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MX2023012611A - Proceso para la sintesis de apremilast. - Google Patents

Proceso para la sintesis de apremilast.

Info

Publication number
MX2023012611A
MX2023012611A MX2023012611A MX2023012611A MX2023012611A MX 2023012611 A MX2023012611 A MX 2023012611A MX 2023012611 A MX2023012611 A MX 2023012611A MX 2023012611 A MX2023012611 A MX 2023012611A MX 2023012611 A MX2023012611 A MX 2023012611A
Authority
MX
Mexico
Prior art keywords
apremilast
synthesizing
processes
ethan
methylsulfonyl
Prior art date
Application number
MX2023012611A
Other languages
English (en)
Inventor
Neil Fred Langille
Matthew G Beaver
Carolyn Cohen
Simone Spada
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2023012611A publication Critical patent/MX2023012611A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

En el presente documento, se proporcionan procesos para la síntesis de apremilast, que comprenden hacer reaccionar anhídrido 3-acetamidoftálico y (S)-1-(3-etoxi-4-metoxifenil)-2-(metilsulfoni l)etan-1-amina o una sal de la misma para formar apremilast. También se proporcionan procesos para el aislamiento de apremilast de la mezcla de reacción, tal como se describe en el presente documento.
MX2023012611A 2021-04-26 2022-04-25 Proceso para la sintesis de apremilast. MX2023012611A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163179632P 2021-04-26 2021-04-26
PCT/US2022/026163 WO2022232037A1 (en) 2021-04-26 2022-04-25 Process for synthesizing apremilast

Publications (1)

Publication Number Publication Date
MX2023012611A true MX2023012611A (es) 2023-11-03

Family

ID=81748612

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023012611A MX2023012611A (es) 2021-04-26 2022-04-25 Proceso para la sintesis de apremilast.

Country Status (9)

Country Link
US (1) US12351555B2 (es)
EP (1) EP4330230A1 (es)
JP (1) JP2024514972A (es)
AR (1) AR125097A1 (es)
AU (1) AU2022268257A1 (es)
CA (1) CA3216107A1 (es)
MX (1) MX2023012611A (es)
TW (1) TW202308995A (es)
WO (1) WO2022232037A1 (es)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2276483T3 (pl) 2008-03-27 2014-09-30 Celgene Corp Stałe postacie zawierające (+)-2-[1-(3-etoksy-4-metoksyfenylo)-2-metylosulfonyloetylo]-4-acetyloaminoizoindolino-1,3-dion, kompozycje je zawierające i ich zastosowania
CZ2015383A3 (cs) * 2015-06-05 2016-12-14 Zentiva, K.S. Způsob přípravy klíčového intermediátu apremilastu, využívající enzymatické štěpení racemických aminů
JP2018518489A (ja) 2015-06-09 2018-07-12 ドクター レディズ ラボラトリーズ リミテッド アプレミラスト及びその中間体の調製方法
WO2017033116A1 (en) 2015-08-26 2017-03-02 Glenmark Pharmaceuticals Limited Process for preparation of apremilast
US9765026B2 (en) 2015-08-28 2017-09-19 Scinopharm Taiwan, Ltd. Forms of apremilast and the process of making the same
CN105085373B (zh) 2015-09-01 2018-02-09 苏州大学 一种对阿普斯特产品的纯化方法
WO2017059040A1 (en) 2015-09-29 2017-04-06 Pliva Hrvatska D.O.O. Processes for the preparation of apremilast and intermediates thereof
US10919855B2 (en) 2017-05-04 2021-02-16 Unichem Laboratories Ltd Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide
WO2019021303A1 (en) 2017-07-23 2019-01-31 Alkem Laboratories Limited NOVEL PROCESS FOR THE PREPARATION OF APREMILAST IN AMORPHOUS FORM
CN107698485A (zh) 2017-11-23 2018-02-16 中山奕安泰医药科技有限公司 一种高纯度阿普斯特的精制制备工艺
CN111039846A (zh) 2018-10-15 2020-04-21 重庆医药工业研究院有限责任公司 一种阿普斯特杂质化合物及其用途

Also Published As

Publication number Publication date
TW202308995A (zh) 2023-03-01
JP2024514972A (ja) 2024-04-03
US12351555B2 (en) 2025-07-08
WO2022232037A1 (en) 2022-11-03
AU2022268257A1 (en) 2023-10-05
AR125097A1 (es) 2023-06-07
EP4330230A1 (en) 2024-03-06
US20220348542A1 (en) 2022-11-03
CA3216107A1 (en) 2022-11-03

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