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MX2022005134A - Metodos para producir celulas del epitelio pigmentario retiniano. - Google Patents

Metodos para producir celulas del epitelio pigmentario retiniano.

Info

Publication number
MX2022005134A
MX2022005134A MX2022005134A MX2022005134A MX2022005134A MX 2022005134 A MX2022005134 A MX 2022005134A MX 2022005134 A MX2022005134 A MX 2022005134A MX 2022005134 A MX2022005134 A MX 2022005134A MX 2022005134 A MX2022005134 A MX 2022005134A
Authority
MX
Mexico
Prior art keywords
methods
epithelium cells
produce retinal
retinal pigmentary
pigmentary epithelium
Prior art date
Application number
MX2022005134A
Other languages
English (en)
Inventor
Yasuhiro Takagi
Meng-Jiao Shi
Mi Sook Chang
Irina Klimanskaya
Original Assignee
Astellas Inst For Regenerative Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Inst For Regenerative Medicine filed Critical Astellas Inst For Regenerative Medicine
Publication of MX2022005134A publication Critical patent/MX2022005134A/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención proporciona un método mejorado para producir células de epitelio pigmentario retiniano (RPE) altamente puras mediante diferenciación de células madre pluripotentes.
MX2022005134A 2019-10-30 2020-10-28 Metodos para producir celulas del epitelio pigmentario retiniano. MX2022005134A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962928125P 2019-10-30 2019-10-30
PCT/US2020/057654 WO2021086911A1 (en) 2019-10-30 2020-10-28 Methods for producing retinal pigment epithelium cells

Publications (1)

Publication Number Publication Date
MX2022005134A true MX2022005134A (es) 2022-05-30

Family

ID=73476265

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022005134A MX2022005134A (es) 2019-10-30 2020-10-28 Metodos para producir celulas del epitelio pigmentario retiniano.

Country Status (14)

Country Link
US (1) US20230072771A1 (es)
EP (1) EP4051785A1 (es)
JP (1) JP2023500830A (es)
KR (1) KR20220106965A (es)
CN (1) CN114981417A (es)
AU (1) AU2020374884A1 (es)
BR (1) BR112022006644A2 (es)
CA (1) CA3158763A1 (es)
CO (1) CO2022007349A2 (es)
IL (1) IL292610A (es)
MX (1) MX2022005134A (es)
PH (1) PH12022550957A1 (es)
TW (1) TW202130806A (es)
WO (1) WO2021086911A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3334415A1 (en) 2015-08-18 2018-06-20 Astellas Institute for Regenerative Medicine Clinical formulations
EP3447129B1 (en) * 2016-04-22 2022-07-20 Sumitomo Pharma Co., Ltd. Method for producing retinal tissue
KR20240028780A (ko) 2022-08-25 2024-03-05 주식회사 엘지에너지솔루션 유체 수송 배관
CN116254229A (zh) * 2023-01-13 2023-06-13 上海市第一人民医院 诱导多能干细胞分化的方法、分化因子组合和细胞药物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012201562B2 (en) * 2004-01-23 2013-07-04 President And Fellows Of Harvard College Improved modalities for the treatment of degenerative diseases of the retina
MX375061B (es) 2004-01-23 2025-03-06 Harvard College Modalidades mejoradas para el tratamiento de enfermedades degenerativas de la retina.
US7794704B2 (en) * 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
EP2479256A1 (en) 2004-11-04 2012-07-25 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
EP2128244A4 (en) * 2007-01-18 2012-05-09 Riken PROCESS FOR INDUCTION / DIFFERENTIATION TO A PHOTOREZEPTORZELLE
JP6087043B2 (ja) 2007-07-31 2017-03-01 ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． ヒトフィーダー細胞を用いた多能性幹細胞の分化
CN104946591A (zh) 2007-10-12 2015-09-30 奥卡塔治疗公司 制备rpe 细胞和rpe 细胞的组合物的改良方法
CA2721952C (en) * 2008-04-22 2019-11-12 Regenerative Research Foundation Retinal pigment epithelial stem cells
WO2011028524A1 (en) * 2009-08-24 2011-03-10 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
WO2011063005A2 (en) 2009-11-17 2011-05-26 Advanced Cell Technology, Inc. Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells
ES2542226T3 (es) * 2010-04-28 2015-08-03 Technische Universität Dresden Método para producir células progenitoras retinianas polarizadas a partir de células madre pluripotentes y su diferenciación para dar células del epitelio pigmentario retiniano
PT3875599T (pt) 2010-07-23 2025-01-22 Astellas Inst For Regenerative Medicine Métodos para deteção de subpopulações raras de células e composições altamente purificadas de células
EP2694644B1 (en) 2011-03-30 2018-01-24 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
CA2855941A1 (en) 2011-11-14 2013-05-23 Advanced Cell Technology, Inc. Pharmaceutical preparations of human rpe cells and uses thereof
DK2951290T3 (en) 2013-02-01 2018-01-22 Us Health PROCEDURE FOR PREPARING RETINAL PIGMENTAL EPIT (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCS)
SG10201802877WA (en) * 2013-10-09 2018-05-30 Healios Kk Method of producing retinal pigment epithelial cell
WO2015175504A1 (en) * 2014-05-12 2015-11-19 The Johns Hopkins University Differentiation of human pluripotent stem cells into retinal pigment epithelium using hif1 inhibitors
ES2980659T3 (es) 2015-03-23 2024-10-02 Astellas Inst For Regenerative Medicine Ensayos mejorados de potencia de células de epitelio pigmentario retiniano (EPR) humano y progenitores de fotorreceptores
EP3334415A1 (en) 2015-08-18 2018-06-20 Astellas Institute for Regenerative Medicine Clinical formulations
AU2016318774B2 (en) 2015-09-08 2022-08-18 FUJIFILM Cellular Dynamics, Inc. MACS-based purification of stem cell-derived retinal pigment epithelium
DK3347456T3 (da) * 2015-09-08 2024-02-19 Us Health Fremgangsmåde til reproducerbar differentiering af retinale pigmentepitelceller af klinisk kvalitet
WO2017072763A1 (en) * 2015-10-26 2017-05-04 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
CN108728413A (zh) * 2017-06-13 2018-11-02 中山大学中山眼科中心 一种人多能干细胞来源人视网膜色素上皮细胞的制备和扩增培养方法
KR20240161220A (ko) 2017-12-29 2024-11-12 셀 큐어 뉴로사이언시스 리미티드 망막 색소 상피 세포 조성물
CN108531443A (zh) * 2018-04-04 2018-09-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 小分子诱导多能性干细胞分化为视网膜色素上皮细胞的方法

Also Published As

Publication number Publication date
AU2020374884A1 (en) 2022-06-09
CO2022007349A2 (es) 2022-08-30
US20230072771A1 (en) 2023-03-09
PH12022550957A1 (en) 2023-11-20
BR112022006644A2 (pt) 2022-07-12
WO2021086911A1 (en) 2021-05-06
KR20220106965A (ko) 2022-08-01
TW202130806A (zh) 2021-08-16
CA3158763A1 (en) 2021-05-06
EP4051785A1 (en) 2022-09-07
IL292610A (en) 2022-07-01
JP2023500830A (ja) 2023-01-11
CN114981417A (zh) 2022-08-30

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