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MX2024002182A - Proteinas de union al factor de crecimiento transformante receptor beta ii (tgf-beta-rii). - Google Patents

Proteinas de union al factor de crecimiento transformante receptor beta ii (tgf-beta-rii).

Info

Publication number
MX2024002182A
MX2024002182A MX2024002182A MX2024002182A MX2024002182A MX 2024002182 A MX2024002182 A MX 2024002182A MX 2024002182 A MX2024002182 A MX 2024002182A MX 2024002182 A MX2024002182 A MX 2024002182A MX 2024002182 A MX2024002182 A MX 2024002182A
Authority
MX
Mexico
Prior art keywords
antibody
tgf
beta
antibody fragment
binding proteins
Prior art date
Application number
MX2024002182A
Other languages
English (en)
Inventor
Mark Throsby
Kruif Cornelis Adriaan De
Rinse Klooster
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv filed Critical Merus Nv
Publication of MX2024002182A publication Critical patent/MX2024002182A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C07K16/11—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un anticuerpo o fragmento de anticuerpo del mismo que específicamente se une al dominio extracelular de TGF-ßRII humano. La presente invención además se refiere a un vector que comprende un polinucleótido que codifica el anticuerpo o fragmento de anticuerpo de la invención, una célula aislada que produce el anticuerpo o fragmento de anticuerpo de la invención, y una composición farmacéutica que comprende el anticuerpo o fragmento de anticuerpo de la invención. El anticuerpo o fragmento de anticuerpo de la invención se puede usar para tratar cáncer.
MX2024002182A 2019-12-24 2022-06-23 Proteinas de union al factor de crecimiento transformante receptor beta ii (tgf-beta-rii). MX2024002182A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2024576 2019-12-24

Publications (1)

Publication Number Publication Date
MX2024002182A true MX2024002182A (es) 2024-05-03

Family

ID=69700252

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2022007919A MX2022007919A (es) 2019-12-24 2020-12-22 Proteinas de union al factor de crecimiento transformante receptor beta ii (tgf-beta-rii).
MX2024002182A MX2024002182A (es) 2019-12-24 2022-06-23 Proteinas de union al factor de crecimiento transformante receptor beta ii (tgf-beta-rii).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2022007919A MX2022007919A (es) 2019-12-24 2020-12-22 Proteinas de union al factor de crecimiento transformante receptor beta ii (tgf-beta-rii).

Country Status (13)

Country Link
US (1) US20250270331A1 (es)
EP (2) EP4081306A1 (es)
JP (3) JP7633259B2 (es)
KR (2) KR20220117267A (es)
CN (3) CN115038497A (es)
AR (2) AR120914A1 (es)
AU (1) AU2023200779A1 (es)
BR (1) BR112022012522A2 (es)
IL (2) IL294181A (es)
MX (2) MX2022007919A (es)
PH (1) PH12022551527A1 (es)
TW (2) TW202417513A (es)
WO (1) WO2021133167A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115038497A (zh) * 2019-12-24 2022-09-09 美勒斯公司 TGF-β-RII结合蛋白质
KR20240101664A9 (ko) * 2021-11-19 2025-12-10 메뤼스 엔.페. Pd-1 및 tgf-brii 결합 도메인을 포함하는 다중특이성 결합 모이어티
AU2023410354A1 (en) 2022-12-20 2025-07-31 Incyte Corporation FAP BINDING DOMAINS AND BISPECIFIC BINDING MOIETIES THAT BIND FAP AND TGF-βRII

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001206899A (ja) * 1999-11-18 2001-07-31 Japan Tobacco Inc ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途
CA2872136C (en) 2002-07-18 2017-06-20 Merus B.V. Recombinant production of mixtures of antibodies
PT2147594E (pt) 2008-06-27 2014-02-17 Merus B V Mamíferos não humanos que produzem anticorpos
JO3096B1 (ar) 2008-11-07 2017-03-15 Imclone Llc الأجسام المضادة لمستقبل ii مضاد tgfb
JP6062375B2 (ja) 2011-01-06 2017-01-18 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｔｇｆ−ベータ受容体ｉｉに結合するリガンド
SG10201705787VA (en) 2012-09-27 2017-08-30 Merus Nv BISPECIFIC IgG ANTIBODIES AS T CELL ENGAGERS
JP2018527903A (ja) * 2015-07-22 2018-09-27 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． Ｇｄｆ１１結合タンパク質およびその使用
TW201825519A (zh) * 2016-10-18 2018-07-16 美商美國禮來大藥廠 TGFβ受體II抗體
US11952424B2 (en) 2018-03-30 2024-04-09 Merus N.V. Multivalent antibody
CN115038497A (zh) * 2019-12-24 2022-09-09 美勒斯公司 TGF-β-RII结合蛋白质

Also Published As

Publication number Publication date
KR20220117267A (ko) 2022-08-23
BR112022012522A2 (pt) 2022-09-06
AU2020412201A1 (en) 2022-07-14
PH12022551527A1 (en) 2024-01-29
WO2021133167A1 (en) 2021-07-01
MX2022007919A (es) 2022-07-27
CA3165605A1 (en) 2021-07-01
IL304317A (en) 2023-09-01
EP4269433A2 (en) 2023-11-01
AU2023200779A1 (en) 2023-03-09
TW202417513A (zh) 2024-05-01
EP4269433A3 (en) 2024-05-22
AR130991A2 (es) 2025-02-05
TW202128747A (zh) 2021-08-01
IL294181A (en) 2022-08-01
US20250270331A1 (en) 2025-08-28
JP2023076596A (ja) 2023-06-01
KR20230145542A (ko) 2023-10-17
JP2023508202A (ja) 2023-03-01
CN115038497A (zh) 2022-09-09
EP4081306A1 (en) 2022-11-02
CN116375869A (zh) 2023-07-04
CN116199780A (zh) 2023-06-02
JP7633259B2 (ja) 2025-02-19
AR120914A1 (es) 2022-03-30
JP2025083342A (ja) 2025-05-30

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