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MX9708627A - Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas. - Google Patents

Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas.

Info

Publication number
MX9708627A
MX9708627A MX9708627A MX9708627A MX9708627A MX 9708627 A MX9708627 A MX 9708627A MX 9708627 A MX9708627 A MX 9708627A MX 9708627 A MX9708627 A MX 9708627A MX 9708627 A MX9708627 A MX 9708627A
Authority
MX
Mexico
Prior art keywords
spyrocycles
carbazinyl
diazinyl
oxazolidinones
bicycles
Prior art date
Application number
MX9708627A
Other languages
English (en)
Inventor
Michael Robert Barbachyn
Steven J Brickner
Douglas K Hutchinson
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9708627A publication Critical patent/MX9708627A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un compuesto de la formula I o II estructural util para el tratamiento de infecciones microbianas en humanos u otros animales de sangre caliente: Formula I, Formula II, o sus sales farmacéuticamente aceptables como se definieron en la presente.
MX9708627A 1995-05-11 1996-04-18 Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas. MX9708627A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43870595A 1995-05-11 1995-05-11
PCT/US1996/005202 WO1996035691A1 (en) 1995-05-11 1996-04-18 Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones

Publications (1)

Publication Number Publication Date
MX9708627A true MX9708627A (es) 1998-02-28

Family

ID=23741700

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708627A MX9708627A (es) 1995-05-11 1996-04-18 Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas.

Country Status (18)

Country Link
US (1) US6090820A (es)
EP (1) EP0828741B1 (es)
JP (1) JPH11506430A (es)
KR (1) KR100463771B1 (es)
CN (2) CN1068328C (es)
AT (1) ATE204874T1 (es)
AU (1) AU702752B2 (es)
CA (1) CA2218088A1 (es)
DE (1) DE69614847T2 (es)
DK (1) DK0828741T3 (es)
ES (1) ES2162047T3 (es)
FI (1) FI974180A7 (es)
HK (1) HK1042093A1 (es)
MX (1) MX9708627A (es)
NO (1) NO311298B1 (es)
NZ (1) NZ306310A (es)
PT (1) PT828741E (es)
WO (1) WO1996035691A1 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010223A1 (en) * 1995-09-15 1997-03-20 Pharmacia & Upjohn Company Aminoaryl oxazolidinone n-oxides
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
US5837870A (en) * 1996-04-11 1998-11-17 Pharmacia & Upjohn Company Process to prepare oxazolidinones
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
KR100467309B1 (ko) * 1997-09-04 2005-07-18 씨제이 주식회사 옥사졸리디논유도체및그의제조방법및항균제조성물
KR100463111B1 (ko) * 1997-10-30 2005-06-13 씨제이 주식회사 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
NZ508174A (en) 1998-06-05 2003-10-31 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ITVA20000023A1 (it) * 2000-07-19 2002-01-19 Lamberti Spa Composizioni di pvc stabili al calore.
SE0100326D0 (sv) 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
EP1368354A1 (en) 2001-03-07 2003-12-10 Pfizer Products Inc. Modulators of chemokine receptor activity
JP2005511688A (ja) * 2001-11-29 2005-04-28 メルク アンド カンパニー インコーポレーテッド シクロプロピル含有オキサゾリジノン抗生物質及びその誘導体
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
MXPA05001558A (es) 2002-08-12 2005-09-08 Pharmacia & Upjohn Co Llc N-aril-2-oxazolidinonas y sus derivados.
KR100454099B1 (ko) * 2002-08-22 2004-10-26 한국화학연구원 제초활성을 갖는9-(5-이속사졸린메톡시페닐)이미노-8-치아-1,6-디아자비시클로[4.3.0]노난-7-온 유도체
AR042086A1 (es) 2002-11-21 2005-06-08 Upjohn Co N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1671972A1 (en) * 2004-11-24 2006-06-21 Pfizer Limited Octahydropyrrolo[3,4-c]pyrrole derivatives
WO2006056848A1 (en) * 2004-11-24 2006-06-01 Pfizer Limited Octahydropyrrolo[3,4-c]pyrrole derivatives
KR100729344B1 (ko) * 2006-02-16 2007-06-15 스마텍(주) 차량용 사방 감지 카메라의 보호 및 작동 구조
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
EP2188288A1 (en) 2007-09-11 2010-05-26 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole n-oxides
AU2009318783A1 (en) 2008-11-20 2011-06-23 Panacea Biotec Ltd. Novel antimicrobials
CN102803224A (zh) 2009-06-26 2012-11-28 万能药生物有限公司 新的氮杂双环己烷类化合物
KR20130102614A (ko) 2010-11-03 2013-09-17 욱크하르트 리미티드 인산 모노-(1-[4-[(s)-5-(아세틸아미노메틸)-2-옥소-옥사졸리딘-3-일]-2,6-디플루오로페닐]-4-메톡시메틸피페리딘-4-일) 에스테르의 제조 방법
KR101271224B1 (ko) * 2011-07-05 2013-06-10 한국과학기술연구원 항균활성을 갖는 신규 이중고리를 포함하는 옥사졸리디논 유도체 및 이의 제조방법
EP2762480A4 (en) * 2011-09-30 2015-03-18 Xuanzhu Pharma Co Ltd OXAZOLIDINONIBIOTICS WITH CONDENSED RINGS
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
US20180155341A1 (en) 2015-07-02 2018-06-07 Janssen Sciences Ireland Uc Antibacterial Compounds
EA037643B1 (ru) * 2015-07-17 2021-04-26 Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. Замещенные фенилоксазолидиноны для антимикробной терапии
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
EP3472158A1 (en) * 2016-06-16 2019-04-24 Janssen Sciences Ireland Unlimited Company Heterocyclic compounds as antibacterials
EA201991997A1 (ru) 2017-03-01 2020-01-22 Янссен Сайенсиз Айрлэнд Анлимитед Компани Комбинированная терапия
CN108727406B (zh) 2017-03-28 2021-12-07 北京协和制药二厂 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
DE3884563T2 (de) * 1987-10-21 1994-02-17 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE68918792T2 (de) * 1988-09-15 1995-03-30 Upjohn Co 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one.
WO1993009103A1 (en) * 1991-11-01 1993-05-13 The Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物

Also Published As

Publication number Publication date
NO975158L (no) 1998-01-09
DK0828741T3 (da) 2001-11-26
KR19990008399A (ko) 1999-01-25
FI974180A0 (fi) 1997-11-10
JPH11506430A (ja) 1999-06-08
DE69614847T2 (de) 2002-04-04
US6090820A (en) 2000-07-18
AU702752B2 (en) 1999-03-04
ES2162047T3 (es) 2001-12-16
FI974180L (fi) 1997-11-10
CN1336375A (zh) 2002-02-20
WO1996035691A1 (en) 1996-11-14
CN1068328C (zh) 2001-07-11
CA2218088A1 (en) 1996-11-14
AU5484996A (en) 1996-11-29
NO975158D0 (no) 1997-11-10
CN1184481A (zh) 1998-06-10
HK1009449A1 (en) 1999-09-10
KR100463771B1 (ko) 2005-05-16
EP0828741B1 (en) 2001-08-29
PT828741E (pt) 2002-02-28
NZ306310A (en) 2001-05-25
HK1042093A1 (zh) 2002-08-02
ATE204874T1 (de) 2001-09-15
DE69614847D1 (de) 2001-10-04
NO311298B1 (no) 2001-11-12
EP0828741A1 (en) 1998-03-18
FI974180A7 (fi) 1997-11-10

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees