MX2022002878A - Compuestos 5,6-heteroaromaticos que contienen bencilaminas utiles contra la infeccion por micobacterias. - Google Patents
Compuestos 5,6-heteroaromaticos que contienen bencilaminas utiles contra la infeccion por micobacterias.Info
- Publication number
- MX2022002878A MX2022002878A MX2022002878A MX2022002878A MX2022002878A MX 2022002878 A MX2022002878 A MX 2022002878A MX 2022002878 A MX2022002878 A MX 2022002878A MX 2022002878 A MX2022002878 A MX 2022002878A MX 2022002878 A MX2022002878 A MX 2022002878A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- hydrogen atom
- compounds useful
- benzyl amine
- heteroaromatic compounds
- Prior art date
Links
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 title 2
- 206010062207 Mycobacterial infection Diseases 0.000 title 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto representado por la fórmula (I) (ver Fórmula):, o su sal farmacéuticamente aceptable, en donde un grupo representado por la fórmula (II): (ver Fórmula) es un grupo representado por la fórmula (III) o (IV): (ver Fórmulas) cada uno de R1 es independientemente halógeno, hidroxi, ciano o similares; m es 0, 1, 2, 3 o 4; R2 es un átomo de hidrógeno, halógeno, ciano, alquilo sustituido o no sustituido o similar; cada uno de R3a, R3b, R3c y R3d es independientemente un átomo de hidrógeno, halógeno o similar, con la condición de que R3a, R3b, R3c y R3d no sean simultáneamente un átomo de hidrógeno; el anillo C se representa de la siguiente manera (V), (VI), (VII), (VIII), (IX) o (X): (ver Fórmulas) X es CH o N; Y es CH o N; cada uno de R4 es independientemente halógeno, hidroxi, ciano o similares; p es 0 o 1; q es 0, 1, 2, 3 o 4; R5 es CR5C o N; R6 es CR6C o N; R7 es CR7C o N; R8 es CR8C o N; R9 es CR9C o N; con la condición de que R5, R6, R7, R8 y R9 no sean simultáneamente N; R5C, R6C, R7C, R8C y R9C son cada uno independientemente un átomo de hidrógeno o similar.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962898066P | 2019-09-10 | 2019-09-10 | |
| PCT/US2020/050173 WO2021050708A1 (en) | 2019-09-10 | 2020-09-10 | Benzyl amine-containing 5,6-heteroaromatic compounds useful against mycobacterial infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022002878A true MX2022002878A (es) | 2022-05-06 |
Family
ID=74866045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022002878A MX2022002878A (es) | 2019-09-10 | 2020-09-10 | Compuestos 5,6-heteroaromaticos que contienen bencilaminas utiles contra la infeccion por micobacterias. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220340566A1 (es) |
| EP (1) | EP4028130A4 (es) |
| JP (1) | JP7665599B2 (es) |
| CN (2) | CN114401965A (es) |
| AU (1) | AU2020344572A1 (es) |
| BR (1) | BR112022004125A2 (es) |
| CA (1) | CA3153724A1 (es) |
| IL (1) | IL291187B1 (es) |
| MX (1) | MX2022002878A (es) |
| PH (1) | PH12022550559A1 (es) |
| TW (1) | TWI861208B (es) |
| WO (1) | WO2021050708A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202237116A (zh) * | 2020-12-02 | 2022-10-01 | 日商塩野義製藥股份有限公司 | 以組合細胞色素bc1抑制劑與克拉黴素或阿奇黴素為特徵之用於治療分枝桿菌感染之藥物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2572387T3 (es) * | 2010-03-18 | 2016-05-31 | Pasteur Institut Korea | Compuestos anti-infecciosos |
| ES2883565T3 (es) * | 2013-08-02 | 2021-12-09 | Pasteur Institut Korea | Compuestos antiinfecciosos |
| CN105524058B (zh) * | 2014-10-21 | 2018-03-27 | 广州艾格生物科技有限公司 | 吡唑并[1,5‑a]吡啶类化合物及其应用 |
| IL257743B (en) * | 2015-09-17 | 2022-08-01 | Marvin J Miller | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| CN107243008B (zh) * | 2017-04-13 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物 |
| CN108159049B (zh) * | 2018-02-01 | 2021-01-05 | 中国科学院广州生物医药与健康研究院 | 一种吡啶类化合物的新用途 |
| US20220235047A1 (en) * | 2019-05-28 | 2022-07-28 | Shionogi & Co., Ltd. | A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME bc1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMINE |
-
2020
- 2020-09-08 TW TW109130764A patent/TWI861208B/zh active
- 2020-09-10 PH PH1/2022/550559A patent/PH12022550559A1/en unknown
- 2020-09-10 BR BR112022004125A patent/BR112022004125A2/pt unknown
- 2020-09-10 MX MX2022002878A patent/MX2022002878A/es unknown
- 2020-09-10 CN CN202080062740.1A patent/CN114401965A/zh active Pending
- 2020-09-10 CN CN202210604012.XA patent/CN115093408B/zh active Active
- 2020-09-10 WO PCT/US2020/050173 patent/WO2021050708A1/en not_active Ceased
- 2020-09-10 EP EP20863977.3A patent/EP4028130A4/en active Pending
- 2020-09-10 CA CA3153724A patent/CA3153724A1/en active Pending
- 2020-09-10 JP JP2022515760A patent/JP7665599B2/ja active Active
- 2020-09-10 AU AU2020344572A patent/AU2020344572A1/en active Pending
- 2020-09-10 US US17/641,668 patent/US20220340566A1/en active Pending
-
2022
- 2022-03-08 IL IL291187A patent/IL291187B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI861208B (zh) | 2024-11-11 |
| JP7665599B2 (ja) | 2025-04-21 |
| BR112022004125A2 (pt) | 2022-05-31 |
| IL291187A (en) | 2022-05-01 |
| IL291187B1 (en) | 2025-12-01 |
| JP2022547228A (ja) | 2022-11-10 |
| EP4028130A4 (en) | 2023-08-30 |
| TW202124379A (zh) | 2021-07-01 |
| CN115093408B (zh) | 2025-03-11 |
| PH12022550559A1 (en) | 2023-03-20 |
| US20220340566A1 (en) | 2022-10-27 |
| CN114401965A (zh) | 2022-04-26 |
| EP4028130A1 (en) | 2022-07-20 |
| WO2021050708A1 (en) | 2021-03-18 |
| CN115093408A (zh) | 2022-09-23 |
| CA3153724A1 (en) | 2021-03-18 |
| KR20220062021A (ko) | 2022-05-13 |
| AU2020344572A1 (en) | 2022-04-21 |
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