MX9801664A - Formas zwitterionicas de trovafloxacina, procedimiento para su preparacion, composiciones que las contienen y uso de las mismas. - Google Patents
Formas zwitterionicas de trovafloxacina, procedimiento para su preparacion, composiciones que las contienen y uso de las mismas.Info
- Publication number
- MX9801664A MX9801664A MX9801664A MX9801664A MX9801664A MX 9801664 A MX9801664 A MX 9801664A MX 9801664 A MX9801664 A MX 9801664A MX 9801664 A MX9801664 A MX 9801664A MX 9801664 A MX9801664 A MX 9801664A
- Authority
- MX
- Mexico
- Prior art keywords
- trovafloxacin
- zwitterionic forms
- methods
- hygroscopic
- pentahydrate
- Prior art date
Links
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 title abstract 2
- 229960000497 trovafloxacin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004686 pentahydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Processing Of Solid Wastes (AREA)
- Physical Water Treatments (AREA)
Abstract
Una forma zwitterionica de trovafloxacina de formula (I): seleccionada de entre el grupo formado por sus polimorfos higroscopicos y pentahidrato cristalinos y los procedimientos para su preparacion; la invencion se refiere además a procedimientos de uso, y composiciones farmacéuticas que los comprenden, los compuestos de la invencion para el tratamiento de infecciones bacterianas en mamíferos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US297595P | 1995-08-29 | 1995-08-29 | |
| US002975 | 1995-08-29 | ||
| PCT/IB1996/000756 WO1997007800A1 (en) | 1995-08-29 | 1996-07-29 | Zwitterionic forms of trovafloxacin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9801664A true MX9801664A (es) | 1998-08-30 |
| MXPA98001664A MXPA98001664A (es) | 1998-11-12 |
Family
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |