MX9302869A - NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. - Google Patents
NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.Info
- Publication number
- MX9302869A MX9302869A MX9302869A MX9302869A MX9302869A MX 9302869 A MX9302869 A MX 9302869A MX 9302869 A MX9302869 A MX 9302869A MX 9302869 A MX9302869 A MX 9302869A MX 9302869 A MX9302869 A MX 9302869A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- pharmaceutical compositions
- dihydroxybencilamine
- contain
- aryloxycarbonyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 alkoylthio Chemical group 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 2
- KHZCDSSLAQEJBH-UHFFFAOYSA-N 2-(aminomethyl)benzene-1,4-diol Chemical class NCC1=CC(O)=CC=C1O KHZCDSSLAQEJBH-UHFFFAOYSA-N 0.000 abstract 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se describen los nuevos derivados de la 2, 5-dihidroxibencilamina de fórmula general (I), la preparación y las composiciones farmacéuticas que los contienen. En la fórmula general (I), uno de los símbolos R1 ó R2 representa un átomo de hidrógeno o de halógeno o radical hidroxi, alcoxi, alcoilcarboniloxi, arilcarboniloxi, mercapto, alcoiltio, amino, formilamino, alcoilcarbonilamino, arilcarbonilamino y el otro representa un radical alcoxi, alcoximetilo, alcoilcarbonilo, arilcarbonilo, alcoiloxicarbonilo, ariloxicarbonilo, alqueniloxicarbonilo, ariloxicarbonilo, carbamoilo o tiocarbamoilo en donde el átomo de nitrógeno esta eventualmente sustituido por uno o dos radicales alcoilos o fenilos, los radicales alcoilos, fenilos y arilos están eventualmente sustituidos. Los nuevos productos de fórmula (I) manifiestan una actividad antitumoral notable.Novel 2,5-dihydroxybenzylamine derivatives of general formula (I), the preparation and the pharmaceutical compositions containing them are described. In the general formula (I), one of the symbols R1 or R2 represents a hydrogen or halogen atom or hydroxy, alkoxy, alkoxycarbonyloxy, arylcarbonyloxy, mercapto, alkoylthio, amino, formylamino, alkoxycarbonylamino, arylcarbonylamino radical and the other represents a radical alkoxy, alkoxymethyl, alkoxycarbonyl, arylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, alkenyloxycarbonyl, aryloxycarbonyl, carbamoyl or thiocarbamoyl in which the nitrogen atom is optionally substituted by one or two alkyls or phenyl radicals, the alkyls, phenyl and aryl radicals. The new products of formula (I) show remarkable anti-tumor activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9205980A FR2691145A1 (en) | 1992-05-18 | 1992-05-18 | Novel dihydroxybenzylamine derivatives, their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9302869A true MX9302869A (en) | 1993-11-01 |
Family
ID=9429866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9302869A MX9302869A (en) | 1992-05-18 | 1993-05-17 | NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0641311A1 (en) |
| JP (1) | JPH07506585A (en) |
| AU (1) | AU4075693A (en) |
| FR (1) | FR2691145A1 (en) |
| MX (1) | MX9302869A (en) |
| TW (1) | TW252095B (en) |
| WO (1) | WO1993023364A1 (en) |
| ZA (1) | ZA933426B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1060160A2 (en) | 1998-02-27 | 2000-12-20 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
| US7208143B2 (en) * | 2004-09-29 | 2007-04-24 | Isp Investments Inc. | Antiperspirant compositions |
| US7166275B2 (en) * | 2003-07-11 | 2007-01-23 | Isp Investments Inc. | Compositions containing phenethyl aryl esters as solubilizing agents for active organic compounds |
| JP2006008642A (en) * | 2004-06-29 | 2006-01-12 | Sumitomo Bakelite Co Ltd | Aminophenol compound, thermosetting compound and method for producing the same |
| WO2006108864A2 (en) | 2005-04-15 | 2006-10-19 | Dominion Pharmakine S.L. | New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof |
| EP4351548A4 (en) * | 2021-06-08 | 2025-04-30 | ATAI Therapeutics, Inc. | DIMETHOXYPHENYLALKYLAMINE ACTIVATORS OF SEROTONIN RECEPTORS |
| AU2022287974A1 (en) | 2021-06-09 | 2024-01-04 | Atai Therapeutics, Inc. | Novel prodrugs and conjugates of dimethyltryptamine |
