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MX2018007295A - Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos. - Google Patents

Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos.

Info

Publication number
MX2018007295A
MX2018007295A MX2018007295A MX2018007295A MX2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A
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MX
Mexico
Prior art keywords
specific
disease
antigen
lymphocytes
cells
Prior art date
Application number
MX2018007295A
Other languages
English (en)
Inventor
Mccauley Scott
Brian MUMM John
Ho CHAN Ivan
Oft Martin
Ogg Scott
Original Assignee
Armo Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armo Biosciences Inc filed Critical Armo Biosciences Inc
Publication of MX2018007295A publication Critical patent/MX2018007295A/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • A61K2239/50—Colon
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    • C12Q2600/00—Oligonucleotides characterized by their use
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Abstract

La presente descripción proporciona métodos y composiciones que se relacionan con linfocitos T CD8+ aislados que expresan un receptor de linfocitos T especifico del antígeno de una enfermedad, así como ácidos nucleicos que codifican los pares de polipéptidos Va y V13 de los receptores de linfocitos T (TCR) de tales linfocitos T específicos del antígeno de la enfermedad. Tales linfocitos T CD8+ específicos del antígeno de la enfermedad se pueden obtener de la periferia (por ejemplo, la sangre) de un sujeto que padece una enfermedad susceptible de tratamiento con un agente de 1L-10. La presente descripción también contempla métodos terapéuticos y composiciones que se relacionan con la administración de linfocitos T CD8+ específicos del antígeno de la enfermedad aislados a un sujeto, así como métodos terapéuticos y composiciones relacionadas con linfocitos T CD8+ modificados genéticamente para expresar un TCP especifico del antígeno de la enfermedad y/o el receptor del antígeno quimérico.
MX2018007295A 2016-01-11 2017-01-10 Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos. MX2018007295A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277442P 2016-01-11 2016-01-11
PCT/US2017/012882 WO2017123557A1 (en) 2016-01-11 2017-01-10 Interleukin-10 in production of antigen-specific cd8+ t cells and methods of use of same

Publications (1)

Publication Number Publication Date
MX2018007295A true MX2018007295A (es) 2019-03-28

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MX2018007295A MX2018007295A (es) 2016-01-11 2017-01-10 Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos.

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Country Link
US (1) US11814679B2 (es)
EP (1) EP3402512A4 (es)
JP (1) JP7082051B2 (es)
KR (1) KR20180101417A (es)
CN (1) CN108697776A (es)
AU (1) AU2017207282A1 (es)
CA (1) CA3008287A1 (es)
MX (1) MX2018007295A (es)
WO (1) WO2017123557A1 (es)

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