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AU5673399A - Compositions and methods for treating intracellular infections - Google Patents

Compositions and methods for treating intracellular infections

Info

Publication number
AU5673399A
AU5673399A AU56733/99A AU5673399A AU5673399A AU 5673399 A AU5673399 A AU 5673399A AU 56733/99 A AU56733/99 A AU 56733/99A AU 5673399 A AU5673399 A AU 5673399A AU 5673399 A AU5673399 A AU 5673399A
Authority
AU
Australia
Prior art keywords
compositions
methods
microspheres
intracellular infections
treating intracellular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU56733/99A
Inventor
Esther L. Barrow
William W. Barrow
Debra C. Quenelle
Jay K. Staas
Gary A. Winchester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Research Institute
Original Assignee
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Research Institute filed Critical Southern Research Institute
Publication of AU5673399A publication Critical patent/AU5673399A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

A method of treating or preventing an intracellular infection in an animal comprising administering a first effective amount of a suitable drug contained in first biocompatible microspheres that have a diameter of less than or equal to about 10 microns, wherein the first microspheres release the suitable drug upon administration at a first effective rate. A second set of microspheres greater than 10 microns in diameter may also be administered to provide continuing systemic release of the drug.
AU56733/99A 1998-08-18 1999-08-12 Compositions and methods for treating intracellular infections Abandoned AU5673399A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/135,708 US6264991B1 (en) 1998-08-18 1998-08-18 Compositions and methods for treating intracellular infections
US09135708 1998-08-18
PCT/US1999/018308 WO2000010533A2 (en) 1998-08-18 1999-08-12 Compositions and methods for treating intracellular infections

Publications (1)

Publication Number Publication Date
AU5673399A true AU5673399A (en) 2000-03-14

Family

ID=22469290

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56733/99A Abandoned AU5673399A (en) 1998-08-18 1999-08-12 Compositions and methods for treating intracellular infections

Country Status (8)

Country Link
US (1) US6264991B1 (en)
EP (1) EP1105101B1 (en)
AT (1) ATE282406T1 (en)
AU (1) AU5673399A (en)
CA (1) CA2340898C (en)
DE (1) DE69922017T2 (en)
ES (1) ES2234291T3 (en)
WO (1) WO2000010533A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02003463A (en) * 1999-10-04 2004-09-10 R Bernstein Lawrence Gallium complexes of 3 hydroxy 4 pyrones to treat infection by intracellular prokaryotes, dna viruses and retroviruses.
NZ521368A (en) * 2000-03-28 2004-05-28 Biochemie Ges M Granulated particles of an active compound, with a film-forming coating resulting in the masked taste of said active compound
TR200200966T1 (en) * 2000-08-09 2002-09-23 Panacea Biotec Limited New pharmaceutical compositions and preparation processes of tubercular drugs
DE10139965B4 (en) * 2001-08-14 2005-12-29 Biotest Ag Gamma sterilizable culture medium for the detection of yeasts and fungi
US20090149453A1 (en) * 2002-05-23 2009-06-11 Activbiotics Pharma Llc Methods and compositions for treating bacterial infections and diseases associated therewith
EP1531828A4 (en) * 2002-05-23 2005-11-02 Activbiotics Inc Methods of treating bacterial infections and diseases associated therewith
US20040077533A1 (en) * 2002-05-23 2004-04-22 Sayada Chalom B. Methods and compositions for treating bacterial infections and diseases associated therewith
ES2324293T3 (en) * 2002-10-03 2009-08-04 Vertex Pharmaceuticals Incorporated DERIVATIVES OF PIPERACINE AND PIPERIDINE FOR THE TREATMENT OF NEUROLOGICAL DISEASES.
WO2005007143A2 (en) * 2003-07-14 2005-01-27 The Board Of Trustees Of The University Of Illinois Use of makrolides and ketolides for the treatment of tuberculosis
US20050084455A1 (en) * 2003-10-16 2005-04-21 Council Of Scientific & Industrial Research Inhalable biodegradable microparticles for target-specific drug delivery in tuberculosis and a process thereof
RU2318513C1 (en) * 2007-04-10 2008-03-10 Автономная некоммерческая организация "Институт молекулярной диагностики" (АНО "ИнМоДи") D-cycloserine-base drug, nanoparticles-containing preparation of prolonged effect, method for its preparing
RU2327459C1 (en) * 2007-06-26 2008-06-27 Евгений Сергеевич Северин Antimicrobial medicinal agent, method of production of directional medicinal agent containig nanoparticles
WO2009042114A2 (en) 2007-09-21 2009-04-02 The Johns Hopkins University Phenazine derivatives and uses thereof
MX2010006326A (en) * 2007-12-10 2010-10-04 Eurand Inc Orally disintegrating tablets comprising diphenhydramine.
US20110269720A1 (en) * 2010-04-28 2011-11-03 Medtronic, Inc. Minocycline and rifampin microparticles
US9248176B2 (en) * 2010-10-07 2016-02-02 The Texas A&M University System Controlled release vaccines and methods for treating Brucella diseases and disorders
RU2470071C2 (en) * 2010-11-25 2012-12-20 Федеральное государственное учреждение "Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии"Министерства здравоохранения и социального развития Российской Федерации (ФГУ "СПб НИИФ" Минздравсоцразвития России) CULTURE MEDIUM FOR DETERMINING DRUG SUSCEPTIBILITY OF M tuberculosis TO MAIN ANTI-TUBERCULOSIS DRUGS
CN102228439B (en) * 2011-06-21 2013-01-02 中国人民解放军第三0九医院 Gel microsphere capable of being injected with rifamycinoid antibiotics and preparation method thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783484A (en) 1984-10-05 1988-11-08 University Of Rochester Particulate composition and use thereof as antimicrobial agent
WO1988001165A1 (en) 1986-08-11 1988-02-25 Innovata Biomed Limited Pharmaceutical formulations comprising microcapsules
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
JP2670680B2 (en) 1988-02-24 1997-10-29 株式会社ビーエムジー Polylactic acid microspheres containing physiologically active substance and method for producing the same
JP2582186B2 (en) 1989-05-04 1997-02-19 サウザン リサーチ インスティチュート Encapsulation method and its products
WO1991009616A1 (en) 1989-12-22 1991-07-11 Yale University Quinolone antibiotics encapsulated in lipid vesicles
DE69526787T2 (en) 1995-07-05 2002-12-05 European Community, Luxemburg/Luxembourg Biocompatible and biodegradable nanocapsules for the absorption and administration of protein pharmaceuticals
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6515016B2 (en) * 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
SE9801288D0 (en) * 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and method of production
WO1999065531A1 (en) * 1998-06-18 1999-12-23 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids

Also Published As

Publication number Publication date
CA2340898C (en) 2009-06-16
ES2234291T3 (en) 2005-06-16
DE69922017D1 (en) 2004-12-23
US6264991B1 (en) 2001-07-24
WO2000010533A3 (en) 2000-06-08
HK1038310A1 (en) 2002-03-15
EP1105101A2 (en) 2001-06-13
WO2000010533A9 (en) 2000-08-03
DE69922017T2 (en) 2005-11-24
ATE282406T1 (en) 2004-12-15
WO2000010533A2 (en) 2000-03-02
EP1105101B1 (en) 2004-11-17
CA2340898A1 (en) 2000-03-02

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase