[go: up one dir, main page]

MX9603925A - Combinaciones de anticoagulantes y proteinas activas tromboliticamente, y usos de las mismas. - Google Patents

Combinaciones de anticoagulantes y proteinas activas tromboliticamente, y usos de las mismas.

Info

Publication number
MX9603925A
MX9603925A MX9603925A MX9603925A MX9603925A MX 9603925 A MX9603925 A MX 9603925A MX 9603925 A MX9603925 A MX 9603925A MX 9603925 A MX9603925 A MX 9603925A MX 9603925 A MX9603925 A MX 9603925A
Authority
MX
Mexico
Prior art keywords
anticoagulants
active proteins
combinations
thrombolytically
thrombolytically active
Prior art date
Application number
MX9603925A
Other languages
English (en)
Inventor
Ulrich Martin
Stephan Fischer
Original Assignee
Boehringer Mannheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22811809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9603925(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Corp filed Critical Boehringer Mannheim Corp
Publication of MX9603925A publication Critical patent/MX9603925A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a composiciones y métodos terapéuticos efectivos trombolíticamente. Las proteínas activas trombolíticamente son combinadas con anticoagulantes, ya que el anticoagulante no es la heparina. El anticoagulante es administrado en una forma de bolo intravenoso, mientras que la proteína activa trombolíticamente puede ser administrada por bolo intravenoso, o infusion intravenosa.
MX9603925A 1994-03-25 1995-03-22 Combinaciones de anticoagulantes y proteinas activas tromboliticamente, y usos de las mismas. MX9603925A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/217,618 US5510330A (en) 1994-03-25 1994-03-25 Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
PCT/EP1995/001061 WO1995026202A1 (en) 1994-03-25 1995-03-22 Combinations of thrombolytically active proteins and anticoagulants, and uses thereof

Publications (1)

Publication Number Publication Date
MX9603925A true MX9603925A (es) 1997-04-30

Family

ID=22811809

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603925A MX9603925A (es) 1994-03-25 1995-03-22 Combinaciones de anticoagulantes y proteinas activas tromboliticamente, y usos de las mismas.

Country Status (21)

Country Link
US (1) US5510330A (es)
EP (2) EP0751785B2 (es)
JP (1) JPH09510439A (es)
KR (1) KR100366982B1 (es)
CN (1) CN1090029C (es)
AT (1) ATE167631T1 (es)
AU (1) AU702470B2 (es)
BR (1) BR9507189A (es)
CA (1) CA2186390A1 (es)
CZ (1) CZ279596A3 (es)
DE (1) DE69503120T3 (es)
DK (1) DK0751785T4 (es)
ES (1) ES2119411T5 (es)
FI (1) FI120182B (es)
MX (1) MX9603925A (es)
NO (1) NO316584B1 (es)
NZ (1) NZ282417A (es)
PL (1) PL182165B1 (es)
RU (1) RU2166326C2 (es)
UA (1) UA41398C2 (es)
WO (1) WO1995026202A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7867275B2 (en) * 1995-06-07 2011-01-11 Cook Incorporated Coated implantable medical device method
US20070203520A1 (en) * 1995-06-07 2007-08-30 Dennis Griffin Endovascular filter
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7550005B2 (en) 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7846202B2 (en) 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
DK1521603T3 (da) 2002-07-12 2011-04-18 Cook Inc Coated medicinsk anordning
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
JP2007538257A (ja) * 2004-05-17 2007-12-27 メドトロニック・インコーポレーテッド ポイント・オブ・ヘパリン測定システム
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
CN101522206B (zh) * 2006-10-06 2013-03-27 旭化成制药株式会社 弥散性血管内凝血综合征的治疗剂和/或改善剂
RU2371215C2 (ru) * 2007-08-13 2009-10-27 ГОУ ВПО "Саратовский ГМУ Росздрава" Способ коррекции нарушенной функциональной активности гликопротеидных рецепторов тромбоцитов
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
CN101952309A (zh) * 2007-12-21 2011-01-19 Ifxa有限公司 蛋白酶抑制剂
RU2394611C1 (ru) * 2009-06-05 2010-07-20 Алексей Николаевич Иванов Способ коррекции нарушенной функциональной активности гликопротеидных рецепторов эритроцитов
ES2788697T3 (es) 2014-11-03 2020-10-22 Thrombolytic Science Llc Métodos y composiciones para trombólisis segura y eficaz
WO2016122289A2 (ko) * 2015-01-30 2016-08-04 고려대학교산학협력단 베르베논 유도체를 포함하는 재관류 시술의 부작용을 감소 또는 예방하기 위한 조성물
RU2622006C2 (ru) * 2015-06-15 2017-06-08 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Применение рекомбинантного штамма bacillus subtilis eo-11 вкпм в-11978 в качестве продуцента субтилизиноподобной протеиназы, вещества с тромболитическими и антикоагулянтными свойствами
CN105396127A (zh) * 2015-11-13 2016-03-16 中国人民解放军第四军医大学 一种用于急性心肌梗死的冠状动脉溶栓剂
WO2018232305A1 (en) * 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis
CN114292765B (zh) * 2021-09-24 2023-04-07 江西康之康中药科技有限公司 枯草芽孢杆菌纳豆亚种r3及其在发酵水蛭低温干燥品中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
DK43387A (da) † 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
CA2064231A1 (en) * 1989-07-20 1991-01-21 John M. Maraganore Combinations and methods for treating or preventing thrombotic diseases
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
DK0580685T3 (da) † 1991-04-16 1996-03-04 Boehringer Mannheim Gmbh Farmaceutisk emballageenhed indeholdende plasminogenaktivatorer til flerfoldig bolusindgift
WO1993024635A1 (en) † 1992-06-03 1993-12-09 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
GB9303275D0 (en) * 1993-02-18 1993-04-07 Ciba Geigy Ag Pharmaceutical compositions
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione

Also Published As

Publication number Publication date
ATE167631T1 (de) 1998-07-15
CN1144489A (zh) 1997-03-05
EP0751785B1 (en) 1998-06-24
BR9507189A (pt) 1997-09-09
RU2166326C2 (ru) 2001-05-10
NO316584B1 (no) 2004-03-01
NO964007D0 (no) 1996-09-24
DE69503120T2 (de) 1998-11-12
UA41398C2 (uk) 2001-09-17
FI963802L (fi) 1996-09-24
DE69503120T3 (de) 2003-08-14
PL316449A1 (en) 1997-01-20
CA2186390A1 (en) 1995-10-05
AU1951195A (en) 1995-10-17
EP0751785A1 (en) 1997-01-08
EP0850648A3 (en) 2004-03-31
AU702470B2 (en) 1999-02-25
CZ279596A3 (cs) 1998-01-14
CN1090029C (zh) 2002-09-04
ES2119411T3 (es) 1998-10-01
DE69503120D1 (de) 1998-07-30
KR100366982B1 (ko) 2003-08-02
WO1995026202A1 (en) 1995-10-05
US5510330A (en) 1996-04-23
NO964007L (no) 1996-11-25
PL182165B1 (pl) 2001-11-30
DK0751785T3 (da) 1999-04-06
FI120182B (fi) 2009-07-31
FI963802A0 (fi) 1996-09-24
DK0751785T4 (da) 2002-04-15
NZ282417A (en) 1998-02-26
JPH09510439A (ja) 1997-10-21
ES2119411T5 (es) 2002-08-01
EP0850648A2 (en) 1998-07-01
EP0751785B2 (en) 2001-12-19

Similar Documents

Publication Publication Date Title
MX9603925A (es) Combinaciones de anticoagulantes y proteinas activas tromboliticamente, y usos de las mismas.
GEP20012448B (en) Tissue Plasminogen Activators (Improved Variants)
NL300021I2 (nl) ASP-B28 insulinekristallen.
DK0633721T3 (da) Rensning af blodplader med 8-metoxypsoralen
ATE32730T1 (de) Indikatormarkierte konjugate von metallothionein und zielsuchenden, biologisch aktiven molekuelen.
DE59510531D1 (de) Behältnis zur Lagerung und Verabreichung von Injektions-, Infusions- und Diagnostikpräparaten
EP0853121A3 (en) Human DNase
SE9702860D0 (sv) New use
DE69916856D1 (de) Micropartikeln zur verwendung in nadellosen injektion
TR200200620T2 (tr) Levosimendan farmasötik solüsyonları
FI953565A7 (fi) Uusi antikoagulanttikofaktoriaktiivisuus
DK0655089T3 (da) Virkninger af actinfilamenter på fibrinkoagulatstruktur og -lyse
IT1270618B (it) Proteine ad attivita' antitumorale
ATE187890T1 (de) Ligandgerichtete enzyme-prodrug therapie
BG97199A (bg) Антикоагулантен препарат
EP0680763A3 (en) Stable preparation for the treatment of blood coagulation disorders comprising an activated coagulation factor and lipid vesicles
EA199800819A1 (ru) Способ лечения биполярного расстройства
DK0542869T3 (da) Vævsplasminogenaktivatorvarianter med nedsat udskillelse
SE9003181D0 (sv) Use of heparin fraction
EP0340933A3 (en) Heparin-containing formulations
AR002243A1 (es) Anticuerpos contra proteinas alogenicas y xenogenicas, su uso en diagnostico y terapia y metodos para la determinacion de los mismos.
AU2459188A (en) Anticoagulative protein pp4-x, and its preparation and use
MD980129A (en) Antiherpetic remedy
TR200000728T2 (tr) Kronik hepatit C' nin tedavisinde IFN-alfa ve amantadin kullanımı.
UA9703A (uk) Антипротеіназний засіб

Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: ACTAVIS GROUP PTC EHF.

MM Annulment or lapse due to non-payment of fees