[go: up one dir, main page]

MX2022007605A - Metodos de preparacion de n6-((2-azidoetoxi)carbonil)lisina. - Google Patents

Metodos de preparacion de n6-((2-azidoetoxi)carbonil)lisina.

Info

Publication number
MX2022007605A
MX2022007605A MX2022007605A MX2022007605A MX2022007605A MX 2022007605 A MX2022007605 A MX 2022007605A MX 2022007605 A MX2022007605 A MX 2022007605A MX 2022007605 A MX2022007605 A MX 2022007605A MX 2022007605 A MX2022007605 A MX 2022007605A
Authority
MX
Mexico
Prior art keywords
sup
azidoethoxy
lysine
carbonil
carbonyl
Prior art date
Application number
MX2022007605A
Other languages
English (en)
Inventor
Alexander V Shirokov
Nikolai F Sepetov
Randall Scheuerman
Hans Aerni
Original Assignee
Synthorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthorx Inc filed Critical Synthorx Inc
Publication of MX2022007605A publication Critical patent/MX2022007605A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/20—Compounds containing azido groups with azido groups acylated by carboxylic acids
    • C07C247/22—Compounds containing azido groups with azido groups acylated by carboxylic acids with the acylating carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

En la presente se divulgan métodos de preparación N6-((2-azidoetoxi)carbonilo)lisina, N6-((2-azidoetoxi)carbonil)-L- lisina, y N6-((2-azidoetoxi)carbonil)-D-lisina. También se divulgan en la presente los compuestos N2-(terc-butoxicarbonil)-N6 -((2-cloroetoxi)carbonil)-L-lisinato de terc-butilo y N6-((2-azidoetoxi)carbonil)-N2-(terc-butoxicarbonil)-L-lisinato de terc-butilo, y usos de los mismos.
MX2022007605A 2019-12-23 2020-12-22 Metodos de preparacion de n6-((2-azidoetoxi)carbonil)lisina. MX2022007605A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962953089P 2019-12-23 2019-12-23
PCT/US2020/066692 WO2021133839A1 (en) 2019-12-23 2020-12-22 Methods of preparing n6-((2-azidoethoxy)carbonyl)lysine

Publications (1)

Publication Number Publication Date
MX2022007605A true MX2022007605A (es) 2022-07-19

Family

ID=74181388

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022007605A MX2022007605A (es) 2019-12-23 2020-12-22 Metodos de preparacion de n6-((2-azidoetoxi)carbonil)lisina.

Country Status (12)

Country Link
US (1) US20220324792A1 (es)
EP (1) EP4081504A1 (es)
JP (1) JP7579344B2 (es)
KR (1) KR20220118473A (es)
CN (1) CN115087634A (es)
AU (1) AU2020412716A1 (es)
BR (1) BR112022011074A2 (es)
CA (1) CA3162320A1 (es)
IL (1) IL294046A (es)
MX (1) MX2022007605A (es)
TW (1) TWI893037B (es)
WO (1) WO2021133839A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020002272A2 (pt) 2017-08-03 2020-07-28 Synthorx, Inc. conjugados de citocina para o tratamento de doenças autoimunes
TW202031284A (zh) 2018-11-08 2020-09-01 美商新索思股份有限公司 介白素10結合物及其用途
US20200246467A1 (en) 2019-02-06 2020-08-06 Synthorx, Inc. Il-2 conjugates and methods of use thereof
BR112022003046A8 (pt) 2019-08-23 2024-02-06 Synthorx Inc Conjugado de il-15, seu método de preparo e seus usos, bem como composição farmacêutica e método in vitro de expansão de uma ou mais das populações de células t
EP4028060A1 (en) 2019-09-10 2022-07-20 Synthorx, Inc. Il-2 conjugates and methods of use to treat autoimmune diseases
WO2023281480A1 (en) 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Conjugates of checkpoint inhibitors with il-2, and uses thereof
WO2023281484A1 (en) 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Synthetic il-7 and il-7 immunocytokines
JP2024526297A (ja) 2021-07-09 2024-07-17 ブライト ピーク セラピューティクス エージー 抗体コンジュゲートおよびその製造
US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
EP4366779A1 (en) 2021-07-09 2024-05-15 Bright Peak Therapeutics AG Modified tnf-antibodies and uses thereof
US12383631B2 (en) 2022-02-23 2025-08-12 Bright Peak Therapeutics Ag Immune antigen specific IL-18 immunocytokines and uses thereof
WO2023161857A1 (en) 2022-02-23 2023-08-31 Bright Peak Therapeutics Ag Bifunctional cytokine compositions
WO2024150174A1 (en) 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Conditionally activated immunocytokines and methods of use
WO2024150175A1 (en) 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Conditionally activated proteins and methods of use
WO2024150158A1 (en) 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Il-7 polypeptides, immunocytokines comprising same, and uses thereof
US20250186597A1 (en) 2023-08-23 2025-06-12 Bright Peak Therapeutics Ag Targeted immune activation with il-18 immunocytokines
US20250197467A1 (en) 2023-08-23 2025-06-19 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5210925A1 (es) * 1998-11-17 2002-10-30 Novartis Ag Derivados de diamino nitroguanidina tetrasustituidos
WO2012019299A1 (en) * 2010-08-11 2012-02-16 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
JP6571650B2 (ja) * 2013-08-05 2019-09-04 メディミューン リミテッド アミノ酸誘導体
CN104592364B (zh) 2013-10-30 2018-05-01 北京大学 定点突变和定点修饰的腺相关病毒、其制备方法及应用
CN108997168B (zh) * 2018-07-14 2021-09-28 上海应用技术大学 一种含氟非天然赖氨酸衍生物的通用合成方法

