MX9203242A - Anticuerpos policlonales anti-hirudin y metodo para su produccion. - Google Patents
Anticuerpos policlonales anti-hirudin y metodo para su produccion.Info
- Publication number
- MX9203242A MX9203242A MX9203242A MX9203242A MX9203242A MX 9203242 A MX9203242 A MX 9203242A MX 9203242 A MX9203242 A MX 9203242A MX 9203242 A MX9203242 A MX 9203242A MX 9203242 A MX9203242 A MX 9203242A
- Authority
- MX
- Mexico
- Prior art keywords
- hirudin
- production
- polyclonal antibodies
- leeches
- isoforms
- Prior art date
Links
- 229940006607 hirudin Drugs 0.000 title abstract 2
- 241000545744 Hirudinea Species 0.000 abstract 1
- 102000007625 Hirudins Human genes 0.000 abstract 1
- 108010007267 Hirudins Proteins 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención considera un método simple y reproducible para la producción de anticuerpos poligonales específicos para hirudina e isoformas y proteínas semejantes a la hirudina con actividad de antitrombina, derivadas de diferentes especies de sanguijuelas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911767A IT1248565B (it) | 1991-06-27 | 1991-06-27 | Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9203242A true MX9203242A (es) | 1994-04-29 |
Family
ID=11360217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9203242A MX9203242A (es) | 1991-06-27 | 1992-06-24 | Anticuerpos policlonales anti-hirudin y metodo para su produccion. |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0600901B1 (es) |
| JP (1) | JPH06509070A (es) |
| AU (1) | AU2193792A (es) |
| DE (1) | DE69221882T2 (es) |
| ES (1) | ES2107545T3 (es) |
| IE (1) | IE922081A1 (es) |
| IT (1) | IT1248565B (es) |
| MX (1) | MX9203242A (es) |
| NZ (1) | NZ243355A (es) |
| WO (1) | WO1993000363A1 (es) |
| ZA (1) | ZA924773B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1266561B1 (it) * | 1993-07-22 | 1997-01-09 | Mini Ricerca Scient Tecnolog | Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione |
| CA2144523A1 (en) * | 1993-08-04 | 1995-02-16 | Hugo Grossenbacher | High molecular weight desulphatohirudin |
| US5710413A (en) * | 1995-03-29 | 1998-01-20 | Minnesota Mining And Manufacturing Company | H-field electromagnetic heating system for fusion bonding |
| CN115572329B (zh) * | 2021-06-21 | 2024-02-06 | 王大勇 | 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU554859B2 (en) * | 1981-09-04 | 1986-09-04 | Regents Of The University Of California, The | Polymerized albumin vaccine |
| ES2069726T5 (es) * | 1989-01-25 | 1999-09-16 | Novartis Ag | Anticuerpos monoclonales especificos para hirudina. |
-
1991
- 1991-06-27 IT ITMI911767A patent/IT1248565B/it active IP Right Grant
-
1992
- 1992-06-24 MX MX9203242A patent/MX9203242A/es unknown
- 1992-06-26 EP EP92914181A patent/EP0600901B1/en not_active Expired - Lifetime
- 1992-06-26 WO PCT/EP1992/001448 patent/WO1993000363A1/en not_active Ceased
- 1992-06-26 DE DE69221882T patent/DE69221882T2/de not_active Expired - Fee Related
- 1992-06-26 EP EP19920110856 patent/EP0520502A3/en not_active Withdrawn
- 1992-06-26 ZA ZA924773A patent/ZA924773B/xx unknown
- 1992-06-26 JP JP5501337A patent/JPH06509070A/ja active Pending
- 1992-06-26 AU AU21937/92A patent/AU2193792A/en not_active Abandoned
- 1992-06-26 ES ES92914181T patent/ES2107545T3/es not_active Expired - Lifetime
- 1992-06-29 NZ NZ243355A patent/NZ243355A/xx unknown
- 1992-07-01 IE IE208192A patent/IE922081A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0600901A1 (en) | 1994-06-15 |
| IE922081A1 (en) | 1992-12-30 |
| NZ243355A (en) | 1993-09-27 |
| IT1248565B (it) | 1995-01-19 |
| ES2107545T3 (es) | 1997-12-01 |
| ZA924773B (en) | 1993-03-31 |
| ITMI911767A1 (it) | 1992-12-27 |
| JPH06509070A (ja) | 1994-10-13 |
| WO1993000363A1 (en) | 1993-01-07 |
| DE69221882D1 (de) | 1997-10-02 |
| DE69221882T2 (de) | 1998-01-02 |
| EP0520502A2 (en) | 1992-12-30 |
| AU2193792A (en) | 1993-01-25 |
| ITMI911767A0 (it) | 1991-06-27 |
| EP0600901B1 (en) | 1997-08-27 |
| EP0520502A3 (en) | 1993-06-23 |
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