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MX9705185A - Particula de resina, material medico y preparacion farmaceutica que contiene dicha particula de resina. - Google Patents

Particula de resina, material medico y preparacion farmaceutica que contiene dicha particula de resina.

Info

Publication number
MX9705185A
MX9705185A MX9705185A MX9705185A MX9705185A MX 9705185 A MX9705185 A MX 9705185A MX 9705185 A MX9705185 A MX 9705185A MX 9705185 A MX9705185 A MX 9705185A MX 9705185 A MX9705185 A MX 9705185A
Authority
MX
Mexico
Prior art keywords
resin particle
cilostazol
pharmaceutical preparation
medical material
preparation containing
Prior art date
Application number
MX9705185A
Other languages
English (en)
Other versions
MXPA97005185A (es
Inventor
Seiichiro Iguchi
Rika Hamamoto
Minoru Yamato
Hiroaki Yamamoto
Yuzo Kimura
Shinsuke Nakagawa
Keigo Yamada
Toshio Nakamura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MX9705185A publication Critical patent/MX9705185A/es
Publication of MXPA97005185A publication Critical patent/MXPA97005185A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Se provee una partícula de resina que comprende un copolímero de etileno y alcohol vinílico y de 5 a 90% en peso de cilostazol incorporado en el mismo, y tiene un tamaño de partícula no mayor de 2,000 æm; la partícula de resina, al ser administrada oralmente, permite que la concentracion de cilostazol en sangre se mantenga constante durante un periodo prolongado y por lo tanto alivia notablemente los efectos secundarios tales como cefalgia y fuerte malestar, que pueden ocasionarse de otra manera por la liberacion rápida de cilostazol en el cuerpo.
MXPA/A/1997/005185A 1995-01-10 1997-07-09 Particula de resina, material medico y preparacion farmaceutica que contiene dicha particula de resina MXPA97005185A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP7/2287 1995-01-10
JP228795 1995-01-10
JP7-002287 1995-01-10
PCT/JP1996/000004 WO1996021448A1 (en) 1995-01-10 1996-01-04 Resin particle, medical material and pharmaceutical preparation containing said resin particle

Publications (2)

Publication Number Publication Date
MX9705185A true MX9705185A (es) 1997-10-31
MXPA97005185A MXPA97005185A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
EP0794778A1 (en) 1997-09-17
WO1996021448A1 (en) 1996-07-18
CN1168102A (zh) 1997-12-17
KR19980701292A (ko) 1998-05-15
CA2208571A1 (en) 1996-07-18
AU4357096A (en) 1996-07-31

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