MX9700338A - Derivados heterociclicos de azolona anti-helicobacter. - Google Patents
Derivados heterociclicos de azolona anti-helicobacter.Info
- Publication number
- MX9700338A MX9700338A MX9700338A MX9700338A MX9700338A MX 9700338 A MX9700338 A MX 9700338A MX 9700338 A MX9700338 A MX 9700338A MX 9700338 A MX9700338 A MX 9700338A MX 9700338 A MX9700338 A MX 9700338A
- Authority
- MX
- Mexico
- Prior art keywords
- 4alkyl
- optionally substituted
- alkyloxy
- compounds
- azolones
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxypyridinyl Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Polymerization Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invencion se refiere a los compuesto que tienen la formula (I), las sales de adicion farmacéuticamente aceptables y las formas esteroquímicamente isomericas de las mismas, en donde Y es CH o N; R1, R2, y R3 cada uno independientemente es hidrogeno o alquilo de C1-4; R4 y R5 son cada uno independientemente hidrogeno, halogeno, alquilo de C1-4; alquiloxi de C1-4; hidroxilo, trifluorometilo, trifluorometiloxi o difluorometiloxi; R6 es piridinilo opcionalmente sustituido hasta con dos grupos alquilo C1-4; y (alquilo C1-4) hidroxipiridinilo; y (alquilo C1-4) alquiloxipiridinilo de C1-4; piridizanilo opcionalmente sustituido con alquiloxi de C1-4; piridinilo opcionalmente sustituido con hidroxilo o alquiloxi de C1-4; tiazolilo opcionalmente sustituido con alquilo C1-4; tquiazolilo opcionalmente sustituido con alquilo de C1-4; benzoxazolilo o benzotiazolilo; o R6 es pirazinilo o piriddazinilo sustituido con alquilo C1-4; Z es C=O; y (a) es un radical de la formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6) o (a-7); composiciones que comprenden dichos compuestos, procedimientos para preparar los mismos y el uso de estos compuestos como una medicina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94202018 | 1994-07-12 | ||
| PCT/EP1995/002616 WO1996001821A1 (en) | 1994-07-12 | 1995-07-05 | Anti-helicobacter heterocyclic derivatives of azolones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9700338A true MX9700338A (es) | 1997-05-31 |
Family
ID=8217031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9700338A MX9700338A (es) | 1994-07-12 | 1995-07-05 | Derivados heterociclicos de azolona anti-helicobacter. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5607932A (es) |
| EP (1) | EP0770073A1 (es) |
| JP (1) | JPH10502383A (es) |
| CN (1) | CN1067999C (es) |
| AU (1) | AU684986B2 (es) |
| BR (1) | BR9508380A (es) |
| CA (1) | CA2194563A1 (es) |
| CZ (1) | CZ2697A3 (es) |
| FI (1) | FI970110A0 (es) |
| HU (1) | HUT76641A (es) |
| IL (1) | IL114534A (es) |
| MX (1) | MX9700338A (es) |
| MY (1) | MY131785A (es) |
| NO (1) | NO310289B1 (es) |
| NZ (1) | NZ290116A (es) |
| PL (1) | PL318142A1 (es) |
| RU (1) | RU2152940C1 (es) |
| SK (1) | SK2197A3 (es) |
| WO (1) | WO1996001821A1 (es) |
| ZA (1) | ZA955753B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100411190B1 (ko) * | 1995-12-26 | 2004-03-26 | 에스케이케미칼주식회사 | 에틸렌글리콜의회수방법 |
| CN1077892C (zh) * | 1996-06-25 | 2002-01-16 | 武田药品工业株式会社 | 噁唑酮衍生物及其作为抗幽门螺杆菌剂的应用 |
| KR20000005291A (ko) | 1996-06-25 | 2000-01-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 옥사졸론 유도체 및 항-헬리코박터 파일로리 제제로서의 이의용도 |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| WO2006034441A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7919496B2 (en) | 2004-09-20 | 2011-04-05 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
