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MX9800041A - Procedimiento mejorado para sintetizar intermediarios de carbapenem. - Google Patents

Procedimiento mejorado para sintetizar intermediarios de carbapenem.

Info

Publication number
MX9800041A
MX9800041A MX9800041A MX9800041A MX9800041A MX 9800041 A MX9800041 A MX 9800041A MX 9800041 A MX9800041 A MX 9800041A MX 9800041 A MX9800041 A MX 9800041A MX 9800041 A MX9800041 A MX 9800041A
Authority
MX
Mexico
Prior art keywords
improved process
synthesizing
carbapenem intermediates
synthesizing carbapenem
intermediates
Prior art date
Application number
MX9800041A
Other languages
English (en)
Other versions
MXPA98000041A (es
Inventor
Chunhua Yang
Nubuyoshi Yasuda
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602921.0A external-priority patent/GB9602921D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9800041A publication Critical patent/MX9800041A/es
Publication of MXPA98000041A publication Critical patent/MXPA98000041A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describe un procedimiento para sintetizar un compuesto de la formula (1) o (2), en donde R representa H o metilo y P representa trietilsililo o trimetilsililo; se hace reaccionar un compuesto del a formula (3) o (4), con P-CI en donde P es tal como se definio más arriba, en presencia de una base y de un solvente sustancialmente no reactivo, para producir (1) o (2). (ver formulas).
MXPA/A/1998/000041A 1995-06-28 1998-01-07 Procedimiento mejorado para sintetizar intermediarios de carbapenem MXPA98000041A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58595P 1995-06-28 1995-06-28
US000585 1995-06-28
GB9602921.0 1996-02-13
GBGB9602921.0A GB9602921D0 (en) 1996-02-13 1996-02-13 Improved process for synthesizing carbapenem intermediates
PCT/US1996/010783 WO1997001564A1 (en) 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates

Publications (2)

Publication Number Publication Date
MX9800041A true MX9800041A (es) 1998-08-30
MXPA98000041A MXPA98000041A (es) 1998-11-12

Family

ID=

Also Published As

Publication number Publication date
JPH11513979A (ja) 1999-11-30
BR9609338A (pt) 1999-05-11
AU6392196A (en) 1997-01-30
KR19990028406A (ko) 1999-04-15
AR002507A1 (es) 1998-03-25
HUP9903016A3 (en) 2000-04-28
WO1997001564A1 (en) 1997-01-16
SK176597A3 (en) 1998-07-08
CN1193322A (zh) 1998-09-16
CZ419097A3 (cs) 1998-07-15
HUP9903016A2 (hu) 2000-03-28
EP0836607A1 (en) 1998-04-22
AU696543B2 (en) 1998-09-10
EA199800096A1 (ru) 1998-08-27
CA2224439A1 (en) 1997-01-16

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