[go: up one dir, main page]

MX2020012652A - Oligonucleotido bicatenario especifico del gen de anfirregulina y composicion para prevenir y tratar enfermedades relacionadas con la fibrosis y enfermedades respiratorias, que comprende el mismo. - Google Patents

Oligonucleotido bicatenario especifico del gen de anfirregulina y composicion para prevenir y tratar enfermedades relacionadas con la fibrosis y enfermedades respiratorias, que comprende el mismo.

Info

Publication number
MX2020012652A
MX2020012652A MX2020012652A MX2020012652A MX2020012652A MX 2020012652 A MX2020012652 A MX 2020012652A MX 2020012652 A MX2020012652 A MX 2020012652A MX 2020012652 A MX2020012652 A MX 2020012652A MX 2020012652 A MX2020012652 A MX 2020012652A
Authority
MX
Mexico
Prior art keywords
standed
fibrosis
dual
preventing
composition
Prior art date
Application number
MX2020012652A
Other languages
English (en)
Other versions
MX420940B (es
Inventor
Tae- Rim KIM
Pyoung Oh Yoon
Youngho Ko
Seon Joo Bae
Han- Oh PARK
Seung Seob Son
Sung Il Yun
Jun-Hong Park
Original Assignee
Bioneer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of MX2020012652A publication Critical patent/MX2020012652A/es
Publication of MX420940B publication Critical patent/MX420940B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un oligonucleótido bicatenario el cual puede inhibir de forma muy específica y eficazmente una expresión de anfirreguiina y, preferentemente, un oligonucleótido bicatenario que comprende una secuencia en la forma de ARNIARN, ADN/ADN, o un híbrido de ADN/ARN, una estructura de oligonucleótido bicatenario que comprende el oligonucleótido bicatenario, nanopartículas que comprende la estructura de oligonucleótido bicatenario, y un uso preventivo o terapéutico de enfermedades fibrosas o respiratorias del mismo.
MX2020012652A 2018-05-25 2019-05-22 Oligonucleótido bicatenario específico del gen de anfirregulina y composición para prevenir y tratar enfermedades relacionadas con la fibrosis y enfermedades respiratorias, que comprende el mismo. MX420940B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180059783 2018-05-25
PCT/KR2019/006144 WO2019225968A1 (ko) 2018-05-25 2019-05-22 엠피레귤린 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물

Publications (2)

Publication Number Publication Date
MX2020012652A true MX2020012652A (es) 2021-05-27
MX420940B MX420940B (es) 2025-02-10

Family

ID=68617387

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012652A MX420940B (es) 2018-05-25 2019-05-22 Oligonucleótido bicatenario específico del gen de anfirregulina y composición para prevenir y tratar enfermedades relacionadas con la fibrosis y enfermedades respiratorias, que comprende el mismo.

Country Status (12)

Country Link
US (4) US20210189398A1 (es)
EP (1) EP3816285A4 (es)
JP (2) JP7154403B2 (es)
KR (1) KR102746742B1 (es)
CN (2) CN119685309A (es)
AU (2) AU2019272190B2 (es)
BR (1) BR112020023968A2 (es)
MX (1) MX420940B (es)
MY (1) MY199134A (es)
SA (1) SA520420620B1 (es)
WO (1) WO2019225968A1 (es)
ZA (2) ZA202008040B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119685309A (zh) 2018-05-25 2025-03-25 柏业公司 用于预防和治疗纤维化相关疾病和呼吸系统疾病的双调蛋白基因特异性双链寡核苷酸和包含其的组合物
AU2019448656C1 (en) * 2019-05-30 2024-05-30 National Institute Of Biological Sciences, Beijing Drug target of idiopathic pulmonary fibrosis
AU2021252813B2 (en) * 2020-04-10 2025-01-09 Bioneer Corporation Composition using urine sample for diagnosis of kidney disease
CA3178609A1 (en) * 2020-05-14 2021-11-18 Jun Hong Park Composition for preventing or treating obesity-related disease containing amphiregulin-specific double-stranded oligonucleotide structure
BR112022023408A2 (pt) * 2020-05-22 2023-01-31 Bioneer Corp Oligonucleotídeo de fita dupla e composição para tratar covid-19 contendo o mesmo
CA3210813A1 (en) * 2021-03-08 2022-09-15 Han-Oh Park Composition for administration of double-stranded oligonucleotide structures using ultrasonic nebulizer for prevention or treatment of respiratory viral infection including covid-19, pulmonary fibrosis caused by viral infection, or respiratory disease
CN116966302B (zh) * 2023-06-28 2025-11-25 华中科技大学同济医学院附属协和医院 Areg的新用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034323A (en) 1989-03-30 1991-07-23 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5231020A (en) 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US6277967B1 (en) 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
EP1449538A1 (en) * 2003-02-21 2004-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation
US7700299B2 (en) * 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
KR100883471B1 (ko) 2005-08-17 2009-02-16 (주)바이오니아 siRNA의 세포내 전달을 위한 siRNA와 친수성 고분자 간의접합체 및 그의 제조방법
CA2683109A1 (en) * 2006-10-11 2008-04-17 Fusion Antibodies Limited Combination therapy
EP2096171A1 (en) 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
KR101224828B1 (ko) 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
MX2012012075A (es) * 2010-04-18 2013-04-11 Yeda Res & Dev Moleculas y metodos para usarlas para tratar enfermedades asociadas con ligandos erbb/erbb.
KR101241852B1 (ko) * 2012-06-28 2013-03-11 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
EP2905337A4 (en) * 2012-10-05 2016-10-12 Bioneer Corp AMPHIREGULIN SPECIFIC DOUBLE HELIX OLIGO RNA, DOUBLE HELIX OLIGO RNA STRUCTURE WITH THE DOUBLE HELIX OLIGO RNA AND COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASES THEREWITH
BR112016023004B1 (pt) * 2014-04-04 2023-12-05 Bioneer Corporation Sirna, estrutura oligo rna de fita dupla, nanopartícula, composição farmacêutica e estrutura liofilizada para prevenir ou tratar fibrose ou doenças respiratórias contendo a mesma
CA2966092A1 (en) 2014-12-30 2016-07-07 Curevac Ag Artificial nucleic acid molecules
WO2016204515A1 (ko) * 2015-06-15 2016-12-22 (주)바이오니아 STAT3 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체, 이를 포함하는 조성물 및 이의 용도
CN119685309A (zh) 2018-05-25 2025-03-25 柏业公司 用于预防和治疗纤维化相关疾病和呼吸系统疾病的双调蛋白基因特异性双链寡核苷酸和包含其的组合物

