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MX2024002440A - Composiciones de acido ribonucleico de interferencia (arni) del efector b similar al factor de fragmentacion de adn subunidad alfa (dffa) que induce la muerte celular (cideb) y metodos de uso de estas. - Google Patents

Composiciones de acido ribonucleico de interferencia (arni) del efector b similar al factor de fragmentacion de adn subunidad alfa (dffa) que induce la muerte celular (cideb) y metodos de uso de estas.

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Publication number
MX2024002440A
MX2024002440A MX2024002440A MX2024002440A MX2024002440A MX 2024002440 A MX2024002440 A MX 2024002440A MX 2024002440 A MX2024002440 A MX 2024002440A MX 2024002440 A MX2024002440 A MX 2024002440A MX 2024002440 A MX2024002440 A MX 2024002440A
Authority
MX
Mexico
Prior art keywords
cideb
compositions
methods
ribonucleic acid
dffa
Prior art date
Application number
MX2024002440A
Other languages
English (en)
Inventor
Mark K Schlegel
James D Mcininch
Adam Castoreno
Jeffrey Zuber
Lucas Bondurant
Dhaval Oza
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2024002440A publication Critical patent/MX2024002440A/es

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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

La invención se refiere a composiciones de ácido ribonucleico de doble hebra (ARNdh) que se dirigen al gen CIDEB, así como a métodos para inhibir la expresión de CIDEB, y métodos para tratar sujetos que se beneficiarían de la reducción en la expresión de CIDEB, tales como sujetos que tienen una enfermedad, trastorno, o afección asociada a CIDEB, mediante el uso de las composiciones de ARNdh.
MX2024002440A 2021-08-31 2022-08-31 Composiciones de acido ribonucleico de interferencia (arni) del efector b similar al factor de fragmentacion de adn subunidad alfa (dffa) que induce la muerte celular (cideb) y metodos de uso de estas. MX2024002440A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163239271P 2021-08-31 2021-08-31
US202263341848P 2022-05-13 2022-05-13
PCT/US2022/075715 WO2023034837A2 (en) 2021-08-31 2022-08-31 Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2024002440A true MX2024002440A (es) 2024-03-08

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MX2024002440A MX2024002440A (es) 2021-08-31 2022-08-31 Composiciones de acido ribonucleico de interferencia (arni) del efector b similar al factor de fragmentacion de adn subunidad alfa (dffa) que induce la muerte celular (cideb) y metodos de uso de estas.

Country Status (10)

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US (2) US20250034567A1 (es)
EP (1) EP4395790A2 (es)
JP (1) JP2024538859A (es)
KR (1) KR20240056561A (es)
AU (1) AU2022339821A1 (es)
CA (1) CA3230404A1 (es)
IL (1) IL311030A (es)
MX (1) MX2024002440A (es)
TW (1) TW202325311A (es)
WO (1) WO2023034837A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023197001A2 (en) * 2022-04-07 2023-10-12 The Board Of Regents Of The University Of Texas System Compositions and methods for treating liver diseases with sirnas targeting cideb
WO2024188164A1 (en) * 2023-03-10 2024-09-19 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of cell death inducing dffa like effector b (cideb)
CN121057817A (zh) * 2023-04-07 2025-12-02 上海轶诺药业有限公司 调控CIDEB mRNA表达的dsRNA分子
WO2025178854A2 (en) * 2024-02-19 2025-08-28 Flagship Pioneering Innovations Vii, Llc Rnai agents targeting cideb and related methods

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