[go: up one dir, main page]

MX9702252A - Nuevos androstanos para inducir efectos hipotalamicos. - Google Patents

Nuevos androstanos para inducir efectos hipotalamicos.

Info

Publication number
MX9702252A
MX9702252A MX9702252A MX9702252A MX9702252A MX 9702252 A MX9702252 A MX 9702252A MX 9702252 A MX9702252 A MX 9702252A MX 9702252 A MX9702252 A MX 9702252A MX 9702252 A MX9702252 A MX 9702252A
Authority
MX
Mexico
Prior art keywords
androstans
induce
new
hypothalamic effects
hypothalamic
Prior art date
Application number
MX9702252A
Other languages
English (en)
Other versions
MXPA97002252A (es
Inventor
David L Berliner
Nathan W Adams
Clive L Jennings-White
Original Assignee
Pherin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pherin Corp filed Critical Pherin Corp
Publication of MXPA97002252A publication Critical patent/MXPA97002252A/es
Publication of MX9702252A publication Critical patent/MX9702252A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0055—Estrane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/002—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 13 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)

Abstract

La invencion se relaciona con nuevos esteroides androstanos que son semiquímicos ligandos que se unen a receptores neuroepiteliales.
MX9702252A 1994-09-29 1995-09-29 Nuevos androstanos para inducir efectos hipotalamicos. MX9702252A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/316,435 US5969168A (en) 1991-01-07 1994-09-29 Androstanes for inducing hypothalamic effects
US08316435 1994-09-29
PCT/US1995/012538 WO1996010031A1 (en) 1994-09-29 1995-09-29 Novel androstanes for inducing hypothalamic effects

Publications (2)

Publication Number Publication Date
MXPA97002252A MXPA97002252A (es) 1997-06-01
MX9702252A true MX9702252A (es) 1997-06-28

Family

ID=23229039

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702252A MX9702252A (es) 1994-09-29 1995-09-29 Nuevos androstanos para inducir efectos hipotalamicos.

Country Status (17)

Country Link
US (1) US5969168A (es)
EP (1) EP0783512A4 (es)
JP (1) JPH10509692A (es)
KR (1) KR970706296A (es)
CN (1) CN1057767C (es)
AU (1) AU702704B2 (es)
BR (1) BR9509173A (es)
CA (1) CA2199043A1 (es)
CZ (1) CZ92597A3 (es)
FI (1) FI971314L (es)
HU (1) HUT77665A (es)
MX (1) MX9702252A (es)
NO (1) NO971418L (es)
NZ (1) NZ294508A (es)
PL (1) PL319606A1 (es)
RU (1) RU2160740C2 (es)
WO (1) WO1996010031A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE255898T1 (de) * 1993-06-15 2003-12-15 Pherin Corp Androstansteroide als neurochemische initiatoren einer veränderung der hypothalamusfunktion beim menschen und verwandte pharmazeutische präparate und verfahren
US6066627A (en) * 1994-08-04 2000-05-23 Pherin Corporation Steroids as neurochemical initiators of change in human blood levels of LH
CN1167489A (zh) * 1994-09-29 1997-12-10 弗伦有限公司 具有诱导下丘脑作用的新的雌甾烯
DE19509729A1 (de) * 1995-03-13 1996-09-19 Schering Ag 17-Difluormethylen-Estratriene
US5922699A (en) * 1996-06-07 1999-07-13 Pherin Corporation 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function
CA2260253A1 (en) * 1996-07-23 1998-01-29 Clive L. Jennings-White Steroids as neurochemical stimulators of the vno to alleviate symptoms of pms and anxiety
US20030045514A1 (en) * 2001-05-03 2003-03-06 Louis Monti 17-Methyleneandrostan-3alpha-ol analogs as CRH inhibitors
US20040072814A1 (en) 2002-10-11 2004-04-15 Solvay Pharmaceuticals Gmbh Method for obtaining a natural mixture of conjugated equine estrogens depleted in non-conjugated lipophilic compounds
AR041121A1 (es) * 2002-10-11 2005-05-04 Solvay Pharm Gmbh Procedimiento para la obtencion de una mezcla natural de estrogenos conjugados
US8309539B2 (en) * 2005-09-09 2012-11-13 Pherin Pharmaceuticals, Inc. Acute treatment of social phobia
CN112778390B (zh) * 2021-01-22 2022-09-30 厦门欧瑞捷生物科技有限公司 一种雄烯酮的合成方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2846451A (en) * 1953-12-11 1958-08-05 Syntex Sa Cyclopentanophenanthrene derivatives and process
US3043836A (en) * 1961-05-02 1962-07-10 Searle & Co 13beta-carboxy-17beta-hydroxy-10beta-methylgon-4-en-3-one, derivatives thereof and intermediates thereto
GB976215A (en) * 1962-03-15 1964-11-25 Searle & Co Improvements in or relating to steroids
US3264327A (en) * 1962-07-27 1966-08-02 Syntex Corp 17alpha-fluoro-, 17beta-chlorofluoroacetoxy- and 17beta-methyl-delta4-and delta5-androstene derivatives
US3281436A (en) * 1964-08-05 1966-10-25 Abbott Lab Process for making gem-difluorosteroids
US3413321A (en) * 1966-06-03 1968-11-26 Du Pont Selected 17-fluoro-delta16 steroids
US3470216A (en) * 1966-11-29 1969-09-30 Du Pont Selected 17,17-difluoro unsaturated androstanes
GB1175219A (en) * 1967-06-22 1969-12-23 Ici Ltd 3-Aminoalkoxycarbonylmethylene Steroid Derivatives
US3681490A (en) * 1969-07-22 1972-08-01 Nat Res Dev Artificial insemination of pigs
DE2336432A1 (de) * 1973-07-13 1975-01-30 Schering Ag 3.17.18-trihydroxy-1.3.5(10)-oestratriene
FR2255313B1 (es) * 1973-12-20 1976-10-08 Gole Jean
US4239681A (en) * 1974-04-15 1980-12-16 Richardson-Merrell Inc. Androst-4-en-19-ols
US4139617A (en) * 1974-05-13 1979-02-13 Richardson-Merrell Inc. 19-Oxygenated-androst-5-enes for the enhancement of libido
US4022769A (en) * 1974-05-13 1977-05-10 Richardson-Merrell Inc. Androst-4-en-19-ones
US4071625A (en) * 1974-05-13 1978-01-31 Richardson-Merrell Inc. 19-Oxygenated-5α-androstanes for the enhancement of libido
GB1550343A (en) * 1975-07-16 1979-08-15 Gist Brocades Nv Androstane derivatives
DE2758549A1 (de) * 1977-12-23 1979-07-05 Schering Ag Pharmazeutische zubereitung
US4133811A (en) * 1978-02-17 1979-01-09 E. R. Squibb & Sons, Inc. 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes
US4212815A (en) * 1978-07-05 1980-07-15 E. I. Du Pont De Nemours And Company Preparation of vinylene fluorides
US4425339A (en) * 1981-04-09 1984-01-10 Syntex (U.S.A.) Inc. Treatment of menopausal symptoms
US4349474A (en) * 1981-07-27 1982-09-14 G. D. Searle & Co. 2-Cyanosteroids
US5155045A (en) * 1985-01-25 1992-10-13 Trustees Of The University Of Penn. Use of male essence to alter female endocrine response
US4863911A (en) * 1986-08-04 1989-09-05 University Of Florida Method for treating male sexual dysfunction
US4835147A (en) * 1987-05-06 1989-05-30 City Of Hope Dehydroepiandrosterone therapy for ameleoration of prostate hypertrophy and sexual dysfunction
CA2425849C (en) * 1991-11-22 2007-02-27 Alcon Laboratories, Inc. Angiostatic steroids
US5272134A (en) * 1992-03-24 1993-12-21 Erox Corporation Fragrance compositions and other compositions which contain human pheromones
ATE255898T1 (de) * 1993-06-15 2003-12-15 Pherin Corp Androstansteroide als neurochemische initiatoren einer veränderung der hypothalamusfunktion beim menschen und verwandte pharmazeutische präparate und verfahren
CN1167489A (zh) * 1994-09-29 1997-12-10 弗伦有限公司 具有诱导下丘脑作用的新的雌甾烯

