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MX2022012561A - Composiciones y metodos para silenciar la expresion de la subunidad alfa tipo ix dependiente del voltaje del canal de sodio (scn9a). - Google Patents

Composiciones y metodos para silenciar la expresion de la subunidad alfa tipo ix dependiente del voltaje del canal de sodio (scn9a).

Info

Publication number
MX2022012561A
MX2022012561A MX2022012561A MX2022012561A MX2022012561A MX 2022012561 A MX2022012561 A MX 2022012561A MX 2022012561 A MX2022012561 A MX 2022012561A MX 2022012561 A MX2022012561 A MX 2022012561A MX 2022012561 A MX2022012561 A MX 2022012561A
Authority
MX
Mexico
Prior art keywords
compositions
methods
silencing
scn9a
expression
Prior art date
Application number
MX2022012561A
Other languages
English (en)
Inventor
William Cantley
Mark K Schlegel
James D Mcininch
Adam Castoreno
Charalambos Kaittanis
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2022012561A publication Critical patent/MX2022012561A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Biochemistry (AREA)
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  • Physics & Mathematics (AREA)
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  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Ceramic Products (AREA)
  • Silicon Polymers (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La descripción se refiere a composiciones de ácido ribonucleico de doble cadena (ARNdh) dirigidas a SCN9A, y métodos para usar tales composiciones de ARNdh para alterar (por ejemplo, inhibir) la expresión de SCN9A.
MX2022012561A 2020-04-07 2021-04-06 Composiciones y metodos para silenciar la expresion de la subunidad alfa tipo ix dependiente del voltaje del canal de sodio (scn9a). MX2022012561A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063006328P 2020-04-07 2020-04-07
US202163161313P 2021-03-15 2021-03-15
PCT/US2021/025956 WO2021207189A1 (en) 2020-04-07 2021-04-06 Compositions and methods for silencing scn9a expression

Publications (1)

Publication Number Publication Date
MX2022012561A true MX2022012561A (es) 2022-11-07

Family

ID=75660403

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022012561A MX2022012561A (es) 2020-04-07 2021-04-06 Composiciones y metodos para silenciar la expresion de la subunidad alfa tipo ix dependiente del voltaje del canal de sodio (scn9a).

Country Status (12)

Country Link
US (1) US20230159933A1 (es)
EP (1) EP4133079A1 (es)
JP (1) JP2023521094A (es)
KR (1) KR20230008078A (es)
CN (1) CN116134135A (es)
AU (1) AU2021251754A1 (es)
BR (1) BR112022020227A2 (es)
CA (1) CA3179678A1 (es)
IL (1) IL297130A (es)
MX (1) MX2022012561A (es)
TW (1) TW202204617A (es)
WO (1) WO2021207189A1 (es)

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JP2024519204A (ja) * 2021-04-28 2024-05-09 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 複数の標的を介して疼痛を処置するための治療組成物
EP4405484A2 (en) 2021-09-24 2024-07-31 Alnylam Pharmaceuticals, Inc. Microtubule associated protein tau (mapt) irna agent compositions and methods of use thereof
CA3263767A1 (en) 2022-08-03 2024-02-08 Voyager Therapeutics, Inc. COMPOSITIONS AND PROCESSES ALLOWING CROSSING THE BLOOD-BRAIN BARRIER
WO2024211596A1 (en) * 2023-04-04 2024-10-10 Genedit Inc. siRNA COMPOSITIONS TARGETING SCN9A
TW202521696A (zh) * 2023-11-20 2025-06-01 大陸商上海舶望製藥有限公司 抑制鈉電壓門控通道α亞基9(SCN9A)表達的組合物和方法
WO2025140551A1 (en) 2023-12-29 2025-07-03 Neuro3 Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING NaV1.7 (SCN9A) -ASSOCIATED DISORDERS
WO2025212923A1 (en) * 2024-04-04 2025-10-09 Encoded Therapeutics, Inc. Compositions and methods for reducing nav1.7 expression to treat neuropathic pain

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