| JP2024547131A (en) | 2021-12-27 | 2024-12-26 | エーティーエーアイ セラピューティクス，インコーポレイテッド | Aminotetralin activators of serotonin receptors |
| JP2024545787A (en) | 2021-12-30 | 2024-12-11 | アタイ セラピューティクス， インコーポレイテッド | Dimethyltryptamine analogues as nitric oxide delivery agents. |
| US12343319B2 (en) | 2023-05-01 | 2025-07-01 | Atai Therapeutics, Inc. | Compositions and methods for treatment of diseases and disorders |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2120091A1 (en) * | 1971-04-24 | 1972-11-09 | Agfa-Gevaert Ag, 5090 Leverkusen | Color former for the peroxide color intensification process |
-
1992
- 1992-05-18 FR FR9205980A patent/FR2691145A1/en active Pending
-
1993
- 1993-05-14 JP JP5519944A patent/JPH07506585A/en active Pending
- 1993-05-14 EP EP93910121A patent/EP0641311A1/en not_active Withdrawn
- 1993-05-14 AU AU40756/93A patent/AU4075693A/en not_active Abandoned
- 1993-05-14 WO PCT/FR1993/000468 patent/WO1993023364A1/en not_active Ceased
- 1993-05-17 ZA ZA933426A patent/ZA933426B/en unknown
- 1993-05-17 MX MX9302869A patent/MX9302869A/en unknown
- 1993-05-18 TW TW082103887A patent/TW252095B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0641311A1 (en) | 1995-03-08 |
| FR2691145A1 (en) | 1993-11-19 |
| AU4075693A (en) | 1993-12-13 |
| WO1993023364A1 (en) | 1993-11-25 |
| ZA933426B (en) | 1994-08-02 |
| TW252095B (en) | 1995-07-21 |
| JPH07506585A (en) | 1995-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9307748A (en) | NEW TAXOIDS, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| MX9302869A (en) | NEW DERIVATIVES OF DIHYDROXYBENCILAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| AR042658A1 (en) | DERIVATIVES OF 1,5-DIARIL-PIRROL-3-CARBOXAMIDE AND ITS USE AS CANABINOID RECEIVER MODULATORS | |
| AU8581991A (en) | Mercaptoacetylamide derivatives as inhibitors of enkephalinase and ACE, and processes for their production | |
| NO942994L (en) | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE | |
| DK0705254T3 (en) | Phenyl heterocyclic compounds as cyclooxygenase-2 inhibitors | |
| HUT60258A (en) | Aminokumaran derivatives and process for producing aminokumaran derivatives and pharmaceutical compositions comprising such compounds | |
| NO20030619L (en) | Proline derivatives and their use as pharmaceuticals | |
| PT82724B (en) | PROCESS FOR THE PREPARATION OF DIFLUORO DERIVATIVES CETONA-PEPTIDEES AND A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM | |
| AR042572A1 (en) | DERIVATIVES OF LIPOIC ACID, PROCEDURE FOR THE PREPARATION, MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF SUCH DERIVATIVES FOR THE PREPARATION OF THE REFERRED MEDICATIONS | |
| HUT65278A (en) | Process for producing pyrido-, pyrrolo-, thiazino-, oxazino- and pyrazino-benzazepine derivatives and pharmaceutical preparations containing them | |
| ES2095081T3 (en) | PROCEDURE FOR THE PREPARATION OF TAXANE DERIVATIVES. | |
| ES2136037B1 (en) | SULFAMIDE-METALOPROTEASE INHIBITORS | |
| ES2173683T3 (en) | SUPEROXIDE RADICAL INHIBITOR. | |
| ES2118710T3 (en) | NEW PEPTIDASE INHIBITORS. | |
| ES480109A1 (en) | Imidazolidine derivatives, process for their preparation, intermediates for use in this process, pharmaceutical compositions containing them and the use of the active compounds. | |
| ES2422383T3 (en) | Urea glucokinase activators | |
| ES2043862T3 (en) | PREPARATION PROCEDURE OF 19-NOR-STEROIDS REPLACED IN POSITION 7. | |
| AR013462A1 (en) | NEW PEPTIDOMIMETICOS FOR THE TREATMENT OF BONE DISORDERS, METHODS FOR ITS PRODUCTION AND DRUGS THAT CONTAIN THESE COMPOUNDS | |
| AR041340A1 (en) | DERIVATIVES OF THIAZOLPIRIMIDINONE, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| ES2089709T3 (en) | PIRROLIDINE DERIVATIVES AND PROCEDURE TO PREPARE THEM. | |
| MX9300628A (en) | NEW DERIVATIVES OF TAXANE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM. | |
| AR003456A1 (en) | AN ANALOGUE COMPOUND OF DISTAMICINE AND ITS SALTS, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND USES OF THE SAME. | |
| MX9302915A (en) | NEW DERIVATIVES OF TAXANE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| ES2086442T3 (en) | DERIVATIVES OF FLUOROETILCAMPTOTECINA. |