MX2023000044A - Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. - Google Patents
Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble.Info
- Publication number
- MX2023000044A MX2023000044A MX2023000044A MX2023000044A MX2023000044A MX 2023000044 A MX2023000044 A MX 2023000044A MX 2023000044 A MX2023000044 A MX 2023000044A MX 2023000044 A MX2023000044 A MX 2023000044A MX 2023000044 A MX2023000044 A MX 2023000044A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- guanylate cyclase
- soluble guanylate
- intermediaries
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procesos nuevos para la preparación de compuestos de Fórmula I. Algunos de estos compuestos son de utilidad como estimulantes de la guanilato ciclasa soluble (sGC). Otros son intermediarios para usar en la preparación de los estimulantes. Estos procesos son adecuados para preparaciones a gran escala y producen 3-(2-pirimidinil)pirazoles de la Fórmula I estables, de gran pureza y rendimientos elevados. La invención ofrece la ventaja adicional de comprender condiciones de reacción sencillas, adecuadas para aumentar la escala en una producción a gran escala. También se proveen nuevos intermediarios para usar en la preparación de los compuestos. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862615678P | 2018-01-10 | 2018-01-10 | |
| PCT/CN2018/076982 WO2019161534A1 (en) | 2018-02-22 | 2018-02-22 | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023000044A true MX2023000044A (es) | 2023-02-01 |
Family
ID=65279655
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007364A MX2020007364A (es) | 2018-01-10 | 2019-01-10 | Nuevos procesos e intermediarios para la preparación de estimulantes de guanilato ciclasa soluble. |
| MX2023000045A MX2023000045A (es) | 2018-01-10 | 2020-07-13 | Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. |
| MX2023000044A MX2023000044A (es) | 2018-01-10 | 2020-07-13 | Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007364A MX2020007364A (es) | 2018-01-10 | 2019-01-10 | Nuevos procesos e intermediarios para la preparación de estimulantes de guanilato ciclasa soluble. |
| MX2023000045A MX2023000045A (es) | 2018-01-10 | 2020-07-13 | Nuevos procesos e intermediarios para la preparacion de estimulantes de guanilato ciclasa soluble. |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US11274096B2 (es) |
| EP (3) | EP4570797A3 (es) |
| JP (2) | JP7357621B2 (es) |
| KR (3) | KR102739727B1 (es) |
| CN (3) | CN111902410B (es) |
| AU (2) | AU2019206560B2 (es) |
| BR (1) | BR112020013985A2 (es) |
| CA (1) | CA3087943A1 (es) |
| CL (3) | CL2020001814A1 (es) |
| ES (1) | ES2963447T3 (es) |
| IL (3) | IL314714A (es) |
| JO (1) | JOP20200165A1 (es) |
| MA (2) | MA71753A (es) |
| MX (3) | MX2020007364A (es) |
| SG (1) | SG11202006311SA (es) |
| TW (2) | TWI888947B (es) |
| WO (1) | WO2019140095A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA45603A (fr) * | 2016-07-07 | 2019-05-15 | Ironwood Pharmaceuticals Inc | Nouveaux procédés de préparation de stimulateurs de la guanylate cyclase soluble |
| JOP20200165A1 (ar) | 2018-01-10 | 2022-10-30 | Cyclerion Therapeutics Inc | عمليات ووسائط جديدة لتحضير محفزات إنزيم حلقي جوانيلات قابلة للذوبان |
| WO2024131850A1 (zh) * | 2022-12-21 | 2024-06-27 | 广东东阳光药业股份有限公司 | 氟取代的吲唑化合物的晶型及其用途 |
| EP4640677A1 (en) * | 2022-12-21 | 2025-10-29 | Sunshine Lake Pharma Co., Ltd. | Crystal form of fluorine-substituted indazole compound and use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107021951B (zh) * | 2010-06-30 | 2020-10-20 | 赛克里翁治疗有限公司 | sGC刺激物 |
| CN109369635B (zh) * | 2013-03-15 | 2023-06-30 | 赛克里翁治疗有限公司 | 化合物或其药学上可接受的盐及其应用和药物组合物 |
