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MX2018004017A - Deteccion de beta amiloide por espectrometria de masas. - Google Patents

Deteccion de beta amiloide por espectrometria de masas.

Info

Publication number
MX2018004017A
MX2018004017A MX2018004017A MX2018004017A MX2018004017A MX 2018004017 A MX2018004017 A MX 2018004017A MX 2018004017 A MX2018004017 A MX 2018004017A MX 2018004017 A MX2018004017 A MX 2018004017A MX 2018004017 A MX2018004017 A MX 2018004017A
Authority
MX
Mexico
Prior art keywords
amyloid beta
mass spectrometry
methods
beta detection
detection
Prior art date
Application number
MX2018004017A
Other languages
English (en)
Inventor
Tran Diana
WEBER Darren
Clarke Nigel
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2018004017A publication Critical patent/MX2018004017A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se proporcionan métodos para la detección o cuantificación de beta amiloide. En un aspecto particular, se proporcionan métodos para la detección de beta amiloide o sus fragmentos mediante espectrometría de masas. En otro aspecto, se proporcionan métodos para determinar la relación de beta amiloide 42 (Aß42) a beta amiloide 40 (Aß40). En otro aspecto, se proporcionan métodos para el diagnóstico o pronóstico de la enfermedad de Alzheimer o demencia.
MX2018004017A 2015-09-28 2016-09-28 Deteccion de beta amiloide por espectrometria de masas. MX2018004017A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562234027P 2015-09-28 2015-09-28
US201662277772P 2016-01-12 2016-01-12
PCT/US2016/054148 WO2017058895A1 (en) 2015-09-28 2016-09-28 Amyloid beta detection by mass spectrometry

Publications (1)

Publication Number Publication Date
MX2018004017A true MX2018004017A (es) 2018-06-27

Family

ID=58407005

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018004017A MX2018004017A (es) 2015-09-28 2016-09-28 Deteccion de beta amiloide por espectrometria de masas.
MX2023005452A MX2023005452A (es) 2015-09-28 2018-03-28 Deteccion de beta amiloide por espectrometria de masas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023005452A MX2023005452A (es) 2015-09-28 2018-03-28 Deteccion de beta amiloide por espectrometria de masas.

Country Status (7)