Also Published As

Publication number Publication date
JP7645849B2 (ja) 2025-03-14
US20210189398A1 (en) 2021-06-24
JP2021525103A (ja) 2021-09-24
SA520420620B1 (ar) 2024-03-17
CA3101320A1 (en) 2019-11-28
US12037589B2 (en) 2024-07-16
KR20190134506A (ko) 2019-12-04
MY199134A (en) 2023-10-17
ZA202206418B (en) 2025-08-27
JP2023002587A (ja) 2023-01-10
ZA202008040B (en) 2023-02-22
US20230203494A1 (en) 2023-06-29
JP7154403B2 (ja) 2022-10-17
MX420940B (es) 2025-02-10
CN119685309A (zh) 2025-03-25
BR112020023968A2 (pt) 2021-02-23
AU2019272190A1 (en) 2020-12-17
EP3816285A1 (en) 2021-05-05
AU2023201262A1 (en) 2023-04-27
AU2023201262B2 (en) 2025-08-21
AU2019272190B2 (en) 2022-12-01
KR102746742B1 (ko) 2024-12-26
EP3816285A4 (en) 2022-03-16
CN112368382A (zh) 2021-02-12
US20230332154A1 (en) 2023-10-19
WO2019225968A1 (ko) 2019-11-28
CN112368382B (zh) 2024-11-01
US20250207137A1 (en) 2025-06-26

Similar Documents

Publication Publication Date Title
MX2020012652A (es) Oligonucleotido bicatenario especifico del gen de anfirregulina y composicion para prevenir y tratar enfermedades relacionadas con la fibrosis y enfermedades respiratorias, que comprende el mismo.
MX2025007610A (es) Composiciones de arni de 17beta-hidroxiesteroide deshidrogenasa tipo 13 (hsd17b13) y metodos de uso de las mismas
CR20240003A (es) Restos de administración terapéutica novedosos y usos de estos
CO2019003846A2 (es) Tratamiento aav de la enfermedad de huntington
MX2016000019A (es) (arnip) gen especifico relacionado con las enfermedades respiratorias, (arnip) que contiene la estructura arn oligo helicoidal, composicion que contiene la misma para prevencion o tratamiento de las enfermedades respiratorias.
EA201591281A1 (ru) Рибонуклеиновые кислоты с 4'-тиомодифицированными нуклеотидами и связанные с ними способы
CL2020002704A1 (es) Terapia de gen para enfermedades causadas por combinaciones desequilibradas de nucleótidos que incluyen síndromes de agotamiento de adn mitocondrial
MX2019005816A (es) Agentes de arn modificados con efecto reducido fuera de la diana.
WO2015106128A3 (en) Rnai agents modified at the 4'-c-position
AR107579A1 (es) Composiciones y métodos para disminuir la expresión de tau
BR112016029781A2 (pt) composições e métodos para inibir a expressão de gene de alfa-1 antitripsina
CO2021002691A2 (es) Composiciones y métodos para editar el gen hidroxiácido oxidasa 1 (hao1) para tratar la hiperoxaluria primaria tipo 1 (ph1)
CY1120084T1 (el) Oλiγονουκλεοτiδiα για τη ρυθμιση της γονιδιακης εκφρασης και οι χρησεις αυτων
MX388737B (es) Oligonucleótidos terapéuticos.
MX2017011298A (es) Métodos para tratar cáncer que albergan la pérdida hemicigota de tp53.
CO2023018579A2 (es) Composiciones del agente de arni de la cinasa de repetición 2 rica en leucina (lrrk2 ) y métodos de uso de estas
ES2536638T3 (es) Alteración dirigida de ADN
CO2022001192A2 (es) Partículas virales para uso en el tratamiento de sinucleinopatías tal como enfermedad de parkinson mediante terapia génica
AR083445A1 (es) siARN CONTRA LA FIBROSIS
MX2022006122A (es) Oligonucleótido de doble hebra específico del gen ctgf, y una composición que comprende el mismo, para prevenir y tratar enfermedades fibróticas y enfermedades relacionadas con el sistema respiratorio.
MX2018013885A (es) Métodos de tratamiento de enfermedades asociadas con células linfoides innatas del grupo 3 (cli3).
BR112022022868A2 (pt) Composição para prevenir ou tratar doença relacionada à obesidade contendo estrutura de oligonucleotídeo de fita dupla específico de anfiregulina
AR117458A1 (es) COMPOSICIONES DE AGENTES DE ARNi PARA LA PROTEÍNA PRECURSORA AMILOIDE (APP) Y SUS MÉTODOS DE USO
RU2014142752A (ru) Способы воздействия на экспрессию гена лактазы
RU2014142754A (ru) Способы воздействия на экспрессию гена алкогольдегидрогеназы