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MX2023005452A - Deteccion de beta amiloide por espectrometria de masas. - Google Patents

Deteccion de beta amiloide por espectrometria de masas.

Info

Publication number
MX2023005452A
MX2023005452A MX2023005452A MX2023005452A MX2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A
Authority
MX
Mexico
Prior art keywords
amyloid beta
mass spectrometry
methods
beta detection
detection
Prior art date
Application number
MX2023005452A
Other languages
English (en)
Inventor
Diana Tran
Darren Weber
Nigel Clarke
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2023005452A publication Critical patent/MX2023005452A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se proporcionan métodos para la detección o cuantificación de beta amiloide. En un aspecto particular, se proporcionan métodos para la detección de beta amiloide o sus fragmentos mediante espectrometría de masas. En otro aspecto, se proporcionan métodos para determinar la relación de beta amiloide 42 (Aß42) a beta amiloide 40 (Aß40). En otro aspecto, se proporcionan métodos para el diagnóstico o pronóstico de la enfermedad de Alzheimer o demencia.
MX2023005452A 2015-09-28 2018-03-28 Deteccion de beta amiloide por espectrometria de masas. MX2023005452A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562234027P 2015-09-28 2015-09-28
US201662277772P 2016-01-12 2016-01-12

Publications (1)

Publication Number Publication Date
MX2023005452A true MX2023005452A (es) 2023-05-26

Family

ID=58407005

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018004017A MX2018004017A (es) 2015-09-28 2016-09-28 Deteccion de beta amiloide por espectrometria de masas.
MX2023005452A MX2023005452A (es) 2015-09-28 2018-03-28 Deteccion de beta amiloide por espectrometria de masas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018004017A MX2018004017A (es) 2015-09-28 2016-09-28 Deteccion de beta amiloide por espectrometria de masas.

Country Status (7)

Country Link
US (3) US11360098B2 (es)
EP (3) EP3356831B1 (es)
JP (3) JP6979401B2 (es)
CN (2) CN117761323B (es)
CA (1) CA3000178C (es)
MX (2) MX2018004017A (es)
WO (1) WO2017058895A1 (es)

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CN109045311B (zh) * 2018-08-29 2021-07-20 王金环 普鲁士蓝纳米mri示踪剂及其制备方法和应用
CN110045046A (zh) * 2019-03-28 2019-07-23 东莞市中鼎检测技术有限公司 一种生鲜食材的预处理方法及氨基酸含量测定方法
CN110441428B (zh) * 2019-08-19 2021-08-24 江南大学 一种快速分析蛋白质及强极性长氨基酸序列糖肽的方法
JP7599867B2 (ja) * 2019-08-23 2024-12-16 Ｊｃｒファーマ株式会社 脳脊髄液に含まれるＨｅｘ４，ｌｙｓｏ－ＧＭ１，Ｆｕｃ－ＧｌｃＮＡｃ－Ａｓｎ，及びｌｙｓｏ－ｓｕｌｆａｔｉｄｅの定量法
WO2021219917A1 (es) * 2020-04-29 2021-11-04 Araclon Biotech, S.L. Procedimientos para la cuantificación de péptidos beta amiloides en plasma mediante espectrometría de masas
CN113527459B (zh) * 2021-06-28 2023-07-11 广州睿徕医学诊断技术有限公司 一种萃取剂及其制备方法与应用
WO2024133743A1 (en) * 2022-12-21 2024-06-27 EM Scientific Limited Method for diagnosing and/or classifying the severity of a neurodegenerative disease
CN117471007B (zh) * 2023-10-31 2024-08-09 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种血浆β-淀粉样蛋白检测方法

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Also Published As

Publication number Publication date
US20170089917A1 (en) 2017-03-30
MX2018004017A (es) 2018-06-27
EP4275777A2 (en) 2023-11-15
EP4548992A2 (en) 2025-05-07
CN117761323B (zh) 2025-02-21
BR112018006018A2 (pt) 2018-11-06
CA3000178A1 (en) 2017-04-06
US20250147041A1 (en) 2025-05-08
EP3356831A4 (en) 2019-08-21
JP2021192038A (ja) 2021-12-16
CN108291916B (zh) 2024-01-02
JP6979401B2 (ja) 2021-12-15
US12163964B2 (en) 2024-12-10
WO2017058895A1 (en) 2017-04-06
US20220349897A1 (en) 2022-11-03
US11360098B2 (en) 2022-06-14
JP7407776B2 (ja) 2024-01-04
EP3356831A1 (en) 2018-08-08
JP2024050535A (ja) 2024-04-10
EP4275777A3 (en) 2024-01-10
CN108291916A (zh) 2018-07-17
EP4548992A3 (en) 2025-07-23
JP2018535398A (ja) 2018-11-29
EP4275777B1 (en) 2025-05-21
CA3000178C (en) 2022-07-12
EP3356831B1 (en) 2023-09-27
CN117761323A (zh) 2024-03-26

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