアルコ−ル誘導体の製造法
FR2332010A1 (fr) * 1975-11-18 1977-06-17 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
FR2370472A2 (fr) * 1976-11-10 1978-06-09 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
CH615031A5 (es) * 1976-04-30 1979-12-28 Gretag Ag
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
JPS603305B2 (ja) * 1976-12-27 1985-01-26 エーザイ株式会社 ２，３―ジハイドロベンゾフラン誘導体
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
US4130666A (en) * 1977-05-16 1978-12-19 Riker Laboratories, Inc. Anti-inflammatory method
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
EP0026593A1 (en) * 1979-09-15 1981-04-08 Pfizer Limited Bicyclic keto- and amino- acids, esters and amides and pharmaceutical compositions thereof
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
GR81257B (es) * 1982-12-04 1984-12-11 Lilly Industries Ltd
DE3460315D1 (en) * 1983-02-19 1986-08-28 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives
FI842738L (fi) * 1983-07-14 1985-01-15 Syntex Inc Aroylbenzofuran- och benzotiofenaettik- och propionsyror.
US4613611A (en) * 1983-10-14 1986-09-23 American Cyanamid Company Method of treating diabetes mellitus using arylglyoxals
AU4261285A (en) * 1984-06-01 1985-12-05 Tokyo Tanabe Company Limited 1-propanone derivatives
US4708966A (en) * 1986-06-27 1987-11-24 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
DE3777366D1 (de) * 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613365B1 (fr) * 1987-04-01 1989-07-28 Adir Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
IL88674A0 (en) * 1987-12-18 1989-07-31 Norwich Eaton Pharma Preparation of certain substituted aromatic compounds
US4982006A (en) * 1987-12-18 1991-01-01 Norwich Eaton Pharmaceuticals, Inc. Process for the preparation of certain substituted aromatic compounds
JPH07121933B2 (ja) * 1988-03-28 1995-12-25 キッセイ薬品工業株式会社 ジヒドロベンゾフラノン誘導体
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
FR2645537B1 (fr) * 1989-04-05 1994-03-04 Fabre Medicament Pierre Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
JP2808460B2 (ja) * 1989-11-16 1998-10-08 大正製薬株式会社 イミダゾール誘導体
WO1991007396A1 (fr) * 1989-11-17 1991-05-30 Meiji Milk Products Co., Ltd. Derive de benzofurane, procede de preparation de ce derive et produit pharmaceutique contenant ce derive comme ingredient actif
JPH03215485A (ja) * 1990-01-11 1991-09-20 Taisho Pharmaceut Co Ltd ベンゾチエニルイミダゾール誘導体
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
NZ237566A (en) * 1990-03-27 1994-03-25 Smithkline Beecham Corp Substituted amide and hydroxyamine derivatives and pharmaceutical compositions
TW197435B (es) * 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
TW229142B (es) * 1992-04-15 1994-09-01 Nissan Detrochem Corp
JPH06263733A (ja) * 1993-01-14 1994-09-20 Sankyo Co Ltd ベンゼン誘導体
JPH10506615A (ja) * 1994-07-27 1998-06-30 ザ、プロクター、エンド、ギャンブル、カンパニー 抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
JP3095423B2 (ja) 2000-10-03
CA2244402C (en) 2003-10-07
KR100322400B1 (ko) 2002-05-09
EP0904270B1 (en) 2003-09-24
DK0904270T3 (da) 2003-12-01
DE69725133D1 (de) 2003-10-30
KR19990082220A (ko) 1999-11-25
BR9707321A (pt) 1999-04-13
CN1109680C (zh) 2003-05-28
JPH11506120A (ja) 1999-06-02
CA2244402A1 (en) 1997-08-07
NO983527D0 (no) 1998-07-31
ES2208872T3 (es) 2004-06-16
US5684031A (en) 1997-11-04
DE69725133T2 (de) 2004-07-15
NO983527L (no) 1998-09-28
AU1843097A (en) 1997-08-22
CN1210532A (zh) 1999-03-10
WO1997028145A1 (en) 1997-08-07
EP0904270A1 (en) 1999-03-31
ATE250594T1 (de) 2003-10-15
AU730263B2 (en) 2001-03-01

Similar Documents

Publication Publication Date Title
MX9806248A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
MX9701819A (es) Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiiflamatorios.
MX9806250A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
PL330408A1 (en) Dihydrobenzopyrane and affinite compounds useful as antiinflammatory agents
MX9806251A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
MX9806252A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
CA2196054A1 (en) Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
MX9806249A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
MX9700726A (es) Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiinflamatorios.
MX9806247A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
MX9806253A (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.
CA2244245A1 (en) Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: VANDERBILT UNIVERSITY

MM Annulment or lapse due to non-payment of fees