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MX2022016155A - Soluciones de esteroide neuroactivo y sus metodos de uso. - Google Patents

Soluciones de esteroide neuroactivo y sus metodos de uso.

Info

Publication number
MX2022016155A
MX2022016155A MX2022016155A MX2022016155A MX2022016155A MX 2022016155 A MX2022016155 A MX 2022016155A MX 2022016155 A MX2022016155 A MX 2022016155A MX 2022016155 A MX2022016155 A MX 2022016155A MX 2022016155 A MX2022016155 A MX 2022016155A
Authority
MX
Mexico
Prior art keywords
solution
neuroactive steroid
methods
months
weeks
Prior art date
Application number
MX2022016155A
Other languages
English (en)
Inventor
Francesco G Salituro
William Hunke
Albert Jean Robichaud
Paul Watson
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57546448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022016155(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of MX2022016155A publication Critical patent/MX2022016155A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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    • C—CHEMISTRY; METALLURGY
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    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
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Abstract

Se proporcionan en la presente soluciones acuosas farmacéuticamente aceptables que comprenden un esteroide neuroactivo, una sulfobutil éter beta ciclodextrina y una solución amortiguadora; en donde: la solución es una solución estable entre un pH de alrededor de 3 y alrededor de 9, por ejemplo, a temperatura ambiente, por al menos 1, 2, 3, 4 semanas; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 meses; 1, 2, 3 años o más; la solución amortiguadora se presenta a una concentración de al menos 0.1 nM; o la solución se mantiene sustancialmente libre de impurezas (por ejemplo, la solución está sustancialmente libre de impurezas a temperatura ambiente por al menos 1, 2, 3, 4 semanas; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 meses; 1, 2, 3 años o más).
MX2022016155A 2015-06-18 2017-12-18 Soluciones de esteroide neuroactivo y sus metodos de uso. MX2022016155A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562181550P 2015-06-18 2015-06-18

Publications (1)

Publication Number Publication Date
MX2022016155A true MX2022016155A (es) 2023-02-22

Family

ID=57546448

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017016660A MX2017016660A (es) 2015-06-18 2016-06-17 Soluciones de esteroide neuroactivo y sus metodos de uso.
MX2022012383A MX2022012383A (es) 2015-06-18 2017-12-18 Soluciones de esteroide neuroactivo y sus metodos de uso.
MX2022016155A MX2022016155A (es) 2015-06-18 2017-12-18 Soluciones de esteroide neuroactivo y sus metodos de uso.

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Application Number Title Priority Date Filing Date
MX2017016660A MX2017016660A (es) 2015-06-18 2016-06-17 Soluciones de esteroide neuroactivo y sus metodos de uso.
MX2022012383A MX2022012383A (es) 2015-06-18 2017-12-18 Soluciones de esteroide neuroactivo y sus metodos de uso.

Country Status (21)

Country Link
US (3) US20190008873A1 (es)
EP (1) EP3310394A4 (es)
JP (3) JP2018521987A (es)
KR (1) KR20180018730A (es)
CN (2) CN113181112A (es)
AR (1) AR105044A1 (es)
AU (2) AU2016279000A1 (es)
BR (1) BR112017026909A2 (es)
CA (1) CA2988262A1 (es)
CO (1) CO2018000137A2 (es)
HK (1) HK1246676A1 (es)
IL (3) IL315367A (es)
JO (1) JO3759B1 (es)
MA (1) MA45276A (es)
MX (3) MX2017016660A (es)
PE (2) PE20180489A1 (es)
PH (2) PH12021552011A1 (es)
SG (1) SG10202012285QA (es)
TW (2) TWI805540B (es)
WO (1) WO2016205721A1 (es)
ZA (1) ZA201708412B (es)

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