Also Published As

Publication number Publication date
TW202132264A (zh) 2021-09-01
CN115087634A (zh) 2022-09-20
JP7579344B2 (ja) 2024-11-07
CA3162320A1 (en) 2021-07-01
TWI893037B (zh) 2025-08-11
US20220324792A1 (en) 2022-10-13
EP4081504A1 (en) 2022-11-02
WO2021133839A1 (en) 2021-07-01
JP2023508884A (ja) 2023-03-06
IL294046A (en) 2022-08-01
KR20220118473A (ko) 2022-08-25
BR112022011074A2 (pt) 2022-08-23
AU2020412716A1 (en) 2022-08-18

Similar Documents

Publication Publication Date Title
MX2022007605A (es) Metodos de preparacion de n6-((2-azidoetoxi)carbonil)lisina.
CY1126152T1 (el) Ενωσεις-αναστολεις της rip1 και μεθοδοι παρασκευης και χρησης αυτων
MX2022005951A (es) Compuestos de pirrolotriazina que actuan como inhibidor de mnk.
MX2020012679A (es) Compuestos de amino-pirazincarboxamida, conjugados, y usos de los mismos.
EA202192137A1 (ru) Конъюгат аматоксинового аналога с разветвленными линкерами
PE20191235A1 (es) Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente
ZA202103867B (en) Tubulysins and protein-tubulysin conjugates
PH12023550032A1 (en) Tubulysins and protein-tubulysin conjugates
CY1117237T1 (el) Συνθεσεις σταθερων τιακουμυκινων
EA202092054A1 (ru) Пиперидинил-3-(арилокси)пропанамиды и пропаноаты
MY207469A (en) Therapeutic compounds
WO2020123836A3 (en) Herboxidiene splicing modulator antibody-drug conjugates and methods of use
DK1294747T3 (da) Syntetiske fremgangsmåder for aplidine og nye antitumorale derivater, fremgangsmåder til fremstilling og anvendelse deraf
WO2021207433A3 (en) Epitopes of sars-cov-2 neutralizing antibodies
ZA202006071B (en) Antiproliferation compounds and uses thereof
MY198008A (en) Crystal of benzofuran derivative free base and preparation method
MX2020013729A (es) Compuestos de cianotriazol y usos de los mismos.
SA521421375B1 (ar) عمليات بديلة لتحضير مركبات تيوبولايسن ومركبات وسيطة منها
MX2020006292A (es) Complejos de carbamato de aminoacidos.
PH12019502852A1 (en) Novel compounds activating the nrf2 pathway
MX2020013684A (es) Formulaciones/composiciones que comprenden ibrutinib.
WO2023096904A3 (en) C-16 modified trioxacarcins, antibody drug conjugates, and uses thereof
CR20210086A (es) Formulaciones de dendrímeros
MX2020006259A (es) Composiciones para la proteccion de cultivos agrarios y uso de las mismas.
MX2021002923A (es) (r)-5-carbamoilpiridin-3-il-2-metil-4-(3-(trifluorometoxi)bencil) piperazin-1-carboxilato cristalino, composiciones y sus metodos de uso.