Also Published As

Publication number Publication date
NZ294508A (en) 1999-02-25
WO1996010031A1 (en) 1996-04-04
FI971314A7 (fi) 1997-03-27
NO971418D0 (no) 1997-03-25
AU3732995A (en) 1996-04-19
NO971418L (no) 1997-05-23
EP0783512A4 (en) 1998-09-02
KR970706296A (ko) 1997-11-03
RU2160740C2 (ru) 2000-12-20
EP0783512A1 (en) 1997-07-16
CZ92597A3 (en) 1997-09-17
JPH10509692A (ja) 1998-09-22
PL319606A1 (en) 1997-08-18
FI971314A0 (fi) 1997-03-27
FI971314L (fi) 1997-03-27
CN1166836A (zh) 1997-12-03
BR9509173A (pt) 1997-11-25
US5969168A (en) 1999-10-19
AU702704B2 (en) 1999-03-04
CN1057767C (zh) 2000-10-25
HUT77665A (hu) 1998-07-28
CA2199043A1 (en) 1996-04-04

Similar Documents

Publication Publication Date Title
MX9702252A (es) Nuevos androstanos para inducir efectos hipotalamicos.
DE69504071D1 (de) Turbomaschine
DE69321839D1 (de) Zusammensetzung für die lymphatische anwendung
ES2196534T3 (es) Antagonistas del receptor de vitronectina.
DE69501155D1 (de) Leitgitter für einen kompressor
ITMI951313A0 (it) Macchina circolare per treccia
ITMI962644A0 (it) Macchina circolare per treccia
AR019631A1 (es) Agentes terapeuticos nuevos que modulan receptores de 5-ht.
DE69605103D1 (de) Bestückungsautomat für bauelemente
DE69620626D1 (de) Bügeleisen für wäsche
FI941936L (fi) Pilarikenkä
DE59711509D1 (de) Schildvortriebsmaschine
DE59803439D1 (de) Fussmaschine für bassdrum
BR9702153A (pt) Suporte fibroso para um produto abrasivo que incorpora um tal suporte
KR950026890U (ko) 와이어 커팅기의 와이어 연결치구
DE59600007D1 (de) Bindemittel für textile Flächengebilde
DE59507265D1 (de) Bestückungsvorrichtung für Spulengatter
TR199500905A2 (tr) Tetrasiklik triterpenler.
ATA1696A (de) Diarahmen für grossbildprojektion
IT1286207B1 (it) Sottoago modificato con relativi organi di azionamento per macchine circolari per calze e calzini
KR960034585U (ko) 쉐타 편조용 원사
DE69821070D1 (de) Programmablauf für Geschirrspülmaschine und Geschirrspülmaschine die einen solchen Ablauf benutzt
NO942253D0 (no) Maskin for innstöping av anker i betong
KR960029982U (ko) 구근류 채굴 작업기
FR2731720B1 (fr) Ensemble lave-linge