| AR051094A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| US7767677B2 (en) | 2004-09-20 | 2010-08-03 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| CA2580844A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| JP4958785B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用 |
| EP2540296A1 (en) | 2005-06-03 | 2013-01-02 | Xenon Pharmaceuticals Inc. | Arminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| AU2009264242A1 (en) * | 2008-06-27 | 2009-12-30 | Novartis Ag | Organic compounds |
| US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
| EP3464262B1 (en) * | 2016-05-27 | 2020-02-26 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT311956B (de) * | 1971-06-07 | 1973-12-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Phenylimidazolidinonderivate und ihrer Salze |
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| CA2076257A1 (en) * | 1991-09-13 | 1993-03-14 | Jan Heeres | 4-¬4-¬4-(4-hydroxyphenyl)-1- piperazinyl|phenyl|-5-methyl-3h -1,2,4-triazol-3-one derivatives |
| TW279864B (es) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv |
-
1995
- 1995-05-23 US US08/447,503 patent/US5607932A/en not_active Expired - Fee Related
- 1995-07-05 AU AU30755/95A patent/AU684986B2/en not_active Ceased
- 1995-07-05 HU HU9700077A patent/HUT76641A/hu unknown
- 1995-07-05 CA CA002194563A patent/CA2194563A1/en not_active Abandoned
- 1995-07-05 BR BR9508380A patent/BR9508380A/pt unknown
- 1995-07-05 CN CN95194021A patent/CN1067999C/zh not_active Expired - Fee Related
- 1995-07-05 WO PCT/EP1995/002616 patent/WO1996001821A1/en not_active Ceased
- 1995-07-05 SK SK21-97A patent/SK2197A3/sk unknown
- 1995-07-05 PL PL95318142A patent/PL318142A1/xx unknown
- 1995-07-05 EP EP95926390A patent/EP0770073A1/en not_active Withdrawn
- 1995-07-05 CZ CZ9726A patent/CZ2697A3/cs unknown
- 1995-07-05 RU RU97102151/04A patent/RU2152940C1/ru active
- 1995-07-05 MX MX9700338A patent/MX9700338A/es unknown
- 1995-07-05 JP JP8504109A patent/JPH10502383A/ja active Pending
- 1995-07-05 NZ NZ290116A patent/NZ290116A/en unknown
- 1995-07-11 ZA ZA955753A patent/ZA955753B/xx unknown
- 1995-07-11 IL IL11453495A patent/IL114534A/xx active IP Right Grant
- 1995-07-12 MY MYPI95001962A patent/MY131785A/en unknown
-
1997
- 1997-01-09 NO NO19970086A patent/NO310289B1/no unknown
- 1997-01-10 FI FI970110A patent/FI970110A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA955753B (en) | 1997-01-11 |
| NO310289B1 (no) | 2001-06-18 |
| HU9700077D0 (en) | 1997-02-28 |
| CA2194563A1 (en) | 1996-01-25 |
| US5607932A (en) | 1997-03-04 |
| JPH10502383A (ja) | 1998-03-03 |
| NO970086L (no) | 1997-03-10 |
| EP0770073A1 (en) | 1997-05-02 |
| HUT76641A (en) | 1997-10-28 |
| PL318142A1 (en) | 1997-05-12 |
| IL114534A0 (en) | 1995-11-27 |
| CN1067999C (zh) | 2001-07-04 |
| NZ290116A (en) | 1997-11-24 |
| NO970086D0 (no) | 1997-01-09 |
| WO1996001821A1 (en) | 1996-01-25 |
| RU2152940C1 (ru) | 2000-07-20 |
| CZ2697A3 (en) | 1997-09-17 |
| FI970110A7 (fi) | 1997-01-10 |
| CN1152310A (zh) | 1997-06-18 |
| AU3075595A (en) | 1996-02-09 |
| BR9508380A (pt) | 1997-12-23 |
| FI970110A0 (fi) | 1997-01-10 |
| AU684986B2 (en) | 1998-01-08 |
| IL114534A (en) | 1999-08-17 |
| MY131785A (en) | 2007-08-30 |
| SK2197A3 (en) | 1997-11-05 |
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