Country Link
US (3) US11360098B2 (es)
EP (3) EP3356831B1 (es)
JP (3) JP6979401B2 (es)
CN (2) CN117761323B (es)
CA (1) CA3000178C (es)
MX (2) MX2018004017A (es)
WO (1) WO2017058895A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
US11361953B2 (en) * 2017-07-31 2022-06-14 Quest Diagnostics Investments Incoporated Apolipoprotein E isotype detection by mass spectrometry
CN109045311B (zh) * 2018-08-29 2021-07-20 王金环 普鲁士蓝纳米mri示踪剂及其制备方法和应用
CN110045046A (zh) * 2019-03-28 2019-07-23 东莞市中鼎检测技术有限公司 一种生鲜食材的预处理方法及氨基酸含量测定方法
CN110441428B (zh) * 2019-08-19 2021-08-24 江南大学 一种快速分析蛋白质及强极性长氨基酸序列糖肽的方法
JP7599867B2 (ja) * 2019-08-23 2024-12-16 Ｊｃｒファーマ株式会社 脳脊髄液に含まれるＨｅｘ４，ｌｙｓｏ－ＧＭ１，Ｆｕｃ－ＧｌｃＮＡｃ－Ａｓｎ，及びｌｙｓｏ－ｓｕｌｆａｔｉｄｅの定量法
US20230258651A1 (en) * 2020-04-29 2023-08-17 Araclon Biotech, S.L Methods for quantification of amyloid beta peptides in plasma by mass spectrometry
CN113527459B (zh) * 2021-06-28 2023-07-11 广州睿徕医学诊断技术有限公司 一种萃取剂及其制备方法与应用
WO2024133743A1 (en) * 2022-12-21 2024-06-27 EM Scientific Limited Method for diagnosing and/or classifying the severity of a neurodegenerative disease
CN117471007B (zh) * 2023-10-31 2024-08-09 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种血浆β-淀粉样蛋白检测方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774175A (en) * 1985-03-01 1988-09-27 Centocor, Inc. Immunochemical methods for the detection of antibody against HTLV-III
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
ES2201077T3 (es) 1993-05-28 2004-03-16 Baylor College Of Medicine Metodo y espectrometro de masas para la desorcion e ionizacion de analitos.
US5772874A (en) 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
DK0840893T3 (da) 1996-01-19 2000-04-03 Cohesive Tech Inc Fremgangsmåde og apparat til højeffektiv væskekromatografi
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
JP2002502086A (ja) 1998-01-23 2002-01-22 アナリティカ オブ ブランフォード インコーポレーテッド 表面からの質量分光測定
EP1115845A2 (en) * 1998-09-21 2001-07-18 Isis Innovation Limited Fibrils
US20040226056A1 (en) * 1998-12-22 2004-11-11 Myriad Genetics, Incorporated Compositions and methods for treating neurological disorders and diseases
SE0103084D0 (sv) 2001-09-14 2001-09-14 Amersham Pharm Biotech Ab Generation of ion exchange media
US20040096907A1 (en) 2002-11-06 2004-05-20 Bernd Bohrmann Quantification of beta amyloid
WO2006046644A1 (ja) * 2004-10-28 2006-05-04 Sanko Junyaku Co., Ltd. アルツハイマー病の検定方法及び診断試薬
WO2006107814A2 (en) * 2005-04-06 2006-10-12 Washington University In St. Louis Methods for measuring the metabolism of neurally derived biomolecules in vivo
JP2008547003A (ja) * 2005-06-16 2008-12-25 バーミリオン， インコーポレイテッド アルツハイマー病についてのバイオマーカーとしての神経分泌タンパク質ｖｇｆのフラグメント
US20070134802A1 (en) * 2005-06-30 2007-06-14 Heinz Doebeli Ionization modifier for mass spectrometry
US20090297534A1 (en) * 2005-07-13 2009-12-03 Sudhir Paul Catalytic Immunoglobulins BBK32 and Uses Therefor
CN101196526A (zh) * 2006-12-06 2008-06-11 许洋 一种结核快速诊断的质谱分析试剂盒和方法
EP2201058B1 (en) * 2007-09-18 2017-04-12 Dako Denmark A/S A rapid and sensitive method for detection of biological targets
JP5080945B2 (ja) * 2007-11-09 2012-11-21 株式会社日立ハイテクノロジーズ 質量分析装置および質量分析方法
WO2009062152A1 (en) * 2007-11-09 2009-05-14 Washington University In St. Louis Methods for measuring the metabolism of cns derived biomolecules in vivo
US20090134325A1 (en) * 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US8916385B2 (en) 2007-12-13 2014-12-23 Quest Diagnostics Investments, Inc. Methods for detecting estrone by mass spectrometry
AU2014265047A1 (en) * 2008-11-12 2014-12-11 The Washington University Simultaneous measurement of the in vivo metabolism of isoforms of a biomolecule
EP2373988B1 (en) 2008-12-05 2015-02-18 C2N Diagnostics Methods for measuring concentrations of biomolecules
MX2011012933A (es) 2009-06-02 2012-03-07 Univ Texas Identificacion de moleculas pequeñas reconocidas por los anticuerpos en sujetos con enfermedades neurodegerativas.
EP3381466B1 (en) * 2009-11-05 2024-05-29 Quest Diagnostics Investments Incorporated Quantitation of insulin-like growth factor-i and insulin-like growth factor-ii with high-resolution mass spectrometry
WO2011092796A1 (ja) * 2010-01-28 2011-08-04 パナソニック株式会社 アミロイドβ測定方法
DE102010026094B4 (de) * 2010-07-05 2012-01-12 Sigeng Han Ein neues Verfahren zum Charakterisieren und multidimensionalen Darstellen des Faltungsvorgangs der Proteine
MY164038A (en) 2010-10-29 2017-11-15 Thermo Fisher Scientific Oy System layout for an automated system for sample preparation and analysis
AU2012359020B2 (en) 2011-12-19 2017-04-13 The Washington University Methods for diagnosing Alzheimer's disease
EP3392344B1 (en) * 2012-09-20 2021-10-27 Quest Diagnostics Investments Incorporated Thyroglobulin quantitation by mass spectroscopy
EP3304084B1 (en) 2015-06-08 2022-03-23 Arquer Diagnostics Limited Methods and kits
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry

Also Published As

Publication number Publication date
EP3356831A4 (en) 2019-08-21
JP2021192038A (ja) 2021-12-16
EP4548992A2 (en) 2025-05-07
JP2018535398A (ja) 2018-11-29
JP6979401B2 (ja) 2021-12-15
EP3356831A1 (en) 2018-08-08
CN108291916A (zh) 2018-07-17
WO2017058895A1 (en) 2017-04-06
EP4275777B1 (en) 2025-05-21
JP7407776B2 (ja) 2024-01-04
CN117761323A (zh) 2024-03-26
CN108291916B (zh) 2024-01-02
MX2023005452A (es) 2023-05-26
CA3000178C (en) 2022-07-12
CA3000178A1 (en) 2017-04-06
JP2024050535A (ja) 2024-04-10
EP4275777A2 (en) 2023-11-15
US20250147041A1 (en) 2025-05-08
US20220349897A1 (en) 2022-11-03
EP4548992A3 (en) 2025-07-23
EP3356831B1 (en) 2023-09-27
US20170089917A1 (en) 2017-03-30
US12163964B2 (en) 2024-12-10
BR112018006018A2 (pt) 2018-11-06
EP4275777A3 (en) 2024-01-10
US11360098B2 (en) 2022-06-14
CN117761323B (zh) 2025-02-21

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