| WO2015106268A1 (en) * | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
| EP3194382B1 (en) * | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Pyrazole derivatives as sgc stimulators |
| KR20170055531A (ko) * | 2014-09-17 | 2017-05-19 | 아이언우드 파마슈티컬스, 인코포레이티드 | 에스지씨 자극제 |
| CN116637076A (zh) * | 2015-11-30 | 2023-08-25 | 赛克里翁治疗有限公司 | 包含sGC刺激剂的固体分散体 |
| SG11201900125PA (en) | 2016-07-07 | 2019-02-27 | Ironwood Pharmaceuticals Inc | Novel processes for preparation of soluble guanylate cyclase stimulators |
| MA45603A (fr) | 2016-07-07 | 2019-05-15 | Ironwood Pharmaceuticals Inc | Nouveaux procédés de préparation de stimulateurs de la guanylate cyclase soluble |
| JOP20200165A1 (ar) | 2018-01-10 | 2022-10-30 | Cyclerion Therapeutics Inc | عمليات ووسائط جديدة لتحضير محفزات إنزيم حلقي جوانيلات قابلة للذوبان |
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2019
- 2019-01-10 JO JOP/2020/0165A patent/JOP20200165A1/ar unknown
- 2019-01-10 ES ES19703440T patent/ES2963447T3/es active Active
- 2019-01-10 TW TW112138274A patent/TWI888947B/zh active
- 2019-01-10 MA MA71753A patent/MA71753A/fr unknown
- 2019-01-10 SG SG11202006311SA patent/SG11202006311SA/en unknown
- 2019-01-10 JP JP2020538535A patent/JP7357621B2/ja active Active
- 2019-01-10 MA MA051565A patent/MA51565A/fr unknown
- 2019-01-10 IL IL314714A patent/IL314714A/en unknown
- 2019-01-10 MX MX2020007364A patent/MX2020007364A/es unknown
- 2019-01-10 KR KR1020207022640A patent/KR102739727B1/ko active Active
- 2019-01-10 WO PCT/US2019/013060 patent/WO2019140095A1/en not_active Ceased
- 2019-01-10 TW TW108101044A patent/TWI821237B/zh active
- 2019-01-10 KR KR1020257010603A patent/KR20250048609A/ko active Pending
- 2019-01-10 IL IL319883A patent/IL319883A/en unknown
- 2019-01-10 AU AU2019206560A patent/AU2019206560B2/en active Active
- 2019-01-10 KR KR1020247039985A patent/KR20250002720A/ko active Pending
- 2019-01-10 CN CN201980017700.2A patent/CN111902410B/zh active Active
- 2019-01-10 CA CA3087943A patent/CA3087943A1/en active Pending
- 2019-01-10 CN CN202410363184.1A patent/CN118221665A/zh active Pending
- 2019-01-10 CN CN202410363182.2A patent/CN118184645A/zh active Pending
- 2019-01-10 US US16/961,109 patent/US11274096B2/en active Active
- 2019-01-10 IL IL275748A patent/IL275748B2/en unknown
- 2019-01-10 EP EP25174051.0A patent/EP4570797A3/en active Pending
- 2019-01-10 EP EP19703440.8A patent/EP3737679B1/en active Active
- 2019-01-10 EP EP23187776.2A patent/EP4249469A3/en active Pending
- 2019-01-10 BR BR112020013985-8A patent/BR112020013985A2/pt unknown
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2020
- 2020-07-07 CL CL2020001814A patent/CL2020001814A1/es unknown
- 2020-07-13 MX MX2023000045A patent/MX2023000045A/es unknown
- 2020-07-13 MX MX2023000044A patent/MX2023000044A/es unknown
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2021
- 2021-10-08 US US17/497,352 patent/US11708361B2/en active Active
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2022
- 2022-04-08 CL CL2022000904A patent/CL2022000904A1/es unknown
- 2022-04-08 CL CL2022000907A patent/CL2022000907A1/es unknown
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2023
- 2023-04-28 US US18/140,966 patent/US12030874B2/en active Active
- 2023-09-26 JP JP2023162922A patent/JP7744955B2/ja active Active
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2024
- 2024-05-22 US US18/671,182 patent/US12275724B2/en active Active
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2025
- 2025-03-31 AU AU2025202281A patent/AU2025202281A1/en active Pending
- 2025-04-11 US US19/176,742 patent/US20250361228A1/en active Pending
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